| Interacting proteins: Q9UQF2 and P05067 |
Pubmed |
SVM Score :0.74725675 |
| We found that , within the cellular context , JIP 1 preferentially interacts with Thr ( 668 ) phosphorylated APP ( pAPP ) , compared with nonphosphorylated APP . 0.74725675^^^ |
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| Interacting proteins: Q9UQF2 and P05067 |
Pubmed |
SVM Score :0.0 |
| Jun NH 2 terminal kinase ( JNK ) interacting protein 1 ( JIP 1 ) binds the cytoplasmic domain of the Alzheimer ' s beta amyloid precursor protein ( APP ) . ^^^ Hoping to gain clues about the function of APP , we used the yeast two hybrid system to identify interaction between the AID region of APP and JNK interacting protein 1 ( JIP 1 ) . ^^^ |
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| Interacting proteins: Q9UQF2 and P05067 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that the mechanism is different from activation in combination with Fe 65 by first showing that although Fe 65 enters the nucleus in the absence of full length A beta PP , JIP 1 does not . ^^^ Finally , and probably most interestingly , we show that although the A beta PP family members APLP 1 and APLP 2 ( for amyloid beta precursor like protein ) can cause activation in combination with Fe 65 , APLP 1 and APLP 2 show little or no activation in combination with JIP 1 . ^^^ |
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| Interacting proteins: Q9UQF2 and P05067 |
Pubmed |
SVM Score :0.0 |
| Although mDab 1 and Jip 1 have no effect , Shc induces a strong activation of APP cleavage , and the contemporary exposure of cells to PDGF causes a dramatic cooperative effect . ^^^ |
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| Interacting proteins: Q9UQF2 and P05067 |
Pubmed |
SVM Score :0.0 |
| In clonal neuroblastoma cultures , stresses such as hypoxia , ischemia , Abeta peptides , and UV irradiation rapidly reduced JIP 1 expression . ^^^ |
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| Interacting proteins: Q9UQF2 and P05067 |
Pubmed |
SVM Score :0.0 |
| In addition to known interacting proteins containing a phosphotyrosine interaction domain ( PID ) Fe 65 , Fe65L , Fe65L2 , X 11 , and mDab 1 , we identified , as a novel APP interacting molecule , a PID containing isoform of mouse JNK interacting protein 1 ( JIP 1b ) and its human homolog IB 1 , the established scaffold proteins for JNK . ^^^ |
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| Interacting proteins: Q9UQF2 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQF2 and P05067 |
Pubmed |
SVM Score :0.0 |
| NA |
|