| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| Repression of UBC 9 synthesis prevents cell cycle progression at the G 2 or early M phase , causing the accumulation of large budded cells with a single nucleus , a short spindle and replicated DNA . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| These interactions are UBE2I specific , since another DNA repair related ubiquitin conjugating enzyme , RAD 6 ( UBC 2 ) , does not interact with these proteins . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| HUS 5 is essential for DNA damage repair , whereas UBC 9 is necessary for G2 / M progression . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| UBC 9 has been shown to be involved in cell cycle regulation , DNA repair , and p 53 dependent processes . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| This conclusion is based on the following observations : ( 1 ) Mammalian DNA TOP 1 conjugates induced by CPT were cross reactive with SUMO 1 / Smt3p specific antibodies both in yeast expressing human DNA TOP 1 as well as mammalian cells . ( 2 ) The formation of TOP 1 conjugates was shown to be dependent on UBC 9 , the E 2 enzyme for SUMO 1 / Smt3p . ( 3 ) TOP 1 physically interacts with UBC 9 . ( 4 ) Ubc 9 mutant yeast cells expressing human DNA TOP 1 was hypersensitive to CPT , suggesting that UBC9 / SUMO 1 may be involved in the repair of TOP 1 mediated DNA damage . . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| Ubc 9 also interacted with the mouse homologue of the Bloom ' s syndrome gene product , another eukaryotic RecQ type helicase , but not mouse DNA helicase Q1 / RecQL ( RecQL 1 ) . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| Two hybrid screening in yeast with p73alpha isolated SUMO 1 ( small ubiquitin like modifier 1 ) , the enzyme responsible for its conjugation , Ubc 9 , and a number of novel SUMO 1 interacting proteins , including thymine DNA glycosylase , PM Scl 75 , PIASx , PKY , and CHD3 / ZFH . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| These include genes encoding essential DNA replication proteins ( CDC 45 and DPB 11 ) and proteins involved in SUMO or ubiquitination ( UBC 9 and DOA 4 ) . . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| Dnmt3b , de novo DNA methyltransferase , interacts with SUMO 1 and Ubc 9 through its N terminal region and is subject to modification by SUMO 1 . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| Here we show that UBC 9 , a small ubiquitin related modifier ( SUMO ) conjugating enzyme , is also affiliated with this pathway and that proliferating cell nuclear antigen ( PCNA ) a DNA polymerase sliding clamp involved in DNA synthesis and repair is a substrate . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| A Saccharomyces cerevisiae ubc 9 temperature sensitive ( ts ) mutant showed higher sensitivity to various DNA damaging agents such as methylmethanesulfonate ( MMS ) and UV at a semi permissive temperature than wild type cells . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| In particular , in cells treated with adriamycin that is a DNA damaging agent and that enhances phosphorylation of p 53 at Ser 20 , SUMO conjugation of p 53 was severely impaired possibly by reduced affinity of Ubc 9 to p53 . . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| A noteworthy change in the quantitative profile was that histones and a ubiquitin conjugate protein UBC 9 , which are involved in DNA double strand break ( DSB ) repair were significantly down regulated in the PUMA overexpressing apoptotic cells , suggesting the detection of DSB in the apoptotic process . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| The ubc 9 10 mutant exhibited a decrease in global protein sumoylation and increased sensitivity to a wide range of DNA damaging agents independent of Top1p . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| However , inhibitors of DNA unwinding and CTD phosphorylation do reverse the effects of Ubc 9 with high GR concentrations . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| A new and a reclassified ICF patient without mutations in DNMT3B and its interacting proteins SUMO 1 and UBC 9 . ^^^ Similarly , the coding region of two DNMT3B interacting proteins , SUMO 1 and UBC 9 , did not reveal mutations . ^^^ |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UBC3 and P63279 |
Pubmed |
SVM Score :0.0 |
| NA |
|