| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| Miz 1 , a novel zinc finger transcription factor that interacts with Msx 2 and enhances its affinity for DNA . ^^^ Further , Miz 1 is a sequence specific DNA binding protein , and it can function as a positive acting transcription factor . ^^^ Miz 1 interacts directly with Msx 2 in vitro and enhances the DNA binding affinity of Msx 2 for a functionally important element in the rat osteocalcin promoter . ^^^ The p148h mutation in Msx 2 augments the Miz 1 effect on Msx 2 DNA binding , suggesting a reason why this mutation behaves in vivo as a dominant positive , and providing a potential explanation of the craniosynostosis phenotype . . ^^^ |
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| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| Recently described interactions between the CTD and other cellular proteins , including YY 1 , AP 2 , BRCA 1 , TFII 1 , and Miz 1 , suggest levels of regulatory complexity beyond Max in controlling DNA recognition by c Myc . ^^^ |
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| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| The latter functioned as a potent transactivation domain when tethered to DNA , indicating that HCF 1 targets a transactivation function in Miz 1 . ^^^ |
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| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| Myc is directly recruited to the p 21 ( Cip 1 ) promoter by the DNA binding protein Miz 1 . ^^^ |
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| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| DNA sequencing revealed that one encoded Miz 1 ( Myc interacting Zn finger protein 1 ) , and another encoded FLNA ( actin binding protein 280 ) , Miz 1 , being a Zn finger protein , could be bound to p 15 promotor and activated the transcription . ^^^ |
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| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| Akt and 14 3 3eta regulate Miz 1 to control cell cycle arrest after DNA damage . ^^^ The transcription factor Miz 1 is required for DNA damage induced cell cycle arrest . ^^^ We have now identified 14 3 3eta as a gene that inhibits Miz 1 function through interaction with its DNA binding domain . ^^^ Binding of 14 3 3eta to Miz 1 depends on phosphorylation by Akt and regulates the recovery of cells from arrest after DNA damage . ^^^ Miz 1 has two functions in response to DNA damage : first , it is required for upregulation of a large group of genes , a function that is regulated by c Myc , but not by 14 3 3eta ; second , Miz 1 represses the expression of many genes in response to DNA damage in an Akt and 14 3 3eta regulated manner . . ^^^ |
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| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| Myc is known to be recruited to the p21Cip1 promoter by the DNA binding factor Miz 1 . ^^^ |
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| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| The Myc : Max complex regulates specific genes by recognizing `` E box ' ' DNA sequences and promoter bound factors such as Miz 1 . ^^^ Our results further indicate that p 300 can acetylate DNA bound Myc : Max complexes and that acetylated Myc : Max heterodimers efficiently interact with Miz 1 . . ^^^ |
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| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and Q13105 |
Pubmed |
SVM Score :0.0 |
| NA |
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