| STAP 2 / BKS , an adaptor / docking protein , modulates STAT 3 activation in acute phase response through its YXXQ motif . ^^^ In the STAP 2 ( / ) hepatocytes , the interleukin 6 induced expression of acute phase ( AP ) genes and the tyrosine phosphorylation level of STAT 3 were reduced specifically at the late phase ( 6 24 h ) of the response . ^^^ STAP 2 contains a YXXQ motif in the C terminal region that is a potential STAT 3 binding site . ^^^ These data suggest that STAP 2 is a new class of adaptor molecule that modulates STAT 3 activity through its YXXQ motif . . ^^^ STAP 2 / BKS , an adaptor / docking protein , modulates STAT 3 activation in acute phase response through its YXXQ motif . ^^^ |