| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| ZO 1 , ZO 2 , and ZO 3 bound to the COOH terminal YV sequence of claudin 1 to 8 through their PDZ 1 domains in vitro . ^^^ Then , claudin 1 or 2 was transfected into L fibroblasts , which express ZO 1 but not ZO 2 or ZO 3 . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analysis revealed that overexpression of claudin 1 increased expression of ZO 1 but not of occludin or ZO 2 . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To investigate the expression and cellular distribution of putative tight junction ( TJ ) proteins occludin , ZO 1 , ZO 2 , and claudin 1 in rat corneal epithelium and alterations of TJs in cultured human corneal epithelial cells in response to lipopolysaccharide ( LPS ) challenge . ^^^ METHODS : Immunohistochemistry was used to determine tissue distribution of occludin , ZO 1 , ZO 2 , and claudin 1 in the rat cornea . ^^^ RESULTS : Occludin , ZO 1 , and ZO 2 were found at the cell borders of the superficial layer , whereas claudin 1 was localized mainly in the basal and wing cell layers of rat corneal epithelium . ^^^ CONCLUSIONS : Occludin , ZO 1 , and ZO 2 , but not claudin 1 , are components of corneal epithelial TJs . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| IL 15 mediated up regulation of ZO 1 and ZO 2 expression was independent of the IL 2Rbeta subunit , whereas the phosphorylation of occludin and enhanced membrane association of claudin 1 and claudin 2 by IL 15 required the presence of the IL 2Rbeta subunit . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| Both integral ( claudin 1 and occludin ) and membrane associated zonula occluden 1 and 2 ( ZO 1 and ZO 2 ) proteins combine to form these TJ complexes that are anchored to the cytoskeletal architecture ( actin ) . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| In the present work we demonstrate that heterotypic TJs in mixed monolayers of MDCK cells with a different cell type ( LLC PK 1 ) are true TJs through several criteria , such as TER , the ability to stop the membrane diffusion of fluorescent sphingomyelin from the apical to the lateral domain , the presence of ZO 1 , ZO 2 , occludin , claudin 1 and claudin 2 . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| Bryostatin 1 , which has been shown to selectively activate PKC alpha , epsilon , and delta ( 34 ) , was associated with a shift in the subcellular distribution of the tight junction proteins claudin 1 and ZO 2 from a detergent soluble fraction into a detergent insoluble fraction . ^^^ The results suggest that enhanced epithelial barrier function induced by bryostatin 1 involves a PKC epsilon dependent signaling pathway leading to recruitment of claudin 1 and ZO 2 , and phosphorylation of occludin , into the tight junctional complex . . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| Expression of the various genes throughout human preimplantation development showed differing levels of sensitivity of detection ; these genes included claudin 1 , occludin ( TM4+ and TM 4 isoforms ) , ZO 1 ( ZO 1alpha+ and ZO 1alpha isoforms ) , ZO 2 and JAM ( junction adhesion molecule ) , and the desmosome junction gene , DSC 2 ( desmocollin 2 ) . ^^^ Some transcripts appeared to be expressed throughout preimplantation development ( claudin 1 , JAM , occludin TM4+ and TM 4 , ZO 1alpha isoform ) while others tended to be expressed preferentially in later cleavage and associated with blastocyst formation ( ZO 2 , ZO 1alpha+ isoform , DSC 2 ) , illustrating an expression pattern broadly similar to mouse cleavage stages . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| We showed here that cAMP increased gene expression of claudin 5 and decreased that of claudin 1 in porcine blood brain barrier endothelial cells via protein kinase A ( PKA ) independent and dependent pathways , respectively . cAMP also enhanced immunoreactivity of claudin 5 along cell borders and in the cytoplasm , reorganized actin filaments , and altered signals of claudin 5 , occludin , ZO 1 , and ZO 2 along cell boundaries from zipperlike to linear patterns . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| No changes in the cellular distribution of claudin 1 , claudin 5 , or ZO 2 were observed after NH ( 2 ) Cl . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| Importantly , this epithelial DC population expressed high levels of the Langerhans cell marker Langerin and the tight junction proteins Claudin 1 , Claudin 7 , and ZO 2 . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| The transmembrane tight junction proteins occludin , claudin 1 and claudin 5 , as well as the cytoplasmic accessory proteins ZO 1 and ZO 2 displayed a continuous distribution at cell boundaries . ^^^ Abeta 1 42 treatment altered also protein expression : occludin was lower at 1st day , claudin 1 increased at all times , and ZO 2 increased after 1 day and then decreased . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| While molecular expression of junctional adhesion molecule ( JAM ) , ZO 2 , ZO 3 , claudin 2 and claudin 3 were unaltered , ZO 1 , occludin , and claudin 4 were all up regulated ( 1 . 6 , 1 . 6 , 2 . 4 fold , respectively ; P < 0 . 001 0 . 01 ) and claudin 1 down regulated ( 2 . 5 fold ; P < 0 . 05 ) by trans 10 , cis 12 CLA , which may underpin its effects on tight junction function and paracellular Ca transport . ^^^ |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O95832 and Q9UDY2 |
Pubmed |
SVM Score :0.0 |
| NA |
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