| PSD 95 and Lin 7b interact with acid sensing ion channel 3 and have opposite effects on H+ gated current . ^^^ We found that a PDZ binding motif at the ASIC 3 C terminus interacts with four different proteins that contain PDZ domains : PSD 95 , Lin 7b , MAGI 1b , and PIST . ^^^ When expressed in heterologous cells , PSD 95 reduced the amplitude of ASIC 3 acid evoked currents , whereas Lin 7b increased current amplitude . ^^^ PSD 95 and Lin 7b altered current density by decreasing or increasing , respectively , the amount of ASIC 3 on the cell surface . ^^^ |