Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.98109812
The c Myc protein , the product of the c myc proto oncogene , is a nuclear phosphoprotein with DNA binding properties . 0.98109812^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.55232185
In addition , a bacterially synthesized DNA binding domain of L Myc , like that o c Myc , heterodimerizes with purified Max protein to bind the core DNA sequence CACGTG . 0.55232185^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.66043831
During this process , viral DNA integrates near a cellular proto oncogene , such as c myc , and thus de regulates its expression . 0.66043831^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.67851351
The c myc oncogene encoded protein product , p62c myc , was assayed simultaneously with DNA in populations of individual nuclei extracted from archival biopsies of colonic neoplasia . 0.67851351^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.73136148
The c myc nuclear associated oncoprotein has been quantitated simultaneously with DNA in nuclei extracted from archival biopsies of uterine cervix neoplasia . 0.73136148^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.50596623
Site specific modulation of c Myc cotransformation by residues phosphorylated in vivo . c Myc is a nuclear phosphoprotein which binds DNA as a heterodimer with Max . 0.50596623^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.99020251
In this study , we have generated a series of deletion mutations within the MC 29 gag myc gene to define precisely the carboxy terminal transforming region using the co transformation of C3H10T1 / 2 cells as an assay . 5 Myc proteins encoded by selected deletion mutations were also examined for their intracellular location , the ability to interact with the Max protein and the potential to bind specifically to DNA . 0.99020251^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.91044328
Immunoaffinity purification and characterization of CACGTG sequence binding proteins from cultured mammalian cells using an anti c Myc monoclonal antibody recognizing the DNA binding domain . c Myc protein contains a basic helix loop helix and leucine zipper ( bHLHLZ ) structure in its carboxyl terminal region , forms heterodimers with Max , and binds to the CACGTG sequence in DNA . 0.91044328^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.52910591
It has been previously shown that a 14 amino acid ( aa ) modified peptide ( H 1 S6A , F8A ) derived from the helix 1 ( H 1 ) carboxylic region of c Myc can interfere in vitro with specific c Myc DNA binding . 0.52910591^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :1.5407632
Members of the Mad family of transcription factors are thought to modulate the cell proliferative effects of the c myc proto oncogene by binding to Max , directly competing with the Myc protein for both heterodimerization and DNA binding . 1.5407632^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.50158552
The c Myc protein , the product of the c myc protooncogene , is a nuclear phosphoprotein with DNA binding properties when heterodimerized with the Max protein . 0.50158552^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.5718594
Here we show that c Myc can directly bind to the carboxyl terminal region of the cyclin dependent kinase inhibitor p 21 ( cip1 / waf1 / sdi1 ) and thus partially relieves the p 21 of the inhibitory effect on DNA synthesis directed by the proliferating cell nuclear antigen dependent DNA polymerase delta . 0.5718594^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.59771979
The transcription factor MYC binds specific DNA sites in cellular chromatin and induces the acetylation of histones H 3 and H 4 . 0.59771979^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.86881847
These results indicate that polyamine induced nuclear c Myc interacts with Max , binds to the specific DNA sequence , and plays an important role in stimulation of normal intestinal epithelial cell proliferation . . 0.86881847^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.86518461
Here we show that Myc binds the corepressor Dnmt3a and associates with DNA methyltransferase activity in vivo . 0.86518461^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.66732229
Myc associates with ribosomal DNA and activates RNA polymerase 1 transcription . 0.66732229^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.53063302
To illustrate the interaction among the MAP1A heavy chain , light chain , and microtubule , we prepared DNA constructs with Myc , EGFP , or DsRed tags for full length MAP1A DNA expressing whole MAP1A protein , two domains of MAP1A heavy chain , and light chain . 0.53063302^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.61220376
In addition to the known direct binding of Myc to many genes involved in mitochondrial structure and function , we found that Myc binds the TFAM gene , which encodes a key transcriptional regulator and mitochondrial DNA replication factor , both in P 493 6 lymphocytes with high ectopic MYC expression and in serum stimulated primary human 2091 fibroblasts with induced endogenous MYC . 0.61220376^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.56597195
The human lymphocytes gene expression here experimentally probed using commercially available DNA microarrays such as Human Starter , appears compatible both with independent bioinformatic prediction and with existing experimental data , pointing to MYC as the key gene in the G 0 G1 transition induced by PHA in resting lymphocytes . 0.56597195^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Detection of c myc mRNA and immunoreactive nuclear c myc protein in preimplantation mouse embryos at the eight cell / morula and blastocyst stages suggested that this DNA binding protein could be important during early embryo genesis . ^^^ However , at 4 fold higher concentrations of DNA ( 30 microM ) , all unmodified c myc oligos were embryotoxic , causing embryos to arrest at the two cell to four cell stages . ^^^ These results suggest that c myc function becomes particularly critical for preimplantation mouse embryos at the eight cell / morula stage of development and establish that antisense DNA can be successfully applied as an approach toward elucidating the roles of specific genes in preimplantation mammalian embryo development . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inhibition by 1 , 25 dihydroxyvitamin D 3 of c myc down regulation and DNA fragmentation in cytosine arabinoside induced erythroid differentiation of K 562 cells . ^^^ The effect of 1 , 25 dihydroxyvitamin D 3 ( 1 , 25 ( OH ) 2D3 ) on DNA fragmentation , altered expression of the heat shock protein ( hsp ) 70 gene , and protooncogenes c myc and c myb was studied during chemical induction of erythroid differentiation in K 562 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
C sis and c myc oncogene probes , random primed DNA labeling with digoxigenin dUTP and technique of dot blot hybridization by enzyme immunoassay were used to study both c sis and c myc gene expression in the arterial media and atherosclerotic plaques collected from human aortae . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , EGF stimulates DNA synthesis in parental cells and 5 Myc transfected cells ; this result suggests that growth promoting signals from the EGF receptor may not be required in H Ras transformed cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Although TGF beta 1 was able to directly enhance expression of thrombospondin as well as the growth related genes c fos and c myc , and induced c fos expression with identical kinetics as PDGF , it was unable to elicit [ 3H ] thymidine incorporation into DNA in three independent smooth muscle cell strains . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In order to evaluate the incidence and prognostic significance of gene amplification in primary brain neoplasms we measured the number of gene copies per cell of three oncogenes ( epidermal growth factor receptor [ EGFR ] gene , N myc , C myc ) and syntenic control genes in 40 specimens using quantitative DNA dot blots . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This disparate reduction in hybrid stability was found with both the G + C rich human c myc and A + T rich human c Ha ras sequences used , suggesting that methylphosphonate oligodeoxynucleotide analogues generally hybridize with less affinity to RNA than DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Biochemical properties associated with pRB include binding to viral transforming proteins ( E1A , large T , and E 7 ) , binding to cellular proteins ( E2F and Myc ) , and binding to DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , epidermal growth factor increased DNA synthesis as well as c myc expression . ^^^ In these cells , epidermal growth factor did not affect either DNA synthesis or c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
HeLa , CaSki , MCF 7 , Colo 320 and 3T3 cells , which contain various copy numbers of HPV DNA and / or c myc gene , were used as controls . ^^^ The amplification of myc oncogene was found in 14 / 57 lesions , 13 of which showed both myc and ras gene amplification . c myc and / or c Ha ras DNA was more frequently amplified in cutaneous squamous cell carcinomas ( 8 / 14 cases ) and anogenital papillomas ( 4 / 6 cases ) , than in common and plantar warts ( 3 / 14 cases ) or actinic keratoses ( 2 / 10 cases ) . ^^^ HPV , myc and ras oncogene DNAs were not detected in normal epithelia by in situ hybridization with biotinylated DNA probes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
WHV DNA integration into c myc and N myc , resulting in deregulated expression of these genes , has been described previously in woodchuck HCC . ^^^ We have analysed a woodchuck liver tumour in which WHV DNA was integrated in the c myc gene . ^^^ Integrated viral DNA , including promotor and enhancer sequences , acted as an insertional mutagen , leading to enhanced expression of heterogenous c myc transcripts ranging from 7 . 2 to 14 kb in size , strikingly longer than normal 2 . 3 kb c myc RNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The cell lines retained the characteristics of the original tumor i . e . , production of numerous C type and intracisternal A type particles , integration of Ad 12 E1 region DNA and amplification of the myc gene family . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the present study , a series of 38 biopsies of oral lymphomas ( 29 Burkitt ' s lymphomas , 9 malignant lymphomas of other type ) obtained from patients in Tanzania were studied using in situ hybridization ( ISH ) and polymerase chain reaction ( PCR ) for detection of EBV DNA and c myc oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The present study shows that , in cell free systems , azatoxin induces a large number of double strand breaks in linear Simian virus 40 and human c myc DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have investigated the patterns of WHV DNA insertion into N myc 2 , a newly identified retroposed oncogene , in woodchuck hepatomas resulting from either natural or experimental infections . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Opposite orientations of DNA bending by c Myc and Max . ^^^ The control of gene transcription requires specific protein protein and protein DNA interactions . c Myc , the protein product of the c myc protooncogene , is a member of the basic helix loop helix leucine zipper class of transcription factors . ^^^ Although c Myc is able to bind to a specific core hexanucleotide DNA sequence ( CACGTG ) , its precise function in modulating transcription remains unclear . ^^^ By taking advantage of the altered mobility of protein bound DNA in the mobility shift assay , we demonstrate the homo and heterodimeric complexes of c Myc and Max are able to cause increased DNA flexure as measured by the circular permutation assay . ^^^ Based on phasing analysis , c Myc and Max homodimers bend DNA in opposite orientations , whereas c Myc Max heterodimers cause a smaller bend , in an orientation similar to that induced by Max homodimers . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Stimulation of SV 40 DNA replication by the human c myc enhancer . ^^^ The SV 40 enhancer was replaced by the c myc enhancer core in order to see its effect upon SV 40 DNA replication and transcription . ^^^ The results showed that besides stimulating transcription , the c myc enhancer promoted SV 40 DNA replication in monkey CosI cells . ^^^ The promoting function of the c myc enhancer on DNA replication correlated with the transcriptional activation function , as determined by systematic point mutations introduced within the 21 bp core sequence . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Thirty five of 108 ( 32 % ) cell lines from small cell lung cancer patients have myc family DNA amplification ( 16 c myc , 7 N myc , and 12 L myc ) . ^^^ Thirty seven of 183 ( 20 % ) tumors from patients with small cell lung cancer have myc family DNA amplification ( 3 c myc , 13 N myc , and 18 L myc ) . ^^^ The myc family DNA copy number of 291 specimens ( 183 tumors and 108 tumor cell lines ) from patients with small cell lung cancer has been reported in 15 different studies . ^^^ The myc family DNA copy number in tumors from patients with small cell lung cancer is similar in the majority of sites from the same patient . ^^^ The presence of myc family DNA amplification in the tumor cell line is also typically present in the tumor from the same patient . myc family DNA amplification is present in a minority of patients with small cell lung cancer , and the data on its association with shorter survival of patients are meager at present . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Four classes of mutants were obtained : ( 1 ) those with no effects on MyoD site binding or activation of MyoD responsive genes , ( 2 ) those with no effect on MyoD site binding but with a loss of activation potential , ( 3 ) those with a loss of both DNA binding and activation potential , and ( 4 ) one mutant ( mut 9 , Leu 122 Arg ) that left MyoD site binding unaffected but imparted a new c Myc site binding capability . mut 9 competed with wild type protein for the activation of MyoD responsive reporter genes but could , like c Myc , also suppress the adenovirus major late promoter , which contains a c Myc binding site . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To investigate the role of HPV and c myc and c Ha ras cellular oncogenes ' activation in transplanted patients lesions , we used in situ hybridization with biotinylated probes and Southern blot to detect HPV and oncogenes DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transcription of human c myc in permeabilized nuclei is associated with formation of Z DNA in three discrete regions of the gene . ^^^ Here we measure the formation of Z DNA in the c myc gene by crosslinking the antibodies to DNA using laser radiation at 266 nm for 10 ns . ^^^ Three AluI restriction fragments of the c myc gene are shown to form Z DNA when the cell is transcribing c myc . ^^^ However , when U 937 cells start to differentiate and transcription of the c myc gene is down regulated , the Z DNA content goes to undetectable levels within 30 60 min . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Quantitation of biological tumor markers ( p 53 , c myc , Ki 67 and DNA ploidy ) by multiparameter flow cytometry in non small cell lung cancer . ^^^ We did not find any correlation between Ki 67 staining and expression of p 53 and c myc proteins , either with DNA ploidy , S phase fraction or histological type . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
OBJECTIVE : Endothelin 1 ( ET 1 ) has been reported to stimulate the expression of the proto oncogenes c fos and c myc , and to cause DNA synthesis in vascular smooth muscle cells ( VSMC ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Primers which amplify a fragment of the normal cellular gene c myc were included in the reactions to assess the preservation of DNA in the tissue samples . 77 plaques of demyelination from 23 patients with MS were examined . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Further more , in the hepatitis group it was noticed that the detection rate of c myc mRNA in HBV DNA positive cases ( by in situ hybridization ) was significantly higher than that in HBV DNA negative cases ( P < 0 . 025 ) . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , LPS and IFN gamma , but not TNF alpha , inhibited CSF 1 induced BMM c myc mRNA levels , the lack of effect of TNF alpha dissociating the inhibition of DNA synthesis and decreased c myc mRNA expression for this cytokine . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The myc protein forms a sequence specific DNA binding complex with Max and may act as a transcription factor ; thus , it may be possible that myc family oncogenes are involved in DNA synthesis and repair processes mediating drug resistance . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Insertion of SMRV H viral DNA at the c myc gene locus of a BL cell line and presence in established cell lines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We found that antisense oligodeoxynucleotides corresponding to c myc inhibited both the characteristic DNA fragmentation and the loss of cell viability following activation without affecting production of lymphokines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The potential for manipulation of gene expression by oligonucleotides targeted to a DNA sequence of the c myc oncogene promoter and other gene promoters is clear . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A tentative temporal order is : c myc > c myb > IGF 1 receptor > DNA synthesis genes . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Both c myc amplified tumors were primary lesions and histologically classified as grade 2 ; according to flow DNA cytometry , one was diploid and the other aneuploid . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Endothelin 1 ( ET 1 ) induced receptor mediated phosphoinositide breakdown and increased cytosolic free Ca2+ levels in rat VSMC , with concomitant increases in proto oncogenes ( c fos c myc ) mRNA levels as well as DNA and protein syntheses . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The effects of staurosporine were comparable to those induced by the protein kinase C ( PKC ) activator , 12 O tetradecanoyl phorbol 13 acetate ( TPA ) , with respect to induction of neuronal differentiation , i . e . neurite outgrowth , inhibition of DNA synthesis , induction and down regulation of c myc protein expression , induction of mRNA for both neuropeptide Y ( NPY ) and growth associated protein 43 ( GAP 43 ) and stimulation of tyrosine hydroxylase expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have analyzed the localization of four nuclear antigens in different growth conditions : two replicative proteins , DNA polymerase alpha and proliferating cell nuclear antigen ( PCNA ) , and two oncogenic regulatory proteins , c Myc and c Fos . ^^^ DNA polymerase alpha is the first protein to leave the nucleus , with the PCNA protein , c Fos , and c Myc leaving the nucleus later . ^^^ We also noticed that in sparse cell cultures , 10 % of the cells exhibit a perinuclear staining for the DNA polymerase alpha , PCNA , and c Myc proteins but not for c Fos . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot analysis of secondary transfectants induced with XTD DNA indicated that the oncogenic phenotype did not segregate with the myc or raf loci ; nor with nine other oncogenes analysed . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In order to evaluate more objective laboratory methods that may help practicing pathologists to discern malignancy in human adrenocortical neoplasms , we have examined cellular DNA content by flow cytometry and immunohistochemical distribution of c myc , vimentin , proliferating cell nuclear antigen ( PCNA ) , and epidermal growth factor receptor ( EGFR ) in 15 cases of human adrenocortical neoplasms ( nine carcinomas and six adenomas ) . ^^^ Seven of eight adrenocortical carcinomas demonstrated aneuploid DNA content , while all adenomas were diploid by flow cytometry . c myc oncoprotein was observed both in cytoplasms and nuclei in all carcinomas but only in nuclei in adenomas . ^^^ Therefore , we conclude that only DNA ploidy examined by flow cytometry and immunolocalization patterns of c myc oncoprotein expression have any practical value in the pathologic evaluation of adrenocortical neoplasms . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Concurrent analysis of DNA content with markers of genetic expression is feasible ( e . g . , myc oncogene ) and may increase its prognostic power . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Under these conditions , the RNA levels of late growth regulated genes ( such as DNA polymerase alpha , PCNA , thymidine kinase , and core histones ) are markedly decreased or even undetectable , while early growth regulated genes ( for instance , c myc ) are normally expressed , and certain promoters are actually super induced . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c Myc protein is a potential activator of transcription , with the ability to bind in a heterodimer form with Max to DNA sequences containing the core hexanucleotide sequence CAC ( G / A ) TG . ^^^ The c Myc , and probably 5 Myc , proteins also have nonspecific DNA binding function , which may improve the kinetics of specific DNA binding . ^^^ A theory that c Myc plays a role in DNA replication is not as well substantiated at this point . ^^^ DNA binding by the Myc oncoproteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It was found that TGF beta 1 and cadmium both inhibit EGF induced DNA synthesis and cell proliferation in a dose dependent fashion , but that neither inhibits EGF induced myc oncogene accumulation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this study , we demonstrate that B cell activation by IL 6 is associated with an initial induction of c myc , a gene believed to act as a competence factor for increased RNA transcription and DNA replication , and by increases in DNA , RNA , and protein synthesis , as well as cell number . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast to DNA synthesis , H2O2 induction of c myc and c fos mRNA was primarily protein kinase C dependent . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of the upstream regulatory sequences revealed the absence of TATA and CAAT box sequences , and the presence of myb , myc , and ets like DNA binding motifs . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In SEWA cells there is ' spontaneous ' amplification of the c myc oncogene , and transitions between different cytogenetic expressions of gene amplification such as DM ( double minutes ) , CM ( C bandless chromosomes ) and HSR ( homogeneously staining regions ) of the amplified DNA have been recorded during serial in vivo transplantations . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Occasionally DNA amplification of the myc genes is associated with DNA rearrangements . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Applying this technique , we followed the metaphase location and interphase position of amplified DNA sequences corresponding to the SAMK , MYC , and MYCN genes in four cell lines derived from human tumors : two gastric carcinoma lines ( KATO 3 and SNU 16 ) , a neuroblastoma ( NUB 7 ) , and a neuroepithelioma ( NUB 20 ) line . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the second case the mitochondrial DNA sequence encoding cytochrome c oxidase subunit 3 was contiguous with and 5 ' of exons 2 and 3 of the c myc oncogene and the chimeric gene was transcribed . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA was digested with two restriction enzymes , Eco RI and Hin dIII , Southern blotted , and hybridized to six different c onc probes including 5 abl , 5 erb B , c myc , c H ras , c K ras , and 5 src . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hydrocortisone did not alter the basal DNA synthesis level displayed by quiescent 3T3 cells , but it potentiated both the mitogenic effect of platelet derived growth factor and c myc induction by serum growth factors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc protein ( Myc ) contains an amino terminal transcriptional activation domain and a carboxy terminal basic helix loop helix leucine zipper ( bHLH Z ) domain that directs dimerization of Myc with its partner , the max protein ( Max ) , and promotes DNA binding to sites containing a CACGTG core consensus sequence . ^^^ Here we use Saccharomyces cerevisiae as an in vivo model system to show that the Myc protein is a sequence specific transcriptional activator whose DNA binding is strictly dependent on dimerization with Max . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mutational analysis of Max : role of basic , helix loop helix / leucine zipper domains in DNA binding , dimerization and regulation of Myc mediated transcriptional activation . ^^^ The Max protein forms a heterodimeric complex with the Myc family of proteins and binds to DNA in a sequence specific manner . ^^^ We mutagenized the basic , HLH and LZ domains of Max and studied the ability of the normal and mutant proteins to bind to DNA as both homo and heterodimers and their ability to heterodimerize with Myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The effect of wt p 53 protein on the expression of four immediate early genes ( c FOS , c JUN , JUN B , and c MYC ) , one delayed early gene ( ornithine decarboxylase ) , and two late G1 / S phase genes ( B MYB and DNA polymerase alpha ) was also examined . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The changes in transmethylation metabolites in whole cells , although compatible with levels frequently associated with hypomethylation of cellular components , caused no changes in methylation of c myc DNA sequences of the HL 60 cells as detected by HpaII or MspI digestion and Southern blotting . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When P388D1 cells were stimulated by LPS , interferon gamma or the association of both compounds , no direct correlation could be found between the modulation of DNA synthesis and the early expression of the c fos and c myc oncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We report here that the mapping of single stranded DNA in vivo with potassium permanganate ( KMnO 4 ) and nuclear run on transcription assays reveal that polymerase is paused near position +30 relative to the major c myc transcription initiation site . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Amplification of the c myc oncogene has been detected by Southern blotting in the DNA of radiation induced skin cancers in the rat . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this paper , c myc protein and DNA were doubly stained and analysed simultaneously with flow cytometry ( FCM ) . ^^^ After fixation , the cells were stained with a monoclonal antibody against c myc protein , followed by DNA staining with PI . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Down regulation of c MYC antigen expression in lymphocytes of Emu c myc transgenic mice treated with anti c myc DNA methylphosphonates . ^^^ In transgenic mice bearing a murine immunoglobulin enhancer / c myc fusion transgene ( Emu myc ) , it was found that antisense DNA methylphosphonates targeted against c myc mRNA inhibited production of c MYC protein in peripheral lymphocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc / Max and other helix loop helix / leucine zipper proteins bend DNA toward the minor groove . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA from several transformed REC : myc : gamma cell lines induced focus formation in recipient C3H 10T1 / 2 and NIH 3T3 cells . ^^^ A detailed analysis of the NIH 3T3 transformants generated from REC : myc : gamma 33 and gamma 41 DNA failed to detect Ha ras , Ki ras , raf , neu , trk , abl , fms , or src oncogenes of rat origin . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Bladders were removed , and mucosa free detrusor was weighed and frozen for assay of DNA content and expression of c fos and c myc protooncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
For example , active oxygen activates protein kinases , causes DNA breakage , and induces the growth competence related protooncogenes c fos and c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A comparison of cellular characteristics with corresponding DNA methylation changes in different clones suggested that the loss of contact inhibition and the gain of anchorage independency were associated with increases of methylation in many genes , whereas the acquisition of tumorigenicity was often accompanied by a decrease of methylation in the N myc and c myc genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The effects of a c myc antisense phosphorothioate DNA oligonucleotide were assessed on the proliferation rate of human arterial smooth muscle cells ( HSMCs ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cloning and characterization of DNA binding factors which bind sequences required for proper c myc initiation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Max repression is dependent on an intact DNA binding region , while Myc activation depends on both the N terminal activation and the C terminal dimerization domains . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
An exchange of the DNA binding domain of c Myb by that of GAL 4 led only to small transactivation effects indicating that the DNA binding domain of c Myb is essential for transactivation of the c myc gene . ^^^ These results suggest either an indirect transactivation mechanism of the c myc gene by c Myb proteins or a role of the DNA binding domain for additional effects than DNA binding . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc and c myb proto oncogenes encode phosphorylated nuclear DNA binding proteins that are likely to be involved in transcriptional regulation . ^^^ The hyperphosphorylated forms of Myc and Myb from mitotic cells are functionally distinct from the corresponding interphase proteins in that the former have reduced ability to bind nonspecificially to double stranded DNA cellulose . ^^^ We surmise that the decreased DNA binding capacity of hyperphosphorylated Myb and Myc during M phase may function to release these proteins from chromatin during chromosome condensation . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Max and c Myc / Max DNA binding activities in cell extracts . ^^^ We have examined the interactions and DNA binding activities of the c Myc oncoprotein and its partner Max . ^^^ Moreover , DNA binding studies with in vitro translated protein and cell extracts show that both Max alone and c Myc / Max bind the same DNA sequence . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
FSH / IN not only stimulated DNA synthesis but also increased c myc , c fos , and c jun mRNA levels and the percentage of cells staining for c fos and c myc proteins . ^^^ The protein kinase inhibitor , 2 aminopurine ( 2 AP ) , inhibited the FSH / IN induced increases in c myc and c fos mRNA levels , the percentage of cells staining for Myc and Fos protein , and DNA and protein synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Expression of c fos and c myc oncogenes in the P388D1 murine macrophage line treated by immunomodulators : absence of direct correlation with DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The quiescent 3Y1 cells induced c fos and c myc expression within 2 h after serum stimulation and expressed clone 16 and clone 3 transiently at around 8 h before the onset of DNA synthesis ( 10 h ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transforming growth factor alpha induced DNA synthesis and c myc expression in primary rat hepatocyte cultures is modulated by indomethacin . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Six cases of mediastinal large B cell lymphoma ( MLCL ) with sclerosis were analyzed for the presence and patterns of c myc and bcl 2 loci rearrangements , and for the presence of Epstein Barr virus DNA sequences by Southern blot hybridization , c myc gene alterations were found in three of six cases . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A systematic study of primary human breast tumor DNA demonstrated that three proto oncogenes or regions of the genome ( c myc , int 2 , and c erbB 2 ) are frequently amplified and that there is loss of heterozygosity ( LOH ) on chromosomes 1p ( 37 % ) , 1q ( 20 % ) , 3p ( 30 % ) , 7 ( 41 % ) , 11p ( 20 % ) , 13q ( 30 % ) , 17p ( 49 % ) , 17q ( 29 % ) , and 18q ( 34 % ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A major site of DNA bending is located 1 . 6 kb upstream of the P 1 transcription start site of the human c myc gene , near the center of a reported zone of initiation of DNA replication . ^^^ This element is present near centers of regions of two mammalian loci ( human c myc and hamster dhfr ) recently reported as initiation zones for DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have previously reported that the c myc protein or protein ( s ) complexed with the c myc protein bind to a specific sequence in the region upstream of the c myc gene , where there exist an origin of cellular DNA replication ( ori ) and also a transcriptional enhancer . ^^^ It was recently reported that the c myc protein forms complexes with a novel helix loop helix leucine zipper protein ( Max ) , and that the Myc Max complex specifically recognizes a DNA sequence different from the sequence we have defined in the c myc gene . ^^^ Since binding to both sequences was cancelled by pretreatment of the Raji extract with an anti c myc protein antibody , it is suggested that proteins carrying myc like antigenicity are necessary for efficient binding of the nucleoprotein complexes to the two distinct DNA sequences . . ^^^ Protein complexes bearing myc like antigenicity recognize two distinct DNA sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The Max gene encodes a protein that interacts specifically with the Myc protein to form a heterodimer with high affinity for the specific cognate DNA binding site of Myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Max and c Myc proteins , produced in bacteria , were studied for DNA binding activity using the electrophoretic band shift assay ( EMSA ) . ^^^ Both Max homodimers and c Myc Max heterodimers selected the same sequence CA ( C / T ) GTG from an initial pool of 10 ( 6 ) DNA molecules . ^^^ Based on recognition of the same DNA sequence by Max and c Myc Max complexes and differential expression of the two genes , we propose that Max homodimers and c Myc Max heterodimers may bind to a common set of cellular target genes . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Max is a basic helix loop helix leucine zipper protein capable of forming sequence specific DNA binding complexes with Myc proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The ME1a1 and ME1a2 elements are cis acting DNA sequences that exist at positions 46 and 85 , respectively , within the P 2 promoter of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The specific inhibition of colony forming capacity by antisense DNA suggests that the role of myc expression in Colo 320 cells is similar to its role in hematopoiesis , and that the failure to inhibit myc expression maintains colony forming capacity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the present study , we searched for integrated GSHV DNA and genetic alterations of myc genes in ground squirrel HCCs . ^^^ Viral integration into host DNA was detected in only 3 / 14 squirrel tumors and did not result in insertional activation of myc genes , despite the presence of a squirrel locus homologous to the woodchuck N myc 2 gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
