| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| Transcriptional changes in several genes [ Syt 12 ( Synaptotagmin 12 ) , Rcor ( RE 1 silencing transcription factor co repressor ) , Bag 3 ( Bcl associated athanogene 3 ) , p 21 , cyclin D , Bax ( Bcl 2 associated 10 protein ) , and Pcp 2 ( Purkinje cell protein 2 ) ] were confirmed using real time ( RT ) PCR analysis . ^^^ In addition to Rcor , expression of several other genes that code for critical components of the REST ( RE 1 silencing transcription factor ) pathway was shown to be altered in hypothyroid animals . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| Neural restrictive silencer ( NRS ) has been identified in at least twenty neuron specific genes , and its nuclear DNA binding factor , NRSF ( also known as RE 1 silencing transcription factor ( REST ) ) , has been cloned from human and rat , and was shown to repress transcription by recruiting corepressors mSin 3 and / or CoREST via its N and C terminal domains , leading to chromatin reorganization by mSin 3 associated histone deacetylase , HDAC . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the SWI / SNF complex forms a larger complex with neuron restrictive silencer factor ( NRSF ) and its corepressors , mSin3A and CoREST , in human nonsmall cell lung carcinoma cell lines . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| We show here that CoREST , a newly identified human protein , functions as a corepressor for REST . ^^^ A single zinc finger motif in REST is required for CoREST interaction . ^^^ CoREST is present in cell lines that express REST , and the proteins are found in the same immunocomplex . ^^^ Together , REST and CoREST mediate repression of the type 2 sodium channel promoter in nonneural cells , and the REST / CoREST complex may mediate long term repression essential to maintenance of cell identity . . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| The co repressor mSin3A is a functional component of the REST CoREST repressor complex . ^^^ One of these , CoREST , interacts with the COOH terminal repressor domain of REST ( Andres , M . ^^^ REST forms complexes with endogenous mSin3A in mammalian cells , and both mSin3A and CoREST interact with REST in intact mammalian cells . ^^^ The pattern of CoREST gene expression is more restricted , suggesting that mSin3A is required constitutively for REST repression , whereas CoREST is recruited for more specialized repressor functions . . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| Although CoREST initially was cloned as a corepressor to REST ( RE 1 silencing transcription factor / neural restrictive silencing factor ) , we find no evidence for the existence of the eight zinc finger REST transcription factor as an interacting partner in this complex ; however , we do find evidence for association of the putative oncogene ZNF 217 that contains eight zinc fingers . . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| Previous studies have shown that REST mediated repression requires histone deacetylase activity and that recruitment of deacetylases is mediated by two co repressors , Sin3A and CoREST . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| As other Spr genes encode proteins homologous to components of the CoREST co repressor complex that interacts with REST , and the INHAT ( inhibitor of acetyltransferase ) co repressor complex , our data suggest that all Spr genes may function through the same mechanism that involves transcriptional repression of the hop 1 locus . . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| Ttk 88 uses the REST corepressor Drosophila CoREST to coordinately regulate a set of genes encoding the same neuronal hallmarks that are regulated by REST in vertebrates . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| Components of the REST / CoREST / histone deacetylase repressor complex are disrupted , modified , and translocated in HSV 1 infected cells . ^^^ We report that a short sequence of ICP 0 is similar to a sequence in the amino terminus of CoREST , a corepressor that exists in complexes with the repressor REST and histone deacetylases ( HDACs ) 1 or 2 to repress cellular gene expression . ^^^ In wild type virus infected cells , HDAC 1 dissociates from the CoREST / REST complex , CoREST and HDAC 1 are phosphorylated by a process mediated by viral protein kinases , and CoREST and HDAC 1 are partially translocated to the cytoplasm . ^^^ In cells infected with a virus mutant ( DeltaICP 4 ) , in which ICP 0 accumulates , but post alpha gene expression is blocked , HDAC 1 is dissociated from the CoREST / REST complex , but translocation to the cytoplasm does not occur . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| In vitro reconstitution of the BHC complex using recombinant subunits reveals an essential role for the REST corepressor CoREST , not only in stimulating demethylation on core histones but also promoting demethylation of nucleosomal substrates . ^^^ Depletion of CoREST in in vivo cell culture results in de repression of REST responsive gene expression and increased methylation of H3K4 . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| REST represses gene expression by two repressor domains that recruit other factors including mSin 3 and CoREST . ^^^ |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13127 and Q9UKL0 |
Pubmed |
SVM Score :0.0 |
| NA |
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