| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| A new ligand for the urotensin 2 receptor . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Isochromanone based urotensin 2 receptor agonists . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Localization of the urotensin 2 receptor in the rat central nervous system . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 receptor ligands . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 receptor antagonists . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 is a small peptide whose receptor was recently identified in mammals as the orphan G protein coupled receptor 14 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| After the identification of U 2 in humans and the orphan human G protein coupled receptor 14 as the urotensin 2 receptor , UT , many studies have shown that U 2 may play an important role in cardiovascular regulation . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Expression of urotensin 2 and G protein coupled receptor 14 mRNA in human pheochromocytoma tissues ] . ^^^ OBJECTIVE : To investigate the expression of urotensin 2 ( U 2 ) and G protein coupled receptor 14 ( GPR 14 ) mRNA in human pheochromocytoma tissues . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Messenger RNA encoding theurotensin 2 precursor and the urotensin 2 receptor precursor were expressed in various human tissues . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| The urotensin 2 receptor is expressed in the cholinergic mesopontine tegmentum of the rat . ^^^ The urotensin 2 receptor ( UII R ) is expressed not only in peripheral tissues but also in the brain of rodents . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| These somatostatin receptor antagonists displayed moderate affinities for recombinant rat and human urotensin 2 receptor binding sites . ^^^ The data support the suggestion that urotensin 2 receptor and somatostatin type 2 / 5 receptors display similar surface topologies and that analogues of somatostatin could provide useful lead compounds for the development of more potent urotensin 2 receptor antagonists . . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Identification of nonpeptidic urotensin 2 receptor antagonists by virtual screening based on a pharmacophore model derived from structure activity relationships and nuclear magnetic resonance studies on urotensin 2 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| A new , potent urotensin 2 receptor peptide agonist containing a Pen residue at the disulfide bridge . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Pharmacological characterization of SB 710411 ( Cpa c [ D Cys Pal D Trp Lys Val Cys ] Cpa amide ) , a novel peptidic urotensin 2 receptor antagonist . 1 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Discovery of the first nonpeptide agonist of the GPR14 / urotensin 2 receptor : 3 ( 4 chlorophenyl ) 3 ( 2 ( dimethylamino ) ethyl ) isochroman 1 one ( AC 7954 ) . ^^^ A functional cell based screen identified 3 ( 4 chlorophenyl ) 3 ( 2 ( dimethylamino ) ethyl ) isochroman 1 one hydrochloride ( AC 7954 , 1 ) as a nonpeptidic agonist of the urotensin 2 receptor . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Further confirmatory studies with urotensin 2 receptor antagonists are required . . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| These findings could be of value in the development of more potent urotensin 2 receptor antagonists based on the previously identified somatostatin antagonist octapeptides which we have recently found , function as relatively weak urotensin 2 antagonists . . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Functional and binding characterizations of urotensin 2 related peptides in human and rat urotensin 2 receptor assay . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 receptor in the rat airway smooth muscle and its effect on the rat airway smooth muscle cells proliferation . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 receptor system in the myenteric neurons may regulate the gastrointestinal functions . . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| The immunoreactivity of urotensin 2 receptor GPR 14 was expressed extensively in the glial cells within the brainstem , hypothalamus , and thalamus . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| The expression of urotensin 2 receptor ( U2R ) is up regulated by interferon gamma . ^^^ Urotensin 2 ( U 2 ) was identified as the natural ligand of the G protein coupled receptor GPR 14 , which has been correspondingly renamed Urotensin 2 receptor ( U2R ) . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Pharmacology of the urotensin 2 receptor antagonist palosuran ( ACT 058362 ; 1 [ 2 ( 4 benzyl 4 hydroxy piperidin 1 yl ) ethyl ] 3 ( 2 methyl quinolin 4 yl ) urea sulfate salt ) : first demonstration of a pathophysiological role of the urotensin System . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| In cells expressing fusion proteins with Galpha ( 16 ) of G ( q ) coupled receptors , i . e . urotensin 2 receptor and M ( 1 ) receptor , the relevant agonists induced similar increases in intracellular Ca ( 2+ ) and prostaglandin E ( 2 ) generation as in ones expressing the receptor alone . ^^^ In cells expressing urotensin 2 receptor Galpha ( 16 ) fusion protein , prostaglandin E ( 2 ) generation exhibited a lower EC ( 50 ) value than the intracellular Ca ( 2+ ) increase . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Involvement of a cytoplasmic tail serine cluster in urotensin 2 receptor internalization . ^^^ Here we show that the UT receptor ( urotensin 2 receptor ) undergoes internalization , and that specific serine residues of the receptor ' s cytoplasmic tail participate in this process . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Genetic variations at urotensin 2 and urotensin 2 receptor genes and risk of type 2 diabetes mellitus in Japanese . ^^^ When we surveyed genetic polymorphisms in the UTS 2 and urotensin 2 receptor ( GPR 14 ) gene , we identified two SNPs with amino acid substitutions ( designated T21M and S89N and an SNP in the promotor region ( 605G > A ) of the UTS 2 gene , and two SNPs in the non coding region of the GPR 14 gene . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 related peptide , the endogenous ligand for the urotensin 2 receptor in the rat brain . ^^^ These results suggest that URP is the endogenous and functional ligand for urotensin 2 receptor in the rat and mouse , and possibly in the human . . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Increased expression of urotensin 2 and urotensin 2 receptor in human diabetic nephropathy . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Cloning and pharmacological characterization of the cat urotensin 2 receptor ( UT ) . ^^^ The cat urotensin 2 receptor represents a suitable in vitro model to examine the role of the U II / UT system in the etiology of hypertension , assisting in the evaluation of the UT antagonists to help treat cardiovascular disease . . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Architecture of the human urotensin 2 receptor : comparison of the binding domains of peptide and non peptide urotensin 2 agonists . ^^^ The human urotensin 2 receptor ( h UTR ) is a member of the family of rhodopsin like G protein coupled receptors ( GPCRs ) involved in the modulation of the functionality of many tissues and organs . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Nonpeptidic urotensin 2 receptor antagonists 1 : in vitro pharmacological characterization of SB 706375 . 1 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Aminoalkoxybenzyl pyrrolidines as novel human urotensin 2 receptor antagonists . ^^^ High throughput screening of the corporate compound collection led to the discovery of a novel series of substituted aminoalkoxybenzyl pyrrolidines as human urotensin 2 receptor antagonists . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Inhibitory effects of putative peptidic urotensin 2 receptor antagonists on urotensin 2 induced contraction of cat isolated respiratory smooth muscle . ^^^ These findings suggest that the cat represents a suitable species for future studies designed to assess the effects of the urotensin 2 receptor on pulmonary ( patho ) physiology . . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 related peptide ( URP ) is an eight amino acid peptide recently isolated from rat brain and considered as the endogenous ligand for the urotensin 2 receptor . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| However , because we have recently shown that the urotensin 2 receptor ( UII R ) is selectively expressed in rat mesopontine cholinergic ( MPCh ) neurons , we hypothesize that UII may have a central function . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| The urotensin 2 receptor antagonist palosuran improves pancreatic and renal function in diabetic rats . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Alteration of vascular urotensin 2 receptor in mice with apolipoprotein E gene knockout . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Novel potent and efficacious nonpeptidic urotensin 2 receptor agonists . ^^^ Six different series of nonpeptidic urotensin 2 receptor agonists have been synthesized and evaluated for their agonistic activity in a cell based assay ( R SAT ) . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Haplotypes in the urotensin 2 gene and urotensin 2 receptor gene are associated with insulin resistance and impaired glucose tolerance . ^^^ We studied single nucleotide polymorphisms ( SNPs ) and haplotypes in the urotensin 2 ( UTS 2 ) and urotensin 2 receptor gene ( UTS2R ) in Hong Kong Chinese ( 224 hypertensive and 306 normotensive unrelated subjects ) and their relation to hypertension and the metabolic syndrome . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Characterization of urotensin 2 receptor structural domains involved in the recognition of U 2 , URP , and urantide . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Pharmacodynamics and pharmacokinetics of the urotensin 2 receptor antagonist palosuran in macroalbuminuric , diabetic patients . ^^^ We have investigated whether palosuran , a potent , selective , and competitive antagonist of the urotensin 2 receptor , has effects in patients who are prone to the development of renal disease . ^^^ Larger placebo controlled trials in this patient population are needed to investigate whether urotensin 2 receptor antagonists , given as monotherapy or combination therapy , may improve the current treatment of diabetic nephropathy . . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Human urotensin 2 is a potent vasoconstrictor and agonist for the orphan receptor GPR 14 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 is the endogenous ligand of a G protein coupled orphan receptor , SENR ( GPR 14 ) . ^^^ Two molecular species of urotensin 2 ( UII ) were isolated from porcine spinal cords and identified as the endogenous ligands of a G protein coupled orphan receptor , SENR ( sensory epithelium neuropeptide like receptor ) , which is identical to GPR 14 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Identification of urotensin 2 as the endogenous ligand for the orphan G protein coupled receptor GPR 14 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| The observation that the novel G protein coupled receptor ( GPCR ) GPR 14 and its cognate ligand , urotensin 2 ( U 2 ) , are expressed within the mammalian vasculature raises the possibility that they may influence cardiohemodynamic homeostasis . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 ( U 2 ) and its G protein coupled receptor , GPR 14 , are expressed within mammalian cardiac and peripheral vascular tissue and , as such , may regulate mammalian cardiovascular function . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Urotensin 2 ( UII ) is the ligand for the GPR 14 receptor and the most potent vasoconstrictor in the cynomolgus monkey . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| The novel cyclic undecapeptide human urotensin 2 ( hU 2 ) and its high affinity G protein coupled receptor , GPR 14 , are both expressed within the human cardiovasculature ( vascular smooth muscle , endothelium , myocardium , coronary atheroma , etc . ) and may , therefore , contribute to the ( patho ) physiological regulation of cardiovascular homeostasis in humans . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Co expression of urotensin 2 and its receptor ( GPR 14 ) in human cardiovascular and renal tissues . ^^^ BACKGROUND : Urotensin 2 ( UII ) , a cyclic dodecapeptide originally isolated from fish urophysis that has potent cardiovascular effects , has recently been identified as an endogenous ligand for the orphan G protein coupled receptor , GPR 14 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 is a cyclic undecapeptide which activates the GPR 14 receptor and exerts potent vasoconstrictor effects in some species of fish and mammals . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Using novel synthetic radioligands , we have discovered receptors for the recently paired apelin ( APJ orphan receptor ) , ghrelin ( GHS orphan receptor ) , and urotensin 2 ( orphan GPR 14 ) in the human cardiovascular system and determined their anatomical localisation . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Our aim was to ascertain degree of expression of urotensin 2 and its receptor GPR 14 ( now known as UT receptor ) in the myocardium of patients with congestive heart failure ( CHF ) . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Human urotensin 2 ( UTN ) has potent vasoactive and cardiostimulatory effects , acting on the G protein linked receptor GPR 14 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| A urotensin 2 ( U 2 ) peptide analogue containing the photoreactive p benzoyl L phenylalanine ( Bz Phe ) in the sixth position was used to identify ligand binding sites of the rat U 2 receptor , also known as GPR 14 . [ Bz Phe ( 6 ) ] U 2 bound the receptor expressed in COS 7 cells with high affinity ( IC ( 50 ) 0 . 7 nM ) and was as potent as U 2 in the agonist induced production of inositol phosphate . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 mediates ERK1 / 2 phosphorylation and proliferation in GPR 14 transfected cell lines . ^^^ Urotensin 2 ( U 2 ) , a vasoactive cyclic neuropeptide , was recently identified as the natural ligand for the G protein coupled receptor GPR 14 . ^^^ Urotensin 2 induces a rapid and short lasting rise in intracellular calcium in recombinant GPR 14 expressing cells . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| We identified urotensin 2 ( U 2 ) as the endogenous ligand for the orphan G protein coupled receptor GPR 14 or SENR . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 ( U 2 ) is a vasoactive hormone that acts through a recently described seven transmembrane spanning G protein coupled receptor called GPR 14 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Urotensin 2 ( UII ) has been identified as a ligand for the orphan receptor GPR 14 through which it elicits potent vasoconstriction in humans and non human primates . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 ( U 2 ) has been known for over 30 years as an important teleost fish hormone , but only recently has it been recognized as the endogenous ligand of a new human G protein coupled receptor ( GPCR ) homologous to the GPR 14 orphan receptor from rat . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Cellular distribution of GPR 14 and the positive inotropic role of urotensin 2 in the myocardium in adult rat . ^^^ Urotensin 2 is a cyclic neuropeptide recently shown to play a role via its receptor GPR 14 in regulating vascular tone in the mammalian cardiovascular system . ^^^ These data provide the first direct evidence for the cellular localization of GPR 14 receptor protein and a positive inotropic effect of urotensin 2 in normal rat heart . . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Increased expression of urotensin 2 and its cognate receptor GPR 14 in atherosclerotic lesions of the human aorta . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 ( UII ) , originally isolated from goby urophysis , has been shown to be an endogenous ligand for an orphan G protein coupled receptor , GPR 14 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| Urotensin 2 ( UII ) has been described as the most potent vasoconstrictor peptide and recognized as the endogenous ligand of the orphan G protein coupled receptor GPR 14 . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| The peptide urotensin 2 ( U 2 ) is the cognate ligand of the G protein coupled receptor UT ( formerly GPR 14 ) . ^^^ |
|
| Interacting proteins: Q9UKP6 and O95399 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Urotensin 2 ( U 2 ) and its receptor GPR 14 are expressed in the kidney and the cardiovascular system of various mammalian species . ^^^ |
|