However , it scarcely affected DNA synthesis and the level of c myc mRNA . ^^^ These results suggest that the growth inhibitory effect of KNK 41 is the result of G0 / G1 arrest and not of the suppression of DNA synthesis and / or c myc expression . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Recent studies centered on the c Myc basic / helix loop helix / leucine zipper ( B / HLH / LZ ) motifs have led to the identification of a DNA recognition sequence for c Myc and the isolation of a novel protein that forms a DNA binding complex with c Myc in vitro . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Damage induced by gamma rays at levels as low as 2 Gy was measured in bulk DNA and in a one megabase region surrounding the actively transcribed oncogene , c myc , as well as in the inactive alpha satellite DNA of chromosome 17 . ^^^ Although the unwinding kinetics for bulk DNA were consistent with random strand breakage throughout the genome as a whole , measurements at specific loci indicated that the region encompassing c myc was at least 2 fold more susceptible to damage than either the bulk of the genome or the alpha satellite region . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
At this juncture , an examination of c myc oncogene abnormalities at the DNA level appears to have a greater potentials in the field described above than those at mRNA and protein levels . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Quantitative analysis revealed that in colonic adenocarcinomas an average of 66 . 1 % and in metastatic deposits 83 . 1 % of the myc gene DNA was hypomethylated at this site , as compared to a value of 9 . 2 % in normal colonic mucosa . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA binding activities of c Myc purified from eukaryotic cells . c Myc is a nuclear phosphoprotein which contains both a leucine zipper and a helix loop helix dimerization motif . ^^^ Specific sequences that bound to c Myc were selected from a large pool of random DNA sequence . ^^^ Both protein preparations additionally demonstrated a distinct complex , containing both c Myc and a copurifying 26 29 kDa protein , that bound to DNA with higher affinity than Myc alone . ^^^ These data demonstrate that c Myc isolated from eukaryotic cells is capable of sequence specific DNA binding and further refine the optimal sequence for c Myc binding . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Endothelin is a potent vasoconstrictor peptide that increases intracellular calcium , causing a rapid and transient increase in c fos and c myc messenger ( m ) RNA levels and DNA synthesis in rat vascular smooth muscle cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In order to do that on a cell by cell basis , we measured the nuclear c myc protein simultaneously by flow cytometry , via specific monoclonal antibodies , and the DNA content via the intercalating dye propidium iodide . ^^^ Readdition of IL 3 resulted in a slow transition of cells from G1A to late G 1 ( G1B , at higher c myc content ) before DNA synthesis started . ^^^ G1A cells with low c myc content do not undertake DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This phosphoprotein was specifically immunoprecipitated by phosphoprotein nor detectable activities of other kinases , phosphorylated recombinant c Myc proteins in the presence of DNA . ^^^ The c Myc phosphorylation by DNA PK was markedly stimulated by relaxed , double stranded DNA , but neither by single stranded DNA nor by RNA . ^^^ Phosphopeptide mapping and phosphoamino acid analysis indicated that DNA PK phosphorylates c Myc in vitro at several serine residues . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A control oligodeoxynucleotide does not inhibit DNA synthesis , while specific antisense c myc PTO did inhibit DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Sequence analysis of this myc like ( MYCLK 1 ) DNA fragment has revealed the existence of a region with 85 % homology to the 28 base oligonucleotide probe . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Weak relationships were found between c myc amplification and the presence of lymph node metastasis , advanced stage , DNA non diploidy and premenopausal status , but not tumor size , estrogen receptor or progesterone receptor status , or int 2 amplification . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA amplification and transcription of c myc oncogene were also studied with polymerase chain reaction ( PCR ) using beta globin as an intrinsic standard for DNA amplification . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The ratio of tumor DNA values to that of control DNA was used to estimate the c myc copy number . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Studies with transformation defective mutants of E1A and TAg suggested that a cellular protein ( s ) that interacts with a conserved domain of the DNA tumor virus oncoproteins mediates TGF beta 1 suppression of c myc transcription and keratinocyte growth . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have identified a termination site in the promoter region of the c myc gene , whose function correlates with DNA binding by a nuclear factor . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Human papillomavirus type related DNA and c myc oncogene alterations in colon cancer cell lines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These latter leukemias also had not undergone DNA rearrangements in c myc , although retroviruses expressing myc have previously been shown to induce monocyte macrophage tumors in mice undergoing a chronic inflammation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The HPV 16 DNA sequences were integrated near a fragile site and the location of the c myc oncogene at 8q24 . 1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Association of c myc protein with enzymes of DNA replication in high molecular weight fractions from mammalian cells . ^^^ This distribution of c myc protein coincided with the distribution of DNA polymerase alpha and several other enzymes necessary for DNA replication . ^^^ The data suggest that c myc product may be a component of the replitase complex of enzymes involved in nuclear DNA replication . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Reduction by interferon alpha of levels of c myc protein and DNA synthesis in a human hepatoma cell line mediated by inhibition of putrescine synthesis . ^^^ Added putrescine abrogated the effects on c myc protein and DNA synthesis . ^^^ Interferon alpha seemed to inhibit the increase in the c myc protein level post transcriptionally by reducing the putrescine level , inhibiting DNA synthesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Integration of papillomavirus DNA near myc genes in genital carcinomas and its consequences for proto oncogene expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Our results demonstrate that normal rlf and L myc genes are separated by less than 800 kb of DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Replication of test plasmids was not detected in N myc or c myc overexpressing cells when the T antigen expression plasmid was not provided , showing that the myc proteins can not substitute for T antigen in SV 40 DNA replication . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Such cells revealed marked enhancement of EBV DNA and RNA and of endogenous c myc transcripts and protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A comparative study on HBV status and ets 2 , IGF 2 , C myc and N ras expression in 12 pairs of human primary hepatocellular carcinoma ( PHC ) and adjacent non tumorous tissues ( NT ) showed that integrated forms of HBV DNA were present in 91 . 5 % PHC and 75 % NT . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The amplification of a DNA segment located in the junction of the LINE genome and c MYC upstream sequences enabled the testing of the similarity of transmissible venereal tumor samples collected independently in different parts of the world . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This study examines the genetic response in cultured human keratinocytes exposed to a single solar simulated ultraviolet dose and harvested at 1 , 4 , 8 , 24 , and 48 hours postirradiation for northern blot analysis using c DNA probes to well studied stress related genes , heat shock protein 70 and ubiquitin ; to a recently cloned gene associated with growth arrest and DNA damage ( gadd 153 ) ; to c myc and c fos , two proto oncogenes known to be associated with cell growth and differentiation ; and to glyceraldehyde phosphate dehydrogenase , known to be involved in cellular intermediary metabolism , gadd 153 and c fos mRNA levels are increased early ( 1 4 hours ) in keratinocytes , at a time when the cells appear indistinguishable from nonirradiated controls . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In spite of these functional similarities , 8 MOC , caffeine and 8 CC were unable to stimulate the formation of a cleavable complex by purified L 1210 topoisomerase 2 ( p 170 form ) when SV 40 DNA and human c myc DNA were used as substrate . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The probes used are DNA fragment of myc , N , H , K ras , fos , fms , raf , erb A , erb B , and erb B 2 genes and synthetic oligonucleotides corresponding to the part of N , H , K ras genes . ^^^ These data showed that there are no specific proto oncogene expression into RNA except for myc and ras genes , nor DNA rearrangement in these 3 human hepatoma cell lines with regards to at least 10 different oncogenes examined and suggest the relationship between fos gene expression and integration of HBV DNA in host cell DNA . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Through their homologous helix loop helix and leucine zipper structures , Myc and Max proteins form heterodimers that bind to specific DNA sequences more efficiently than Myc or Max alone . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The cases with DNA available were evaluated for MYC rearrangement ( MYC R ) by Southern hybridization of EcoRI digested tumor DNA using an exon 1 probe , a combination of probe and enzyme known to detect over 85 % of breaks in sporadic Burkitt ' s lymphoma . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In our previous study , amplification of c erb B 2 and c myc proto oncogenes in DNA of human breast cancer occurred in 16 % and 4 % of cases , respectively , and increased copy number of these genes is suggested to be associated with aggressive primary tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA synthesis in T CLL and T PLL cells is preceded by expression of G 1 specific messenger RNAs , ie . c myc , 2F1 , Tac , and interferon gamma , in activated cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Spectrum of histologic , histochemical , immunohistochemical ( immunohistochemistry of oncoproteins c fos , c myc , c ras , c sis and c src ) methods , DNA histospectrophotometry by plug method , electron microscopy , semithin section morphometry , statistical and correlation analysis were used . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
PE stimulated PDGF A gene expression was accompanied by increased expression of other growth related genes including c fos , c myc , and ornithine decarboxylase but not DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Primary and metastatic tumor tissues of serous papillary adenocarcinoma of the endometrium were examined for the following : ( 1 ) amplification of int 2 , c erbB 2 and c myc proto oncogenes by Southern blot hybridization ; ( 2 ) DNA ploidy by flow cytometric study ; ( 3 ) and expression of specific proteins , such as estrogen and progesterone receptors , keratin , vimentin , and carcinoembryonic antigen ( CEA ) using immunohistochemical and biochemical techniques . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA and RNA from 11 established NSCLC cell lines ( 4 adenocarcinoma cell lines , 3 squamous cell carcinoma cell lines , 3 large cell carcinoma cell lines and 1 mesothelioma cell line ) were isolated and analysed using the Southern , dot blot and Northern hybridization technique . c myc RNA expression was found in all NSCLC cell line , L myc expression only in 1 adenocarcinoma cell line , N myc and c myb expression in none of the 11 cell lines examined . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The effects of simultaneous addition of endothelin and PMA on c myc mRNA levels were essentially similar to those observed with c fos mRNA . [ 3H ] thymidine incorporation into DNA occurred 8 h after exposing the cells to endothelin . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We found that MYC domains from COLO320HSR showed a higher frequency of double strand DNA breaks than MYC domains from COLO320DM cells . ^^^ We propose that chromatin organization in total cellular DNA and in the amplified MYC domain probably plays an important role in the DNA response to BLM . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Evidence presented elsewhere shows that provirus integration in Mlvi 4 enhances the expression of c myc and Mlvi 1 by cis acting mechanisms operating over long distances of genomic DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Although the amounts of c myc mRNA reached a plateau around 20 h after the initiation of culture and remained at these levels , DNA synthesis has never been found to start without the addition of EGF and insulin to this system . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To elucidate the possible roles of proto oncogenes and growth factors in estrogen regulated cell proliferation of human breast and gynecologic cancers , we have determined the gene expressions of c myc , transforming growth factor alpha and beta 1 ( TGF alpha , beta 1 ) and epidermal growth factor receptor ( EGFR ) in a number of these cancer cell lines by using an intron Differential ( ID ) RNA / PCR method , which differentially identifies the amplified cDNA from PCR products of genomic DNA contaminants . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In situ hybridization with myc , N ras , and raf 1 radiolabeled DNA probes to NAB 2 chromosomes showed that none of these genes was relocated as a result of translocation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this study we investigated the effects of PGD 2 on cAMP level , DNA synthesis , and c myc expression using EBTr cells growth arrested by serum starvation . ^^^ Time course studies support the association between the reduction of c myc expression and the successive inhibition of DNA synthesis by PGD 2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using this material , not only a thorough mutational analysis of DNA of preneoplastic foci is possible after a simultaneous PCR amplification of various genomic sequences , but also an investigation of transcription activity after reverse transcription of mRNA into cDNA , as shown for c myc expression during preneoplasia . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA repair in the c myc proto oncogene locus : possible involvement in susceptibility or resistance to plasmacytoma induction in BALB / c mice . ^^^ This report describes an unexpected difference in the efficiency of removal of UV induced DNA damage in the c myc locus in splenic B lymphoblasts from two inbred strains of mice . ^^^ In contrast , DNA repair in the 5 ' flank of c myc is not strand specific ; in DNA from DBA / 2N cells , UV damage is rapidly removed from both the transcribed and nontranscribed strands . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot hybridization of KHC 287 DNA showed 20 and 40 fold co amplification of c myc and c ki ras , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hepato specific regulatory ( promoter / enhancer ) DNA sequences were used for targeting the expression of onc genes , such as murine c myc and Simian Virus 40 T Antigen , to hepatocytes of transgenic mice which subsequently developed hepatocellular carcinomas after a variable period of time ( depending on the type of onc gene employed ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Verapamil ( 5 20 microM ) , a calcium channel inhibitor , inhibited hepatocyte DNA synthesis and c myc expression , induced by EGF ( 50 ng / dish ) and prostaglandins ( 1 12 micrograms / dish ) . ^^^ Indomethacin ( 20 100 microM ) decreased significantly the EGF induced hepatocyte DNA synthesis and c myc expression . ^^^ Addition of PGs ( 1 9 micrograms ) in hepatocyte cultures treated with EGF+indomethacin ( 100 microM ) restored the capacity of EGF to increase c myc expression and DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Treatment with IL 6 caused a rapid increase in the c myc mRNA level , and resulted in increases in DNA synthesis and cell number . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Previous studies have shown that this effect involves the transient activation of c fos and c myc expression , followed by significant increases in both DNA synthesis and cell proliferation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
As an approach to a better understanding of the relationship between the different phenotypic traits , we analyzed the expression of myc and ras oncogenes in the drug sensitive DC 3F cells and in variants resistant to 9 hydroxyellipticine ( 9 OH E ) ( DNA topoisomerase 2 alteration ) or to actinomycin D ( AD ) ( multidrug ( MDR ) expression ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Newly established uterine cervical carcinoma cell line with co amplification of human papillomavirus DNA and c myc gene . ^^^ This cell line harbored approximately 50 to 100 copies of human papillomavirus ( HPV ) type 18 DNA per haploid genome , and contained about 16 fold amplified c myc gene with rearrangement . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Premalignant and malignant lesions of the cervix uteri and endometrium were analyzed for the presence of human papillomavirus ( HPV ) DNA and c myc or c erbB2 / neu oncogene expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Chem . , 263 : 13324 13332 , 1988 ) , the other clone , mYc , was demonstrated to be a novel complementary DNA clone encoding a glutathione S transferase homologous to rat Yc ( subunit 2 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The product of the c myc proto oncogene is a DNA binding protein , the deregulated expression of which is associated with a variety of malignant neoplasms . ^^^ Full length c Myc alone can not bind DNA . ^^^ However , a truncated c Myc protein comprising the basic , helix loop helix , and leucine zipper regions can bind specifically to DNA bearing the sequence GGGCAC ( G / A ) TGCCC . ^^^ Using a novel combination of chemical and photo cross linking analysis , we demonstrate that either Max or a c Myc / Max heteromeric complex binds to DNA virtually exclusively in a dimeric structure . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Quantitative dissociation between EGF effects on c myc and c fos gene expression , DNA synthesis , and epidermal growth factor receptor tyrosine kinase activity . ^^^ The exact relationship between EGF stimulated tyrosine phosphorylation , induction of the cellular proto oncogenes c myc and c fos , and DNA synthesis remains uncertain . ^^^ They also suggest that , in MDCK cells , the EGF dependent induction of the c fos and c myc genes is not strictly correlated to the extent of EGF receptor autophosphorylation or EGF stimulated DNA synthesis , and that EGF stimulation of DNA synthesis likely involves additional rate limiting intermediate steps . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Prolonged inhibition by 10 rays of DNA synthesis in cells obtained by transformation of primary rat embryo fibroblasts with oncogenes H ras and 5 myc . ^^^ We examined radiation ( 10 rays ) induced inhibition of DNA synthesis in cell lines derived from such transformed clones and compared the results to those obtained with the nontransformed parental cells , rat embryo fibroblasts , as well as with cells immortalized either spontaneously , or after transfection with nuclear oncogenes ( 5 myc , E1A ) . ^^^ Inhibition by 10 rays of DNA synthesis was higher and persisted for longer periods of time in the H ras plus 5 myc transformed cell lines as compared to their nontrasformed counterparts . ^^^ A substantially larger inhibition of DNA synthesis was observed between 0 and 30 Gy in H ras plus 5 myc transformed cell lines , as compared to their nontransformed counterparts , presumably caused by sustained inhibition of replicon initiation . ^^^ These results suggest a direct or indirect involvement of the oncogene H ras in cooperation with the oncogene 5 myc ( or other nuclear oncogenes such as E1A ) in the control of DNA synthesis in irradiated cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Expression of exogenous c myc oncogene does not initiate DNA synthesis in primary rat hepatocyte cultures . ^^^ Overexpression of c myc did not initiate significant DNA synthesis in rat hepatocyte cultures alone , although it cooperated with added EGF to super induce thymidine incorporation into DNA . ^^^ From our results , it is suggested that EGF is also necessary to initiate hepatocyte DNA synthesis probably by inducing a battery of cell cycle related genes if incubated with c myc transfected cultures for only 5 hours . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Predicted structural similarities of the DNA binding domains of c Myc and endonuclease Eco RI . ^^^ The c Myc oncoprotein belongs to a family of proteins whose DNA binding domains contain a basic region helix loop helix ( bHLH ) motif . ^^^ Systematic mutagenesis of c Myc revealed that dimerized bHLH motifs formed a parallel four helix bundle with the amino termini of helices 1 and 2 directed toward the inner and outer nucleotides of the DNA binding site , respectively . ^^^ The DNA binding domain of c Myc may therefore be structurally similar to that of restriction endonuclease Eco RI . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Its nuclear localization signal allows c Myc to be targeted to and retained in the nucleus , where the protein seeks out and binds to specific DNA sites , perhaps facilitated by c Myc ' s ability to bind non specifically to DNA . ^^^ Once bound to specific DNA sequences , c Myc then activates or inhibits transcription of a number of target genes , with consequent alterations in cell growth and differentiation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
As for c myc , PMA and thrombin synergistically increased expression of the PDGF A chain under conditions where PMA inhibits thrombin induced DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We measured cell proliferation , DNA synthesis , and c myc proto oncogene expression , in response to growth stimuli such as fetal bovine serum ( FBS ) and platelet derived growth factor ( PDGF ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Expression of the proto oncogenes N myc and c myc in the human neuroblastoma cell line , IMR 32 , was examined after reversible inhibition of DNA synthesis by treatment with deferoxamine . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of the DNA from the electron induced carcinomas indicated that K ras and / or c myc oncogenes were activated in all tumors tested . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mithramycin , a DNA binding antibiotic which binds G C rich DNA , inhibits c myc expression in both differentiating and nondifferentiating cells . ^^^ Gel retardation experiments performed in the presence of mithramycin demonstrate that drug binding can prevent the formation of discrete complexes between HeLa cell nuclear proteins and c myc promoter DNA fragments . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Sequence specific DNA binding by Myc proteins . ^^^ By using recombinant 5 Myc proteins obtained by bacterial expression of full length or partially deleted avian 5 myc alleles , the functional relevance of these sequence motifs for Myc protein oligomerization and for DNA binding was investigated . ^^^ All recombinant 5 Myc proteins that have retained the carboxyl terminal domain dimerize and specifically bind to double stranded DNA containing the palindromic core sequence CACGTG . ^^^ It is shown that a 61 amino acid peptide sequence containing only the bipartite basic motif / helix loop helix domain of Myc is necessary and sufficient for dimerization and sequence specific DNA binding of 5 Myc recombinant proteins . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NRAS , MYCN , CSFIR , MYB , MYC , ABL , HRASI , TP 53 , and ERBB 2 did not reveal any consistent alterations in tumour DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have used 13 anonymous DNA markers from an 8q24 . 1 specific microdissection library , as well as c myc and thyroglobulin gene probes , to map the deletion breakpoints in 16 patients with LGS . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Association of Myn , the murine homolog of max , with c Myc stimulates methylation sensitive DNA binding and ras cotransformation . ^^^ Myn , a novel murine approximately 18 kd basic / helix loop helix / ' ' leucine zipper ' ' ( B / HLH / LZ ) protein , forms a specific DNA binding complex with the c Myc oncoprotein through the HLH / LZ motif in both proteins . c Myc / Myn recognizes a c Myc binding site ( GACCACGTGGTC ) with higher affinity than either protein by itself . ^^^ CpG methylation of the recognition site greatly inhibits DNA binding , suggesting that DNA methylation may regulate the c Myc / Myn complex in vivo . ^^^ We suggest that interaction of Myn with c Myc stabilizes sequence specific DNA binding in vivo . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We studied 107 specimens ( 38 tumors and 69 tumor cell lines ) from 90 patients with small cell lung cancer to determine the characteristics and clinical situations of patients from whom tumor cell lines could be established and the myc family DNA copy number . ^^^ The myc family DNA amplification occurred in 17 of 54 ( 31 % ) of the specimens from patients treated with cyclophosphamide based combinations and 2 of 13 ( 15 % ) of the specimens from patients treated with etoposide / cisplatin ( P = 0 . 25 ) . ^^^ Both tumors and tumor cell lines were obtained from 17 patients with small cell lung cancer and the myc family DNA copy number was similar in 16 of the 17 patients . ^^^ We conclude that : ( a ) myc family DNA amplification occurs more commonly in specimens from treated than untreated patients ( b ) there are no prominent differences in the frequency of amplification following treatment with different chemotherapy regimens ; and ( c ) myc family DNA amplification is similar in tumors and tumor cell lines from the same patients . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
EBV DNA was present in 19 of 20 tumors with breakpoints outside c myc , in none of 7 with a breakpoint in the immediate 5 ' region of c myc , in 4 of 5 tumors with breakpoints in the first exon , and in 7 of 12 tumors with breakpoints in the first intron . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In their analysis , Southern hybridization and DNA dot blot analysis were used to screen 49 breast cancer DNAs for Myc , Neu , and Int 2 gene amplification . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Studies of woodchucks infected with a virus closely related to the human hepatitis B virus suggest that integration of the viral DNA in the host genome often plays a direct role by activating myc cellular oncogenes through insertional mutagenesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Primers suitable for amplifying c myc were included in the PCRs for assessment of DNA preservation . ^^^ This was found to be adequate to allow amplification of c myc DNA in sections from all of the brains studied . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Site specific hypomethylation of c myc protooncogene in liver nodules and inhibition of DNA methylation by N nitrosomorpholine . ^^^ The protooncogene c myc was investigated in N nitrosomorpholine induced rat liver nodules to elucidate the role of altered DNA methylation in chemical carcinogenesis . ^^^ DNA methylation analysis using the restriction endonucleases HpaII / MspI indicated hypomethylation in the first intron of c myc DNA in liver nodules . ^^^ The results suggest that genotoxic lesions may cause stably inherited , aberrant DNA methylation patterns which may be responsible for site specific hypomethylation of the c myc protooncogene in liver nodules . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The expression of the c myc protein product ( p 62 c myc ) and deoxyribonucleic acid ( DNA ) ploidy status was determined by a flow cytometric technique in 83 patients with colorectal cancer followed up for a median of 30 months ( range 6 60 months ) . ^^^ Levels of p 62 c myc varied in colorectal cancer and low levels ( less than 20 fluorescein units ) correlated with improved survival ( log rank chi 2 = 4 . 69 , df = 1 , P = 0 . 03 ) , and this was a better prognostic index than DNA ploidy ( log rank analysis chi 2 = 2 . 38 , df = 1 , P less than 0 . 1 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequencing analysis , further , revealed that this recombination is consistent with an insertion of the IgH enhancer ( E mu ) S mu sequences , 2341 bp in length , into the c myc 5 ' flanking region , resulting in 5 ' : c myc 5 ' flanking E mu S mu c myc 5 ' flanking c myc exon 1 : 3 ' segment . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
At the onset of the formation of the feather bud , cells within each rudiment cease DNA replicative activities and c myc transcripts are detected both in the epidermis and in the underlying dermis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To provide information about oncogenes for molecular biological studies of tumors in domestic animals , the proto oncogenes homologous to the c myc , c erbB 2 , c ros 1 , c yes 1 , 5 myc , 5 Ki ras , and 5 Ha ras oncogenes of genomic DNA in cattle , horses , pigs , dogs , cats , and chickens were investigated by Southern blot hybridization . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have hypothesized that the c myc oncogene might promote DNA amplification . ^^^ Given the likely role of the c myc product in DNA replication , these results strongly suggest that expression of c myc plays a role in methotrexate resistance by promoting DNA amplification . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot analysis indicates that the nuclear matrix DNA contains sequences homologous with the 5 ' flanking domains of the rapidly steroid regulated c myc and c jun protooncogenes and the beta actin gene , but not genomic sequences of the late sex steroid regulated gene , ovalbumin , or the alpha actin gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hybridization analysis of the DNAf from the enriched NAPf demonstrates sequence homologies with the nuclear matrix DNA as well as with genomic sequences of the rapid steroid responding nuclear protooncogenes c myc and c jun . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A synthetic 27 base long oligodeoxyribonucleotide , termed PU 1 , has been shown to bind to duplex DNA to form a triplex at a single site within the human c myc P 1 promoter . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Replicating DNA was isolated in CsCl gradients and probed with 32P labeled gene probes for early replicating genes ( e . g . , Ha ras , mos , and myc ) and a late replicating gene ( VH Ig ) . ^^^ The delay in replication of myc and mos correlated well with the slowing of DNA replication by APC . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Simultaneous quantification of c myc oncoprotein , total cellular protein , and DNA content using multiparameter flow cytometry . ^^^ FITC labelled antibody coupled with indirect immunofluorescence was used to quantify the c myc oncoprotein , whereas SR 101 and DAPI were used to measure total cellular protein and cellular DNA , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Insulin binding to its receptor stimulates DNA synthesis and cell division and induces an increase in abundance of mRNA for c fos , c jun , Krox 20 , Krox 24 ( zif / 268 ) , fra 1 , jun B , c myc , and JE . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
