| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| Here we show that the human homologs of Argonaute 1 ( AGO 1 ) and Argonaute 2 ( AGO 2 ) link the silencing pathways that target mRNA with pathways mediating recognition of DNA . ^^^ |
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| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| An RNAi based screen performed in Drosophila S 2 cells has revealed that Dicer 1 , Argonaute 1 ( Ago 1 ) and Ago 2 , components involved in microRNA ( miRNA ) processing and function , are required for the rapid decay of mRNA containing AREs of tumor necrosis factor alpha . ^^^ |
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| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| Thus , in Drosophila , unlike in humans , both AGO 1 and AGO 2 have Slicer functions . ^^^ Further , reconstitution of Slicer activity with recombinant PIWI domains of AGO 1 and AGO 2 demonstrates that other regions in the Argonautes are not strictly necessary for small interfering RNA ( siRNA ) binding and cleavage activities . ^^^ |
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| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| To gain insight into the function and composition of RNA silencing complexes , we purified Ago 1 and Ago 2 containing complexes from human cells . ^^^ Several known Ago 1 and / or Ago 2 associated proteins including Dicer were identified , but also two novel factors , the putative RNA helicase MOV 10 , and the RNA recognition motif ( RRM ) containing protein TNRC6B / KIAA1093 . ^^^ |
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| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| To identify transcripts regulated by silencing pathways at the genomic level , we examined mRNA expression profiles in Drosophila melanogaster cells depleted of four Argonaute paralogs ( i . e . , AGO 1 , AGO 2 , PIWI , or Aubergine ) that play essential roles in RNA silencing . ^^^ Moreover , AGO 1 and AGO 2 silence the expression of a common set of mobile genetic elements . ^^^ Together , these results indicate that the functional overlap between AGO 1 and AGO 2 in Drosophila is more important than previously thought . . ^^^ |
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| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| By using affinity tagged siRNAs , we demonstrate that a single stranded siRNA resides in the RNA induced silencing complex ( RISC ) together with eIF2C1 and / or eIF2C2 ( human GERp 95 ) Argonaute proteins . ^^^ |
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| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| In Drosophila , the Argonaute proteins AGO 1 and AGO 2 have been implicated in post transcriptional gene silencing ( PTGS ) / RNA interference ( RNAi ) . ^^^ In this study , we found that AGO 1 and AGO 2 depletion caused the accumulation of multicopied enhanced green fluorescence protein ( EGFP ) transgene transcripts in Drosophila S 2 cells . ^^^ Our findings suggest that AGO 1 and AGO 2 mediate multicopied transgene silencing by different mechanisms . ^^^ |
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| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| In the developing lung , we found expression of Ago 1 and Ago 2 localized to branching regions , in distal epithelium and mesenchyme , respectively . ^^^ |
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| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKV8 and Q9UL18 |
Pubmed |
SVM Score :0.0 |
| NA |
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