| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| Here we show that in vivo mammalian FMRP interacts with microRNAs and the components of the microRNA pathways including Dicer and the mammalian ortholog of Argonaute 1 ( AGO 1 ) . ^^^ |
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| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| Short interfering RNA mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors . ^^^ Here , we show that Dicer and eIF2C translation initiation factors belonging to the PIWI family ( eIF2C1 4 ) play an essential role in mammalian siRNA mediated PTGS , most probably through synergistic interactions . ^^^ Immunoprecipitation experiments suggest that , in human and mouse cells , complex formation occurs between Dicer and eIF2C1 or 2 and that the PIWI domain of eIF2C is essential for the formation of this complex . . ^^^ |
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| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed . ^^^ |
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| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain dependent manner . ^^^ In adult mouse brain , dicer and the RNA induced silencing complex ( RISC ) component eIF2c were expressed in the somatodendritic compartment of principal neurons and some interneurons in many regions , and dicer was enriched in dendritic spines and postsynaptic densities ( PSDs ) . ^^^ A portion of dicer and eIF2c were associated with each other and with fragile 10 mental retardation protein ( FMRP ) , as assessed by co immunoprecipitation . ^^^ Purified PSDs did not exhibit RNAse 3 activity , but calpain caused release of dicer from PSDs in an enzymatically active form , together with eIF2c . ^^^ The findings support a model whereby acute neuronal stimulation at excitatory synapses increases intracellular calcium , which activates calpain , which liberates dicer and eIF2c bound to PSDs . ^^^ |
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| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| An RNAi based screen performed in Drosophila S 2 cells has revealed that Dicer 1 , Argonaute 1 ( Ago 1 ) and Ago 2 , components involved in microRNA ( miRNA ) processing and function , are required for the rapid decay of mRNA containing AREs of tumor necrosis factor alpha . ^^^ |
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| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| We show that the RNAi components , Argonaute ( Ago 1 ) , Dicer ( Dcr 1 ) and RNA dependent RNA polymerase ( Rdp 1 ) , are required to maintain silencing , lysine 9 methylation of histone H 3 and association of Swi 6 via this dg ectopic silencer . ^^^ |
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| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| The Schizosaccharomyces pombe genome encodes only one of each of the three major classes of proteins implicated in RNA silencing : Dicer ( Dcr 1 ) , RNA dependent RNA polymerase ( RdRP ; Rdp 1 ) , and Argonaute ( Ago 1 ) . ^^^ |
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| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| Interestingly , in cells lacking the Argonaute ( Ago 1 ) protein component of the RITS complex , or lacking Dicer ( and hence siRNAs ) , Chp 1 and Tas 3 can still bind to noncentromeric loci , although their association with centromeres is lost . ^^^ |
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| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| Several known Ago 1 and / or Ago 2 associated proteins including Dicer were identified , but also two novel factors , the putative RNA helicase MOV 10 , and the RNA recognition motif ( RRM ) containing protein TNRC6B / KIAA1093 . ^^^ |
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| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UL18 and Q9UPY3 |
Pubmed |
SVM Score :0.0 |
| NA |
|