SA mouse and another transgenic mouse carrying Ig H chain enhancer driven c myc oncogene , expressed about equal levels of the trans mRNA and the transgenic mu mRNA without DNA rearrangement in either the transgene or the endogenous mouse switch region . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The peak of DNA synthesis , as assessed by expression of message for DNA polymerase alpha , histone 3 , and the proto oncogenes c fos and c myc , which are stimulated by binding of growth factors including PDGF , occurred during the canalicular stage of lung development on days 19 and 20 of gestation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Recombinant DNA technology ( Northern blotting , slot blotting and in situ hybridization ) was used to detect c myc mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The function of the c myc protein , the product of a proto oncogene , is not clearly understood although many reports , including ours , suggest that the c myc protein plays several roles in the regulation of transcription and DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
HeLaTG cells have mitochondrial DNA inserted into the c myc oncogene . ^^^ Hybridization of ScaI digested DNA with a 1 . 05 kb c myc probe revealed a unique band in HeLaTG cells , as well as a band common to HeLaTG and 13 other cell types examined . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A c myc DNA with a deletion which includes 5 ' flanking , exon 1 and intron 1 sequences has been found in normal white blood cells of a mother and one daughter in a Northern Italian family . ^^^ However , our results demonstrate that the c myc truncated DNA with the abnormal methylation pattern here reported is a genomic variant which by itself is not related to neoplastic transformation . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
HL 60 cells , a human promyelocytic leukemia cell line , contain amplified c myc DNA sequences and mRNA transcripts . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To determine the role of c myc and H ras in progressive , dysplastic Barrett ' s mucosa ( BM ) , and the usefulness of these oncogenes as markers for dysplastic lesions at high risk for malignant transformation , sequential formaldehyde solution fixed , paraffin embedded biopsy specimens that were obtained from 12 patients with BM were evaluated by in situ hybridization with the use of biotinylated complimentary DNA probes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Incubation with TNF in vitro has been shown to increase viability , DNA synthesis and the expression of the protooncogenes myc , fos and jun in the tumour cells from these patients . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA synthesis but not of malignancy in human gastrointestinal tissues and tumours . c myc is a conserved cellular gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Differential induction of secondary DNA fragmentation by topoisomerase 2 inhibitors in human tumor cell lines with amplified c myc expression . ^^^ Secondary DNA fragmentation was also induced in the human colon cancer cell lines COLO 320 , which have c myc amplification . ^^^ Since HL 60 cells also have c myc amplification and HT 29 do not , it is possible that c myc overexpression may be involved in secondary DNA fragmentation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Proteins encoded by the proto oncogenes c myc , L myc , and N myc contain at their carboxy terminus a tripartite segment comprising a basic DNA binding region ( BR ) , a helix loop helix ( HLH ) and a leucine zipper motif ( Zip ) , that are believed to be involved in DNA binding and protein protein interaction . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Slot blot hybridization against the DNA of the cells demonstrated 15 times and 5 times c myc gene amplification in OMC 2 and OMC 4 , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Conserved chromatin structure in c myc 5 ' flanking DNA after viral transduction . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
N myc gene amplification of KCC 1b was more than 3 5 fold that of KCC 1a . c myc gene amplifications of KCC 1a and KCC 1b were more than 5 7 fold that of the control DNA . 2 ) p 21 was observed in tubular adenocarcinoma but not in clear cell carcinoma . p 21 was detected in KCC 1b cells but not in KCC 1a cells . 3 ) KCC 1a and KCC 1b cells had quite different characteristics in molecular biology . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
TNF thus rapidly increases a class of high molecular weight DNA fragments which are enriched for c myc related sequences and may arise preferentially from higher molecular weight structures which are detectable following linearization by NotI or gamma irradiation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA from 24 ovarian tumors , including 16 carcinomas , was examined for amplification of the proto oncogenes c myc , int 2 , and rc erbB 2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot and dot blot analysis of processed and native DNA was performed using a c myc and an actin probe . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Methylation sensitive sequence specific DNA binding by the c Myc basic region . ^^^ A basic region of c Myc is structurally related to the basic motifs of helix loop helix ( HLH ) and leucine zipper proteins , which provide sequence specific DNA binding function . ^^^ The c Myc basic region was tested for its ability to bind DNA by attaching it to the HLH dimerization interface of the E 12 enhancer binding factor . ^^^ Expression of E 6 ( but not an E 6 DNA binding mutant ) suppressed the ability of c myc to cooperate with H ras in a rat embryo fibroblast transformation assay , suggesting that the DNA recognition specificity of E 6 is related to that of c Myc in vivo . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA analysis from these tumors showed rearrangements at the Ig heavy chain , kappa and lambda light chains , BCL 2 and c MYC loci . ^^^ Utilizing multiple enzyme digests and different probes spanning the BCL 2 , c MYC and Ig genes , mapping of DNA break points was performed . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of DNA sequences present in complexes of 5 Myc and cellular DNA . ^^^ We have isolated cellular DNA sequences from the myelocytomatosis virus transformed quail fibroblastic cell line ( MC 29 Q8 ) by indirect immunoprecipitation of 5 Myc DNA complexes and subsequent cloning of the DNA . ^^^ The 5 Myc DNA complexes were obtained from isolated nuclei pretreated with 150 mM salt and indirect immunoprecipitation of the p 110 Gag Myc protein with the IgG of a Gag specific monoclonal antibody . ^^^ The data presented here suggest that the Myc protein may be involved in DNA amplification and therefore may play a role in DNA replication . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc protein structure : localization of DNA binding and protein dimerization domains . ^^^ Wildtype and mutant 5 Myc proteins were overexpressed in Escherichia coli using the T 7 RNA polymerase system , and the in vitro DNA binding activities of partially or highly purified proteins were analysed by native DNA cellulose chromatography . ^^^ For the construction of the expression plasmids , cloned proviral DNA from wildtype MC 29 or from its spontaneous deletion mutant Q10C was used , the latter lacking internal 5 myc sequences . ^^^ All proteins , except p 53 which lacks the carboxyl terminal Myc protein sequences , bound to native DNA cellulose and were eluted with 200 500 mM NaCl . ^^^ Based on the DNA binding activities of recombinant or spontaneous mutant 5 Myc proteins extracted from bacterial or from transformed avian cells , we conclude that the DNA binding domain of avian Myc proteins is confined within the last 86 carboxyl terminal amino acids . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Daily addition of an anti c myc DNA oligomer induces granulocytic differentiation of human promyelocytic leukemia HL 60 cells in both serum containing and serum free media . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have studied the binding of proteins to a synthetic DNA fragment corresponding to a 21 base pair sequence in the upstream region of the human c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A DNA fragment covering the chimpanzee c myc locus was cloned from the DNA of peripheral blood lymphocytes , sequenced , and compared to its human c myc counterpart . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Therefore , it is proposed that the inefficiency of DNA repair may play an important role in the origin of c myc rearrangements . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Pituitary hormones regulate c myc and DNA synthesis in lymphoid tissue . ^^^ Treatment of hypophysectomized animals with growth hormone ( GH ) or prolactin ( PRL ) stimulated the expression of the c myc proto oncogene and DNA synthesis and reversed the involution in these organs . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The bHLH Zip region of c Myc was used to screen a complementary DNA ( cDNA ) expression library , and a bHLH Zip protein , termed Max , was identified . ^^^ The DNA binding activity of the complex was dependent on both the dimerization domain and the basic region of c Myc . ^^^ Max : a helix loop helix zipper protein that forms a sequence specific DNA binding complex with Myc . ^^^ The carboxyl terminus of Myc family proteins contains a basic region helix loop helix leucine zipper motif ( bHLH Zip ) , which has DNA binding activity and has been predicted to mediate protein protein interactions . ^^^ Furthermore , the Myc Max complex bound to DNA in a sequence specific manner under conditions where neither Max nor Myc exhibited appreciable binding . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These findings suggest that c myc levels may influence therapeutic success in some tumors and may regulate specific processes by which cells cope with DNA damage caused by DNA cross linking agents such as the platinum analogues , but not ionizing radiation . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc deoxyribonucleic acid ( DNA ) fragments detected at higher stringency in Southern blotting , showed a difference in size and gene copy number between human and rat glioma cells . ^^^ The above discrepancy in manifestation of c myc DNA fragments , transcript and protein could be due to the difference in nucleotide sequence of c myc gene between human and rat glioma cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Our results indicate a low incidence of N myc and c myc gene amplification in medulloblastomas , suggesting that the oncogenic mechanism in these neoplasms is not closely related to DNA gene amplification . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA repair in the c neu and c myc protooncogenes was examined in confluent cells by measuring the reappearance of these same bands . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Growth arrest of cells , either by metabolite starvation or by drugs which inhibit DNA synthesis , does not affect expression of the c myc protein , which remains completely dependent upon the presence of mitogens . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cd++ inhibits EGF induced DNA synthesis but not EGF induced myc mRNA accumulation in serum starved NRK 49F cells . ^^^ EGF induced myc mRNA accumulation in NRK 49F cells and the effects of Cd++ on this response were examined under conditions that result in partial or complete inhibition of EGF induced DNA synthesis . ^^^ It was found that doses of Cd++ that inhibit EGF induced DNA synthesis do not inhibit EGF induced protein synthesis and myc mRNA accumulation . ^^^ These results show that the effect of Cd++ on EGF induced DNA synthesis is not due to inhibition of entrance into G 1 , but rather that Cd++ acts on events subsequent to myc accumulation ; that is , events associated with either G 1 progression , entry into S or DNA synthesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot analysis was employed to analyze the structural alterations of the c myc oncogene in genomic DNA derived from tumor specimens of 35 adults with pathologically classified and immunophenotyped non AIDS related , non Hodgkin ' s lymphoma in Japan . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When hybridized with oncogene probes by means of Southern hybridization , samples of human fetal esophageal epithelium treated with AME showed marked amplification of c H ras and c myc genes ; DNA from transformed NIH / 3T3 cells via transfection of genes of tissues mentioned above showed also significant amplification of c H ras gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Determination of the c MYC DNA binding site . ^^^ The carboxyl terminus of the protein encoded by the c MYC protooncogene has similarity to the helix loop helix family of DNA binding proteins and recognizes a six nucleotide long DNA sequence . ^^^ We have used in vitro translated c MYC protein to further define its DNA binding specificity . ^^^ The hexanucleotide originally identified is necessary for DNA binding by c MYC , but not sufficient ; the c MYC target site is a 12 nucleotide long palindrome . ^^^ Point mutations within the helix loop helix motif of c MYC abolish DNA binding and transforming activities , indicating that c MYC acts as a DNA binding protein to transform cells . c MYC may transform cells by activating transcription of genes required for cell division . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA discontinuities in the domain of amplified human MYC oncogenes . ^^^ Upon blotting and hybridization with a MYC probe , the autoradiograms showed the existence of discontinuities in the amplified DNA domains . ^^^ Additional evidence indicating a preferential concentration of DNA breaks in the region containing the MYC amplicons was obtained with the alkaline unwinding technique . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Studies utilizing DNA tumour virus transforming gene constructs have shown that the retinoblastoma gene product , pRb , or a related protein , is needed for TGF beta 1 suppression of c myc transcription . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA repair in the c myc locus . ^^^ We have studied DNA repair after UV damage in the murine c myc locus . ^^^ DNA fragments located in the coding region of c myc and in another gene , dihydrofolate reductase ( DHFR ) , are repaired with equal efficiency in cells from these two strains of mice . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Age associated changes in DNA methylation of the c myc gene in liver were compared between humans and mice which have large differences in aging rate . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , the homologies shared among myc genes and two groups of DNA binding , transcriptional regulatory proteins suggests a role in regulating gene expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Some experiments , however , favour a different role for c myc , in DNA replication . ^^^ The proteins encoded by the various myc genes share substantial sequence homology . c , N and Lmyc proteins are all nuclear phosphoproteins that possess very short biological half lives and bind DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Addition of PGG 2 ( 10 ( 7 ) to 10 ( 5 ) M ) in the presence of indomethacin and EGF restored the ability of EGF to elevate c myc RNA levels and DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These data demonstrate that 1 ) c fos and c myc are expressed in ovarian granulosa cells ; 2 ) the expression of the genes encoding c fos , c myc , and beta actin is rapidly increased by gonadotropin ; and 3 ) the increase in the corresponding products of the c fos and the c myc genes precedes an increase in DNA synthesis and steroid production . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using pairs of flanking primers , each pair including one annealing to repeat sequences within the switch region and one of three primers from the c myc region ( first intron , 3 ' , or 5 ' flanking sequence of the first exon of c myc ) , we have been able to amplify DNA fragments containing the corresponding breakpoint regions from chromosome 14 in both cell lines and biopsied tumor samples . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Simultaneous flow cytometric detection of cellular c myc protein , incorporated bromodeoxyuridine , and DNA . ^^^ We applied this technique to measure c myc protein , incorporated BrdUrd , and DNA content in subpopulations present in a recombinant Chinese hamster ovary ( CHO ) cell line carrying approximately 800 copies of murine c myc sequences under control of an inducible heat shock promoter . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Thus , cisplatin treatment in A2780DDP cells differentially induces expression of certain nuclear oncogenes ( c fos / c myc ) , as well as genes possibly involved in the repair of cisplatin mediated DNA damage , an induction suppressed by CSA treatment . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
CCA failed to inhibit c myc mRNA induction , but did delay the decrease in c myc mRNA levels that normally occurs with the onset of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
All three compounds increased steady state mRNA concentration of c fos , c jun and c myc proto oncogenes to comparable levels ( 2 hrs after treatment ) , whereas only 17 beta estradiol was found to stimulate significantly DNA synthesis ( 20 22 hrs later ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Differences in relative abundance of c myc transcripts suggests a relationship with the ability of DNA from these cell lines to efficiently transform NIH 3T3 cells and form colonies on soft agar . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Rearrangement of the c myc and bcl 2 genes was detected by Southern blot analysis of the KHM 2B DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Estrogen is a mitogen for the rat uterus , where it induces transient activation of c fos and c myc protooncogene expression , followed by increases in DNA synthesis and cell proliferation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When added to quiescent cells , 17 beta estradiol ( E 2 ) alone affected neither c fos and c myc gene expression , nor DNA synthesis and cell proliferation . ^^^ A response including c fos induction ( maximal expression at 75 min ) , but not c myc expression , DNA synthesis and a marked cell proliferation was only obtained when 17 beta estradiol was associated with insulin plus EGF . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
There is increasing evidence that c myc exerts these biological activities by modulating transcription and by directly affecting the initiation of DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Since TGF beta 1 appears to inhibit keratinocyte growth through down regulation of c myc , it was hypothesized that these DNA tumor viruses might be modulating the response to TGF beta 1 via this pathway . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
There was a corresponding amplification in DNA copy number of the c myc ( 2X ) , H ras ( 4X ) , and c fos ( 15X ) oncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA binding activity of E2F is increased 4 fold upon serum stimulation and the kinetics of activation parallel activation of c myc transcription . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The examples of oncogene products analyzed by FCM are ras , myc , p 53 , myb and fos ; those of cell proliferation related proteins are Ki 67 , PCNA and DNA polymerase alpha . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The G C specific DNA binding drug mithramycin selectively inhibits expression of the c myc gene in a number of cell types . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA restriction fragments or cloned vectors of five oncogenes ( abl , myc , myb , fos , Ki ras ) and of IL 2 , IL 2 receptor , T cell receptor beta chain and transferrin receptor were dotted onto nitrocellulose filters . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In order to validate the use of the nude mouse as a model for studying lung cancers , 21 different lung cancers were xenografted onto nude mice and the tumoral DNA and RNA were analyzed for abnormality in the myc family genes ( c myc , L myc , and N myc ) . ^^^ No variation of DNA amplification was observed during long term growth in nude mice for any of the myc oncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA and antisense RNA probes complementary to Xenopus c myc , cytoskeletal actin and albumin mRNAs served as controls or developmental markers . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Autonomous replication of a DNA fragment containing the chromosomal replication origin of the human c myc gene . ^^^ To characterize the replication origin further a 2 . 4 HindIII Xhol subfragment of the c myc 5 ' flanking DNA was cloned in a selectable vector and transfected into HeLa cells . ^^^ Myc 2 . 4 insert suggested that c myc 5 ' flanking DNA within 1 . 2 kb 5 ' to promoter P 1 was sufficient to confer autonomously replicating sequence activity on the plasmid vector in transient replication assays . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Rat 1 cells and rat embryo fibroblasts ( REF ) immortalized by c myc or E1A were transfected with a specific EBV DNA fragment coding for EBNA 1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA from the tumours was digested with specific enzymes and hybridized with DNA probes from the c myc ( first and third exons ) and IGH locus ( C mu , S mu and JH ) . ^^^ Our analysis shows that all tumours carried the t ( 8 ; 14 ) as shown by clonal rearrangements of c myc in DNA treated with the enzymes Hind 3 and Eco RI . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The activation of the three cascades induced the expression of the protooncogenes c fos and c myc with dose response curves similar to those for DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results indicate that TGF beta 1 might regulate cell growth , in part , by modulating c myc expression , although there is no direct proof that c myc expression is really relevant to DNA synthesis mediated by TGF beta 1 . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Both showed rearrangements of c myc and Pim 1 genes that appeared to result from integration of recombinant mink cytopathic focus forming ( MCF ) proviruses but failed to reveal evidence for activation of ras oncogenes , either by DNA transfection experiments or by hybridization of DNA to specific oligonucleotide probes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Avian leukosis virus ( ALV ) induced neoplasias are commonly found associated with integrations of proviral DNA in proximity to the myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The recent finding of c myc activation by insertion of woodchuck hepatitis virus DNA in two independent hepatocellular carcinoma has given support to the hypothesis that integration of hepatitis B viruses into the host genome , observed in most human and woodchuck liver tumours , might contribute to oncogenesis . ^^^ We report here high frequency of woodchuck hepatitis virus DNA integrations in two newly identified N myc genes : N myc 1 , the homologue of known mammalian N myc genes , and N myc 2 , an intronless ' complementary DNA gene ' or ' retroposon ' that has retained extensive coding and transforming homology with N myc . ^^^ Activation of myc genes by insertion of hepadnavirus DNA now emerges as a common event in the genesis of woodchuck hepatocellular carcinoma . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have previously demonstrated that over expression of c myc facilitates the replication of SV 40 DNA in human Burkitt lymphoma cells ( BL ) . ^^^ In this paper we investigated the ability of N myc and L myc to substitute for c myc in promoting SV 40 DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Integration of hepatitis virus DNA near c myc in woodchuck hepatocellular carcinoma . ^^^ In two hepatomas , elevated expression and allelic alterations of c myc were subsequent to integration of WHV DNA near the c myc coding domain . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
While overexpression of c myc was detected in transformed cells induced by HPV 18 DNA , but no amplification was observed . ^^^ CIN 2 showed the highest incidence of positive HPV DNA ( 91 % ) , and the positive ratio decreased in CIN 3 ( 56 % ) . 2 ) Immunohistochemical study of paraffin embedded specimens with monoclonal antibodies to oncogene products revealed that only some of cervical invasive carcinomas expressed c myc protein , ras p 21 or EGFR . 3 ) HPV DNA was detected in 46 % of invasive cervical carcinomas by Southern blot hybridization . ^^^ However , it increased up to 58 % by use of polymerase chain reaction ( PCR ) , suggesting that there are many cervical cancer tissues in which a number of cells lack viral DNA . 4 ) Northern blot hybridization analysis revealed overexpression of c myc mRNA in 30 % of cervical invasive carcinomas although amplification of c myc oncogene was detected in only one of invasive carcinomas . ( ABSTRACT TRUNCATED AT 400 WORDS ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
By the immunohistochemical and molecular biologic study , there was no correlation HPV DNA with c myc product and c myc gene amplification . 2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transformation of chicken embryo fibroblasts by direct DNA transfection of single oncogenes : comparative analyses of src , erbB , myc , and ras . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The relationship between gene copy number and expression and cellular consequences of elevated levels of c myc protein has been investigated using recombinant Chinese hamster ovary cell lines transfected with DNA coding for the murine c myc gene . ^^^ Multivariate flow cytometric analysis and clonogenic assays were used to measure the relationship among c myc expression , rate of DNA synthesis , and cell survival . ^^^ The presence of high levels of recombinant c myc protein was associated with a decreased rate of bromodeoxyuridine incorporation into DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We investigated the copy number and possible rearrangement of the four protooncogenes , c myc , N myc , N ras , and c erb B , in DNA from seven untreated primary cancers or metastases of medullary thyroid carcinoma and an established human medullary thyroid carcinoma cell line , TT , using the Southern blotting technique . ^^^ Our results suggest that DNA evident amplification and rearrangement of the c myc , N myc , N ras , and c erb B oncogenes may not be mechanisms through which these oncogenes become activated in this malignancy . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequence analysis of the CBF 1 gene reveals homology with the transforming protein myc and a family of regulatory proteins known as the helix loop helix ( HLH ) proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In passages 46 62 of the cells , the cells contain amplified c myc sequences on submicroscopic circular extrachromosomal DNA ( episomes ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Tumor hypersensitive DNA is enriched in c myc sequences and reacts differentially with normal and malignant genomic DNA . ^^^ Dot blot studies showed that the hypersensitive DNA is enriched in c myc sequences compared to total tumor genomic DNA , and hybridizes preferentially to the latter , compared to normal genomic DNA , particularly when prepared from BrdU treated cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A simultaneous flow cytometric assay of the nuclear expressed protein product of the c myc oncogene p 62 and deoxyribonucleic acid ( DNA ) ploidy in archival paraffin embedded tumor material was undertaken in 179 patients with colorectal cancer , followed for up to 9 years . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
An initiation zone of chromosomal DNA replication located upstream of the c myc gene in proliferating HeLa cells . ^^^ We found that DNA replication through the c myc gene initiates in a zone centered approximately 1 . 5 kilobases upstream of exon 1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast to normal myogenic differentiation , multinucleated cells continue to synthesize DNA and express abundant c myc transcripts . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The increased expression of these genes is analogous to the increased expression of c myc and c Ha ras that occurs early in liver regeneration , preceding the first increase in DNA synthesis by at least 20 hr . ^^^ However , there was no increase in DNA synthesis in the liver despite the dramatic increase in c myc and c Ha ras expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA from 18 centrocytic lymphomas ( 14 patients ) was analyzed using Southern blotting and probes for immunoglobulin heavy ( JH ) and kappa light chain ( JK ) joining gene , T cell receptor beta chain constant gene ( CB ) , bcl 1 , bcl 2 , and c myc gene rearrangements . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA extracted from canine osteosarcomas ( n = 9 ) and normal canine control tissues ( n = 17 ) was examined for amplification of the c sis , c myc , N myc and c H ras protooncogenes . ^^^ DNA and total cellular RNA from cultured canine and human osteosarcoma and fibroblast cell lines were examined for amplification or enhanced expression of c sis and c myc . ^^^ Very low levels of c myc and c sis DNA amplification were noted in canine osteosarcoma cells as compared to canine fibroblasts . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The structure of the c myc locus and the flanking chromosomal region was investigated by Southern blot analysis of DNA from bone marrow aspirates from 42 patients with multiple myeloma . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In culture , hepatocytes from PD rats had higher levels of c myc mRNA , underwent morphological changes more rapidly , and reached maximum rates of DNA synthesis earlier than normal hepatocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cloned origin of DNA replication in c myc gene can function and be transmitted in transgenic mice in an episomal state . ^^^ The c myc protein has recently been shown to interact with a region possessing putative origin of DNA replication and enhancer activities located 2 kb upstream of the c myc gene itself . ^^^ Moreover , pmyc ( H P ) was transmittable to the progeny throughout several generations , which suggests that the fragment derived from the region upstream of the c myc gene possesses sequences necessary for partition , stability and DNA replication of the plasmid in the cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
GTP gamma S inhibits early c myc protein accumulation but not DNA synthesis in Swiss 3T3 fibroblasts . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc oncogene codes for a DNA binding protein that appears to play an important role in the regulation of cell growth . c myc gene amplification has been documented to occur in both hematopoietic and solid neoplasms and often indicates more biologically aggressive tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc oncogene codes for a DNA binding protein and is believed to regulate cellular proliferation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Treatment of the SBW 1 cells with 5 azacytidine , TPA or forskolin did not release the downregulated expression of the rearranged c myc , suggesting no causative involvement of DNA methylation or protein phosphorylation in the downregulation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Antisense oligodeoxynucleotides could reduce the increase in cdc 2 expression and inhibited DNA synthesis , but had no effect on several early and mid G 1 events , including blastogenesis and expression of interleukin 2 receptors , transferrin receptors , c myb , and c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Bivariate flow cytometry was used to evaluate the c myc protein and DNA content of PB 3 and PB 1 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Amplification of c myc , a gene that codes for a DNA binding protein involved in the regulation of cell growth , was seen in two tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this study DNA from 62 cases of low grade B cell lymphoma , classified using the Kiel classification , were analysed by Southern blotting and hybridization with probes to bcl 1 , bcl 2 , and c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Sequence specific DNA binding by the c Myc protein . ^^^ While it has been known for some time that the c Myc protein binds to random DNA sequences , no sequence specific binding activity has been detected . ^^^ At its carboxyl terminus , c Myc contains a basic helix loop helix ( bHLH ) motif , which is important for dimerization and specific DNA binding , as demonstrated for other bHLH protein family members . ^^^ In this study , the technique of selected and amplified binding sequence ( SAAB ) imprinting was used to identify a DNA sequence that was recognized by c Myc . ^^^ These results suggest that some of the biological functions of Myc family proteins are accomplished by sequence specific DNA binding that is mediated by the carboxyl terminal region of the protein . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
