| Interacting proteins: Q9UMX3 and Q07820 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UMX3 and Q07820 |
Pubmed |
SVM Score :0.84962601 |
| In the yeast two hybrid system , Bok interacted strongly with some ( Mcl 1 , BHRF 1 , and Bfl 1 ) but not other ( Bcl 2 , Bcl xL , and Bcl w ) anti apoptotic members . 0.84962601^^^ |
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| Interacting proteins: Q9UMX3 and Q07820 |
Pubmed |
SVM Score :0.0 |
| In the yeast cell assay , BOD interacts with diverse antiapoptotic Bcl 2 proteins [ Mcl 1 , Bcl 2 , Bcl xL , Bcl w , Bfl 1 , and Epstein Barr virus ( EBV ) BHRF 1 ] but not with different proapoptotic Bcl 2 proteins ( BAD , Bak , Bok , and Bax ) . ^^^ |
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| Interacting proteins: Q9UMX3 and Q07820 |
Pubmed |
SVM Score :0.0 |
| Bok ( Bcl 2 related ovarian killer ) is a proapoptotic Bcl 2 family protein identified in the ovary based on its dimerization with the antiapoptotic protein Mcl 1 . ^^^ |
|
| Interacting proteins: Q9UMX3 and Q07820 |
Pubmed |
SVM Score :0.0 |
| In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^ |
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| Interacting proteins: Q9UMX3 and Q07820 |
Pubmed |
SVM Score :0.0 |
| We identified Mcl 1 as the main ovarian antiapoptotic Bcl 2 protein , the novel Bok ( Bcl 2 related ovarian killer ) as the proapoptotic protein , as well as BOD ( Bcl 2 related ovarian death agonist ) and BAD as the proapoptotic ligands . ^^^ In contrast , the channel forming Mcl 1 and Bok regulate cytochrome c release and , together with the recently discovered Diva / Boo , control downstream apoptosis activating factor ( Apaf ) 1 homologs and caspases . ^^^ |
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| Interacting proteins: Q9UMX3 and Q07820 |
Pubmed |
SVM Score :0.0 |
| Tumor sections were analyzed by immunohistochemistry for the expression of regulators of the cell cycle ( p 21 ; retinoblastoma protein ( pRb ) ) , of the intrinsic or extrinsic proapoptotic pathways ( p 53 ; murine double minute gene 2 protein ; tumour necrosis factor related apoptosis inducing ligand ( TRAIL ) R1 / DR4 ; TRAIL R2 / DR5 ) and of Bcl 2 related proteins ( Bcl 2 , Mcl 1 , Bax , Bak , Bok ) , which regulate the common mitochondrial apoptotic pathway . ^^^ |
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