| In contrast to the predominant plasma membrane localization in control cells , the H Ras fusion protein EGFP H Ras was localized within a discrete cytoplasmic compartment where it co localized with RIG 1 . ^^^ RIG 1 reduced the levels of activated Ras ( Ras GTP ) and total Ras protein in cells transfected with mutated H , N , or K Ras ( G12V ) , or in cells transfected with the wild type H or N Ras followed by stimulation with epidermal growth factor . ^^^ RIG 1 inhibited more than 93 % of the Elk and CHOP mediated transactivation induced by H or K Ras ( G12V ) . ^^^ |