| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| Toll / IL 1 receptor domain containing adaptor inducing IFN beta ( TRIF ) associates with TNF receptor associated factor 6 and TANK binding kinase 1 , and activates two distinct transcription factors , NF kappa B and IFN regulatory factor 3 , in the Toll like receptor signaling . ^^^ Moreover , the association between TRIF and TBK 1 appeared to require the kinase activity of TBK 1 , as well as phosphorylation of TRIF . ^^^ Because TRAF 6 and TBK 1 bind close the region of TRIF , it seems that TRAF 6 physically prevents the association between TRIF and TBK 1 . ^^^ Taken together , these results demonstrate that TRIF associates with TRAF 6 and TBK 1 independently , and activates two distinct transcription factors , NF kappaB and IFN regulatory factor 3 , respectively . . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| Finally , TRIF ( TIR domain containing adapter inducing IFN beta ) , fails to activate IRF 3 dependent genes in Tbk 1 ( / ) MEFs . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| Recent studies suggest that a Toll / interleukin 1 receptor domain containing adapter protein ( TRIF ) and two protein kinases ( TANK binding kinase 1 ( TBK 1 ) and IkappaB kinase ( IKK ) epsilon ) are critically involved in Toll like receptor 3 mediated IFN beta production through activation of IFN regulatory factor ( IRF ) 3 and IRF 7 . ^^^ TRIF induced IRF 3 and IRF 7 activation was mediated by TBK 1 and its downstream kinases IKKbeta and IKKepsilon . ^^^ TRIF induced NF kappaB activation through an IKKbeta and tumor necrosis factor receptor associated factor 6 dependent ( but not TBK 1 and IKKepsilon dependent ) pathway . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| A 20 also inhibited TRIF , but not its downstream signaling components TBK 1 , IKKbeta , and IKKepsilon mediated activation of ISRE and NF kappaB and IFN beta promoter . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| In the present study , we demonstrate that inhibition by the protease occurs upstream of the noncanonical IKK related kinases IKKepsilon and TBK 1 , which phosphorylate IRF 3 , through partial inhibition of the TLR adapter protein TRIF / TICAM1 dependent pathway . ^^^ Expression of IFN signaling components including IKKepsilon , TBK 1 , TRIF , and wild type or constitutively active forms of RIG 1 in the HCV replicon cells resulted in IFN beta promoter transactivation , with IKKepsilon displaying the highest efficiency . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| Recent studies suggest that a TIR domain containing adaptor protein , TRIF , and two protein kinases , TANK binding kinase 1 ( TBK 1 ) and IkappaB kinase epsilon ( IKKepsilon ) , play essential roles in TLR 3 mediated IFN beta production through the activation of the transcriptional factor interferon regulatory factor 3 ( IRF 3 ) . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| Together , these results demonstrate that resveratrol specifically inhibits TRIF signaling in the TLR 3 and TLR 4 pathway by targeting TANK binding kinase 1 and RIP 1 in TRIF complex . ^^^ Specific inhibition of MyD 88 independent signaling pathways of TLR 3 and TLR 4 by resveratrol : molecular targets are TBK 1 and RIP 1 in TRIF complex . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| Overexpression of SIKE disrupted the interactions of IKKepsilon or TBK 1 with TRIF , RIG 1 and IRF 3 , components in virus and TLR 3 triggered IRF 3 activation pathways , but did not disrupt the interactions of TRIF with TRAF 6 and RIP , components in TLR 3 triggered NF kappaB activation pathway . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that TRAF 3 associates with the TLR adaptors TRIF and IRAK 1 , as well as downstream IRF3 / 7 kinases TBK 1 and IKK epsilon , suggesting that TRAF 3 serves as a critical link between TLR adaptors and downstream regulatory kinases important for IRF activation . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| TRAF 3 is also recruited to the adaptor TRIF ( Toll / IL 1 receptor domain containing adaptor inducing IFN beta ) and is required for marshalling the protein kinase TBK 1 ( also called NAK ) into TIR signalling complexes , thereby explaining its unique role in activation of the IFN response . . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| These results suggest that the molecular target of EGCG is TBK 1 in TRIF dependent signaling pathways of TLR 3 and TLR 4 . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| Virus infection , TBK 1 / IKKepsilon expression or co expression of different signaling adaptors such as RIG 1 , MAVS and TRIF , all stimulated pSer477 / 479 phosphorylation . ^^^ |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8IUC6 and Q9UHD2 |
Pubmed |
SVM Score :0.0 |
| NA |
|