| Interacting proteins: Q9UIV8 and P07711 |
Pubmed |
SVM Score :0.0 |
| Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet induced apoptosis . ^^^ Here we demonstrate that hurpin is a potent and selective inhibitor of the archetypal lysosomal cysteine proteinase cathepsin L ( catL ) . ^^^ Recombinant hurpin inhibits human catL with a stoichiometry of inhibition ( SI ) of 1 . 7 and a rate constant k ( assoc ) of ( 4 . 6 + / 0 . 14 ) 10 10 ( 5 ) M ( 1 ) s ( 1 ) . ^^^ The results of assays using these proteins suggest that inhibition of catL by hurpin occurs via the conventional serpin inhibitory mechanism and that the CD loop plays no role in the process . ^^^ Given that lysosomal disruption , release of catL , and catL mediated caspase activation are known to occur in response to cellular stress , we propose that a physiological role of hurpin is to protect epithelial cells from ectopic catL . . ^^^ |
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| Interacting proteins: Q9UIV8 and P07711 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that hurpin mRNA is overexpressed in psoriatic skin compared to non lesional or normal skin ; hurpin inhibits cathepsin L and that , after overexpression in keratinocytes , hurpin decreases UV induced apoptosis . ^^^ |
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| Interacting proteins: Q9UIV8 and P07711 |
Pubmed |
SVM Score :0.0 |
| Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases . ^^^ |
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