| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :1.3933355 |
| Human MYH has been shown to interact physically with human proliferating cell nuclear antigen ( hPCNA ) . 1.3933355^^^ |
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| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :0.57562147 |
| Expression of a mutant MYH in which the PCNA binding motif was disrupted did not increase the repair efficiency , thus suggesting that the interaction between PCNA and MYH is critical for MYH initiated repair of A : 8 oxoG . . 0.57562147^^^ |
|
| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :1.2160081 |
| MYH has been shown to interact with the proliferating cell nuclear antigen ( PCNA ) in both human and fission yeast Schizosaccharomyces pombe systems . 1.2160081^^^ |
|
| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :0.0 |
| The human MutY homolog ( hMYH ) is a DNA glycosylase involved in the removal of adenines or 2 hydroxyadenines misincorporated with template guanines or 7 , 8 dihydro 8 oxodeoxyguanines . hMYH is associated in vivo with apurinic / apyrimidinic endonuclease ( APE 1 ) , proliferating cell nuclear antigen ( PCNA ) , and replication protein A ( RPA ) in HeLa nuclear extracts as shown by immunoprecipitation and Western blotting . ^^^ By using constructs containing different portions of hMYH fused to glutathione S transferase , we have demonstrated that the APE 1 binding site is at a region around amino acid residue 300 , that the PCNA binding activity is located at the C terminus , and that RPA binds to the N terminus of hMYH . ^^^ A peptide consisting of residues 505 527 of hMYH that contains a conserved PCNA binding motif binds PCNA , and subsequent amino acid substitution identified Phe 518 and Phe 519 as essential residues required for PCNA binding . ^^^ The PCNA and RPA binding sites of hMYH are further confirmed by peptide and antibody titration . ^^^ |
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| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :0.0 |
| It binds the DNA glycosylase MutY homolog , and stimulates DNA polymerase beta , flap endonuclease 1 , and DNA ligase 1 . 9 1 1 resembles proliferating cell nuclear antigen ( PCNA ) , which stimulates some of these same repair enzymes , and is loaded onto DNA in a similar manner . ^^^ |
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| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :0.0 |
| The expression of wild type mMUTYH or mutant mMUTYH protein with amino acid substitutions at the proliferating cell nuclear antigen binding motif restored the increased spontaneous mutation rates of the MUTYH null ES cells to the wild type level . ^^^ |
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| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :0.0 |
| The candidate genes belong to different DNA repair pathways : base excision repair ( OGG 1 , LIG 3 , APEX , POLB , XRCC 1 , PCNA , and MUTYH ) , nucleotide excision repair ( ERCC 1 , ERCC 2 , ERCC 4 , and ERCC 5 ) , double strand breaks repair ( XRCC 2 , XRCC 3 , and XRCC 9 ) , and reversion repair ( MGMT ) genes . ^^^ |
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| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :0.0 |
| Two DNA N glycosylases among those so far cloned from human , UNG 2 and MYH , are found to have the same PCNA binding motif . ^^^ Therefore , UNG 2 and MYH may serve for replication coupled base excision repair through the direct interaction with PCNA in the replication machinery . . ^^^ |
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| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :0.0 |
| The in vitro and in vivo activities of MYH can be modulated by several proteins including apurinic / apyrimidinic endonuclease ( APE 1 ) , proliferating cell nuclear antigen ( PCNA ) , and mismatch recognition enzymes MSH2 / MSH6 . ^^^ |
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| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :0.0 |
| The temporally declining expression of embryonic MYH resembles the pattern of proliferating cell nuclear antigen ( PCNA ) decline during this period . ^^^ Immunohistochemical analyses of the embryonic brain show that cells staining for MYH initially coincide with cells staining for PCNA . ^^^ At later stages PCNA declines , while MYH is detected primarily outside the nucleus . ^^^ |
|
| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UIF7 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|