| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| When a dominant negative mutant of JNK kinase 2 ( dnJNKK 2 ) , an upstream regulator of JNK , and JNK interacting protein 1 ( JIP 1 ) were expressed in myocytes by recombinant adenovirus , the activation of JNK by simulated MI was reduced 53 % . ^^^ |
|
| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| The JNK interacting protein 1 ( JIP 1 ) scaffold protein specifically binds JNK , MAP kinase kinase 7 , and members of the MLK family and is essential for stress mediated JNK activation in neurones . ^^^ |
|
| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| Coexpression of dominant negative versions of kinases of the JNK pathway , such as catalytically inactive forms of MEKK 1 , MKK 7 , and JNKK , and of cytoplasmic JNK inhibitor JIP 1 , as well as treatment of cells with curcumin ( which blocks JNK activation by MNNG ) , inhibited MNNG induced uPA transcriptional activity . ^^^ |
|
| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| JIP 1 , one of the scaffold proteins , has been shown to be associated with MLKs , MKK 7 , and JNK [ Whitmarsh , A . ^^^ |
|
| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| JIP 1 specifically scaffolds JNK , MKK 7 , and members of the mixed lineage kinase ( MLK ) family , implicating these kinases upstream of JNK in the apoptotic pathway induced by PBOX 6 in K 562 cells . . ^^^ |
|
| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| The JNK activation requires the presence of the murine scaffold protein JNK interacting protein 1 ( JIP 1 ) or human Islet brain 1 ( IB 1 ) , which organizes MLK 3 , MKK 7 and JNK for proper signaling specificity . ^^^ |
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| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| Interestingly , at the same time point the binding of JIP 1 to p MKK 7 reached a maximum . ^^^ The result showed that the levels of MKK 7 activation , translocation and binding of p MKK 7 to JIP 1 were obviously limited by N acetylcysteine in the cytosol at 30 min after reperfusion . ^^^ The findings suggested that MKK 7 activation , translocation and binding to JIP 1 were closely associated with reactive oxygen species and might play a pivotal role in the activation of the JNK signaling pathway in brain ischemic injury . . ^^^ |
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| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| Conversely , overexpression of JIP 1 decreased both nuclear translocation of activated JNK , and c Jun phosphorylation induced by either UV irradiation , or the JNK upstream activators , MKK 7 or MEKK 1 . ^^^ |
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| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| Peptide versions of the D sites from MKK 4 or the JIP 1 scaffold protein inhibited MKK 7 JNK binding , suggesting that all three JNK regulators bind to the same region of JNK . ^^^ |
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| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| The B1R JIP 1 complex increases the amount of MAPK bound to JIP 1 ; thus , MKK 7 and TAK 1 either bind with higher affinity or bind more stably to JIP 1 , while there is an increase in the phosphorylation state of JNK bound to JIP 1 . ^^^ |
|
| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14733 and Q9UQF2 |
Pubmed |
SVM Score :0.0 |
| NA |
|