| Interacting proteins: Q9UMX6 and P51841 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UMX6 and P51841 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UMX6 and P51841 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UMX6 and P51841 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UMX6 and P51841 |
Pubmed |
SVM Score :0.0 |
| The present study shows that : ( 1 ) GCAP 2 is a specific modulator of ROS GC 2 ; ( 2 ) through systematic remodeling of ROS GC modules , the study also shows that the modulated domain resides within the amino acid segment 736 1020 . ^^^ |
|
| Interacting proteins: Q9UMX6 and P51841 |
Pubmed |
SVM Score :0.0 |
| Functionally therefore , the retGC 2 and GCAP 2 mutations are similar in reducing the feedback inhibition of Ca2+ on cyclase activity and thereby on cGMP levels in the photoreceptors . . ^^^ |
|
| Interacting proteins: Q9UMX6 and P51841 |
Pubmed |
SVM Score :0.0 |
| RetGC 1 and RetGC 2 are photoreceptor membrane guanylyl cyclases that are regulated by the Ca2+ binding protein , GCAP 2 . ^^^ We also found that RetGC 2 and GCAP 2 interact cooperatively with high affinity , but RetGC 1 and GCAP 2 interact noncooperatively with low affinity . ^^^ By analyzing RetGC 1 / RetGC 2 chimeras we demonstrated that the affinity and cooperativity of the interaction with GCAP 2 is dictated by the structure of the KHD . ^^^ These findings suggest that GCAP 2 interacts constituitively with the KHDs of RetGC 1 and RetGC 2 and that cGMP synthesis is controlled by Ca2+ dependent conformational changes in the RetGC / GCAP complex . . ^^^ |
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| Interacting proteins: Q9UMX6 and P51841 |
Pubmed |
SVM Score :0.0 |
| Substitution of these three domains in GCAP 2 with corresponding neurocalcin sequences also affects activation of individual recombinant RetGC 1 and RetGC 2 expressed in HEK 293 cells . . ^^^ |
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| Interacting proteins: Q9UMX6 and P51841 |
Pubmed |
SVM Score :0.0 |
| The photoreceptor membrane guanylyl cyclases , RetGC 1 and RetGC 2 ( also referred to as GC E and GC F ) , are regulated intracellularly by two Ca ( 2+ ) binding proteins , GCAP 1 and GCAP 2 . ^^^ |
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