| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| Beta arrestin 2 : a receptor regulated MAPK scaffold for the activation of JNK 3 . beta Arrestins , originally discovered in the context of heterotrimeric guanine nucleotide binding protein coupled receptor ( GPCR ) desensitization , also function in internalization and signaling of these receptors . ^^^ Thus , beta arrestin 2 acts as a scaffold protein , which brings the spatial distribution and activity of this MAPK module under the control of a GPCR . . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| Our study thus suggests that beta arrestin 2 may serve as a cross talk linker between GPCR and p 53 signaling pathways . . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| To test the existence and function of this putative GpCR , we utilized a mammalian G protein coupled receptor kinase ( GRK 3 ) and beta arrestin 2 , which together are known to cause GpCR desensitization . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| Because beta arrestins are key components in GPCR internalization , it is interesting to note that the receptor that is known to internalize rapidly ( Y 1 ) exhibits the most rapid association with beta arrestin 2 , whereas the receptor that is known to internalize slowly , or not at all ( Y 2 ) associates slowly with beta arrestin 2 . . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| Endocytosis of Frizzled 4 ( Fz 4 ) in human embryonic kidney 293 cells was dependent on added Wnt5A protein and was accomplished by the multifunctional adaptor protein beta arrestin 2 ( betaarr 2 ) , which was recruited to Fz 4 by binding to phosphorylated Dvl 2 . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| Molecular insight into the role of arrestins in GPCR trafficking has suggested that arrestin interaction with clathrin , beta ( 2 ) adaptin ( the beta subunit of the adaptor protein AP 2 ) , and phosphoinositides contributes to this process . ^^^ In an effort to clarify the role of these interactions in GPCR trafficking we generated arrestin mutants that were completely and selectively defective in either clathrin ( arrestin 2 DeltaLIELD ) or beta ( 2 ) adaptin ( arrestin 2 F391A ) interaction . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| The efficiency of GPCR signaling is tightly regulated and ultimately limited by the coordinated phosphorylation of the receptors by specific GPCR kinases and the subsequent interaction of the phosphorylated receptors with beta arrestin 1 and beta arrestin 2 . ^^^ These results provide evidence in vivo for the physiological importance of beta arrestin 2 in regulating the function of a specific GPCR , the muOR . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| In the present studies , we investigated expression of GRKs and arrestins in osteoblastic cell lines concentrating on the enzymes ( GRK 2 and GRK 3 ) and protein co factors ( beta arrestint 1 and beta arrestin 2 ) that play dominant roles in regulating GPCR responsiveness in most tissues and cell types . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| The AT ( 1 ) R is a class B GPCR that recruits both beta arrestin 1 and beta arrestin 2 , forming stable complexes that cotraffic to deep core endocytic vesicles . beta Arrestins contain one amphipathic and potentially amphitropic ( membrane targeting ) alpha helix ( helix 1 ) that may promote translocation to the membrane or influence receptor internalization or trafficking . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| The G protein coupled receptor ( GPCR ) adaptor beta arrestin 2 is also a JNK 3 scaffold . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| In Drosophila norpA and rdgC mutants , endocytosis of abnormally stable complexes of rhodopsin ( Rh 1 ) and fly photoreceptor Arrestin 2 ( Arr 2 ) triggers cell death , implicating Rh1 / Arr2 bearing endosomes in pro cell death signaling , potentially via arrestin mediated GPCR activation of effector kinase pathways . ^^^ |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32121 and Q9ULV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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