| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.55654894 |
| In this study , we demonstrate that VPS 28 , a second component of ESCRT 1 , binds to a sequence close to the Tsg 101 C terminus and is therefore recruited to the plasma membrane by HIV 1 Gag . 0.55654894^^^ |
|
| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| TSG101 / mammalian VPS 23 and mammalian VPS 28 interact directly and are recruited to VPS 4 induced endosomes . ^^^ |
|
| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| In addition , we characterize a 350 kDa complex , ESCRT 1 ( composed of Vps 23 , Vps 28 , and Vps 37 ) , that recognizes ubiquitinated MVB cargo and whose function is required for sorting into MVB vesicles . ^^^ |
|
| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| The endosomal sorting complex required for transport ( ESCRT 1 ) is a 350 kDa complex of three proteins , Vps 23 , Vps 28 , and Vps 37 . ^^^ |
|
| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| Detailed studies produced four lines of evidence that human VPS37B is a Vps37p ortholog . 1 ) TSG 101 bound to several different sites on VPS37B , including a putative coiled coil region and a PTAP motif . 2 ) TSG 101 and VPS 28 co immunoprecipitated with VPS37B FLAG , and the three proteins comigrated together in soluble complexes of the correct size for human ESCRT 1 ( approximately 350 kDa ) . 3 ) Like TGS 101 , VPS37B became trapped on aberrant endosomal compartments in the presence of VPS4A proteins lacking ATPase activity . 4 ) Finally , VPS37B could recruit TSG101 / ESCRT 1 activity and thereby rescue the budding of both mutant Gag particles and HIV 1 viruses lacking native late domains . ^^^ Further studies of ESCRT 1 revealed that TSG 101 mutations that inhibited PTAP or VPS 28 binding blocked HIV 1 budding . ^^^ |
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| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| ESCRT 1 is characterized in yeast as a complex consisting of Vps 23 , Vps 28 , and Vps 37 . ^^^ Whereas mammalian homologues of Vps 23 and Vps 28 ( named Tsg 101 and hVps 28 , respectively ) have been identified and characterized , a mammalian counterpart of Vps 37 has not yet been identified . ^^^ |
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| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| In yeast , ESCRT 1 is composed of three proteins , VSP 23 , VPS 28 , and VPS 37 , whereas in mammals only Tsg 101 ( VPS 23 ) and VPS 28 were originally identified as ESCRT 1 components . ^^^ VPS37C can form a ternary complex with Tsg 101 and VPS 28 by binding to a domain situated toward the carboxyl terminus of Tsg 101 and binds to another class E VPS factor , namely Hrs . ^^^ |
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| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| Using genetic analysis , we characterized the pathway by which VPS 15 , VPS 34 , VPS 22 , VPS 23 and VPS 28 affect the telomeres . ^^^ |
|
| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| The yeast ESCRT 1 complex contains the Vps 23 , Vps 28 , and Vps 37 proteins , and its assembly is directed by the C terminal steadiness box of Vps 23 , the N terminal half of Vps 28 , and the C terminal half of Vps 37 . ^^^ The crystal structures of a Vps 23 : Vps 28 core subcomplex and the Vps 23 : Vps 28 : Vps 37 core were solved at 2 . 1 and 2 . 8 A resolution . ^^^ The structure shows how ESCRT 1 is assembled by a compact core from which the Vps 23 UEV domain , the Vps 28 C domain , and other domains project to bind their partners . . ^^^ |
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| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| TSG 101 and VPS 28 , components of the mammalian ESCRT 1 ( endosomal sorting complex required for transport ) , which is part of the cellular extravesiculation machinery critical for HIV 1 budding , are also recruited to cell surface TEMs upon virus expression , suggesting that HIV 1 egress can be gated through these newly mapped microdomains . . ^^^ |
|
| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| Co expression experiments of Vps 28 CTD , Vps 23 and Vps 37 suggest that Vps 28 CTD does not directly participate in ESCRT 1 assembly and may thus act as an adaptor module for downstream interaction partners . ^^^ |
|
| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UK41 and Q99816 |
Pubmed |
SVM Score :0.0 |
| NA |
|