| Interacting proteins: P20701 and Q9UMF0 |
Pubmed |
SVM Score :0.5482299 |
| However , the interaction of TLN with LFA 1 on HL 60 cells was divalent cation independent and phorbol 12 myristate 13 acetate stimulation independent . 0.5482299^^^ |
|
| Interacting proteins: P20701 and Q9UMF0 |
Pubmed |
SVM Score :0.0 |
| TLCN binds to lymphocyte function associated antigen 1 ( LFA 1 ) integrin . ^^^ In the central nervous system , LFA 1 is selectively and constitutively expressed by microglia , suggesting that TLCN / LFA 1 binding may mediate cell cell interactions between telencephalic neurons and microglia . ^^^ Furthermore , the TLCN induced spreading of microglia was accompanied by a clustering of LFA 1 on cell surface membrane . ^^^ These results provide evidence that TLCN binding to the surface of microglia transduces signals into microglia that mediate or accelerate cell spreading and LFA 1 redistribution , implying that neuronal TLCN may control the state and / or function of microglia in both physiological and pathological conditions . . ^^^ |
|
| Interacting proteins: P20701 and Q9UMF0 |
Pubmed |
SVM Score :0.0 |
| Because HI injury induces microglial activation with increases in CD11a / CD18 ( lymphocyte function antigen [ LFA ] 1 ) counterreceptors to ICAM 5 , we investigated whether modulation of interactions between LFA 1 receptors and brain ICAM 5 during HI injury are associated with changes in levels of serum ICAM 5 . ^^^ Pretreatment with anti LFA 1 antibodies before HI injury or LFA 1 receptor knockout mice with HI injury had markedly reduced levels of serum ICAM 5 . ^^^ |
|
| Interacting proteins: Q9UMF0 and P20701 |
Pubmed |
SVM Score :0.5482299 |
| However , the interaction of TLN with LFA 1 on HL 60 cells was divalent cation independent and phorbol 12 myristate 13 acetate stimulation independent . 0.5482299^^^ |
|
| Interacting proteins: Q9UMF0 and P20701 |
Pubmed |
SVM Score :0.0 |
| Because HI injury induces microglial activation with increases in CD11a / CD18 ( lymphocyte function antigen [ LFA ] 1 ) counterreceptors to ICAM 5 , we investigated whether modulation of interactions between LFA 1 receptors and brain ICAM 5 during HI injury are associated with changes in levels of serum ICAM 5 . ^^^ Pretreatment with anti LFA 1 antibodies before HI injury or LFA 1 receptor knockout mice with HI injury had markedly reduced levels of serum ICAM 5 . ^^^ |
|
| Interacting proteins: Q9UMF0 and P20701 |
Pubmed |
SVM Score :0.0 |
| TLCN binds to lymphocyte function associated antigen 1 ( LFA 1 ) integrin . ^^^ In the central nervous system , LFA 1 is selectively and constitutively expressed by microglia , suggesting that TLCN / LFA 1 binding may mediate cell cell interactions between telencephalic neurons and microglia . ^^^ Furthermore , the TLCN induced spreading of microglia was accompanied by a clustering of LFA 1 on cell surface membrane . ^^^ These results provide evidence that TLCN binding to the surface of microglia transduces signals into microglia that mediate or accelerate cell spreading and LFA 1 redistribution , implying that neuronal TLCN may control the state and / or function of microglia in both physiological and pathological conditions . . ^^^ |
|