After experimental treatment of rats with clofibrate or ciprofibrate , two peroxisomes proliferators with hypolipidemic activity , RNAs were prepared from liver , kidney , heart and brain ; hybridization was done with DNA probes for c myc and c Ha ras oncogenes and for cyanide insensitive Acyl CoA oxidase , a peroxisomal protein . c myc mRNA is highly abundant in liver and at a lower extent in kidney , especially after treatment with ciprofibrate ; clofibrate also allows a c myc mRNA increase , but at a lower extent . c Ha ras , which is already expressed in all tested tissues from control animals , is stimulated by clofibrate and ciprofibrate treatments . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transfection of cloned plasmid DNA into benign tumor cells has revealed that transforming constructs of the fos oncogene induce malignant conversion , whereas myc and adenovirus E1A oncogenes do not . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Our studies show that the ability of c myc to inhibit 3T3 L 1 cell differentiation requires its transforming activity , and the ability of c myc to bind sequence nonspecific DNA and to form oligomers is not sufficient for this effect . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A novel sequence specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC motif in the 5 ' flanking sequence of the chicken c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Molecular cloning studies showed that the c myc gene was joined to chromosome 18 DNA . ^^^ Nucleotide sequence analysis of cloned breakpoint DNA revealed that the crossover between chromosomes 8 and 18 occurred at the 3 ' end of the bcl 2 gene resulting in replacement of the bcl 2 gene on the 14q+ chromosome with the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
There is evidence that this locus normally regulates expression of the c myc oncogene , which in turn probably has a regulatory function in DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Examination of DNA from early cultures of Namalwa cells showed that the alternations in Ig and c myc structure had occurred on prolonged culture of the cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA analysis did not show deletion , rearrangement , or amplification in the c myc proto oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA index did not correlate with myc gene amplification or expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Furthermore , down regulation of the rearranged c myc in the hybrid was also not restored by treatment with 5 azacytidine ( 5 AzaC ) , 12 O tetradecanoylphorbol 13 acetate ( TPA ) or forskolin , suggesting no causative involvement of DNA methylation or protein phosphorylation in down regulation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Assays for gene amplification were performed with probes for murine erythropoietin ( EPO ) gene and H ras , c fos , c myc , and N myc oncogenes , using deoxyribonucleic acid ( DNA ) samples isolated from injected kidneys and renal neoplasms , as well as from the contralateral , non injected kidneys . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Individual colonies of cells were expanded from cultures transfected with SV 40 virion DNA , SV 40 large T antigen gene , Ha ras oncogene , human and mouse c myc and adenovirus E1A gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA from 13 ( 6 alveolar and 7 embryonal ) childhood rhabdomyosarcomas ( RMS ) was examined to determine the incidence and prognostic relevance of N and c myc genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We compared the effects of alpha amanitin and actinomycin D on the transcription of c fos and c myc with the effects of each inhibitor on the distribution of the corresponding oncogenic DNA sequences in the chromatographically separated nucleosome fractions . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The MyoD 1 protein , a nuclear phosphoprotein in part similar to the myc family of proteins , is a DNA binding protein binding to the enhancer sequences of the muscle specific creatine phosphokinase gene . ^^^ Deletion of the myc like domain in the MyoD 1 gene eliminates the inhibition of DNA synthesis , but substitution of the basic domain with the analogous domain from the E 12 transcription factor inhibits growth yet fails to induce differentiation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The pattern of immunoglobulin ( Ig ) gene rearrangement and the genomic structure of the Myc locus were investigated in the DNA of 20 lymphnode biopsies of patients suffering from lymphoadenopathy associated syndrome ( LAS ) and from 3 patients with Burkitt ' s lymphoma . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The growth inhibition was accompanied by changes related to proliferation : ( 1 ) remarkable inhibition of DNA synthesis , ( 2 ) the decrease in the number of high affinity receptors for epidermal growth factor , with almost no change in total receptor number , ( 3 ) the rapid decrease in c myc mRNA level . ^^^ The inhibition of DNA synthesis and the decrease of c myc mRNA expression occurred at 3 h after the addition of 1 , 25 ( OH ) 2D3 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA sequence of the c myc regulated gene mrl ( G . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA synthesis induced by the neuropeptide substance K correlates to the level of myc gene transcripts . ^^^ Contrarily , myc transformed cells , that inspite of a decrease demonstrated a high level of myc mRNA after 48 h in serum free medium , maintained their ability to initiate DNA synthesis when stimulated with substance K . ^^^ The results suggest that the intracellular signal of substance K induced DNA synthesis interacts with the myc protein . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Interestingly , there was an inverse relationship between expression of some glycolipid antigens and DNA amplification of the c myc oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The correlation between expression and extent of DNA methylation of c myc and c abl oncogenes has been investigated in the human leukemic K 562 cell line before and after 5 azacytidine mediated erythroid induction . ^^^ The HpaII pattern shows that the c myc DNA region is undermethylated and that the c abl gene is hypermethylated both before and after the erythroid induction . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The splice donor and acceptor sites at the boundary of the first intron were assigned by comparing a sequence of an LL 6 c myc cDNA clone with a genomic DNA sequence and confirmed by RNase protection of labeled RNA probes by normal and LL 6 derived mRNAs . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Among six carcinomas , four presented abnormal c myc DNA structure : Three cases showed a mutation in the 5 ' flanking region of the gene , originating a new EcoRI site ; the other case showed a deletion of 5 kb involving the first exon of the gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Under stringent conditions , the N myc DNA probe hybridized with a single 3 kilobase ( kb ) transcript which was virtually undetectable in ovariectomized rat uteri and increased 6 fold within 15 min after E 2 treatment . ^^^ Under conditions of slightly reduced stringency , N myc DNA also hybridized with a 2 . 2 kilobase transcript . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Effect of actinomycin D on DNA replication and c myc expression during rat liver regeneration . ^^^ In an attempt to elucidate the mechanisms that control the hepatic DNA replication , effect of low doses of actinomycin D on DNA synthesis and c myc expression during the early stage of liver regeneration was investigated . ^^^ DNA synthesis and c myc expression in these rats were compared with those in untreated rats . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have shown elsewhere that microinjected plasmid DNA carrying a normal , intact human c myc gene directs efficient faithful transcription from its own two promoters in Xenopus laevis oocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
There was no detectable amplification or rearrangement of c myc DNA sequences in any of the cell lines examined as determined by DNA dot blot and restriction endonuclease Southern blotting analyses . ^^^ Therefore , increased c myc expression in the four transformed lines did not generally correlate with changes in DNA methylation in the vicinity of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA of MO 5 was found to be more methylated than that of BALB / c 3T3 in the vicinity of c myc as well as the metallothionein 1 gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A plasmid carrying antisense human MYC DNA and the gene encoding Escherichia coli xanthine / guanine phosphoribosyltransferase ( Ecogpt ) was introduced into human promyelocytic leukemia cell line HL 60 by protoplast fusion . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc locus was found to be variably methylated in all examined tissues , except blood , where erythrocytic DNA showed no evidence of significant methylation of c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Our observations are of significance because they suggest a dissociation between the transient rise of c myc RNA which occurs before DNA synthesis and the events that initiate DNA synthesis in quiescent fibroblasts ; c myc may not play as central a role in stimulating noncycling , quiescent cells to progress through the cell cycle , as has been generally assumed . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Expression of c myc and induction of DNA synthesis by platelet poor plasma in human diploid fibroblasts . ^^^ These results suggest that , also under physiological conditions , the expression of c myc and other growth regulated genes can cooperate with platelet poor plasma in inducing cellular DNA synthesis in human diploid fibroblasts . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A point mutation in the binding region of the PA 682 c myc DNA abolished binding of this nuclear protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Therefore , the control of mRNA production of the nuclear oncogenes c fos and c myc , and the cytoplasmic oncogene c ras are independent and hydrocortisone may enhance DNA synthesis by increasing c fos expression . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the present study , employing over 100 DNA samples obtained from Lin xian patients who underwent surgery for esophageal cancer , we have found a significant frequency of amplification of either the human epidermal growth factor receptor ( HER 1 ) gene or the c myc oncogene . ^^^ Thus , changes in gene copy number or level of expression of HER 1 or c myc DNA sequences may play an important role in the pathogenesis of esophageal cancer in this high risk region . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequences that mediate attenuation of transcription from the mouse protooncogene myc . ^^^ We show that the first exon of mouse myc contains specific DNA sequences that may mediate transcriptional attenuation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
PVT begins 57 kilobase pairs downstream of MYC and occupies a minimum of 200 kilobase pairs of DNA . ^^^ Identification of PVT should facilitate the exploration of how translocations downstream of MYC and insertions of retroviral DNA in the vicinity of pvt 1 might contribute to tumorigenesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA from tumors overexpressing the myc gene was analyzed by Southern blotting . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the four subclones that expressed the myc gene , the peak thymidine incorporation into DNA was significantly higher than in BALB / MK cells , ranging from 340 to 650 fold control levels . ^^^ Thus , the constitutive expression of c myc in BALB / MK appears to affect predominantly the reinitiation of DNA synthesis by EGF . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Both papilloma cell lines were stably transfected with plasmid DNA containing either a rearranged murine plasmacytoma derived c myc ( minus exon 1 ) , adenovirus 5 E1A , FBJ 5 fos or a human c fos / FBJ 5 fos chimera , using cotransfection with the neomycin resistance gene contained in pSV2neo to select for transformants . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA replication and RNA transcription regulated by c myc protein ] . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The opaque 2 protein contains a domain similar to the leucine zipper motif identified in DNA binding proteins of animal protooncogenes such as fos , jun and myc , and in the transcriptional activators GCN 4 and C / EBP . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern analysis of tracheal cell DNA did not demonstrate amplification of the c myc gene in any of the positive cell lines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The s Myc protein predicted from the DNA sequence has approximately 60 % amino acid sequence homology with that of the mouse N Myc protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A new DNA binding and dimerization motif in immunoglobulin enhancer binding , daughterless , MyoD , and myc proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The region of the C / EBP polypeptide required for direct interaction with DNA has been identified and shown to bear amino acid sequence relatedness with the product of the myc , fos , and jun proto oncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of DNA synthesis by TGF beta is preceded in 5 established cell lines by induction of PDGF B chain mRNA as well as of other mRNAs associated with cell replication such as fos , myc , and JE . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have determined the prevalence of amplification of c myc , N myc , L myc , H ras , Ki ras , and N ras oncogenes in 23 cases of squamous cell carcinoma of the oral cavity , using Southern hybridization analysis of DNA extracted from the primary tumor tissues . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
However , the oncogene c myc was in the germline configuration in the initial lymphoma but had one allele rearranged near the 3 ' end of exon 1 in the high grade tumor ; DNA sequence analysis was consistent with a chromosomal breakpoint at that site . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The mitogenic effect of 1 , 25 dihydroxyvitamin D 3 was correlated with an increase in c myc mRNA and a decrease in c fos mRNA levels , whereas its inhibitory action on DNA synthesis was accompanied by increased myofibrillar and microsomal protein synthesis and an elevation of creatine kinase activity , the latter suggesting a stimulation of muscle cell differentiation by the sterol . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We compared the effect of tert butyl hydroperoxide ( Bu OOH ) on DNA strand breakage , poly ADP ribosylation of chromosomal proteins and the expression of the proto oncogenes c fos and c myc between non promotable clone 30 and promotable clone 41 of mouse epidermal cells JB 6 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Our previously reported data from DNA sequence studies of the c myc locus show that the human c myc exon 1 has an open reading frame capable of encoding a protein of 188 amino acid residues . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It has been recently proposed that certain DNA binding proteins ( including C / EBP , GCN 4 and the myc , jun , and fos oncogene proteins ) share a common structural motif based on helix promoting regions containing heptad repeat sequences of leucines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A DNA sequence with homology to the myc family of proto oncogenes has been characterized and found to be a processed gene related to L MYC ( MYCL 1 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
No transformation was observed using an activated myc oncogene with either HPV 6 or HPV 16 DNA . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MyoD is a sequence specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer . ^^^ The contiguous basic and myc homology regions of MyoD that are necessary and sufficient for specific DNA interaction are the same regions of the protein required to convert 10T1 / 2 fibroblasts into muscle . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Accordingly , we probed lysates of long slenders , short stumpies and procyclics ( insect midgut stage ) with antibody to myc proteins and also hybridized myc gene family sequences to procyclic DNA . ^^^ We found that antibody to myc family proteins of mammals reacts with 40 kDa and 55 kDa proteins in all three life cycle stages , and that procyclic DNA contains three EcoRI fragments that are homologous to a 5 myc probe . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The deduced amino acid sequence of the 5 maf gene product contains a `` leucine zipper ' ' motif similar to that found in a number of DNA binding proteins , including the gene products of the fos , jun , and myc oncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Activation and proliferation signals in murine macrophages : relationships among c fos and c myc expression , phosphoinositide hydrolysis , superoxide formation , and DNA synthesis . ^^^ When BMM are treated with a range of stimuli , there is some , although not perfect , correlation between transient elevations in both c myc mRNA and c fos mRNA levels and increases in DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Some of the tumors had DNA rearrangements near the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Stimulation of the topoisomerase 2 induced DNA cleavage sites in the c myc protooncogene by antitumor drugs is associated with gene expression . ^^^ In mAMSA treated N 417 cells , the overall genomic DNA cleavage detected by alkaline elution was found to be about 20 times lower than the c myc gene cleavage . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Occurrence of human papillomavirus type 16 DNA sequences and c myc oncogene alterations in uterine cervix carcinoma . ^^^ Using genetic engineering and molecular biology techniques , we have examined sixteen human carcinomas in the uterine cervix tumors ( the most frequent tumor in Mxico , representing 34 % of malignant tumors in women ) , for the presence of Human Papillomavirus type 16 ( HPV 16 ) DNA sequences and possible alterations of the cellular myc ( c myc ) proto oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
All hybrid clones investigated displayed a marked decrease in the number of copies of c myc DNA ( an average of 5 copies ) , while the level of c myc RNA in the hybrids was similar to that found in both parents . ^^^ Ten hybrid clones were found to contain an average of 47 copies of N myc DNA , significantly less than the 91 copies predicted had no loss occurred . ^^^ This hybrid also displayed reduced copies of N myc DNA in comparison to its parent hybrid but surprisingly showed a 2 fold increase in N myc RNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using gene specific DNA probes , we examined the levels of the expression ( transcription ) of heat shock protein genes and two nuclear proto oncogenes , c fos and c myc , in the embryos removed from irradiated pregnant mother rats 4 or 5 days after the irradiation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Flow cytometry showed that 90 % ( P less than 0 . 01 ) of the analysed tumours with c erbB 2 and c erbA co amplification , and 70 % ( P less than 0 . 1 ) of those with c myc amplification were DNA aneuploid . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Amplifications of the myc , ras , and erbB family genes might be one of the crucial DNA abnormalities involved in the development of human lung carcinomas . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have analyzed genomic DNA sequences from 125 prospectively collected single unilateral primary breast carcinoma samples for the presence of alterations of c myc , c erbB 1 , c erbB 2 , c Ki ras and c Ha ras protooncogenes . ^^^ Amplification of the c myc gene was found in 18 % of the samples , and in one sample a non germ line c myc related DNA fragment or rearrangement was detected . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using Southern blot analysis of DNA from mouse hamster somatic cell hybrids , we have mapped Lmyc and Bmyc , two members of the myc family of genes , to mouse chromosomes 4 and 2 , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In two samples with a high degree of c myc DNA amplification ( 15 to 30 fold ) , double minute chromosomes were observed in karyotype analysis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The entire nucleotide sequence of the cloned DNA was determined , showing that the s myc gene contains an open reading frame consisting of 1287 base pairs without introns . ^^^ The amino acid sequence predicted from the DNA sequence showed that the s Myc protein is closely related to the murine N Myc protein but lacks an acidic amino acid rich sequence commonly present in the Myc family proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Although different at their 3 ' untranslated regions , both cDNAs predict a protein with primary amino acid sequence homology to the previously described amphipathic helix loop helix DNA binding and dimerization motif of the Ly 1 1 , myc , MyoD , immunoglobulin enhancer binding , daughterless , and achaete scute families of genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have analyzed c myc protein expression during the cell cycle in malignant B cell lymphomas by dual flow cytometric detection of a fluoresceinated polyclonal anti myc antibody and propidium iodide which binds stochiometrically to DNA . ^^^ The c myc protein level was strongly correlated to parameters of DNA synthesis / content . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Recent DNA transfection experiments , in which MEL cells were transfected with myc expression vectors , indicate that both the early decrease in c myc expression and its subsequent reexpression are important events in the differentiation pathway . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To investigate whether this transition involves the activation of oncogenes capable of transforming fibroblasts , we transfected DNA from 14 E mu myc lymphomas into NIH3T3 cells and tested the tumorigenicity of the transfectants in nude mice . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot and DNA sequence analyses showed that both tumors have undergone translocations of immunoglobulin heavy chain loci to positions 5 ' of the c myc gene promotors resulting in removal of DNA sequences encoding a negative transcriptional regulatory element . ^^^ DNA sequence analysis showed that the presence of first intron sequences in the large myc RNAs is due to mutations affecting the splice donor region at the 3 ' end of exon 1 in both tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc oncogene codes for a DNA binding protein that functions in a cell cycle related manner . ^^^ We have developed a flow cytometric assay for correlating c myc oncoprotein levels with DNA content . ^^^ The cells with G 1 DNA content show the greatest decrease in c myc protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A cis acting transcription element of the c myc gene can assume an H DNA conformation . 1 have used chemical probes and an oligonucleotide association assay to determine the structure of a nuclease sensitive , c myc DNA region . 1 find that this DNA region can form a triplex single stranded conformer in vitro the H DNA conformer . ^^^ This DNA region has been shown previously to be a positive , cis acting transcription element of the c myc gene and to bind nuclear factors , including a base paired ribonucleoprotein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have investigated the structure and expression of the c myc proto oncogene in DNA isolated from the immortal cell line LNCaP . ^^^ Msp 1 digest of LNCaP DNA when hybridized to a human c myc probe showed a 1 . 45 kb band of intensity about two fold greater than that observed in normal lymphocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The inhibition of RNA and DNA synthesis by BE without a corresponding alteration in the level of expression of the c myc gene suggests that this agent dissociates c myc expression and cellular proliferation in these cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot analysis of the genomic DNA of HT 29 cells did not reveal any rearrangement within the region containing the c myc gene and the flanking sequences ( approximately five kilobases upstream and approximately three kilobases downstream ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA of the samples was analyzed after restriction nuclease treatment by Southern blot hybridization , using different probes specific for the three exons of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA replication origin and transcriptional enhancer in c myc gene share the c myc protein binding sequences . ^^^ We have previously reported that c myc protein , or protein ( s ) complexed with c myc protein , binds to the region upstream of the first exon of the c myc gene and that this region contains an origin of cellular DNA replication ( ori ) and also a transcriptional enhancer . ^^^ Thus , c myc protein is a sequence specific factor which is apparently used both in initiation of DNA replication and in regulation of RNA transcription . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Elevation of c myc protein by DNA strand breakage . ^^^ The intracellular level of the c myc protein is elevated in a dose and time dependent manner by DNA strand breakage . ^^^ In addition , inhibition of DNA strand break rejoining maintains the level of the c myc protein in an elevated state , whilst inhibition of DNA replication does not cause an increase in c myc protein . ^^^ We conclude that chromatin perturbation via DNA strand breakage both increases the endogenous amounts of the c myc protein and maintains its elevated level . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA sequencing analysis demonstrated that the c myc gene has juxtaposed directly to S mu 5 ' flanking sequence in a ' head to tail ' orientation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Ribonucleoprotein and protein factors bind to an H DNA forming c myc DNA element : possible regulators of the c myc gene . ^^^ We have located a positive , cis acting DNA sequence element within the 5 ' flanking DNA of the c myc gene ( 125 base pairs ) . ^^^ The interaction of the c myc DNA sequence element and the RNP involves an RNase H sensitive mechanism and , therefore , may involve an RNA . ^^^ These results suggest that RNP and protein factors act as positive transcriptional regulators of the c myc gene , perhaps by altering DNA topology . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot analysis showed that the pattern of repetitive DNA bands and the structures of 28s , rDNA , c H ras and c myc genes in THPGC 1 were identical to the original primary gastric cancer DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Our study suggests that the appropriate level of hypergravity stimulates HeLa cell proliferation by reducing the G 1 phase duration without affecting DNA synthesis rate , mediated through induction of c myc gene expression . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of DNA from the two patients revealed that oncogene of c myc was amplified about 5 to 10 folds in the leukemic cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The changes in the levels of the mRNAs for NHI and EB subunits were compared with the changes in the levels of the mRNAs for actin , p 53 , c myc , thymidine incorporation into DNA , and DNA content by flow cytometric measurements . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To identify proteins and target structures for MYC regulation , a DNA region was analyzed that is critical for P 2 promoter activity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Exon 1 and most of intron 1 of MYC have been displaced from DMMYC by a rearrangement of DNA . ^^^ We encountered three abnormal configurations of MYC and PVT in the cell lines analyzed here : ( 1 ) amplification of the genes , accompanied by insertion of exon 1 and an undetermined additional portion of PVT within intron 1 of MYC to create DMMYC ; ( 2 ) selective deletion of exon 1 of PVT from amplified DNA that contains downstream portions of PVT and an intact allele of MYC ; and ( 3 ) coamplification of MYC and exon 1 of PVT , but not of downstream portions of PVT . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The predicted protein product of the lyl 1 gene contains a potential helix loop helix DNA binding motif also found in several proteins involved in the control of cellular proliferation and differentiation : all members of the Myc family , MyoD 1 , myogenin , the Drosophila achaete scute , twist , and daughterless proteins , and two recently described immunoglobulin enhancer binding proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
From 79 biopsies ( 50 of which were obtained by fiberoptic bronchoscopy ) , DNA hybridization was performed using the Southern blot technique , with myc family genes probes and a polymorphic probe located on the short arm of chromosome 3 . ^^^ Our study indicates that : 1 ) in 88 % cases , enough DNA can be obtained by 3 or 4 fiberoptic bronchoscopy biopsies : from 5 to 80 micrograms DNA with an average of 25 ; 2 ) the quality of DNA is good for analysis by the Southern blot technique ; 3 ) the loss of allele on chromosome 3 ( 3p 14 23 ) can be detected both in the small cell and in the non small cell type , but contamination of the specimens by non tumoral tissue ( based on the cytological and histological analysis of each biopsy ) remains a problem for this type of study ; 4 ) gene amplifications and rearrangements can be easily evaluated for the genes of the myc family . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In these lymphomas MuLV DNA is integrated near either the c myc or N myc gene , suggesting that pim 1 and myc synergize in lymphomagenesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Polymerase 3 transcription of c myc was very inefficient compared to other polymerase 3 genes , however , and was observed only when large amounts of template DNA were injected . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
