| Interacting proteins: Q9UBD9 and P26992 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBD9 and P26992 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBD9 and P26992 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBD9 and P26992 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBD9 and P26992 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBD9 and P26992 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that the CLF / CLC complex is a second ligand for CNTFR with potentially important implications in nervous system development . . ^^^ |
|
| Interacting proteins: Q9UBD9 and P26992 |
Pubmed |
SVM Score :0.0 |
| Modelling studies of the interleukin 6 family member cardiotrophin like cytokine ( CLC ) revealed structural similarities with CNTF , including the conservation of a site 1 domain involved in binding to CNTFR . ^^^ Co expression of CLC and CNTFR in mammalian cells generates a secreted composite cytokine , displaying activities on cells expressing the gp 130 LIFR complex on their surface . ^^^ Correspondingly , CLC CNTFR activates gp 130 , LIFR and STAT 3 signalling components , and enhances motor neuron survival . ^^^ Together , these observations demonstrate that CNTFR induces the secretion of CLC , as well as mediating the functional responses of CLC . . ^^^ |
|
| Interacting proteins: Q9UBD9 and P26992 |
Pubmed |
SVM Score :0.0 |
| In this present study we examined the membrane binding of the CLC / CLF composite cytokine and observed a preferential interaction of the cytokine with the CNTFR subunit . ^^^ In contrast to that reported before for CNTF , soluble CNTFR failed to promote the action CLC / CLF , and an absolute requirement of the membrane form of CNTFR was required to generate a functional response to the composite cytokine . ^^^ This study reinforces the functional similarity between CNTF and the CLC / CLF composite cytokine defining the second ligand for CNTFR . . ^^^ |
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