| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.94902412 |
| Here , we demonstrate that hExoI binds strongly to hMLH 1 , and we describe interaction regions between hExoI and the MMR proteins hMSH 2 , hMSH 3 , and hMLH 1 . 0.94902412^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that these mutant HNPCC hMLH 1 proteins are unable to form complexes with hEXO 1 and hPMS 2 in vivo . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| Recently , eight missense mutations in hEXO 1 were identified in atypical HNPCC patients , who have been screened to be negative for hMSH 2 , hMLH 1 , and hMSH 6 mutations . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| Surprisingly , MSI was not detected in 86MI and it appears to express all the major MMR components hMSH 2 , hMSH 6 , hMLH 1 , hPMS 2 , hMSH 3 , hMLH 3 , MBD 4 ( MED 1 ) and hExo 1 . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| The genes , hPMS 2 and hEXO 1 , were studied by denaturing high performance liquid chromatography ( DHPLC ) analysis in 21 families that have previously been determined not to have mutations in hMSH 2 or hMLH 1 . hPMS 2 accounts for a small proportion of HNPCC families , and none were deemed to be associated with hEXO 1 . ^^^ In addition , a sixth gene ( hEXO 1 ) has been associated with a disease phenotype that is consistent with HNPCC . ^^^ In this report , we examine the contribution of hPMS 2 and hEXO 1 to a well defined set of families that fulfill the diagnostic criteria for HNPCC . ^^^ Mutations in hPMS 2 appear to account for a small proportion of families adhering to the Amsterdam 2 criteria , whereas hEXO 1 does not appear to be associated with HNPCC . . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| Germline mutations of EXO 1 gene in patients with hereditary nonpolyposis colorectal cancer ( HNPCC ) and atypical HNPCC forms . ^^^ The recently cloned EXO 1 gene might be involved in the pathogenesis of HNPCC because the EXO 1 protein strongly interacts with the MSH 2 protein . ^^^ To determine its role in HNPCC , EXO 1 was scanned for germline mutations . ^^^ METHODS : All 14 exons of EXO 1 were scanned for mutations in index patients from 33 families with HNPCC fulfilling the Amsterdam criteria and in 225 index patients suspected of HNPCC . ^^^ RESULTS : Germline variants of EXO 1 were detected in 14 patients , including one splice site mutation in a family with HNPCC and 13 missense mutations in patients with atypical HNPCC . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| The mutator phenotype exhibited in mlh 1 I296S strains was partially suppressed at 35 degrees by EXO 1 overexpression . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| Recently , mutations in the DNA repair gene EXO 1 have been implicated in HNPCC . ^^^ Thus , little evidence was obtained to support a major causative role of EXO 1 in HNPCC , although we can not exclude a role for EXO 1 as a low penetrance cancer susceptibility or modifying gene . . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| We compare a MMR proficient strain to strains deleted for the MMR genes MSH 2 , MSH 6 , MLH 1 , or EXOI . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| In one recent study , germline variants of EXO 1 were reported to be associated with predisposition to colorectal cancer in families with phenotypes similar to hereditary nonpolyposis colon cancer ( HNPCC ) . ^^^ We investigated these families for any indication of predisposition to colorectal cancer or other HNPCC spectrum cancers by means of detailed questionnaires , interviews , and examination of EXO 1 null skin leiomyomata for microsatellite instability ( MSI ) . ^^^ This study questions the functional significance of previously reported variants of EXO 1 reported in HNPCC like families and suggests that in humans there may be other as yet undiscovered proteins that have exonuclease function overlapping with that of EXO 1 in DNA mismatch repair . ^^^ |
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| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| The phenotype of Exo 1 ( / ) mice and the finding that Exo 1 and Mlh 1 are physically associated with mutating variable regions support the idea that Exo 1 and MMR participate directly in SHM and CSR . . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| Here we review data for the role of Msh 4 , Msh 5 , Mlh 1 , Mlh 3 and Exo 1 in crossing over . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| Reduced viability is observed in the absence of any of the core MMR proteins Msh 2 , Mlh 1 , or Pms 1 and severe sensitivity to PAA is observed in the absence of the core proteins Msh 6 or Exo 1 , but not Msh 3 . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| These studies have shown that PCNA interacts directly with several MMR components , including MSH 3 , MSH 6 , MLH 1 , and EXO 1 . ^^^ |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQ84 and P40692 |
Pubmed |
SVM Score :0.0 |
| NA |
|