| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis indicates that EZH 2 encodes a 746 amino acid polypeptide that shows 60 . 5 % identity to the Drosophila E ( z ) protein and contains a trithorax like domain and a DNA binding motif . ^^^ |
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| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| Moreover , ENX 1 antisense oligodeoxynucleotide suppressed DNA synthesis in HL 60 cells . ^^^ |
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| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| Both Ezh 2 and pRb2 / p130 repress gene expression by recruiting histone deacetylase ( HDAC 1 ) , which decreases DNA accessibility for activating transcription factors . ^^^ |
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| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| The Polycomb group protein EZH 2 impairs DNA repair in breast epithelial cells . ^^^ Here we report that EZH 2 decreased the expression of five RAD 51 paralog proteins involved in homologous recombination ( HR ) repair of DNA double strand breaks ( RAD51B / RAD51L1 , RAD51C / RAD51L2 , RAD51D / RAD51L3 , XRCC 2 , and XRCC 3 ) , but did not affect the levels of DMC 1 , a gene that only functions in meiosis . ^^^ EZH 2 overexpression impaired the formation of RAD 51 repair foci at sites of DNA breaks . ^^^ Overexpression of EZH 2 resulted in decreased cell survival and clonogenic capacity following DNA damage induced independently by etoposide and ionizing radiation . ^^^ We provide mechanistic insights into the function of EZH 2 in mammalian cells and uncover a link between EZH 2 , a regulator of homeotic gene expression , and HR DNA repair . ^^^ |
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| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| We find that the PcG protein EZH 2 ( Enhancer of Zeste homolog 2 ) interacts within the context of the Polycomb repressive complexes 2 and 3 ( PRC2 / 3 ) with DNA methyltransferases ( DNMTs ) and associates with DNMT activity in vivo . ^^^ The Polycomb group protein EZH 2 directly controls DNA methylation . ^^^ Furthermore , we show by bisulphite genomic sequencing that EZH 2 is required for DNA methylation of EZH 2 target promoters . ^^^ Our results suggest that EZH 2 serves as a recruitment platform for DNA methyltransferases , thus highlighting a previously unrecognized direct connection between two key epigenetic repression systems . . ^^^ |
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| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q15910 |
Pubmed |
SVM Score :0.0 |
| NA |
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