| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that in these cells , IkappaB kinase alpha ( IKKalpha ) , IKKbeta , and IKKgamma also partially localize to the nucleus , whereas IKK related kinases ( IKKepsilon , TANK binding kinase 1 ) are strictly cytoplasmic , and the NF kappaB inducing kinase is strictly nuclear . ^^^ |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| NAK induces IkappaB degradation and NF kappaB activity through IKKbeta . ^^^ |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| Comparison of the phase and position of intron insertions within the human NAK gene with those within IKKalpha , IKKbeta and IKK epsilon indicated that the exon / intron organization of IKK epsilon is more highly conserved than that of IKKalpha or IKKbeta . ^^^ |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| Messenger RNA was detected for IkappaBalpha , and IkappaB kinase gamma ( IKKgamma , a scaffolding protein ) and the protein kinases , IKKalpha , IKKbeta , NF kappaB inducing kinase ( NIK ) , mitogen activated protein kinase Erk kinase kinase 1 ( MEKK 1 ) and TANK binding kinase 1 ( TBK 1 ) using real time quantitative polymerase chain reaction ( PCR ) . ^^^ |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| Kinetic mechanisms of IkappaB related kinases ( IKK ) inducible IKK and TBK 1 differ from IKK 1 / IKK 2 heterodimer . ^^^ TBK 1 and IKK 1 show sequence and structural homology to IKK 1 and IKK 2 . ^^^ |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| IKK 1 and TBK 1 are enzymatically distinct from the homologous enzyme IKK 2 : comparative analysis of recombinant human IKK 1 , TBK 1 , and IKK 2 . ^^^ |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| In addition to TBK 1 and IKKepsilon , our results indicate that IKKbeta can also phosphorylate IRF 3 and activate the IFN stimulated response element . ^^^ TRIF induced IRF 3 and IRF 7 activation was mediated by TBK 1 and its downstream kinases IKKbeta and IKKepsilon . ^^^ TRIF induced NF kappaB activation through an IKKbeta and tumor necrosis factor receptor associated factor 6 dependent ( but not TBK 1 and IKKepsilon dependent ) pathway . ^^^ |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| A 20 also inhibited TRIF , but not its downstream signaling components TBK 1 , IKKbeta , and IKKepsilon mediated activation of ISRE and NF kappaB and IFN beta promoter . ^^^ |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| Peak 1 represents an unknown kinase , whereas peak 2 contained IKKalpha , IKKbeta , IKKepsilon , and TBK 1 . ^^^ |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UHD2 and O14920 |
Pubmed |
SVM Score :0.0 |
| NA |
|