| Interacting proteins: Q92540 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| In smg 5 , smg 6 , and smg 7 mutants , a phosphorylated isoform of SMG 2 accumulated to abnormally high levels . ^^^ In smg 2 ( r 866 ) and smg 2 ( r 895 ) mutants , which harbor single amino acid substitutions of the SMG 2 nucleotide binding site , phosphorylated SMG 2 accumulated to abnormally high levels , similar to those observed in smg 5 , smg 6 , and smg 7 mutants . ^^^ |
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| Interacting proteins: Q92540 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| SMG 5 interacts with at least four proteins : ( 1 ) SMG 7 , a previously identified protein required for NMD ; ( 2 ) SMG 2 , a phosphorylated protein required for NMD in worms , yeasts and mammals ; ( 3 ) PR 65 , the structural subunit of protein phosphatase 2A ( PP2A ) ; and ( 4 ) PP2A ( C ) , the catalytic subunit of PP2A . ^^^ Previous work demonstrated that both SMG 5 and SMG 7 are required for efficient dephosphorylation of SMG 2 . ^^^ |
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| Interacting proteins: Q92540 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| Characterization of human Smg5 / 7a : a protein with similarities to Caenorhabditis elegans SMG 5 and SMG 7 that functions in the dephosphorylation of Upf 1 . ^^^ |
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| Interacting proteins: Q92540 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| Here we show that the Drosophila orthologs of UPF 1 3 , SMG 1 , SMG 5 and SMG 6 are required for the degradation of PTC containing mRNAs , but that there is no SMG 7 ortholog in this organism . ^^^ |
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| Interacting proteins: Q92540 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| Here we show that phosphorylated hUPF 1 , the human ortholog of UPF1 / SMG 2 , forms a complex with human orthologs of the C . elegans NMD proteins SMG 5 and SMG 7 . ^^^ |
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| Interacting proteins: Q92540 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| The proteins UPF 1 , SMG 5 , SMG 6 , and SMG 7 are essential NMD factors in metazoa . ^^^ SMG 5 and SMG 7 form a complex with UPF 1 and interact with each other via their N terminal domains . ^^^ Here we show that SMG 5 and SMG 7 colocalize in cytoplasmic mRNA decay bodies , while SMG 6 forms separate cytoplasmic foci . ^^^ When SMG 7 is tethered to a reporter transcript , it elicits its degradation , bypassing the requirement for a PTC , UPF 1 , SMG 5 , or SMG 6 . ^^^ In contrast , SMG 5 requires SMG 7 to trigger mRNA decay and to localize to decay bodies . ^^^ |
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| Interacting proteins: Q92540 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| UPF 1 is targeted for dephosphorylation by three related proteins , SMG 5 , SMG 6 , and SMG 7 . ^^^ The 14 3 3 site of SMG 7 is conserved in SMG 5 and SMG 6 . ^^^ |
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| Interacting proteins: Q92540 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| These include SMG 5 , SMG 7 , and UPF 1 , which function in nonsense mediated mRNA decay ( NMD ) , and the Argonaute proteins that are essential for RNA interference ( RNAi ) and the micro RNA ( miRNA ) pathway . ^^^ |
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| Interacting proteins: Q92540 and Q9UPR3 |
Pubmed |
SVM Score :0.0 |
| NA |
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