KH 2 cells are integrated by HTLV 1 proviral DNA and expressed mRNA for c myc , IL 2 receptor alpha chain ( IL 2R alpha ) , and T cell receptor beta chain ( TCR beta ) while it did not express IL 2 mRNA . 1 , 25 ( OH ) 2D3 and dexamethasone did not suppress the mRNA levels of HTLV 1 , IL 2R alpha or TCR beta but reduced the c myc mRNA level . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Stimulation of topoisomerase 2 cleavage activity by antitumor drugs with or without DNA intercalative ability has been tested in vivo on the c myc proto oncogene . ^^^ Two human tumor cell lines ( N 417 and HL 60 cells ) were treated with mAMSA , OH 9 ellipticine , VM 26 , and BD 40 ( an aza ellipticine analog ) , and DNA breaks were mapped in the gene locus by Southern blot hybridization with c myc probes . ^^^ Most of the major cleavage sites induced in vivo by drugs in the 5 ' end of c myc were also observed in vitro using purified topoisomerase 2 and a c myc gene DNA insert . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the cellular DNA of Mz Sto 1 cells no amplification of 19 oncogenes studied is observed , c myc included . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The mechanism of this altered expression is obscure because the structure and quantity of myc DNA are very rarely disturbed . ^^^ The COLO 320 cell line is discussed as one unusual example of myc DNA rearrangement and amplification . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Of these 4 cases , one ( Case 1 ) showed a DNA rearrangement in the 5 ' portion of the c myc locus associated with integration of feline leukemia virus ( FeLV ) genome . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Elevated c myc expression facilitates the replication of SV 40 DNA in human lymphoma cells . ^^^ The c myc gene product is a DNA binding , nuclear phosphoprotein that is involved in the control of cell proliferation and possibly in DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The BPV 1 DNA alone or the c myc gene alone has no activity in this assay . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Previous studies of 21 highly lymphomatous AKXD recombinant inbred mouse strains demonstrated correlations between lymphoma type , the somatic proviral DNA content of the lymphoma , and the frequency of virally induced rearrangements in eight common sites of viral integration ( Myc , Pim 1 , Pvt 1 , Mlvi 1 , Mlvi 2 , Fis 1 , Myb , and Evi 1 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA replication : separation of c myc antibodies from an inhibitor of DNA synthesis . ^^^ Antibodies against human c myc protein have been reported to inhibit DNA polymerase activity and endogenous DNA synthesis in isolated nuclei , suggesting a role for c myc in DNA replication . ^^^ However , the c myc antibodies could be completely separated from the DNA synthesis inhibition activity . c myc antibodies prepared in other laboratories also did not interfere with initiation of simian virus 40 DNA replication , DNA synthesis at replication forks , or DNA polymerase alpha or delta activity . ^^^ Therefore , the previously reported inhibition of DNA synthesis by some antibody preparations resulted from the presence of an unidentified inhibitor of DNA polymerases alpha and delta and not from the action of c myc antibodies . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transgenic rabbits with the rabbit c myc oncogene fused with the rabbit immunoglobulin heavy chain enhancer region ( E mu ) DNA were developed by microinjecting pronuclei of single cell zygotes with the gene construct and implanting the microinjected eggs into pseudopregnant females . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here we identify distinct 7S nuclear transcripts by hybridization with DNA and RNA probes derived from regulatory regions of SV 40 and c myc genes . 7SK RNA hybridized to both early and late strands within the 21bp repeat region of SV4C and only to the sense strand within the first c myc intron . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have identified a rearranged c myc gene in DNA from tumour tissue from a patient with an aggressive carcinoma of the breast . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The PKC activator tetradecanoyl phorbol acetate ( TPA ) alone induced a time and concentration dependent stimulation of the incorporation of [ 3H ] thymidine into the DNA of quiescent FRTL 5 cells , an effect anteceded by an increase in the levels of the mRNAs of the proto oncogene c myc and associated with a stimulation of cell replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have determined the nucleotide sequences of two independent DNA clones which contained the activated c myc genes from avian leukosis virus induced B cell lymphomas . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Tumor specimens procured from 38 different small cell lung cancer patients were studied for DNA amplification of the myc family of protooncogenes ( c myc , N myc , and L myc ) . ^^^ Six of the 38 specimens ( 16 % ) had 4 fold or greater myc family DNA amplification ( N myc in 4 and L myc in 2 ) . ^^^ The myc family gene copy number of the DNA prepared from 9 tumor cell lines established from these 38 patients was similar to the myc family gene copy number in the DNA prepared from fresh tumor specimens from these same patients . myc family DNA amplification is present in 16 % of small cell lung cancer patients ' tumors and the amplification pattern in the tumor cell lines is representative of the fresh tumors obtained from the same patients . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This study was performed to determine the relationship of the activation of ras and c myc oncogenes in human hepatocellular carcinoma to the hepatitis B virus gene expression or the presence of hepatitis B virus DNA / RNA at the cellular level . ^^^ In addition , immunocytochemical assay for the detection of ras p 21 or c myc protein was performed in combination with in situ hybridization for hepatitis B virus DNA / RNA using 35S labeled hepatitis B virus DNA as a probe . ^^^ These findings suggest that continued expression of HBsAg or the presence of hepatitis B virus DNA / RNA in a given human hepatocellular carcinoma cell id not necessary for enhanced expression of ras or c myc proteins . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A fragment of cloned B myc was used to map the corresponding rat locus by Southern blotting of DNA prepared from rat 10 mouse somatic cell hybrids . ^^^ The DNA regions conserved among the myc family members , designated myc boxes , were highly conserved between c myc and B myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We found that microinjected plasmid DNA carrying an intact human c myc gene directs efficient and faithful transcription from its own two promoters in 10 . laevis oocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analyses of total DNA from the peripheral blood cells during relapse showed that the c myc oncogene was amplified about 30 fold in the leukaemic cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using this assay , inverted duplications were detected in amplified DNA ( both DM and HSR configurations ) containing the myc gene ( 16 50 copies / cell ) in four human tumor cell lines and in amplified DNA containing the CAD gene ( 30 200 copies / cell ) in three PALA resistant BHK cell lines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A survey of wild mouse DNA with a c myc exon 1 probe revealed a Taq 1 restriction fragment length polymorphism ( RFLP ) among Mus species . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
PFG analysis of DNA containing the t ( 3 ; 8 ) rearrangement shows that the breakpoint is not located in the mapped region , making it unlikely that MYC is involved in this form of renal cell carcinoma . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We examined the structure and expression of the myc protooncogene in DNA extracted from a primary ( uncultured ) endemic Burkitt ' s lymphoma sample designated eBL 3 . ^^^ Nearly complete sequence data of the altered myc locus isolated from eBL 3 DNA demonstrated extensive mutations ( duplications , insertions , and deletions ) in critical myc regulatory regions . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Although both E1A gene products localized to the nucleus and stimulated adenovirus gene transcription , these proteins did not directly bind to DNA under conditions in which a known DNA binding protein , the human c myc gene product , bound DNA efficiently . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of c myc by aortic constriction in vivo may correlate with the respective capacity of atrial and ventricular myocytes to replicate DNA during cardiac hypertrophy . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Augmentation of the expression of c myc and c fos oncogenes as a function of the mechanical activity of the isolated adult rat heart ] . c myc and c fos oncogenes encode nuclear DNA binding proteins , and are involved in both growth regulation and differentiation . ^^^ Using the molecular hybridization technique and DNA probes complementary to c myc and c fos mRNA , we report an increase in c myc and c fos expression level in the isolated beating adult rat heart with reference to the arrested isolated heart . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In vitro transcription studies on cloned tumor DNA containing a deleted chicken syncytial virus provirus integrated upstream from , and in the same transcriptional orientation as , the chicken c myc coding region were utilized to map possible transcriptional promoters and initiation sites . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The tumor DNA contains a 16 . 8 kilobase pair ( kbp ) rearranged c myc fragment in addition to the normal 15 kbp and 7 . 5 kbp fragments . ^^^ We compared the structure of the cloned rearranged c myc ( re myc ) with that of a cloned normal c myc and found that the rearrangement was due to the insertion of a 1 . 8 kbp DNA upstream to the first exon of c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Frequencies of transformation are in the same range as those usually observed for transformation with complete polyoma DNA or with a mixture of cloned myc and ras oncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Nucleotide sequence analysis of CMII proviral DNA at the delta gag 5 myc and the 5 myc delta pol junctions revealed significant homologies between avian retroviral structural genes and the cellular oncogene c myc precisely at the positions corresponding to the gene junctions in CMII . ^^^ Molecular cloning of proviral DNA and structural analysis of the transduced myc oncogene of avian oncovirus CMII . ^^^ Molecularly cloned proviral DNA of avian oncogenic retrovirus CMII was isolated by screening a genomic library of a CMII transformed quail cell line with a myc specific probe . ^^^ The gene order of CMII proviral DNA is 5 ' delta gag 5 myc delta pol delta env 3 ' . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Primary cell lines derived from these tissues contained both myc and SV 40 DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
One DNA segment was known to have sequence homology to the c myc oncogene , and both DNA segments had previously been shown to be amplified in neuroblastoma cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Moreover , cultured trophoblasts display abundant high affinity PDGF receptors and respond to exogenous authentic PDGF by an activation of the c myc gene and DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
However , genomic Southern blotting and analysis of the cloned oncogene in the present study reveal that ( 1 ) chromosome 12 sequences lie 365 base pairs 5 ' of the rearranged c myc ; ( 2 ) this DNA consists of immunoglobulin alpha switch region and 5 ' immunoglobulin mu switch region sequences that are rearranged in an aberrant fashion ; and ( 3 ) the immunoglobulin heavy chain gene enhancer element now resides approximately 2 . 5 kilobase pairs 5 ' of c myc . ^^^ In contrast to several of its counterparts in Burkitt lymphomas , DNA sequence analysis of the translocated c myc gene of ABPC 45 reveals that it has not acquired point mutations in the noncoding first exon . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The putative onc sequences of S 13 do not hybridize to DNA probes representing src , erb A , erb B , myc , myb , fps , fms , H ras , B lym , abl , rel , and ets . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Blot hybridization of thymocyte DNA from AKR / J mice was used to detect new proviral junction fragments as markers of clonality at different stages of viral leukemogenesis and to detect DNA rearrangements at the c myc locus due to proviral insertion . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Rat thymic lymphomas induced by Moloney murine leukemia virus carry DNA rearrangements due to provirus integration in at least five independent cellular DNA domains ( Mlvi 1 , Mlvi 2 , Mlvi 3 , RMoInt 1 , and c myc ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have performed cytogenetic analyses of tumours formed after transfection of Syrian hamster embryo cells with either 5 Ha ras plus 5 myc DNAs or polyoma DNA alone . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The presence of a rearrangement of the proto oncogene c myc was investigated in the DNA of fresh cells isolated from the blood of two patients with Burkitt ' s leukemia ( L 3 ) , and from the node biopsy of a patient with Burkitt ' s lymphoma . ^^^ Only one of the leukemic DNA ' s presented a rearranged c myc pattern , with the breakpoint region located between the first and the second exon . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here we describe a third myc related gene ( L myc ) cloned from SCLC DNA with homology to a small region of both the c myc and N myc genes . ^^^ Human genomic DNA shows an EcoRI restriction fragment length polymorphism ( RFLP ) of L myc defined by two alleles ( 10 . 0 and 6 . 6 kilobase ( kb ) EcoRI fragments ) , neither associated disproportionately with SCLC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These cell lines contained proviral DNA sequences integrated upstream from the c myc proto oncogene , expressed increased levels of c myc RNA , and were tumorigenic in syngeneic animals . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These stereotyped translocations have been shown in many cases to be related to DNA molecular rearrangements of the immunoglobulin genes and the c myc oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cellular DNA regions involved in the induction of rat thymic lymphomas ( Mlvi 1 , Mlvi 2 , Mlvi 3 , and c myc ) represent independent loci as determined by their chromosomal map location in the rat . ^^^ The induction of thymic lymphomas by Moloney murine leukemia virus in the rat is linked to provirus integration in at least four independent cellular DNA regions ( Mlvi 1 , Mlvi 2 , Mlvi 3 , and c myc ) . ^^^ Because sequences homologous to at least three of these regions ( Mlvi 1 , Mlvi 2 , and c myc ) map to chromosome 15 in the mouse , the question was raised whether they are closely linked in the rat genome and whether provirus integration in any one of these regions affects the same functional domain in rat DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The gene product of c myc may be involved in the cellular response of cells stimulated by PDGF or FGF , but not directly in the signal transmission which leads to DNA synthesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Antibodies against the product of the human cellular myc gene ( c myc ) were prepared against a bacterially expressed human c myc protein by inserting the ClaI / BclI fragment of the human c myc DNA clone in an expression vector derived from pPLc 24 . ^^^ The protein binds to double stranded DNA in vitro , a reaction that can be inhibited to more than 90 % by c myc specific IgG . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Similar to cases of Burkitt ' s lymphoma unrelated to AIDS , there were DNA sequences in the lymphoma that hybridized to EBV specific probes and demonstrated evidence of c myc rearrangement . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We compared the chromatin structure of c myc in H 82 to that in H 378 using DNase 1 sensitivity and DNA methylation patterns . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results strongly suggest that three messenger systems , diglyceride , Ca2+ and cyclic AMP , may be involved in c myc gene activation which may be implicated in DNA synthesis in Swiss 3T3 cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The presence of DNA lesions in c myc was investigated by Southern blot hybridization with a human c myc probe . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This 760 bp segment of 5 ' flanking c myc DNA dramatically inhibits CAT gene expression in the pSV2CAT vector when placed in either orientation approximately 1 . 7 kb 3 ' ( and approximately 3 . 2 kb 5 ' on the circular plasmid ) from the SV 40 promoter region . ^^^ By employing this strategy , we were unable to identify an analogous DNA segment that is closer to or within the first c myc exon . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The effect of these compounds on expression of c myc was investigated using a DNA probe for c myc to detect RNA transcripts . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Steady state levels of the mitochondrial ( mt ) mRNA encoding subunit 2 of cytochrome oxidase ( COII ) were increased 5 10 fold in fully transformed cell lines derived from rodent embryonic fibroblasts after transfer of polyoma virus DNA , and in immortalized cell lines established by transfer of plt ( polyoma large T protein ) , E1A ( adenovirus ) and myc oncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Clones were isolated with one to six copies of c myc stably integrated into DNA that expressed c myc mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Activation of the c myc proto oncogene , in the form of DNA rearrangements that lead to constitutive expression , has been implicated in the genesis of a wide range of tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A correlation was evident between the potency of these compounds as inducers of differentiation demonstrated by nonspecific esterase activity , the degree of reduction in calmodulin concentration , the rate of the inhibition of DNA synthesis and of expression of c myc and c myb genes , and the induction of the expression of oncogenes c fos and c fms . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Also , the established cells did not show DNA rearrangements or RNA alterations of the c myc gene . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In one patient , Southern blot analysis revealed additional c myc fragments in the tumor DNA but not in the germ line DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the DNA of one small cell carcinoma , an extra c myc and N myc cross hybridizing restriction fragment was observed , possibly owing to an amplification of a yet uncharacterized myc related gene . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In avian leukosis virus induced lymphoma and erythroblastosis , the expression of the proto oncogenes c myc and c erbB is activated by downstream or readthrough transcripts initiated within integrated proviral DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The blot hybridization analysis of DNA from primary and secondary NIH 3T3 transformants identified additional sequences homologous to the c Ha ras 1 oncogene , and revealed amplification of nucleotide sequences homologous to the 5 myc oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Prostaglandin E 1 ( PGE 1 ) caused a rapid and dose dependent increase in cAMP levels , followed by elevation of c myc mRNA levels and then increased DNA synthesis in quiescent cultures of Swiss 3T3 fibroblasts . ^^^ Both 8 bromo cAMP and forskolin increased c myc mRNA levels to 40 50 % and DNA synthesis to 70 80 % of those caused by a maximally effective dose of PGE 1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
WHV DNA was not integrated near the c myc coding exons , excluding a direct role of the virus in c myc activation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In an attempt to get an insight into the activity of mAMSA ( a DNA topoisomerase 2 mediated drug ) on the human proto oncogene c myc , an in vitro system consisting of purified calf thymus DNA topoisomerase 2 and a c myc DNA inserted in lambda phage was utilized . ^^^ The occurrence of discrete bands , detected by hybridization of Southern blots with appropriate c myc probes , indicated the presence of cleavage sites in the sole presence of DNA topoisomerase 2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cloning of a non c myc DNA fragment from the double minutes of a human colon carcinoid cell line . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The murine pvt 1 locus lies an unknown distance 3 ' of c myc ; analysis of DNA from several tumours with c myc amplification reveals that pvt 1 is co amplified in at least one case , placing pvt 1 approximately 100 500 kb 3 ' of c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Efficient transfer of the plasmid in each cell type was demonstrable within 1 . 5 h of transfection by Southern blotting of extrachromosomal DNA extracts , which unexpectedly revealed that 5 myc plasmid DNA was unstable in normal lymphocytes but not in the other cell types . ^^^ Even though plasmid stability and expression were achieved in myc ras cotransfected lymphocytes , no effects on cellular DNA synthesis or immortalization were observed , in contrast to efficient transformation of NIH 3T3 fibroblasts by the same procedure . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transformed foci were obtained in rat 3Y1 fibroblasts cotransfected with pRmyc 27 ( transcriptionally activated c myc ) and pSV2neo DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern analysis of tumour DNA revealed that 2 / 30 spontaneous tumours and 2 / 52 MNU induced tumours contained alterations in the c myc gene while 5 / 29 spontaneous tumours and 6 / 56 MNU induced tumours contained alterations in the Pim 1 gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Enhancement of cmyc mRNA concentration in dog thyrocytes initiating DNA synthesis in response to thyrotropin , forskolin , epidermal growth factor and phorbol myristate ester . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the canine transmissible venereal tumour we found that c myc was rearranged due to the insertion of an 1 . 8 kilobase pair cellular DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The Southern blot analysis of malignant tumour DNA reveals amplification of c myc protooncogene of 3 from 11 patients . ^^^ The structure of DNA sequences homologous to the viral myc oncogene from ovarian tumours , intact tissues and the same patients peripheral blood leukocytes has been studied . ^^^ The presence of extra copies of myc related sequences has been shown in two from three DNA samples from peripheral blood leukocytes of patients with ovarian cancer . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Finally , in two cervical carcinoma cell lines , HeLa and C 4 1 , HPV 18 DNA is integrated in chromosome 8 , 5 ' of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA structure equilibria in the human c myc gene . ^^^ We have employed analytical S 1 nuclease analysis to identify sites with altered DNA secondary structure in the human c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Expression of genes c myc , c myb and histone H 4 varied coordinately and in parallel with the rates of DNA synthesis , while the rates of total and ribosomal RNA synthesis , the expression of gene c Ha ras , unrelated to proliferation of these cells , and gene p 72 , a constitutively expressed human gene , were unchanged . ^^^ Thus , transcription of genes c myc and c myb in HL 60 cells appears to be linked to DNA replication in a manner previously demonstrated for core histone gene expression . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
An aberrant avian leukosis virus provirus inserted downstream from the chicken c myc coding sequence in a bursal lymphoma results from intrachromosomal recombination between two proviruses and deletion of cellular DNA . ^^^ A chicken bursal lymphoma , LL 6 , contains avian leukosis virus DNA integrated 3 ' of the c myc coding sequences , unlike all other examined bursal lymphomas , which have integrations 5 ' to c myc . ^^^ To better understand this unusual mutation , we examined a molecular clone containing the LL 6 c myc gene and determined the structure of the proviral insertion by DNA sequencing . ^^^ Viral DNA begins 575 base pairs downstream of the c myc coding sequences within the untranslated region , disrupting the use of the normal polyadenylation signal . ^^^ The DNA sequences immediately downstream of the LL 6 recombinant provirus are not part of the c myc gene ; they originate from the same chromosome as c myc , but at least 15 kilobases ( kb ) away . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
No abnormalities for Ha ras , Ki ras , N ras , myb , or myc were detected by Southern blot analysis of the tumor DNA . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA amplification ( c myc , N myc , and L myc ) . ^^^ Two of 19 lines ( 11 % ) established from untreated patients ' tumors had DNA amplification ( one N myc and one L myc ) , compared with 11 of 25 ( 5 c myc , 3 N myc , and 3 L myc ) cell lines ( 44 % ) established from relapsed patients ' tumors ( P = 0 . 04 ) . ^^^ Relapsed patients whose cell lines had c myc DNA amplification survived a shorter period ( median of 33 wk ) than patients whose cell lines did not have c myc amplification ( median of 53 wk ; P = 0 . 04 ) . ^^^ We conclude that myc family DNA amplification is more common in tumor cell lines established from treated than untreated patients ' tumors , and c myc amplification in treated patients ' tumor cell lines is associated with shortened survival . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The presence of additional sequences upstream of the PvuII fragment had an overall negative effect on c myc promoter activity detectable by titration analysis with small amounts of transfected plasmid DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results indicate that the c myc protein can be substituted for SV 40 T antigen in SV 40 DNA replication . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The nonadhesive conditions established by suspension culture cause BALB / c 3T3 ( A 31 ) cells to enter a G 0 state of growth arrest within 48 hr as defined by an inhibition of DNA synthesis and a suppression of c myc and histone mRNA expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Electroporation of cultured adult rat hepatocytes with the c myc gene potentiates DNA synthesis in response to epidermal growth factor . ^^^ The human c myc gene was introduced and transiently expressed in adult rat hepatocyte cultures by the technique of electroporation and its effect on DNA synthesis was examined . ^^^ Hepatocyte cultures electroporated with the c myc gene showed a potentiation of this EGF effect exhibiting rates of DNA synthesis up to 50 % greater than those of control electroporated cultures , as determined by [ 3H ] thymidine labeling of cell nuclei . ^^^ This potentiation was dependent on the amount of c myc DNA transfected . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Moreover , computer analyses revealed that the intron sequences of various oncogenes ( both human and rodent sequences available from GenBank DNA sequence data bank ) such as ras , fos , c myc , N myc and int 1 , are in general significantly more highly conserved when compared with sequences of non oncogene introns . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
An initiation site of DNA replication with transcriptional enhancer activity present upstream of the c myc gene . ^^^ We have previously reported that c myc protein may promote cellular DNA replication by binding to initiation sites of replication . ^^^ Here we report that a putative origin of human cellular DNA replication ( ori ) is present at approximately 2 kb upstream of the coding region of the c myc gene itself . ^^^ The c myc protein , or protein ( s ) complexed with c myc protein , bind to the upstream region ( approximately 200 bp in length ) which has transcriptional enhancer activity as well as autonomously replicating activity in human cells , suggesting that the c myc protein may be an enhancer binding protein as well as a DNA replication protein . ^^^ Furthermore , when cloned DNA containing putative c myc protein binding sequences was transfected as competitor into HL 60 cells , expression of c myc was inhibited , suggesting that c myc protein itself may be necessary for c myc expression . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Translation of the son 3 sequence in the unique open reading frame into the amino acid sequence by computer and comparison with the NBRF protein data bank showed that the son 3 fragment codes for a new previously unknown polypeptide with the following properties : a ) it contains a cluster of short tandemly arranged repeats 7 12 amino acid in length located in the middle part of son 3 ; b ) it comprises a region homologous to DNA binding structural proteins ( for example , gallin , 55 % ) and to regulatory proteins coded by the family of proto oncogene myc ; c ) it comprises a region homologous to the oncoprotein coded by proto oncogene mos ( human , murine ) . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In c myc transfected cells the overproduced protein product accumulated in large amorphous globules that displaced the normal chromatin and did not stain for DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The data also show that neither early c fos nor c myc expression is sufficient to commit the cells to DNA synthesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA amplification of the c myc and c erbB 1 genes in a human stomach cancer . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Rearrangement of the c myc oncogene with heavy chain immunoglobulin enhancer in tumor DNA from an acute lymphoblastic leukemia patient . ^^^ The DNA obtained from the leukemia cells of an acute lymphoblastic leukemia ( ALL , L 3 type ) with a pre B phenotype and a typical t ( 8 ; 14 ) chromosomal translocation showed a rearrangement juxtaposing the c myc gene and the immunoglobulin ( Ig ) heavy chain gene enhancer . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The peptide [ D Arg 1 , D Pro 2 , D Trp 7 , 9 , Leu 11 ] substance P which inhibits the binding of bombesin to its receptor and bombesin stimulated DNA synthesis in Swiss 3T3 cells blocked the increase in c fos and c myc mRNA levels promoted by bombesin . ^^^ In the presence of insulin , bombesin stimulated DNA synthesis at subnanomolar concentrations but had only a small effect on c fos and c myc mRNA levels . ^^^ In these cells bombesin stimulated DNA synthesis in the presence of insulin but failed to enhance c fos and c myc mRNA levels at comparable concentrations . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The distance between the c myc gene and the breakpoint in J kappa amounts to at least 90 kilobases on the DNA level . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This recombination has resulted in the loss of 5 ' proximal DNA and , consequently , potential regulatory information from the body of the c myc structural gene via joining to the epsilon heavy chain switch region in a head to head , i . e . , 5 ' to 5 ' , configuration . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Frequency on N ras as a transforming gene , DNA rearrangement and amplification , and over expression of C myc in human primary hepatic cancer ] . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The effects of phorbol ester and Ca ionophore on c fos and c myc expression and on DNA synthesis in human lymphocytes are not directly related . ^^^ This result indicates that the induction of c fos and c myc expression is not sufficient to commit these cells to DNA synthesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transcription was activated less strongly by similar proteins in which the DNA binding region of LexA was fused to vMyc and cMyc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We examined the effects of PRL , calcium ionophores , and calcium antagonists on 45Ca2+ flux , c myc gene expression , and DNA synthesis in the PRL dependent rat Nb 2 lymphoma cell line . ^^^ However , the putative intracellular calcium antagonist TMB 8 inhibited both c myc expression and DNA synthesis in a dose dependent manner ( IC 50 = 16 microM ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
EDT caused a rapid and transient increase in the c fos and c myc mRNA levels and stimulated the DNA synthesis of VSMCs in a dose dependent manner . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The data also showed that W 14 TRA was acquired in the event of cell transformation , since it was not detected on parental non transformed WFB cells or Wmyc 4 clone which is a transfectant of WFB by mouse plasmacytoma derived c myc DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This antigen was highly expressed on WFB EJras and polyoma middle T DNA transformants , but was undetectable or at the best only faintly recognized on WFB parental cells , transfectants of WFB with c myc , and normal thymus , liver and kidney of WKA adult rats . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Production of fos and myc RNA was measured by S 1 mapping , using fos DNA probes which identified either primary unspliced transcripts or steady state spliced mRNA levels , and using a myc probe which spanned the two major c myc start sites , P 1 and P 2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the liver and muscle of the same animals there is neither elevation of c fos and c myc expression nor increase of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Compared to HL 60 , the proto oncogene myc of HL60 / MRI is amplified about twofold less in genomic DNA and is expressed about twofold less at the transcriptional level . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA hybridization showed evidence of c myc amplification in only one of the samples tested . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It is unknown whether this developmental block to mitotic division and DNA replication might involve irreversible repression of the cellular oncogene c myc . ^^^ Despite failure to induce DNA replication or division after 15 d of mitogen withdrawal , serum elicited both c myc and alpha skeletal actin as found during hypertrophy of the intact heart . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA replication analysis via bromodeoxyuridine pulse labelling reveals an aberrant banding pattern in the c myc chromosomal domain in tumour cells and highly tumorigenic hybrids . ^^^ Aberrant DNA replication in tumour cells and highly tumorigenic hybrids coincides with enhanced c myc expression . ^^^ In hybrids with suppressed tumorigenicity and with normal DNA replication banding c myc expression is also reduced . ^^^ Reversion of aberrant DNA replication and reduction of c myc expression to normal in hybrid cells may be due to a site specific trans effect which overrides the control brought about in cis by retroviral insertion near the c myc gene . . ^^^ Suppression of tumorigenicity in T cell lymphoma hybrids is correlated with changes in myc expression and DNA replication of the myc chromosomal domain . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We previously described a murine monocyte tumor which was induced by a helper free c myc retrovirus and which also contained a DNA rearrangement at the colony stimulating factor 1 ( CSF 1 ) locus . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Molecular analysis revealed that the T 34 cells contained 8 to 16 fold amplified c myc DNA . ^^^ There was no gross rearrangement of the c myc DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To test whether bcl 2 influences the growth of haematopoietic cells , either alone or together with a deregulated c myc gene , we have introduced a human bcl 2 complementary DNA using a retroviral vector into bone marrow cells from either normal or E mu myc transgenic mice , in which B lineage cells constitutively express the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In one case , somatic cell hybrid studies revealed that the cloned rearranged DNA was entirely derived from chromosome 8 , thus indicating a novel mechanism of c myc activation different from that in Burkitt ' s lymphoma . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The rearranged c myc DNA fragment from this thymoma was cloned and examined by restriction endonuclease mapping , hybridization to MoMuLV proviral DNA probes , and DNA sequence analysis . ^^^ The sequences at the 3 ' flanking side of the LTR structure were derived from a cellular DNA region which maps to the same chromosome as c myc ( chromosome 7 ) , although to a site distant from this proto oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
