| Interacting proteins: Q9UKB1 and P63208 |
Pubmed |
SVM Score :1.2972334 |
| HOS is a WD 40 repeats / F box containing protein that actually associates with the substrates and binds to Skp 1 via the F box . 1.2972334^^^ RESULTS : We identified specific amino acid residues ( I 143 and L 152 ) within the F box of HOS that play a critical role in maintaining the hydrophobic interface of HOS Skp 1 interaction and found substantial similarity between interaction of Skp 1 with HOS and with another F box protein Skp 2 . 0.63001965^^^ |
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| Interacting proteins: Q9UKB1 and P63208 |
Pubmed |
SVM Score :0.0 |
| Recruitment of a ROC 1 CUL1 ubiquitin ligase by Skp 1 and HOS to catalyze the ubiquitination of 1 kappa B alpha . ^^^ ROC 1 , a novel SCF associated protein , is recruited by cullin 1 to form a quatemary SCFHOS ROC 1 holenzyme ( with Skp 1 and the beta TRCP homolog HOS ) . ^^^ |
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| Interacting proteins: Q9UKB1 and P63208 |
Pubmed |
SVM Score :0.0 |
| HOS , a human homolog of Slimb , forms an SCF complex with Skp 1 and Cullin 1 and targets the phosphorylation dependent degradation of IkappaB and beta catenin . ^^^ Being a part of SCF complex with Skp 1 and Cullin 1 , HOS specifically interacted with the phosphorylated IkappaB and beta catenin , targeting these proteins for proteasome dependent degradation in vivo . ^^^ |
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| Interacting proteins: Q9UKB1 and P63208 |
Pubmed |
SVM Score :0.0 |
| In this study , we identified a novel murine F box / WD40 repeat containing protein , mHOS ( a homologue of HOS / betaTrCP2 ) . mHOS efficiently binds Skp 1 protein ( a ' core ' component of SCF ubiquitin ligase ) , and phosphorylated IkappaB ( alpha ) . ^^^ |
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| Interacting proteins: Q9UKB1 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UKB1 and P63208 |
Pubmed |
SVM Score :0.0 |
| NA |
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