| Interacting proteins: Q15276 and Q9UJ41 |
Pubmed |
SVM Score :0.51408044 |
| Rabex 5 forms a tight physical complex with Rabaptin 5 , and this complex is essential for endocytic membrane fusion . 0.51408044^^^ |
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| Interacting proteins: Q15276 and Q9UJ41 |
Pubmed |
SVM Score :0.0 |
| Rab 15 does not interact directly with the Rab 5 effectors rabex 5 and rabaptin 5 in a yeast two hybrid binding assay . ^^^ |
|
| Interacting proteins: Q15276 and Q9UJ41 |
Pubmed |
SVM Score :0.0 |
| Rabaptin 5beta does not heterodimerize with Rabaptin 5 , and forms a distinct complex with Rabex 5 , the GDP / GTP exchange factor for Rab 5 . ^^^ |
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| Interacting proteins: Q15276 and Q9UJ41 |
Pubmed |
SVM Score :0.0 |
| Caspase dependent cleavage of rabaptin 5 generates two physically separated coiled coil forming domains , the C terminal of which retains the ability to bind the Rab 5 exchange factor rabex 5 . . ^^^ |
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| Interacting proteins: Q15276 and Q9UJ41 |
Pubmed |
SVM Score :0.0 |
| Several Rab 5 effectors are required in homotypic endosome fusion , including EEA 1 , which mediates endosome membrane docking , as well as Rabaptin 5 10 Rabex 5 complex and phosphatidylinositol 3 kinase hVPS 34 . ^^^ |
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| Interacting proteins: Q15276 and Q9UJ41 |
Pubmed |
SVM Score :0.0 |
| Functional synergy between Rab 5 effector Rabaptin 5 and exchange factor Rabex 5 when physically associated in a complex . ^^^ We have previously shown that Rab 5 , which regulates various steps of transport along the early endocytic pathway , is activated by a complex consisting of Rabex 5 , a Rab 5 nucleotide exchange factor , and the effector Rabaptin 5 . ^^^ First , we show that Rabaptin 5 increases the exchange activity of Rabex 5 on Rab 5 . ^^^ Second , Rab 5 dependent recruitment of Rabaptin 5 to early endosomes is completely dependent on its physical association with Rabex 5 . ^^^ Third , complex formation between Rabaptin 5 and Rabex 5 is essential for early endosome homotypic fusion . ^^^ |
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| Interacting proteins: Q15276 and Q9UJ41 |
Pubmed |
SVM Score :0.0 |
| Identification of rabaptin 5 , rabex 5 , and GM 130 as putative effectors of rab33b , a regulator of retrograde traffic between the Golgi apparatus and ER . ^^^ A GST rab33b fusion protein stabilised in its GTP form was found to interact by Western blotting or mass spectroscopy with Golgi protein GM 130 and rabaptin 5 and rabex 5 , two rab effector molecules thought to function exclusively in the endocytic pathway . ^^^ In contrast , rab 5 was as expected , shown to bind rabaptin 5 and rabex 5 as well as the endosomal effector protein EEA 1 but not GM 130 . ^^^ |
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| Interacting proteins: Q15276 and Q9UJ41 |
Pubmed |
SVM Score :0.0 |
| Rabex 5 forms a tight complex with Rabaptin 5 , a multivalent adaptor protein that also binds to Rab 4 , Rab 5 , and to domains present in gamma adaptins and the Golgi localized , gamma ear containing , ARF binding proteins ( GGAs ) . ^^^ Rabaptin 5 augments the Rabex 5 exchange activity , thus generating GTP bound , membrane associated Rab 5 that , in turn , binds Rabaptin 5 and stabilizes the Rabex 5 . ^^^ In this study , we identify the 401 462 and 551 661 coiled coils as the regions in Rabex 5 and Rabaptin 5 , respectively , that interact with one another . ^^^ These observations extend our understanding of the regulation of Rabex 5 by Rabaptin 5 . ^^^ |
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