| Interacting proteins: Q9UKV0 and P41182 |
Pubmed |
SVM Score :0.0 |
| Moreover , we show that LAZ 3 also interacts with an HDAC ( HDAC 1 ) through its POZ domain in vitro while the immunoprecipitation of LAZ 3 results in the coretention of an endogenous HDAC activity in vivo . ^^^ Taken together , we conclude that LAZ 3 recruits a repressing complex containing SMRT , mSIN3A and a HDAC , and that its full repressing potential on transcription requires HDACs activity . ^^^ |
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| Interacting proteins: Q9UKV0 and P41182 |
Pubmed |
SVM Score :0.0 |
| In the human B cell lymphoma ( BCL 6 ) and promyelocityc leukemia ( PLZF ) oncoproteins , this domain mediates transcriptional repression through its ability to recruit a silencing mediator of retinoid and thyroid hormone receptor ( SMRT ) / nuclear receptor corepressor ( N CoR ) mSin3A histone deacetylase ( HDAC ) complex , a mechanism shared with numerous transcription factors . ^^^ However , in striking contrast with BCL 6 and PLZF , both HIC 1 and gammaFBP B similarly fail to interact with members of the HDAC complexes ( SMRT / N CoR , mSin3A or HDAC 1 ) in vivo and in vitro . ^^^ |
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| Interacting proteins: Q9UKV0 and P41182 |
Pubmed |
SVM Score :0.0 |
| Recently , acetylation has been identified as a mode for down regulating Bcl 6 activity by inhibition of the ability of Bcl 6 to recruit complexes containing histone deacetylases ( HDAC ) . ^^^ The pharmacologic inhibition of two recently identified deacetylation pathways , HDAC and silent information regulator ( SIR ) 2 dependent deacetylation , results in the accumulation of inactive acetylated Bcl 6 and thus in cell cycle arrest and apoptosis in B cell lymphoma cells . ^^^ |
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| Interacting proteins: Q9UKV0 and P41182 |
Pubmed |
SVM Score :0.0 |
| Expression of p 53 , a direct target gene of Bcl 6 , was downregulated in the IL 6 stimulated cells , and this process was impaired by an HDAC inhibitor . ^^^ |
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| Interacting proteins: Q9UKV0 and P41182 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that three related class 2 deacetylases , HDAC 4 , HDAC 5 , and HDAC 7 can associate with BCL 6 in vivo and in vitro . ^^^ A highly conserved domain in the N terminal region of HDAC 5 and HDAC 7 as well as the zinc finger region of BCL 6 were found necessary for the complex formation in vivo and in vitro . ^^^ |
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