| Interacting proteins: Q9UPR3 and Q92900 |
Pubmed |
SVM Score :0.0 |
| Characterization of human Smg5 / 7a : a protein with similarities to Caenorhabditis elegans SMG 5 and SMG 7 that functions in the dephosphorylation of Upf 1 . ^^^ |
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| Interacting proteins: Q9UPR3 and Q92900 |
Pubmed |
SVM Score :0.0 |
| Here we show that phosphorylated hUPF 1 , the human ortholog of UPF1 / SMG 2 , forms a complex with human orthologs of the C . elegans NMD proteins SMG 5 and SMG 7 . ^^^ |
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| Interacting proteins: Q9UPR3 and Q92900 |
Pubmed |
SVM Score :0.0 |
| The proteins UPF 1 , SMG 5 , SMG 6 , and SMG 7 are essential NMD factors in metazoa . ^^^ SMG 5 and SMG 7 form a complex with UPF 1 and interact with each other via their N terminal domains . ^^^ When SMG 7 is tethered to a reporter transcript , it elicits its degradation , bypassing the requirement for a PTC , UPF 1 , SMG 5 , or SMG 6 . ^^^ Our findings indicate that SMG 7 provides a link between the NMD and the mRNA degradation machinery by interacting with SMG 5 and UPF 1 via its N terminal domain and targeting bound transcripts for decay via its C terminal domain . . ^^^ |
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| Interacting proteins: Q9UPR3 and Q92900 |
Pubmed |
SVM Score :0.0 |
| UPF 1 is targeted for dephosphorylation by three related proteins , SMG 5 , SMG 6 , and SMG 7 . ^^^ |
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| Interacting proteins: Q9UPR3 and Q92900 |
Pubmed |
SVM Score :0.0 |
| These include SMG 5 , SMG 7 , and UPF 1 , which function in nonsense mediated mRNA decay ( NMD ) , and the Argonaute proteins that are essential for RNA interference ( RNAi ) and the micro RNA ( miRNA ) pathway . ^^^ |
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| Interacting proteins: Q9UPR3 and Q92900 |
Pubmed |
SVM Score :0.0 |
| We show that UPF 1 , UPF 2 , UPF 3 , SMG 1 , SMG 5 , and SMG 6 regulate in concert the expression of a cohort of genes with functions in a wide range of cellular activities , including cell cycle progression . ^^^ |
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| Interacting proteins: Q9UPR3 and Q92900 |
Pubmed |
SVM Score :0.0 |
| NA |
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