| Further , CBP interacts directly with the POU domain of Skn 1a , and increasing concentrations of CBP can overcome Skn 1a mediated repression , suggesting that POU domain factors may repress keratin 14 gene expression by interfering with the activity of co activators such as CBP / p300 . . ^^^ A possible role for interactions between Skn 1a and CREB binding protein / p300 . ^^^ |