| Interacting proteins: Q9UQ80 and P10275 |
Pubmed |
SVM Score :0.74608872 |
| We demonstrate in this study that Ebp 1 bound to AR in vitro and in vivo , and that this binding was increased by androgen treatment . 0.74608872^^^ |
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| Interacting proteins: Q9UQ80 and P10275 |
Pubmed |
SVM Score :1.5686634 |
| Ebp 1 , a protein cloned via its association with the ErbB 3 receptor , binds the AR and inhibits androgen regulated transactivation of wild type AR in COS cells . 1.5686634^^^ In contrast , HRG treatment enhanced both the association of Ebp 1 with AR and also the ability of Ebp 1 to repress AR transactivation . 0.64170386^^^ |
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| Interacting proteins: Q9UQ80 and P10275 |
Pubmed |
SVM Score :0.0 |
| The ErbB 3 binding protein Ebp 1 suppresses androgen receptor mediated gene transcription and tumorigenesis of prostate cancer cells . ^^^ We report that Ebp 1 , a protein identified by its interactions with the ErbB 3 receptor , down regulates expression of AR and AR regulated genes in the LNCaP prostate cancer cell line . ^^^ Using microarray analysis , we identified six endogenous AR target genes , including the AR itself , that are down regulated by ebp 1 overexpression . ^^^ Chromatin immunoprecipitation assays revealed that Ebp 1 was recruited to the prostate specific antigen gene promoter in response to the androgen antagonist bicalutamide , suggesting that Ebp 1 directly affected the expression of AR regulated genes in response to androgen antagonists . ^^^ Androgens failed to stimulate either the growth of ebp 1 transfectants or transcription of AR regulated reporter genes in these cells . ^^^ |
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| Interacting proteins: Q9UQ80 and P10275 |
Pubmed |
SVM Score :0.0 |
| Ebp 1 inhibits transcription of E2F1 and androgen receptor regulated genes such as prostate specific antigen ( PSA ) through its interactions with histone deacetylases ( HDACs ) . ^^^ Functionally , Sin3A enhanced the ability of Ebp 1 to repress transcription of androgen receptor ( AR ) and E2F1 regulated genes . ^^^ The ErbB 3 binding protein Ebp 1 interacts with Sin3A to repress E2F1 and AR mediated transcription . ^^^ |
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| Interacting proteins: Q9UQ80 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UQ80 and P10275 |
Pubmed |
SVM Score :0.0 |
| NA |
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