C myc expression plays an essential role towards the induction of DNA replication following mitogen stimulation of quiescent cells . ^^^ Hence , functional homology between N myc and c myc extends to their joint ability to stimulate DNA replication . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern and DNA dot blot analyses revealed c myc amplification in three of the six cell lines . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In order to characterize these insertions , we have isolated recombinant DNA clones from normal rat DNA containing all of the normal rat c myc gene , and from two Moloney murine leukemia virus induced lymphomas containing both proviral and adjacent rat c myc sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Stimulation of an alpha like DNA polymerase by 5 myc related protein of Halobacterium halobium . ^^^ Partial DNA sequencing of a genomic clone of the archaebacterium Halobacterium halobium , which hybridized with an avian 5 myc probe , showed especially the presence , in the organism of one of the conserved regions through myb , myc and adenovirus E1a oncogenes . ^^^ In accordance with the partial DNA sequencing which assured a sufficient homology to have similar epitopes , a protein having a molecular weight of 70 , 000 and possessing high antigenicity with a polyclonal antiserum against avian 5 myc protein was isolated and purified from H . halobium extracts . ^^^ The purified 5 myc like protein stimulated in vitro DNA synthesis carried out by the alpha like DNA polymerase of H . halobium . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Two step stimulation of B lymphocytes to enter DNA synthesis : synergy between anti immunoglobulin antibody and cytochalasin on expression of c myc and a G 1 specific gene . ^^^ Thus there are synergistic effects of competence and progressionlike factors on the expression of the c myc and 2F1 genes , and these effects correlate with the progression of B lymphocytes to DNA synthesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The restriction analysis of breast cancer DNA revealed amplification of c myc and c Ha ras oncogenes in 3 of 19 and 4 of 22 carcinomas , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Is c myc protein directly involved in DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Sequence analysis of a yeast genomic DNA fragment sharing homology with the human c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A 27 base long DNA oligonucleotide was designed that binds to duplex DNA at a single site within the 5 ' end of the human c myc gene , 115 base pairs upstream from the transcription origin P 1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We used recombinant DNA vectors to express either N myc or its kindred gene c myc in transfected cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Other growth factors , including epidermal growth factor , appear not to affect these cells either in terms of DNA synthesis or c myc mRNA induction . ^^^ The phorbol ester phorbol 12 myristate 13 acetate ( PMA ) also induces c myc and c fos mRNAs without inducing DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Rat genomic regions covering c myc were cloned from the DNA of both normal liver and two lines of Morris hepatomas , one of which had c myc amplification . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The nuclear associated protein product of the c myc gene , p62c myc , was assayed simultaneously with total DNA using flow cytometry in nuclei extracted from archival biopsies of serous papillary carcinoma of the ovary . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , the possibility of aberrant gene rearrangements was supported by noting the alteration of the c myc gene locus in genomic DNA from peripheral blood leukocytes of 6 and CH . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This induction of DNA synthesis was inefficient , and cell proliferation was not evident , suggesting that growth factors act through stimulation of c myc expression together with other intracellular events . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When growth is stimulated in normally quiescent hepatocytes , steady state levels of c fos , c myc , and p 53 mRNAs increase sequentially and transiently before DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Results from our studies of the c myc oncogene and its product in human solid tumours , using DNA and RNA hybridization and a set of monoclonal antibodies ( MCAs ) raised against synthetic peptides , are presented . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These membranes were hybridized to a 32P labelled third exon c myc DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These membranes were hybridized with nick translated 32P labelled c myc DNA ( exon 3 ) , washed at high stringency and subjected to autoradiography . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Finally , we have observed a low level of amplification of c myc in DNA from a benign fibrocystic breast lesion . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
EcoRI digests of DNA isolated from the sublibraries ( G 1 , S , G2 / M ) were submitted to Southern hybridizations with radiolabeled probes either ( a ) for genes whose phase specific expression is clearly documented , thymidine kinase , dihydrofolate reductase , and thymidylate synthase , or ( b ) for genes whose change of expression during the cell cycle is likely , lamin C , beta actin , alpha and beta tubulin , c myc , c fos , p 53 . ^^^ Sequences belonging to group ( b ) were also found to be enriched in DNA isolated from the sublibraries : c fos in G 1 phase , lamin C , beta actin , tubulins , c myc in S phase , and p 53 in G1 / S phase . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transfection of c myc DNA into rat fibroblastic 3Y1 cell line resulted in the neosynthesis of GD 3 ganglioside , as has been previously shown to occur after transfection of 3Y1 cells with adeno El ( Nakakuma , H . , Sanai , Y . , Shiroki , K . , and Nagai , Y . ( 1984 ) J . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc proto oncogene appeared to be amplified 2 to 15 fold in the DNA of 20 tumors ( 41 % ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A number of DNA sequences specifically bound by nonhistone factors within 5 ' flanking regions of the chicken beta A globin , beta H globin and c myc genes are shown to contain short DNase 1 resistant DNA domains . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA prepared from seven primary carcinomas , the two transplanted tumors , and the in vitro cell lines was hybridized with a 5 myc probe . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The possible roles in experimental colon carcinogenesis of two protooncogenes ( c myc and c H ras ) , two endogenous retrovirus related DNA sequences [ rat leukemia virus ( RaLV ) and the 30S sequence ] , and two cell cycle related genes ( beta actin and ornithine decarboxylase ) were studied by analyzing the levels of their corresponding RNAs during the course of azoxymethane induced and high fat promoted colon carcinogenesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Increased c myc protein synthesis is detectable within an hour of oestrogen exposure , while increased VP 16 induced DNA cleavage is detectable within 4h and increased DNA synthesis within 16h . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Although both tumors expressed the same immunologic surface markers ( mu k ) and carried the same t ( 8 ; 14 ) translocation , Southern blot analysis of DNA from each tumor , using specific restriction endonucleases and probes to the c myc and the immunoglobulin heavy chain loci , demonstrated that the chromosomal breakpoints relevant to the translocations differed between the tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We were able to reliably detect N and c myc gene amplification in tumor DNA by dot blot hybridization . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Agarose gel electrophoresis of total RNA extracts of RINr cells , followed by hybridization with 5 myc DNA yielded a 2 . 4 kilobase c myc messenger RNA ( mRNA ) transcripts . ^^^ The level of c myc transcripts then declined as the cells proceeded through G 1 to the cycle . [ 3H ] Thymidine uptake into DNA was dramatically increased after 24 h of glucose addition , suggesting that glucose itself stimulates DNA synthesis in RINr cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results indicate that the reduction in CTP levels leads to rapid inhibition of DNA synthesis and reduction in c myc mRNA levels which precede the appearance of differentiated cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The test assay consisted of cotransfecting the indicator gene with competing fragments of DNA derived from suspected control regions of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Pertussis toxin sensitive pathway in the stimulation of c myc expression and DNA synthesis by bombesin . ^^^ At nanomolar concentrations , bombesin increased levels of c myc messenger RNA and stimulated DNA synthesis in Swiss 3T3 cells . ^^^ Treatment of the cells with pertussis toxin ( 5 nanograms per milliliter ) completely blocked bombesin enhanced c myc expression and eliminated bombesin stimulated DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The reversal was accompanied by the resumption of normal rates of DNA synthesis , mitosis , and reaccumulation of c myc and c myb transcripts . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA sequence contents of the HgII bound and unbound nucleosome fractions were compared by slot blot hybridizations to 32P labeled cloned probes for c fos and c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We evaluated the c myc expression and the RNA , DNA and protein synthesis in K 562 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In peripheral blood mononuclear cells ( PBMC ) c myc DNA showed hypomethylation in human lymphoproliferative diseases , in comparison to normal subjects matched in age and sex . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The present results conform to the view that the c fos and c myc proto oncogenes may be important ( or necessary ) but not sufficient for the initiation of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The addition of EGF to cells expressing wild type receptors caused the stimulation of various responses , including enhanced expression of proto oncogenes c fos and c myc , morphological changes , and stimulation of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Purified human B lymphocytes were examined for transcriptional expression of c myc in response to mitogenic stimulation by the method of in situ hybridization using 35S labeled DNA probes . ^^^ To determine whether c myc expression in human B lymphocytes is phase specific within the cell cycle , mitogen stimulated cells were sorted by DNA content into populations of cells in G0 / G1 , S , and G2 / M phases of the cell cycle . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Murine splenic T lymphocytes display maximal cellular myc gene ( c myc ) expression already 3 h after concanavalin A stimulation and subsequent down regulation before the onset of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When growth is stimulated in the normally quiescent adult rat liver by partial hepatectomy , steady state levels of messenger RNAs ( mRNAs ) for c fos , c myc , and p 53 increase sequentially during the prereplicative phase which precedes DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We therefore constructed an amplifiable plasmid vector containing a full length mouse c myc complementary DNA and introduced it stably into recipient F MEL cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Participation of c myc protein in DNA synthesis of human cells . ^^^ Experiments presented here show that the addition of affinity purified antibodies against the human c myc protein to nuclei isolated from several types of human cells reversibly inhibited DNA synthesis and DNA polymerase activity of these nuclei . ^^^ This suggests that c myc encodes a protein that is functionally involved in DNA synthesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Altogether , these observations suggest that , in contrast with the model of fibroblast growth mentioned above , EL 2 cells require the presence of a single growth factor ( EGF ) for induction of DNA synthesis , and the expression of myc and fos proto oncogenes may represent an obligatory step in the pathway of commitment of EL 2 cells to proliferation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Chromatin structures of c myc and c fos were compared by measuring their sequences in nucleosome associated DNA fragments . ^^^ C myc related sequences were detected in nucleosomal DNA fragments of differentiated cells only , while the c fos related sequences were found in nucleosomal DNAs of noninduced HL 60 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA from 10 of the 12 tumors also showed c myc gene amplification and restriction polymorphisms . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using various oncogenes ( DNA tumor virus oncogenes : adenovirus 12 E 1 and its transcriptional subunits , myc and SV 40 T antigens ; RNA tumor retrovirus oncogens : fos , src and H ras ) for the transfer , it was demonstrated that these genes invariably caused remarkable and characteristic changes of the cellular expression of gangliosides in the same recipient rat embryonic cell line , 3Y1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
C myc expression is dissociated from DNA synthesis and cell division in Xenopus oocyte and early embryonic development . ^^^ This observation suggests that the function of the c myc gene in the cell cycle may not be implicated directly in sustaining DNA synthesis or mitosis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Preliminary experiments using DNA slot blots indicated that erb a and b , 5 fes , 5 mos , c myc , n myc , 5 src , and 5 sis showed no sequence amplification in GM 1492 cells or subclones . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Our studies have revealed four common DNA regions for provirus insertion in these tumors ( Mlvi 1 , Mlvi 2 , Mlvi 3 and c Myc ) , while studies from other laboratories have revealed two additional ones ( pvt 1 / mis 1 and pim 1 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Possible function of the c myc product : promotion of cellular DNA replication . ^^^ Specific binding activity of the c myc product to pARS 65 was detected by an immunobinding assay , suggesting that the c myc protein promotes DNA replication through binding to the initiation site of replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have used this model system to determine if a close temporal coupling exists between the time of expression of two proto oncogenes associated with cell growth , c fos and c myc , and the time of entry into DNA synthesis . ^^^ Our results show that the time and pattern of c fos and c myc mRNA accumulation after stimulation is determined only by the time which the cells are treated with serum even when they exhibit a 19 h delay in the entry into DNA synthesis . ^^^ Likewise , the peak of c myc accumulation occurred at about 3 h after serum addition , regardless of how long it took to initiate DNA synthesis . ^^^ These results suggest that the time of c fos and c myc induction clearly is not the only factor which determines the length of the prereplicative period and thus the ultimate time of initiation of DNA synthesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
By Southern blot hybridization of DNA extracted from these cells , 8 fold amplification of c myc gene and rearrangement of c fms gene were shown in ENAMI cells , although the role of these alterations remained unknown . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Two other monoclonal antibodies of the same class , one directed against the cellular p 53 protein ( PAb 122 ) , and one directed against the c myc protein ( PM 8 ) were also tested for their ability to inhibit ongoing DNA synthesis by direct microinjection and in lysolecithin permeabilized cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Molecularly cloned MH 2 PA200 DNA was found to stimulate the growth of neuroretina cells by transfection assays and our results indicate that this recombinant virus was derived from the RAV 1 helper virus , in which 5 mil and a small part of 5 myc of MH 2 were acquired at the expense of helper ( delta gag pol delta env ) sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Sequence specific DNA binding proteins which interact with ( G + C ) rich sequences flanking the chicken c myc gene . ^^^ The interaction of nuclear sequence specific DNA binding proteins from definitive chicken erythrocytes , thymus and proliferating transformed erythroid precursor ( HD 3 ) cells with the 700 base pair ( 700 bp ) DNA 5 ' flanking region of the chicken c myc gene was investigated by in vitro footprint analysis . ^^^ The DNA binding activities were partially fractionated by high performance liquid chromatography gel filtration and include an erythrocyte specific protein which binds to a c myc gene poly ( dG ) homopolymer sequence similar to that found upstream of the chicken beta A globin gene . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We further show that PA evokes growth factor like effects in that it raises cytoplasmic pH , induces expression of the c fos and c myc proto oncogenes and stimulates DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inhibition of DNA synthesis by an inducer of differentiation of leukemic cells , 1 alpha , 25 dihydroxy vitamin D 3 , precedes down regulation of the c myc gene . ^^^ This treatment resulted in a rapid , selective , inhibition of DNA synthesis , which was accompanied by reduced cellular levels of c myc mRNA , and a more gradual appearance of c fos mRNA . ^^^ After removal of the inducer from the cultures , DNA synthesis and c myc mRNA levels returned rapidly to near normal levels , but the expression of c fos gene continued to increase for 24 hr and then declined slowly . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
At nanomolar concentrations it stimulates DNA synthesis in quiescent cultures of 3T3 cells and also induces the expression of c fos and c myc mRNA . c fos mRNA transcripts dramatically increase 15 min after the addition of bombesin , are still abundant after 30 60 min and then decrease . c myc mRNA induction is detectable later , 1 h after bombesin treatment . ^^^ These results demonstrate that the increased expression of c fos and c myc mRNAs appears to be a common response to diverse agents that induce DNA synthesis and cell proliferation . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Agarose gel electrophoresis of poly ( A ) RNA extracts of adenoma tissues followed by hybridization with 5 myc DNA yielded two distinct c myc mRNA species [ 2 . 1 and 4 . 0 kilobases ( kb ) ] . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Interaction of the oncogene protein myc with specific DNA fragments . ^^^ The DNA fragments which were retained by the p110gag myc protein were eluted from the filter and analyzed by agarose gel electrophoresis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When nuclear DNA synthesis is stimulated in the normally quiescent rat liver by a dietary manipulation , we examined the changes of the steady state levels of messenger RNA for c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA rearrangement and expression of the c myc gene in a human myeloma . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot analysis of thyroid tissue and cultured cell DNA indicated that gene amplification did not account for the increase in c myc mRNA levels in cultured cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hybridization of a 32P labeled 5 myc viral oncogene DNA probe to RNA extracted from differentiating explants and immobilized on nitrocellulose filters indicates that levels of 2 . 5 kb c myc mRNA are transiently elevated 5 10 fold in the differentiating cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Examination of a human glioblastoma cell line displaying a relatively stable karyotype and absence of both copies of chromosome # 13 ( HeRo ) as well as of a SV 40 transformed subline ( HeRo SV ) using analysis on the DNA and RNA level showed that both cell lines express high levels of abl , erb B , myc , and Ha ras mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern analysis of the c myc locus in these tumors indicated the absence of amplification or DNA rearrangement in a 35 kilobase region encompassing the gene . ^^^ In a parallel study , elevated expression of c myc without amplification or DNA rearrangement was also observed in three of six colon carcinoma cell lines examined ; in addition , unlike a normal colon cell line control , these three cell lines exhibited constitutive , high level expression of the gene during their growth in cultures . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
N myc is a DNA sequence which shares limited homology to the proto oncogene c myc and has been found to be amplified in both primary tissue and cell lines from neuroblastoma , a childhood tumour of neuroectodermal origin . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA from these transformed follicles contained the HB 1 5 myc gene but lacked the ability to transform NIH / 3T3 mouse cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
However , the extent to which c myc homologous DNA sequences are amplified in the genomes of these cells varies from 4 to 30 fold . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A relationship between these chromosomal aberrations and amplification of c myc DNA has been suggested . ^^^ We report the localization by cytologic hybridization of amplified c myc DNA to a marker chromosome , M3q+ , in an early passage of HL 60 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results indicate that NPC is an effective inhibitor of RNA and DNA methylation resulting from its conversion to an analog of AdoMet , and that these effects appear to be responsible for reduced c myc RNA expression and the induction of myeloid differentiation in this cell line . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have compared the primary DNA structure , DNA methylation , and S 1 nuclease sensitivity of the myc protooncogene in HL 60 cells before and after chemically induced differentiation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A series of extraction procedures were applied to avian nuclei which allowed us to define three types of association of 5 myc and c myc encoded proteins with nuclei : ( 1 ) a major fraction ( 60 to 90 % ) which is retained in DNA and RNA depleted nuclei after low and high salt extraction , ( 2 ) a small fraction ( 1 % ) released during nuclease digestion of DNA in intact nuclei in the presence of low salt buffer , and ( 3 ) a fraction of myc protein ( less than 10 % ) extractable with salt or detergents and found to have affinity for both single and double stranded DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hydroxyurea and 42 / 6 antibody ( anti transferrin receptor ) , which impair the G 1 S transition in cycling cells , failed to inhibit c myc expression and instead delayed the decrease in c myc mRNA levels that normally occurs with the onset of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Expression and characterization of the human c myc DNA binding protein . ^^^ Furthermore , we demonstrate that the bacterially made human c myc protein is a DNA binding protein and that it exhibits a high nonspecific affinity for double stranded DNA . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The above mentioned method is used for fractionation of chromosomal DNA according to the molecular weight ; for isolation of the plasmid containing the insertion of the viral oncogene myc and for separation of the viral oncogene myc insertion from the vector ( a linear form of plasmid pBR 322 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A simultaneous flow cytometric assay for c myc oncoprotein and DNA in nuclei from paraffin embedded material . ^^^ A simultaneous flow cytometric assay for the c myc oncoprotein and DNA in nuclei extracted from archival paraffin wax embedded clinical biopsies is presented . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Since the 14q11 chromosomal band has been found to be involved in several T cell leukemias and lymphomas , the importance of the rearrangement of c myc discovered in the KE 37 cell line lies in the possibility of analyzing chromosome 14 DNA near the breakpoint involved in the translocation . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NF 1 protects a 25 base pair ( bp ) double stranded segment of DNA which shares a consensus sequence , 5 ' TGGA / CNNNNNGCCAA 3 ' , with similar binding sites in the Ad 5 terminal repeat and the human c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequencing studies predict five changes in the amino acid sequence of the myc protein , two of which occur in a region within the second exon which is highly conserved in evolution . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of DNA revealed that c Ki ras 2 gene was amplified approximately 10 fold in this carcinoma , while c Ha ras , c myc and c sis were not amplified . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Comparative restriction mapping and DNA sequence analyses demonstrated that an intracisternal A particle ( IAP ) element inserted approximately 2 kilobases 3 ' of an alpha 4 type myc gene to generate the alpha 25 gene copy . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blots of Eco R 1 digested DNA showed 2 fragments of similar size hybridizing to c myc sequences in both early and late passage cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The transcripts from one such gene , the proto oncogene c myc , increase approximately 20 fold shortly after cells are stimulated to proliferate and then decline before the onset of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc protein , upon microinjection into nuclei of quiescent Swiss 3T3 cells , cooperated with platelet poor plasma in the stimulation of cellular DNA synthesis . ^^^ The presence in the medium of an antibody against PDGF abolished DNA synthesis induced by microinjected PDGF ; however , the microinjected c myc protein stimulated DNA synthesis even when its own antibody was present in the medium . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A 30 to 40 fold amplification of c myc was observed in the tumor DNA as compared to the DNA of normal colonic mucosa and liver . ^^^ Digestion with three different restriction enzymes demonstrated that there was no major alteration in the genomic structure of c myc in the amplified DNA . ^^^ Probes specific for the three myc exons were used in hybridization experiments and demonstrated that all three exons were present in the amplified DNA and in the mRNA . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Amplification of nucleotide sequences homologous to the viral myc oncogene in DNA of colonic mucosa in a patient with cancer of the same location ] . ^^^ Genomic DNA of intact colonic mucosa obtained from a female patient suffering colonic cancer revealed amplified nucleotide sequences ( multiple copies ) related to viral myc oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Density dependent arrest of DNA replication is accompanied by decreased levels of c myc mRNA in myogenic but not in differentiation defective myoblasts . ^^^ The level of c myc transcripts was lowered when myogenic rat L 6 myoblasts reached a high cell density , stopped DNA synthesis and formed myotubes . ^^^ This shows that DNA replication and c myc expression are independently regulated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
By using probes specific for the c mos and c myc genes , we have analysed the genomic DNA from peripheral blood and bone marrow samples from 15 patients with various malignant myeloid diseases , including leukemia and myelodysplasia , and from one patient with non Hodgkin ' s lymphoma , all of whom have trisomy for chromosome No . 8 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
