| Interacting proteins: Q9UQ80 and P21860 |
Pubmed |
SVM Score :0.52431618 |
| The interaction of Ebp 1 with ErbB 3 was examined in vitro and in vivo . 0.52431618^^^ |
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| Interacting proteins: Q9UQ80 and P21860 |
Pubmed |
SVM Score :0.0 |
| Specificity and heregulin regulation of Ebp 1 ( ErbB 3 binding protein 1 ) mediated repression of androgen receptor signalling . ^^^ |
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| Interacting proteins: Q9UQ80 and P21860 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of the ErbB 3 binding protein ebp 1 inhibits growth and induces differentiation of human breast cancer cell lines . ^^^ Ebp 1 , an ErbB 3 binding protein , translocates from the cytoplasm to the nucleus of human breast cancer cells after treatment with the ErbB 3 ligand , heregulin . ^^^ The purpose of these studies was to examine the effects of ectopic expression of ebp 1 on the biological properties of human ErbB 3 expressing breast carcinoma cell lines . ^^^ Ectopic expression of ebp 1 in ErbB 2 , ErbB 3 expressing breast carcinoma cell lines resulted in inhibition of colony formation , a decreased proliferation rate , an accumulation of cells in the G2 / M phase of the cell cycle , and suppression of growth in soft agar . ^^^ These data demonstrate that ectopic expression of the ErbB 3 binding protein Ebp 1 inhibits proliferation and induces differentiation of ErbB 2 , ErbB 3 expressing human breast carcinoma cell lines . . ^^^ |
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| Interacting proteins: Q9UQ80 and P21860 |
Pubmed |
SVM Score :0.0 |
| Regulation of the ErbB 3 binding protein Ebp 1 by protein kinase C . ^^^ Ebp 1 , a 47 kDa ubiquituously expressed protein , binds the ErbB 3 receptor in human serum starved breast cancer cell lines and dissociates from ErbB 3 on treatment with the ErbB 3 ligand , Heregulin ( HRG ) . ^^^ The ability of Ebp 1 to associate with ErbB 3 in serum starved NIH3T3 cells overexpresssing ErbB 3 was abrogated by treating cells with a PKC inhibitor . ^^^ |
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| Interacting proteins: Q9UQ80 and P21860 |
Pubmed |
SVM Score :0.0 |
| Repression of androgen receptor mediated transcription by the ErbB 3 binding protein , Ebp 1 . ^^^ Ebp 1 , an ErbB 3 binding protein recently cloned in our laboratory , possesses an LXXLL motif important in mediating interactions with nuclear hormone receptors . ^^^ |
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| Interacting proteins: Q9UQ80 and P21860 |
Pubmed |
SVM Score :0.0 |
| Repression of E2F1 mediated transcription by the ErbB 3 binding protein Ebp 1 involves histone deacetylases . ^^^ Ebp 1 , an ErbB 3 binding protein that is a member of the proliferation associated PA2G4 family , inhibits the proliferation and induces the differentiation of human ErbB positive breast and prostate cancer cell lines . ^^^ |
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| Interacting proteins: Q9UQ80 and P21860 |
Pubmed |
SVM Score :0.0 |
| Heregulin regulates the ability of the ErbB 3 binding protein Ebp 1 to bind E2F promoter elements and repress E2F mediated transcription . ^^^ Ebp 1 , a protein isolated by its binding to ErbB 3 , inhibits cell growth and represses transcription of E2F regulated cell cycle genes . ^^^ |
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| Interacting proteins: Q9UQ80 and P21860 |
Pubmed |
SVM Score :0.0 |
| The ErbB 3 binding protein Ebp 1 suppresses androgen receptor mediated gene transcription and tumorigenesis of prostate cancer cells . ^^^ We report that Ebp 1 , a protein identified by its interactions with the ErbB 3 receptor , down regulates expression of AR and AR regulated genes in the LNCaP prostate cancer cell line . ^^^ |
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| Interacting proteins: Q9UQ80 and P21860 |
Pubmed |
SVM Score :0.0 |
| The ErbB 3 binding protein Ebp 1 interacts with Sin3A to repress E2F1 and AR mediated transcription . ^^^ |
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| Interacting proteins: Q9UQ80 and P21860 |
Pubmed |
SVM Score :0.0 |
| Ebp 1 , an ErbB 3 receptor binding protein , inhibits the proliferation and induces the differentiation of human cancer cells . ^^^ EGF strongly stimulates p 42 to bind ErbB 3 , and the association depends on PKC mediated phosphorylation of Ebp 1 . ^^^ |
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