| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :1.0903583 |
| S . cerevisiae EXO 1 interacted with both S . cerevisiae and human MSH 2 in two hybrid and coimmunoprecipitation experiments . exo 1 mutants showed a mutator phenotype , and epistasis analysis was consistent with EXO 1 functioning in the MSH 2 dependent mismatch repair pathway . exo 1 mutations were lethal in combination with rad 27 mutations , and overexpression of EXO 1 suppressed both the temperature sensitive and mutator phenotypes of rad 27 mutants . . 1.0903583^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Here we show that mice mutant for exonuclease 1 ( Exo 1 ) , which participates in DNA mismatch repair ( MMR ) , have decreased CSR and changes in the characteristics of SHM similar to those previously observed in mice mutant for the MMR protein Msh 2 . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that these mutant HNPCC hMLH 1 proteins are unable to form complexes with hEXO 1 and hPMS 2 in vivo . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Recently , eight missense mutations in hEXO 1 were identified in atypical HNPCC patients , who have been screened to be negative for hMSH 2 , hMLH 1 , and hMSH 6 mutations . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| In addition , a sixth gene ( hEXO 1 ) has been associated with a disease phenotype that is consistent with HNPCC . ^^^ In this report , we examine the contribution of hPMS 2 and hEXO 1 to a well defined set of families that fulfill the diagnostic criteria for HNPCC . ^^^ The genes , hPMS 2 and hEXO 1 , were studied by denaturing high performance liquid chromatography ( DHPLC ) analysis in 21 families that have previously been determined not to have mutations in hMSH 2 or hMLH 1 . hPMS 2 accounts for a small proportion of HNPCC families , and none were deemed to be associated with hEXO 1 . ^^^ Mutations in hPMS 2 appear to account for a small proportion of families adhering to the Amsterdam 2 criteria , whereas hEXO 1 does not appear to be associated with HNPCC . . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Further , it suggests that the EXO 1 , RAD 51 and MSH 2 genes control independent mechanisms for the maintenance of UV resistance . . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| The EXO 1 gene was identified in Saccharomyces cerevisiae as a gene encoding an exonuclease that interacts with MSH 2 and functions in mismatch repair and genetic recombination . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Schizosaccharomyces pombe exo 1 is involved in the same mismatch repair pathway as msh 2 and pms 1 . ^^^ Furthermore , msh 2 delta was epistatic over exo 1 delta , and the ExoI enzyme is likely to be redundant with other exonucleases . . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Genetic interactions were examined among DNA polymerase epsilon ( pol 2 4 ) and delta ( pol 3 01 ) mutants defective in 3 ' > 5 ' proofreading exonuclease , mutants defective in the 5 ' > 3 ' exonuclease Exo 1 , and mismatch repair mutants ( msh 2 , msh 3 , or msh 6 ) . ^^^ Surprisingly , the mutation rate in an exo 1 pol3 01 mutant was comparable to that in an msh 2 pol3 01 mutant , suggesting that they participate directly in postreplication mismatch repair as well as in other DNA metabolic processes . . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| EXO 1 and MSH 6 are high copy suppressors of conditional mutations in the MSH 2 mismatch repair gene of Saccharomyces cerevisiae . ^^^ The conditional inviability of two mutants , msh 2 L560S pol 3 01 and msh 2 L910P pol 3 01 , was suppressed by overexpression of EXO 1 and MSH 6 , respectively . ^^^ High copy plasmids bearing mutations in the conserved EXO 1 nuclease domain were unable to suppress msh 2 L560S pol 3 01 conditional lethality . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Germline mutations of EXO 1 gene in patients with hereditary nonpolyposis colorectal cancer ( HNPCC ) and atypical HNPCC forms . ^^^ The recently cloned EXO 1 gene might be involved in the pathogenesis of HNPCC because the EXO 1 protein strongly interacts with the MSH 2 protein . ^^^ To determine its role in HNPCC , EXO 1 was scanned for germline mutations . ^^^ METHODS : All 14 exons of EXO 1 were scanned for mutations in index patients from 33 families with HNPCC fulfilling the Amsterdam criteria and in 225 index patients suspected of HNPCC . ^^^ RESULTS : Germline variants of EXO 1 were detected in 14 patients , including one splice site mutation in a family with HNPCC and 13 missense mutations in patients with atypical HNPCC . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Moreover , defective rhp 14 caused instability of a GT repeat , similar to swi 10 and synergistically with msh 2 and exo 1 . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Recently , mutations in the DNA repair gene EXO 1 have been implicated in HNPCC . ^^^ Thus , little evidence was obtained to support a major causative role of EXO 1 in HNPCC , although we can not exclude a role for EXO 1 as a low penetrance cancer susceptibility or modifying gene . . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Such duplications were less frequent in double mutants additionally defective in msh 2 , msh 6 , rad 2 , or exo 1 . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| We compare a MMR proficient strain to strains deleted for the MMR genes MSH 2 , MSH 6 , MLH 1 , or EXOI . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| In one recent study , germline variants of EXO 1 were reported to be associated with predisposition to colorectal cancer in families with phenotypes similar to hereditary nonpolyposis colon cancer ( HNPCC ) . ^^^ We investigated these families for any indication of predisposition to colorectal cancer or other HNPCC spectrum cancers by means of detailed questionnaires , interviews , and examination of EXO 1 null skin leiomyomata for microsatellite instability ( MSI ) . ^^^ This study questions the functional significance of previously reported variants of EXO 1 reported in HNPCC like families and suggests that in humans there may be other as yet undiscovered proteins that have exonuclease function overlapping with that of EXO 1 in DNA mismatch repair . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Mutation rates and spectra and synergistic interactions of the pol 3 L523X mutations with msh 2 , exo 1 , and rad27 / fen1 defects were indistinguishable from those observed with previously studied exonuclease defective mutants of the Pol delta . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| Therefore , PSO 2 , EXO 1 , and MSH 2 also appear to have overlapping roles in the processing of some forms of endogenous DNA damage that occur at an irreversibly collapsed replication fork . ^^^ |
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| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQ84 and P43246 |
Pubmed |
SVM Score :0.0 |
| NA |
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