On the other hand , the nonrearranged c myc gene in plasmacytoma DNA ( which is transcriptionally silent ) is extensively methylated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA from primary leukemic cells was analyzed on the basis of restriction endonuclease mapping by hybridization with various human c myc and Ig heavy chain probes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analyses of the cloned chicken c mil and c myc loci by nucleic acid hybridization employing specific probes from the mil myc junction of MH 2 proviral DNA revealed that c mil and c myc related sequences are directly adjacent in the viral genome and that MH 2 contains additional 5 ' c myc related sequences not present in the genomes of other leukemia viruses carrying the 5 myc oncogene . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hypomethylation of DNA in human cancer cells : a site specific change in the c myc oncogene . ^^^ The presence of methylation in specific regions of the c myc gene was analyzed by use of the restriction endonuclease isoschizomers MspI and HpaII , which recognize the sequence 5 ' CCGG 3 ' ( CCGG = DNA sequence of 2 cytosine bases followed by 2 guanine bases ) but differ in their abilities to cleave at the internal cytosine residue when it is methylated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Two feline c myc DNA clones ( CM 2 and CM 3 ) , isolated from a cat DNA library , are structurally very similar . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In a patient with Ph positive chronic granulocytic leukaemia who had 3 separate episodes of promyelocytic transformation associated with new cytogenetic and genetic changes DNA from the peripheral blood leucocytes obtained during the second episode of transformation showed an 8 fold to 16 fold amplification of cellular myc proto oncogene ( c myc ) sequences , and rearrangement of these sequences . ^^^ There was no amplification or rearrangement of c myc sequences in DNA from leucocytes collected during the chronic phase , nor were these sequences amplified in DNA from leucocytes collected during the third episode of transformation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transcriptionally active c myc oncogene is contained within NIARD , a DNA sequence associated with chromosome translocations in B cell neoplasia . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using hybrid selection of RNAs with myc DNA , followed by in vitro translation , we detected translation of myc related proteins from RNA of all four cell lines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have cloned a 2 . 0 kb EcoRI fragment of human genomic DNA ( NB 19 21 ) which has homology to the 5 myc oncogene but is distinct from the classical c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The drop in c myc precedes cessation of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In K 562 cells in which the epsilon globin gene is transcribed , six DNase 1 hypersensitive sites are found in 6 kilobases ( kb ) of upstream flanking DNA ; in HL 60 cells in which the c myc gene is expressed , two DNase 1 hypersensitive sites are observed in 2 kb of upstream DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analyses of DNA and RNA from avian leukosis virus ( ALV ) induced lymphomas have provided strong evidence that , in most tumours , ALV induces neoplastic disease by activating the c myc gene , the cellular counterpart of the transforming gene of MC 29 virus . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Bursal lymphomas of chickens infected with lymphoid leukosis viruses contain at least two distinct activated transforming genes : 1 ) a c myc gene activated by integration of viral DNA and 2 ) a cellular gene , not linked to viral DNA , which efficiently induces transformation of NIH 3T3 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have isolated chicken DNA ( c myc ) that is homologous to the oncogene ( 5 myc ) of the avian myelocytomatosis virus MC 29 and have compared the structures of the cellular and viral genes . ^^^ Results from restriction endonuclease mapping of c myc and from analysis of heteroduplexes between the DNAs of the cellular and viral genes show that c myc is homologous to 1 , 500 nucleotides in 5 myc DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Restriction mapping and DNA sequencing demonstrated that normal proviral integration events occurred adjacent to c myc in both tumors , without gross structural alteration of c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Orientation and position of avian leukosis virus DNA relative to the cellular oncogene c myc in B lymphoma tumors of highly susceptible 15I5 10 7 ( 2 ) chickens . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Several recombinant phages which represent different regions of the genome containing c myc related sequences were isolated from a human DNA library . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Restriction enzyme analysis of the MC 29 10H B 1 proviral DNA also showed that myc sequences had been acquired . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The oncogenic potential of the virus is mediated by the gene 5 myc , acquired from sequences ( c myc ) present in normal uninfected chicken DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hybridization to cloned DNA of the normal chicken locus c myc shows a close relationship between HBI 5 myc RNA and c myc DNA , especially in the sequences which were deleted from td10H MC 29 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The organization of the OK 10 genome was determined by electron microscopic analysis of heteroduplexes formed between the cloned OK 10 DNA and DNAs representing the c myc gene and the genomes of two other avian retroviruses , Rous associated virus 1 and MC 29 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blots of DNA from tumors that contained 2 . 4 kilobase or larger myc RNA showed myc hybridization to an EcoRI fragment of about 21 kilobase pairs , similar to the myc band in normal DNA . ^^^ EcoRI digests of DNA from two tumors that expressed myc RNA of 1 . 8 kilobases showed an additional smaller myc band , suggesting that the myc gene is rearranged in these plasmacytomas . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Recently , Colby et al . reported the nucleotide sequence of the human c myc DNA isolated from a genomic recombinant DNA library derived from human fetal liver . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Recombinant DNA clones have been used to directly demonstrate that the Burkitt lymphoma cell line Raji , t ( 8 ; 14 ) ( q 24 ; q 32 ) , has a rearranged copy of the c myc gene adjacent to the gamma 1 constant region gene of the human immunoglobulin heavy chain locus ; the genes are arranged in the opposite direction for transcription . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Characterization and location of myc homologous sequences in human cytomegalovirus DNA . ^^^ Specific DNA fragments from human cytomegalovirus ( HCMV ) strains Towne and AD 169 exhibited homology to myc DNA sequences under hybridization conditions corresponding to a 22 28 % base mismatch . ^^^ In Towne DNA , myc homologous sequences mapped in four regions within the long unique segment ( 0 . 070 0 . 094 , 0 . 134 0 . 156 , 0 . 454 0 . 470 , and 0 . 591 0 . 605 map unit ) and one region in each of the short terminal repeats ( 0 . 832 0 . 847 and 0 . 984 1 . 0 map unit ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Integration of retroviral DNA near or within c myc in avian lymphomas apparently enhances expression of the gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequences near the site of reciprocal recombination between a c myc oncogene and an immunoglobulin switch region . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Molecular analysis showed HBI proviral DNA in 36 of 39 tumors analyzed , with no obvious alteration of c myc , and the HBI gag myc fusion protein , p 108 , could be detected in tumor cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have shown that the human cellular oncogene c myc is composed of three exons and is transcribed from two initiation sites separated by 175 base pair DNA in HeLa cells . ^^^ In a non Hodgkin lymphoma , Manca , harboring a t ( 8 ; 14 ) translocation , c myc gene is broken within intron 1 , and its exons 2 and 3 are translocated to a site between the heavy chain joining region cluster and C mu coding DNA segment of the immunoglobulin heavy chain locus . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We used the 1 . 5 kilobase ( kb ) PstI fragment of MC 29 5 myc in Southern blot analysis to characterize the structure of the c myc locus in the DNA of 31 naturally occurring feline lymphomas . ^^^ Analysis of a cloned c myc gene from one lymphoma demonstrated that sequences homologous to 5 myc occupy 2 . 6 kb of feline DNA in which a putative intron of 0 . 5 kb separates sequences homologous to the 5 ' and 3 ' exons represented in avian 5 myc . ^^^ We also observed in the DNA of this lymphoma tumour specific fragments homologous to 5 myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In both cases c myc and its surrounding DNA appeared unaltered . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These disturbances could be explained by novel structural alterations that occur in the c myc gene and include a duplication of a 2 . 5 kb segment of DNA containing the two c myc promoters and their untranslated leader exons . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here we have determined the nucleotide sequence of 3 . 5 kb from the 3 ' end of delta gag to the 3 ' end of molecularly cloned proviral MH 2 DNA , in order to elucidate the genetic structure of the virus and to compare it with other mht and myc containing oncogenic viruses as well as with the chicken proto myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of cellular DNA from the primary and metastatic tumors demonstrated the clonal nature of these neoplasms and revealed altered c myc loci , as reported in other studies , suggesting the importance of this locus in the development of these tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Like the endogenous retrovirus genes , c myb and c myc loci of the cat genomic DNA were also transcribed at differential levels in normal tissues of the cat . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The Burkitt ' s rearrangement involved the insertion of new DNA sequences upstream from the c myc 5 ' coding region , presumably replacing the normal c myc transcriptional promoter . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Similar translocations are found in mouse plasmacytomas and both diseases involve interchanges between one of the immunoglobulin loci and DNA in the vicinity of the myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inhibition of DNA binding of purified p55v myc in vitro by antibodies against bacterially expressed myc protein and a synthetic peptide . ^^^ To identify viral myc proteins , we have prepared myc specific antibodies : ( 1 ) against a synthetic peptide corresponding to the nine carboxy terminal amino acids of the viral myc ( C 9 ) ; ( 2 ) against a bacterially expressed viral myc protein obtained by inserting the SalI BamHI fragment of the viral MC 29 DNA clone in the expression vector pPLc 24 . ^^^ Antibodies against the C 9 peptide were used to purify the p55v myc by immunoaffinity column purification ( 3000 fold ) from OK 10 and MH 2 transformed fibroblasts . p55v myc binds to double stranded DNA in vitro as does p110gag myc . ^^^ DNA binding in vitro is inhibited by the immunoglobulin fraction of antibodies against the bacterially expressed myc protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results suggest that myc proteins not only bind to DNA or chromatin , but are also associated with other structural systems in the nuclei . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here we identify a DNA rearrangement in a mouse hybridoma that has brought c myc close to C gamma 2b and show that this rearrangement occurred by reciprocal chromosome translocation , as recombinant clones were isolated from the same cell line in which a rearranged variable region ( VH ) gene has been brought close to 5 ' c myc sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Recent reports from several laboratories have demonstrated that in many BALB / c mouse myelomas , including MOPC 315 , the DNA segment encoding the c myc oncogene is translocated to a C alpha allele . ^^^ The mRNA coding strand of DNA for the c myc gene is on the opposite strand from the immunoglobulin gene in this locus . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Not only the plasmacytomas with chromosome translocations , but also the translocation negative plasmacytomas showed the either rearrangement or germline type of c myc DNA . ^^^ Concerning the c myc DNA , the germline type was 21 kb and the rearranged type of c myc DNA was estimated , mostly , to be 14 kb by EcoRI digestion . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Nuclear localization and DNA binding properties of a protein expressed by human c myc oncogene . ^^^ The p65Kc myc protein binds to double and single stranded DNA as measured by a DNA affinity chromatography assay . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequences involved in the rearrangement and expression of the murine c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In liver regeneration after partial hepatectomy or chemical injury , changes in c myc transcripts occur before DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We show here that the incoming DNA bears the cellular gene ( c myc ) homologous to the oncogene ( 5 myc ) of avian retrovirus MC 29 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hybridizations with normal chicken DNA and cloned chicken c myc DNA indicate that the mht sequence probably derives from a normal cellular gene that is distinct from the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Recently , it was demonstrated that , compared with several normal and leukaemia human cells , DNA sequences representing the human homologue of the onc gene of the avian myelocytomatosis virus ( MC 29 ) , the so called c myc gene , were amplified in HL 60 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Enhanced expression of the human gene N myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma . ^^^ Previous studies had revealed that DNA with partial similarity to the myc oncogene ( N myc ) is frequently amplified in human neuroblastoma cell lines and neuroblastoma tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Of 18 human lung cancer cell lines tested , 8 showed an amplified 12 . 5 kilobase ( kb ) EcoRI c myc DNA band . ^^^ Of particular interest are five SCLC lines with a high degree of c myc DNA amplification ( 20 76 fold ) and greatly increased levels of c myc RNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Recently , we isolated a DNA segment having limited similarity to c myc ( termed N myc ) from a human neuroblastoma cell line . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The nucleotide sequence of a HindIII EcoRI DNA fragment , 8 kbp long , of a lambda recombinant containing the whole human c myc gene has been deduced by the method of Maxam and Gilbert . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In two t ( 8 ; 14 ) human Burkitt cell lines , c myc appears to have been translocated directly into a DNA restriction fragment that also encodes the immunoglobulin mu chain gene . ^^^ In the case of a specific cloned fragment of DNA derived from a mouse plasmacytoma , we demonstrate directly that c myc has been translocated into the immunoglobulin alpha switch region . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA recombination was found to correlate with the production of a novel 2 . 1 kb species of myc RNA that was 0 . 4 kb shorter than the normal cellular transcript . ^^^ No elevated levels of myc RNA were evident , suggesting that DNA rearrangements have altered the myc oncogene product . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A 5 myc probe , containing sequences from the 3 ' domain of the gene , hybridized to single human HindIII and mouse EcoRI genomic DNA fragments of the cellular myc genes whose segregation could be followed in interspecies somatic cell hybrids . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour . ^^^ We show here that a DNA domain detectable by partial homology to the myc oncogene is amplified up to 140 fold in cell lines derived from different human neuroblastomas and in a neuroblastoma tumour , but not in other tumour cells showing cytological evidence for gene amplification . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
By using a DNA probe that is specific for the complete gene ( c myc ) , different somatic cell hybrids possessing varying numbers of human chromosomes were analyzed by the Southern blotting technique . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA diagnostic techniques are being introduced rapidly into the clinical laboratory setting . 1 ) In lung cancer , several oncogenes and tumor suppressor genes , such as ras , myc , p 53 , RB , allelic loss of chromosomes , play very important roles . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot analysis of tumor DNA from MMuLV infected transgenic mice revealed a proviral insertion at the c myc gene in 26 % ( 9 / 35 ) of tumors , at the pim 1 gene in 6 % ( 2 / 35 ) and at the pim 2 ( recently renamed tic 1 ) gene in 23 % ( 8 / 35 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Under in situ incubation conditions with explant tissues in culture , TCDD rapidly enhanced the DNA binding activity of the transcriptional factor AP 1 , whereas the same treatment reduced c Myc DNA binding activity . ^^^ Genistein , a specific protein tyrosine kinase inhibitor , abolished the stimulatory effect of TCDD on AP 1 binding activity , but not on DNA binding activity of c Myc . ^^^ These observations are consistent with the idea that TCDD regulates the DNA binding activity of AP 1 and c Myc mainly through modulating their states of phosphorylation by altering protein kinase and phosphatase activities . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Following treatment of MCF 7 breast tumour cells with 2 10 Gy gamma rays , strand breakage and rejoining were measured in bulk DNA , in the centromeric alpha satellite region of chromosome 17 , and in the chromatin regions containing the unexpressed beta globin gene and the expressed c myc oncogene , which is known to be important for growth in the MCF 7 cell line . ^^^ Damage in both the c myc and beta globin regions was markedly greater than in either alpha satellite or bulk DNA . ^^^ However , the kinetics of strand break repair were approximately the same in c myc as in alpha satellite or bulk DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The oncoprotein c Myc must heterodimerize with Max to bind DNA and perform its oncogenic activity . ^^^ The c Myc Max heterodimer binds DNA through a basic helix loop helix leucine zipper ( b HLH zip ) motif and it is proposed that leucine zipper domains could , in concert with the HLH regions , provide the specificity and stability of the b HLH zip motif . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using a 1 . 4 kb cDNA probe coding for the third exon of the MYC oncogene , DNA slot blots indicated MYC gene sequences were amplified in both samples . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To elucidate the prevalence and biologic significance of the c myc gene in human hepatocellular carcinoma ( HCC ) , DNA samples were taken from the paired tumorous and nontumorous tissues of 77 cases of resected primary HCC and were analyzed by Southern blot hybridization . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The transcriptional level of c myc , c jun and XRCC 1 genes after 10 irradiation was compared in human cells originating from subjects presumably with different DNA repair abilities . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Baculovirus constructs containing either the DNA encoding the dopamine D 1 receptor or a DNA encoding a c myc epitope tagged dopamine D 1 receptor ( c myc dopamine D 1 receptor ) were used to infect Spodoptera frugiperda ( Sf 9 ) insect cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Downregulation of oncogenes H ras , c raf 2 , c kit , whose proteins are associated with cell surfaces or are cytosolar transducers , occurs before those oncogenes c myc , c myb , and c fos , whose products are DNA binding proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The size distribution of cloned c myc DNAs was estimated by Southern blot analysis of phage DNA prepared from the amplified library and by analysis of isolated clones . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The upstream stimulatory factor ( USF ) is a helix loop helix transcription factor that interacts with specific sites on the DNA that are also recognized by the MYC oncoproteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA repair in the MYC and FMS proto oncogenes in ultraviolet light irradiated human HL 60 promyelocytic cells during differentiation . ^^^ In order to better understand the role of transcription in cellular processing of damage in specific DNA sequences , we have used an in vitro differentiation system to modulate the activity of the MYC gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When high salt extracted nuclei were digested with EcoRI , which is known to produce fragments containing the entire c myc locus , the sequences of the gene were found separated between the pellet , containing sequences firmly associated with the heavier matrix structures , and the supernatant , containing sequences from the free length of the DNA loops . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Lymphomas were also evaluated for the presence of Epstein Barr virus ( EBV ) DNA sequences and c myc gene rearrangements . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
PCR amplified products of cDNA from oocyte , two cell , four cell , early and late morula , and blastocyst stage embryos demonstrated the expected 313 bp product in Southern blot hybridization using a c myc specific DNA probe , with an indication of lower levels in oocytes and early morulae . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We measured DNA , RNA , and protein content , number of nuclei per tubular section , as well as c fos , c jun , c myc , c H ras , c sis , and c erb B 2 protooncogene expression in kidneys taken at time of surgery and 2 , 7 , and 14 days after sham operation ( control rats ) , Uni , or Nx . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA analysis using the CD1A c myc probe did not reveal rearrangements of the c myc gene by Southern blotting . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Correlation between malignancy of gastric cancer and c myc DNA amplification or overexpression of c myc protein ] . ^^^ The amplification of c myc DNA for fresh frozen tissue of 31 gastric adenocarcinomas was examined with dot blot hybridization method . ^^^ Using the avidin biotin peroxidase complex method , the expression of c myc protein was examined immunohistochemically for formalin fixed paraffin embedded tissue of 51 gastric adenocarcinomas including the same cases for c myc DNA analysis . c myc DNA amplification was detected in only 4 cases ( 12 . 9 % ) . ^^^ Only one of 4 cases showing c myc DNA amplification indicated overexpression of c myc protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mad : Max heterodimers recognize the same DNA binding sites as Myc : Max heterodimers . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Dietary protein restriction inhibits growth hormone induced DNA synthesis without impairing c myc and c Ha ras expression in the liver of hypophysectomized rats . ^^^ To test this hypothesis , we studied the effects of dietary protein restriction on DNA synthesis and c myc and c Ha ras proto oncogene mRNA responses to growth hormone in the liver of hypophysectomized rats . ^^^ In rats fed a normal protein diet ( 15 % protein ) , growth hormone injection induced a sequential activation of c myc expression ( 13 times the baseline value , after 1 h ) and c Ha ras expression ( two times the baseline value , after 6 h ) , which was followed by a stimulation of liver DNA synthesis ( 9 times the baseline value , after 24 and 36 h ) . ^^^ These results show that dietary protein restriction inhibits growth hormone induced DNA synthesis without impairing c myc and c Ha ras activation in the liver of hypophysectomized rats . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have used density shift analysis to monitor the autonomous replicating sequence ( ARS ) activity of plasmids containing various DNA fragments from the 5 ' flanking region of the human c myc gene . ^^^ The ARS activity of certain of these plasmids implied that structures in the c myc DNA could be recognized for the initiation of replication in the absence of chromosomal integration . ^^^ Myc 2 . 4 contains 2 . 4 contains 2 . 4 kb of c myc 5 ' flanking DNA , and replicated semiconservatively as a circular extrachromosomal element . ^^^ Myc 2 . 4 containing either of two nonoverlapping regions of c myc DNA semiconservatively incorporated bromodeoxyuridine into discrete populations of heavy light supercoiled molecules to roughly the same extent as the chromosomal DNA in the same cultures . ^^^ Some constructs displayed lower ARS activity , implying that distinct cis acting sequences in the c myc 5 ' flanking DNA may independently affect DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The long range distribution of DNA cleavage sites in the amplified c myc gene locus was then analyzed by pulsed field gel electrophoretic separation of the released 50 kilobase to 1 megabase DNA fragments followed by indirect end labeling . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA binding , transcriptional activation and transforming activities of the Myc protein require dimerization with Max . ^^^ Max can form also homodimers which are able to bind the same DNA sequence as Myc / Max heterodimers and suppress Myc induced transcription and transformation . ^^^ Surprisingly , delta Max does not require the DNA binding basic region for enhancement of transformation and has no effect on Myc induced transcription activation from Myc / Max binding site containing promoter construct . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Native Mad / Max heterodimers bound specifically to a c Myc / Max consensus DNA binding site . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Linoleic acid induces DNA synthesis , c fos , c jun , and c myc mRNA expression and MAPK activation in VSMC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The level of bcl 2 oncogene was similar in both cell lines ; however , treatment with VP 16 resulted in a time and dose dependent degradation of the genomic DNA into oligo sized DNA only in the sensitive cells , indicating that differential expressions of oncogenes ( c myc , c jun , and c fos ) and susceptibility to apoptosis may play important roles in the sensitivity and resistance to VP 16 in HL 60 cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , only p 64 c Myc is present in Xenopus somatic cells . p 61 c Myc is the direct translation product from both endogenous c myc mRNAs and c myc recombinant DNA . ^^^ During early development , when the entire embryonic genome is transcriptionally inactive , c Myc does not exhibit a DNA binding activity with Max . ^^^ These peculiar aspects of c Myc behavior suggest a function that could be linked to the rapid DNA replication cycles occurring during the early cell cycles rather than a function involving transcriptional activity . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We tested this hypothesis in 100 consecutive ovarian carcinomas by molecular biology techniques at the DNA and protein levels in three genes ( erbB 2 , myc , ras ) , which are frequently altered in this tumor system . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Crucial role of c myc in 1 , 25 ( OH ) 2D3 control of C cell carcinoma proliferation . 1 , 25 ( OH ) 2D3 ( 1 , 25D3 ) enhances DNA synthesis and cell proliferation in the human C cell carcinoma cell line ( TT ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Their gene products encode proteins involved in the regulation of cell growth ( proto oncogenes c myc and c fos ) , a gene inducible by growth arrest and DNA damage ( GADD 153 ) , the cytokine interleukin ( IL ) 1 alpha and beta and finally a differentiation associated small proline rich gene ( SPR 2 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A truncated protein ( p53dl214 ) , containing only the first 214 amino terminal residues of murine p 53 , induced extensive apoptosis , albeit at a slower rate than trans activation competent wild type p 53 . p53dl214 also suppressed the transformation of rat fibroblasts by several oncogene combinations and particularly by myc plus ras and HPV E 7 plus ras . p53dl214 lacks a major portion of the DNA binding domain and can not activate p 53 responsive promoters . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The enzyme catalyses phosphoryl transfer , binds DNA , and can activate the transcription of the c myc oncogene in vitro . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hela cell extract overphosphorylated with endogenous protein kinases was used for in vitro transcription of human c myc DNA . ^^^ Three phosphoproteins of 70 , 35 and 23 kDa are found , whose binding to DNA correlates with activation of c myc transcription . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The data reported here support the conclusion that Py DNA integrated into and next to the c myc gene , adding further importance to this tumor system which , in its modifications of c myc expression , appears to be similar to some human mammary cancers . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transient transfection assays with a construct containing six NF kappa B binding DNA consensus sites linked to a luciferase reporter gene indicated that asbestos induced transcriptional activation of NF kappa B dependent genes , an observation that was confirmed by northern blot analyses for c myc mRNA levels in HTE cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The administration of an excess of choline was able to modulate the protein kinase C isozyme pattern in females in relation to DNA synthesis and c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using double label fluorescence in situ hybridization with DNA probes unique to each amplicon type , we have observed that both chromosomal and extrachromosomal MYC amplicon arrays in COLO 320 cells frequently consist of heterogeneous mixtures of each MYC amplicon type . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Molecular events induced by 5 aza 2 ' deoxycytidine included a decrease in DNA methylation , along with a dramatic , permanent reduction in the levels of c myc transcripts ; both these events were detectable early ( 24 to 48 hours ) after the start of drug administration . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
On a chemically synthesized 36 mer DNA template , a part of upstream region of human c myc gene , the primer synthesis started from a doublet of deoxythymidine ( TT ) in the deoxypyrimidine rich sequence . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
While the c myc oncogene in all cell lines was overexpressed when compared with the Burkitt ' s lymphoma Raji Cell line , the c myc DNA sequence in each cell line showed neither amplification nor rearrangement . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Probes identified clonally rearranged DNA fragments in the J region of IgH chains and clonal rearrangements in the c myc gene were also observed but EBV sequences could not be demonstrated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In an attempt to clarify this issue , sequences flanking the c myc gene were screened for c Myc or Max binding sites using a novel procedure to facilitate the detection of DNA binding dependent upon long distance interactions or DNA secondary structure . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transcription of the c myc proto oncogene and thymidine incorporation into DNA were both used to assay the mitogenic effects of estradiol and progesterone on the testicular germinal epithelium of the starfish Asterias vulgaris . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Stepwise progression in malignancy can be disclosed not only by cytological and histological examination but also by proliferative activity of the tumor , such as mitotic activity , the percentage of DNA synthesizing cells and the frequency of proliferating cell nuclear antigen positive cells , the mean nuclear DNA content of tumor cells and occurrence of aneuploid cell lines , and abnormalities of oncogenes ( c Ki ras , myc family , and c erbB 2 ) , such as point mutation , rearrangement , amplification , and tumor suppressor genes ( point mutation and deletion ) such as p53 . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Targeted melting and binding of a DNA regulatory element by a transactivator of c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Binding of AP 2 to Myc does not preclude association of Myc with Max , but impairs DNA binding of the Myc / Max complex and inhibits transactivation by Myc even in the absence of an overlapping AP 2 binding site . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA repair in the endogenous and episomal amplified c myc oncogene loci in human tumor cells . ^^^ We have studied the repair of u . v . induced cyclobutane pyrimidine dimers ( CPDs ) in amplified c myc oncogene loci in human colon cancer cells to better understand the relationship between chromatin structure , transcription and DNA repair . ^^^ To assess the variation in DNA repair in the same gene whether located in a chromosomal site or in a extra chromosomal site , we have quantitated the efficiency of excision repair after u . v . exposure in the endogenous and episomal c myc genes isolated from COLO320HSR and DM cells . ^^^ We have studied the relationship between DNA repair and transcriptional activity in the c myc locus by measuring the efficiency of excision repair after u . v . exposure in the normal and rearranged alleles of the c myc gene . ^^^ However , u . v . damage is selectively removed from the transcribed strand of the active c myc allele , but DNA repair is not strand specific in the non expressed c myc allele . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Moderate folate deficiency does not cause global hypomethylation of hepatic and colonic DNA or c myc specific hypomethylation of colonic DNA in rats . ^^^ Furthermore , c myc protooncogene specific DNA methylation in the colonic mucosa was not significantly different between these two groups of animals . ^^^ These results indicate that moderate folate depletion does not cause a significant reduction in global DNA methylation in liver or colonic mucosa or in c myc specific colonic mucosal DNA methylation in this rat model . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We investigated the effect of recombinant platelet derived growth factor ( PDGF ) isomers on low density lipoprotein ( LDL ) receptor gene expression and compared this with two indexes of cell growth response : expression of the immediate early gene c myc and the rate of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Based on these findings , we investigated the expression of HPV DNA ( 16 and 18 ) as well as nuclear proto oncogenes ( c fos , c jun and c myc ) in nine cervical cancers by in situ hybridisation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Whereas little evidence to any functional significance of the CKII sites in c Myc has been obtained , phosphorylation of its heterodimeric partner Max alters DNA binding properties . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We found that constitutive c myc expression in cells incubated at low density in medium containing 0 . 1 % serum correlates with increased cell death due to apoptosis , as indicated by oligonucleosomal DNA fragmentation and a requirement for ongoing protein synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The expression of the cell cycle related genes ' products c myc , p 53 , and c erbB 2 proteins which increase during the prereplicative phase that precedes DNA synthesis was affected by interferon administration , being in accordance with liver proliferative status . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The predicted amino acid sequence of the SGC 1 gene product includes a region with substantial similarity to the basic helix loop helix domain of the Myc family of DNA binding proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA synthesis was stimulated in cells incubated in the presence of Lp ( a ) as were the mRNA levels for c fos and c myc , two `` early genes ' ' that serve as transcription factors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Over expression of ZF 5 did not cause c myc down regulation or arrest of the cell cycle , but increased the DNA content . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In cells that are already permissive , amplification can be stimulated by overexpressing oncogenes such as c myc or ras , or by damaging DNA in a variety of ways . ^^^ Loss of these pathways by , for example , loss of p 53 or pRb tumour suppressor function , or by increased expression of ras and myc oncogenes , causes non permissive rat and human cells to become permissive both for amplification and for other manifestations of DNA damage . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
