| Interacting proteins: P62324 and Q9UIV1 |
Pubmed |
SVM Score :0.85282645 |
| We found that BTG 1 and BTG 2 , probably through their interaction with CAF 1 via a CCR 4 like complex , can play both positive or negative roles in regulating the ERalpha function . 0.85282645^^^ |
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| Interacting proteins: P62324 and Q9UIV1 |
Pubmed |
SVM Score :0.0 |
| Using yeast two hybrid screening , protein binding assays , and transient transfection assays in HeLa cells , we demonstrated the physical in vitro and in vivo interaction of both Btg 1 and Btg 2 with the mouse protein mCaf 1 ( i . e . mouse CCR 4 associated factor 1 ) . mCaf 1 was identified through its interaction with the CCR 4 protein , a component of a general transcription multisubunit complex , which , in yeast , regulates the expression of different genes involved in cell cycle regulation and progression . ^^^ |
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| Interacting proteins: P62324 and Q9UIV1 |
Pubmed |
SVM Score :0.0 |
| Cell synchrony experiments with primary cultures of rat aortic smooth muscle cells ( RSMCs ) demonstrated that message and protein levels of rat CAF 1 ( rCAF 1 ) were up regulated under conditions of cell contact , as previously reported for BTG 1 [ Wilcox , Scott , Subramanian , Ross , Adams Burton , Stoltenborg and Corjay ( 1995 ) Circulation 92 , I 34 I35 ] . ^^^ In vitro the hCAF 1 / BTG1 complex formation was dependent on the phosphorylation of a putative p34cdc2 kinase site on BTG 1 ( Ser 159 ) . ^^^ Western blot and immunohistochemical analysis showed that rCAF 1 localizes to the nucleus of contact inhibited RSMCs , where it was physically associated with BTG 1 , as determined by co immunoprecipitation with anti hCAF 1 antisera . ^^^ Taken together , these results indicate that formation of the hCAF 1 / BTG1 complex is driven by phosphorylation at BTG 1 ( Ser 159 ) and implicates this complex in the signalling events of cell division that lead to changes in cellular proliferation associated with cell cell contact . . ^^^ |
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| Interacting proteins: P62324 and Q9UIV1 |
Pubmed |
SVM Score :0.0 |
| Nucleotide blast analysis revealed that this gene has a 100 % sequence identity with the sequence for BTG 1 ( B cell translocation gene ) binding factor 1 ( human CCR 4 associated factor 1 gene , hCAF 1 ) . ^^^ |
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| Interacting proteins: P62324 and Q9UIV1 |
Pubmed |
SVM Score :0.0 |
| NA |
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