| Hsp 90 regulates activation of interferon regulatory factor 3 and TBK 1 stabilization in Sendai virus infected cells . ^^^ In addition , TBK 1 is found to be a client protein of Hsp 90 in vivo . ^^^ Treatment of 293 cells with GA interferes with the interaction of TBK 1 and Hsp 90 , resulting in TBK 1 destabilization and its subsequent proteasome mediated degradation . ^^^ Besides maintaining stability of TBK 1 , Hsp 90 also forms a novel complex with TBK 1 and IRF 3 , which brings TBK 1 and IRF 3 dynamically into proximity and facilitates signal transduction from TBK 1 to IRF 3 . ^^^ |