They differ in dimerization and functional properties such as DNA binding and transcriptional activation , and their association is required for malignant transformation by Myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Differential transcriptional regulation of c myc promoter through the same DNA binding sites targeted by Sp 1 like proteins . ^^^ To begin to delineate the specific roles of these two members of the Sp 1 like gene family , here we have analysed the DNA binding specificity and their effects on activation of human c myc promoter . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Exposure of VSMCs to rHuEpo for various times gradually increased the levels of c myc and junB and transiently induced c fos expression , as determined by Northern analysis . rHuEpo induced DNA synthesis was markedly enhanced in VSMCs from SHR compared to those from WKY . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Ligation of the venous drainage of the salivary gland results in the same inhibitory effect on DNA synthesis , indicating 1 ) that the salivary gland must release circulating factor ( s ) , and 2 ) that the early increase in c myc expression and the subsequent DNA synthesis , both of which reflect the stimulation of cellular proliferation in the regenerating liver , are induced by humoral factor ( s ) released from the salivary glands . ^^^ Injection of exogenous epidermal growth factor ( EGF ) in salivectomized rats results in restoration of both the DNA synthetic and c myc responses at levels characteristic of those of liver regeneration . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When T cells and fibroblasts were stimulated to transit from G 0 into the cell cycle , there was a dramatic rise of both FBP mRNA and DNA sequence specific nuclear FBP binding activity , which correlated with the appearance of c myc mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc oncogene c Myc is commonly activated in cancer and transactivates gene expression by binding to CACGTG DNA sequences as a heterodimeric complex with Max . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Heterodimerization of Max with the nuclear oncoprotein Myc and the differentiation associated proteins Mad and Mxi 1 enables these factors to bind E box sites in DNA and control genes implicated in cell proliferation and differentiation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A mammalian DNA fragment containing a replication initiation zone upstream of the c myc gene as well as the yeast ARS fragment acted as a cis element in this system using DNA helicase B . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In vitro replication of plasmids containing human c myc DNA . ^^^ A chromosomal replication initiation zone was previously mapped in cell cultures to the 5 ' flanking DNA of the human c myc gene . ^^^ Myc 2 . 4 replication time course showed a clear preference for initiation within a restriction fragment containing the c myc DNA . ^^^ These data show that bidirectional , semiconservative replication can originate preferentially in vitro in the 5 ' flanking DNA of the c myc gene , and that replicative intermediates present at low levels can be distinguished from molecules generated by competing , repair type processes . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
However , the IL 3 treatment coincided with an upregulation of DNA topoisomerase 2 alpha ( Topo 2 alpha ) at mRNA and protein level after 24 h , which was preceded by an upregulation of c myc mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We developed transgenic rabbits with a DNA construct containing the proto oncogene c myc conjugated to the Ig kappa chain enhancer gene , E kappa . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In turn , mad max or mxi 1 max heterodimers or max homodimers can compete for DNA binding sites with dimers formed between max and myc oncoproteins and antagonize the transcriptional activities of this latter class of proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA ploidy and clonal selection in ras + myc induced mouse prostate cancer . ^^^ In this study we examined the temporal relationships between morphological alterations , growth , DNA ploidy status and clonal selection as determined by Southern blotting in ras + myc initiated carcinomas . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
C myc , c Ha ras and N ras DNA probes labeled with biotin were used . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , NMDA virtually did not alter DNA binding activities of both CREB and Myc in discrete structures of murine brain under similar experimental conditions . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Then total RNA was prepared for dot blot with 32P nick translated c myc DNA probe . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inhibition by genistein of a subset of IL 3 / GM CSF mediated signals , including c myc induction , resulted in the abrogation of DNA synthesis , however , IL 3 still protected cells from apoptotic cell death . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Molecular cloning of MSSP 2 , a c myc gene single strand binding protein : characterization of binding specificity and DNA replication activity . ^^^ MSSP 1 binds to a DNA replication origin / transcriptional enhancer of the human c myc gene and has turned out to be identical with Scr 2 , a human protein which complements the defect of cdc 2 kinase in S . pombe [ Kataoka and Nojima ( 1994 ) Nucleic Acid Res . , 22 , 2687 2693 ] . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc induced apoptosis is dependent upon the level at which it is expressed and deletion mapping shows that regions of c Myc required for apoptosis overlap with regions necessary for co transformation , autoregulation , inhibition of differentiation , transcriptional activation and sequence specific DNA binding . ^^^ Myc induced apoptosis is dependent upon the level at which it is expressed and deletion mapping shows that regions of c Myc required for apoptosis overlap with regions necessary for co transformation , autoregulation , inhibition of differentiation , transcriptional activation and sequence specific DNA binding . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Incubation of neonatal rat lenses in epidermal growth factor plus insulin , which stimulated endogenous 12 HETE production 8 to 10 fold , also produced a transient induction of c fos and c myc mRNAs after 2 to 3 h , followed by a round of DNA synthesis approximately 20 h later . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Bovine papillomavirus type 1 ( BPV 1 ) transformed mouse fibroblast cell lines were analyzed via flow cytometry ( FCM ) for expression of p 53 and c myc proteins along with their DNA content . ^^^ Quantitation of p 53 and c myc proteins in cell lines containing BPV 1 DNA revealed that the tumorigenic cell lines expressed higher levels of both the p 53 ( P = 0 . 0034 ; Mann Whitney U test ) and the c myc protein ( P = 0 . 0039 ; Mann Whitney U test ) as compared to the nontumorigenic cell lines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MAP kinases might link the G 0 to G 1 transition with the regulation of the cell cycle whereas phosphorylation of replication protein factors , c Myc , AP 1 , Oct 1 , T antigen , retinoblastoma , and p 53 might link the G 1 to S transition with the control of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Tumor initiating activity was assayed by measuring the induction of unscheduled DNA synthesis ( UDS ) and DNA single strand scission ; tumor promoting activity was assayed by measuring the induction of ornithine decarboxylase ( ODC ) activity , increased replicative DNA synthesis ( RDS ) , and of c fos and c myc oncogene expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Glutamine was required for EGF stimulation of DNA , RNA , and protein synthesis and cell replication ; however , EGF stimulated expression of zif 268 , jun B , and c myc occurred in the absence of glutamine . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
However , we found that increasing the rate of induction of apoptosis in the fibroblast line 208F , by transfecting it with human c myc , did not lead to a change in its clonogenic survival dose response for either gamma irradiation or 125I induced DNA damage . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc promoter binding protein ( MBP 1 ) is a DNA binding protein which negatively regulates the expression of the human c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Although image analysis did not show a difference in p 53 and c myc gene expression , the appearance of chromatin aggregation and DNA fragmentation points to apoptosis or programmed cell death . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , no hybridization signal was detected with a DNA probe specific for the c myc protooncogene , which is amplified and transcriptionally active in COLO 320DM cells but lacks CAG tandem repeats . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , the ischemic injury similarly tripled DNA binding activities of CREB without markedly affecting those of Myc in hippocampal CA 1 and CA 3 subfields . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Since defective DNA repair provides a mechanistic explanation for genomic instability , we measured the efficiency of repair in IgH alpha and c myc using an assay that quantitates the removal of UV induced pyrimidine dimers within specific genomic regions . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Triplex forming oligonucleotides ( TFOs ) have been shown to bind to target DNA sequences in several human gene promoters such as the c myc oncogene , the epidermal growth factor receptor , and the dihydrofolate reductase genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Assay for dominant oncogenes via DNA mediated gene transfer into NIH3T3 cells was positive for nine of 13 REC : myc : alpha transformants . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To determine the frequency and clinicopathologic correlates of chromosome 11q13 amplification in breast carcinoma , DNA from 50 invasive tumors was analyzed by Southern blot hybridization using probes for the 11q13 loci bcl 1 , PRAD 1 , hst 1 , EMS 1 , and GST pi , as well as oncogenes c erbB 2 and c myc . ^^^ Amplification of 11q13 was unassociated with patient age , tumor size , axillary lymph node status , hormone receptors , DNA content , histologic grade , mitotic rate , nuclear pleomorphism , or tubule formation . c myc amplification correlated with the lack of tubule formation ( p = 0 . 04 ) , whereas c erbB 2 amplification correlated with axillary lymph node positivity ( p = 0 . 04 ) , high histologic grade ( p = 0 . 003 ) , increased nuclear pleomorphism ( p = 0 . 008 ) , and a high mitotic rate ( p = 0 . 02 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We examined HPV DNA typing and its gene expression , oncogenes ( c myc , EGF R , c erb B 2 ) and p 53 in cervical dysplasia and cancer with molecular biologic , immunohistochemical technique and binding assay to establish a gene diagnosis of uterine cervical cancer . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Furthermore , an overall similarity was seen in the hypomethylation patterns in the c myc and c Ha ras genes in the DNA of nodules initiated with either 1 , 2 DMH or AA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Messenger RNA 3 ' end formation of a DNA fragment from the human c myc 3 ' end region in Saccharomyces cerevisiae . ^^^ A DNA fragment containing the two AATAAA polyadenylation signals of the c myc gene was inserted into a plasmid designed for the in vivo testing of polyadenylation signals in yeast . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA copy number abnormalities detected in this study include previously identified increases at 1p22 32 ( L myc ) , 2p24 25 ( N myc ) , and 8q24 ( c myc ) and decreases at 17p13 ( p 53 ) , 13q14 ( RB ) , and 3p . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Burkitt ' s lymphoma cells , exhibiting a c myc translocation that can be distinguished from the native allele by Southern blotting , provide a useful model system in which to explore regulatory elements that govern DNA repair in transcriptionally active genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transfection studies of the 5 ' up stream flanking region ( UFR ) of c myc / chloramphenicol acetyltransferase chimera genes suggest the presence of a TGF beta 1 responsive DNA element in the 2 . 3 kilobase c myc 5 ' UFR . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The relationship between c myc oncogene amplification in neoplastic cells as determined by means of Southern blot analysis , and their nuclear DNA content as assessed by combined flow and image cytometry , was investigated in fresh tumor specimens from 33 patients with musculoskeletal neoplasms . ^^^ Among the 10 cases with c myc amplification , 2 were found to be cytometrically DNA diploid , 2 DNA tetraploid , and 6 DNA aneuploid . ^^^ Conversely , there were 10 tumors displaying extremely aneuploid DNA patterns without c myc oncogene amplification . ^^^ Thus , there was no relationship between c myc amplification and DNA ploidy ; neither did the percentage of S phase cells , as determined by means of image cytometry , correlate significantly with the occurrence of c myc amplification . ^^^ When the clinical follow up data of the patients were scrutinized , it was found that the DNA ploidy pattern of the neoplastic cell nuclei , in combination with the S phase values , as well as the occurrence of c myc amplification , yielded prognostic information , being statistically significant 2 years after the diagnosis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inhibition of DNA synthesis was detectable within 6 h of treatment and was preceded by down regulation of c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Specific mRNA was detected using cDNA probes encoding the proto oncogenes c fos and c myc and the growth arrest and DNA damage ( GADD 153 ) gene , all recently shown by our laboratory to be modulated by UV in newborn keratinocytes ; interleukin ( IL ) 1a , IL 1b , and the IL 1 receptor antagonist ( IL 1ra ) , two keratinocyte cytokines and their competitive inhibitor , implicated in the immunomodulatory effect of UV ; and SPR 2 , a recently cloned gene known to be induced during normal keratinocyte differentiation and by lethal UV C irradiation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When negatively supercoiled DNA containing an initiation zone ( 2 kb ) upstream of the human c myc gene was incubated with simian virus 40 T antigen as a DNA helicase , HSSB ( also called replication protein A ) , and DNA polymerase alpha primase complex isolated from HeLa cells , DNA replication was specifically initiated from the center of the initiation zone , which was elongated bidirectionally in the presence of a DNA swivelase . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Dominant negative CREB and Myc proteins that bind DNA , but do not transactivate , block 5 src induction of a luciferase reporter driven by the first 80 nucleotides of the TIS10 / PGS2 promoter . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Role of c myc in simian virus 40 large tumor antigen induced DNA synthesis in quiescent 3T3 L 1 mouse fibroblasts . ^^^ Stably transfected NIH 3T3 L 1 mouse fibroblasts ( L 1 cells ) expressing the simian virus 40 large tumor antigen ( LTAg ) maintain c myc expression and proliferation in low serum , whereas cells expressing the mutant form LTAg K 1 , defective in binding of the retinoblastoma suppressor gene product pRb , showed reduced levels of c myc RNA and only background levels of DNA synthesis in low serum . ^^^ The role of the c Myc protein in LTAg induced DNA synthesis was studied in microinjection experiments . ^^^ Coexpression of dominant negative c Myc or Max mutants with LTAg inhibited DNA synthesis , indicating that functional c Myc is necessary for induction of DNA synthesis by LTAg . ^^^ Coexpression of c Myc with LTAg K 1 restored induction of DNA synthesis without apoptosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of differentiation and growth arrest associated with nascent ( nonoligosomal ) DNA fragmentation and reduced c myc expression in MCF 7 human breast tumor cells after continuous exposure to a sublethal concentration of doxorubicin . ^^^ Doxorubicin also produced a sustained decline in c myc mRNA levels that paralleled both growth arrest and induction of DNA fragmentation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc contains a transcriptional activation domain and a basic helix loop helix leucine zipper DNA binding and dimerization domain . ^^^ As a heterodimer with a structurally related protein , Max , Myc can bind DNA in a sequence specific manner . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , DNA from the other 11 sets of nude mice tumours indicated absence of c myc , N myc , L myc , H ras , K ras , N ras and EGF R genes on Southern analysis . ^^^ The secondary transformants contained discrete human Alu sequences ; however , the DNA did not hybridise with myc / ras / EGF R probes . ^^^ The lack of association of the nude mice tumour DNA with myc / ras / EGF R showing aberrations in the primary human tumour , implies activation of an alternative potent transforming gene ( s ) in the chewing tobacco related oral carcinomas in India . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mithramycin is a commercially available G C specific DNA binding drug that selectively inhibits transcription of genes , such as c myc , that have G C rich promoter sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The floating cells exhibited ultrastructural features of dying or apoptotic cells , including chromatin condensation , cytoplasmic and nuclear vesicularization , and DNA degradation with evidence of internucleosomal DNA `` laddering . ' ' Despite inhibition of cell proliferation , steady state c myc mRNA levels were 3 . 6 + / 0 . 6 fold higher in cells exposed to TGF beta 1 compared to those in control cells ( P < 0 . 001 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast to its well established antiproliferative action in other cell systems , addition of 1 , 25D3 to TT cells led to a 2 . 3 fold stimulation of DNA synthesis , which was maximal after 48 h and was preceded by a 4 . 8 fold increase in c myc gene expression . c Myc antisense DNA oligomers abolished the proliferative effect of 1 , 25D3 , but not the latter ' s inhibition of CT gene expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A DNA fragment containing all four HSs ( HS 1234 ) synergistically activates c myc transcription in plasmacytoma and Burkitt ' s lymphoma cells in transient assays and induces high level transcription , a promoter shift from P 2 to P 1 , and an increase in readthrough transcription in stable transfections . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The alternatively initiated c Myc proteins differentially regulate transcription through a noncanonical DNA binding site . ^^^ We have now found that the c Myc proteins regulate transcription through another , noncanonical , DNA sequence . ^^^ The Myc proteins , as heterodimers with Max protein , have been shown to function as activators of transcription through an E box DNA binding element , CACGTG . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA triplexes and regulation of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Tumours and peripheral lymphocyte DNA from 21 localized early stage prostatic carcinomas were analysed by Southern blot electrophoresis for amplification of the c myc and c erbB2 / neu genes and the 11q13 region ( int2 / FGF3 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We investigated the effects of Bryo and TPA on DNA synthesis , proliferation , viability and c myc protooncogene expression of the human carcinoma cell lines COLO 320 , MEL HO , and KB 3 1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A tumor cell line , BLC 3 , established from calf C 924 in nude mice was examined for immunophenotype , DNA rearrangement of immunoglobulin ( Ig ) genes and expression of cellular oncogenes c abl , c myc and c myb . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The effects of TNP 470 on DNA synthesis and the expression of c myc and cyclin D 1 mRNAs were investigated in human umbilical vein endothelial ( HUVE ) cells synchronized by serum depletion and stimulated with bFGF and serum . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Furthermore , BAF 3 cells with disregulated c Myc expression were more sensitive to the induction of apoptosis by DNA damaging agents . ^^^ Disregulation of Myc expression in murine bone marrow cells results in an inability to proliferate in sub optimal growth factor and an increased sensitivity to DNA damage . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Heat treatment induces c Myc overexpression and thus apoptosis as determined by internucleosomal DNA fragmentation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Similarity between the antisense nucleotide sequence of the first c myc intron and the SV 40 DNA fragment containing the binding sites for transcriptions factors GT 1 , GT 2 , TC 1 , and TC 2 has been revealed by computer analysis . ^^^ It has been established that the DNA fragment of the first c myc intron is able to form complexes with proteins from the HeLa cell extract . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Fluorescent staining with propidium iodide ( a DNA marker ) demonstrated chromatin condensation and agarose gel electrophoresis demonstrated a DNA `` ladder . ' ' These data suggest that apoptosis may play a role in hypoxic cell death and that in this paradigm , expression of c myc is unnecessary . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The detection , on serial frozen sections , of proteins and DNA of c myc and c Ha ras , showed a possible amplification of the c myc and c Ha ras genes in various benign and malignant lesions . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The repair of gamma ray induced DNA single strand breaks ( SSB ) in transcribed ( Alu enriched DNA , proto oncogene c myc ) and non transcribed ( human satellite 3 ) DNA of HeLa cells has been investigated . ^^^ The induction of DNA SSB after irradiation ( 100 Gy ) in Alu enriched DNA and c myc gene was shown to be 1 . 3 1 . 4 time more often while than in satellite DNA , and 1 . 4 time lower compared to that in total DNA . ^^^ For this time 60 67 , 50 66 , 35 50 and 45 50 % DNA SSB were eliminated from transcribed DNA ( c myc , Alu ) , non transcribed DNA ( satellite 3 ) and total DNA , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Tumour DNA samples of 20 patients with colorectal carcinoma were tested for c myc amplification , using a quantitative dot blot hybridization . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of topoisomerase 2 mediated DNA cleavage in the human c myc origin by the two drugs was similar , reaching a maximum at 0 . 5 microM . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We also found that apoptotic mouse 3T3 fibroblasts express c fos , c myc , c jun , and cdc 2 , as well as the upregulation of RB phosphorylation and BrdU incorporation , just before final DNA fragmentation and death . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The characteristic DNA fragmentation into a nucleosomal ladder and induction of expression of specific apoptosis related genes , such as TRPM 2 / SGP 2 , and TGF beta 1 , but not the growth related genes , c myc , c fos , and p 53 , temporally correlated with activation of apoptotic cell death in both systems . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Partial sequence analysis of this clone reveals that a portion of the DNA lost in the rearrangement shows a high degree of homology to a member of the myc family of oncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The specificity of drug induced topoisomerase 2 pattern of cleavage , one of the cellular determinants of cytotoxicity , was investigated in human c myc DNA . ^^^ Sequencing of drug induced topoisomerase 2 cleavages in c myc DNA showed a common cleavage pattern for anthrapyrazoles and mitoxantrone . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Base preferences for DNA binding by the bHLH Zip protein USF : effects of MgCl 2 on specificity and comparison with binding of Myc family members . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Down regulation of c myc gene expression with induction of high molecular weight DNA fragments by fluorodeoxyuridine . 5 Fluoro 2 ' deoxyuridine ( FdUrd ) , a potent inhibitor of thymidylate synthase , induces extensive bulk DNA damage at drug concentrations that produce significant in vitro growth inhibition of human ileocecal carcinoma ( HCT 8 ) cells . ^^^ Constant and pulsed field gel electrophoresis ( CFGE and PFGE ) , to detect size distribution of DNA double strand breaks and repair kinetics , in parallel with northern and western blot analyses , to quantitate c myc gene and protein expression , were utilized to analyze drug effects . ^^^ At 24 hr post in vitro drug treatment , when maximum bulk DNA damage was detected , FdUrd produced a broad range of high molecular weight DNA fragments , clustering between 0 . 1 and 5 . 7 megabases in size , and resulted in a decrease in the level of c myc transcripts and protein with no significant effect on the level of 5 myc and H ras . ^^^ Addition of the reduced folate leucovorin potentiated the effects induced by FdUrd , indicating that thymidylate synthase inhibition is an important initial step in drug effect followed by DNA fragmentation and suppression of c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This regulation of expression may be caused by hypermethylation of c myc DNA sequences , which we find to follow a similar pattern . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Elevated glucose concentrations inhibit DNA synthesis and expression of c myc in cultured hepatocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Activation of c myc expression by c Abl is independent of both the DNA binding function of c Abl and the c myc EP site . ^^^ We have shown by transient transfection assays that c Abl increases expression of a c myc promoter construct although to a lesser extent than 5 Abl . c Abl has been reported to bind to a specific DNA sequence , the EP element , in the hepatitis B virus enhancer . ^^^ Next , we demonstrated that the DNA binding domain of c Abl was not required for the transcriptional activation of c myc . ^^^ We conclude that c Abl activates c myc transcription indirectly with no requirement for DNA binding by c Abl . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Adhesion of hepatocytes to the EHS gel for the same period of time dramatically alters this program : it arrests growth and inhibits AP 1 DNA binding activity and the expression of c jun , junB , and c myc mRNAs , but , in addition , it restores C / EBP alpha mRNA and protein as well as C / EBP alpha and C / EBP beta DNA binding activities to the abundant levels present in freshly isolated hepatocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A general and sensitive method for the mapping of initiation sites of DNA replication in vivo , developed by Vassilev and Johnson , has revealed replication origins in the region of simian virus 40 ori , in the regions upstream from the human c myc gene and downstream from the Chinese hamster dihydrofolate reductase gene , and in the enhancer region of the mouse immunoglobulin heavy chain gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of the DNA extracted from the colonic mucosa of 13 patients operated for colorectal carcinoma revealed c myc rearrangements in three of them . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The product of the c myc proto oncogene , c Myc , is a sequence specific DNA binding protein with an N terminal transactivation domain and a C terminal DNA binding domain . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Furthermore , IL 2 induced activation of JAK 3 paralleled induction of the c myc gene and DNA synthesis but not induction of the c fos and c jun genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using flow cytometry , thymidine uptake into DNA , and expression of two growth related genes , histone 3 and c myc , we found an increase in the proportion of distal lung epithelial cells in the G0 / G1 phase of the cell cycle with advancing gestation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In most cell types , c Myc forms a sequence specific DNA binding complex with the stable , constitutively expressed Max . ^^^ Nevertheless , treatment of PC 12 cells with NGF and serum caused an increase in the expression of the c Myc protein and the transcription of a reporter gene linked to the Myc / Max DNA binding site . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Streptonigrin induced topoisomerase 2 cleavage sites were mapped in the c myc proto oncogene DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The exposure to taxol moderately decreased c myc expression , but did not induce c jun expression which has been previously noted for a variety of DNA interactive , antileukemic drugs . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Correlation between DNA content and amplification of oncogenes ( c myc , L myc , c erbB 2 ) and correlation with prognosis in 143 cases of resected lung cancer ] . ^^^ DNA content analysis using flow cytometry and amplification of c myc , L myc , and c erbB 2 oncogenes in 143 cases of resected lung cancer were analyzed using the same specimen , and we examined the correlation with prognosis of DNA content and amplification of oncogenes . ^^^ In DNA diploid cases , there were 4 cases of c myc , and 6 cases of c erbB 2 . ^^^ In DNA aneuploid cases , there were 15 cases of c myc , 4 cases of L myc , and 15 cases of c erbB 2 . ^^^ In DNA multiploid cases , there were 3 cases of c myc , and 1 cases of c erbB 2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Evidence of amplification or rearrangement of 10 recognized cellular oncogenes ( N ras , mycL 1 , mycN , myc , H ras , bcl 1 , H stf 1 , sea , kraS 2 , and fos ) was sought in tumor DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To assess the impact of viral integration on liver cell transformation , we have generated transgenic mice carrying the mutated c myc gene and adjacent viral DNA from a woodchuck tumor , in original configuration . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA region around the c myc gene and its amplification in human tumour cell lines . ^^^ In addition we have cloned 130 kb of continuous DNA around the c myc gene which includes 65 kb of 5 ' sequence and 65 kb of 3 ' sequence . ^^^ Furthermore we analysed the chromosomal location of amplified c myc DNA in NCI N 417 and SkBr 3 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We found that E2F1 could activate some ( dhfr , thymidine kinase , and DNA polymerase alpha ) but not all ( thymidylate synthase , cad , and c myc ) of these promoters . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of DNA aneuploidy and c myc oncoprotein content of canine plasma cell tumors using flow cytometry . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot hybridization did not reveal abnormal DNA rearrangements associated with the expressed oncogenes ( c myc and c myb ) in the 3 bovine tumor lines . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A sequence specific , single strand binding protein activates the far upstream element of c myc and defines a new DNA binding motif . ^^^ The role of single stranded DNA and single strand binding proteins in c myc regulation is discussed . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
USF is a helix loop helix transcription factor that , like Myc , recognizes the DNA binding motif CACGTG . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Both topoisomerase 1 and 2 cleavage patterns were modified by CpG methylation in c myc gene DNA fragments . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , the H118F mutant protein lacking enzymatic activity displayed normal DNA binding affinity for the c myc promoter in electrophoretic mobility shift assays , and retained full transcriptional activity using the c myc gene in vitro . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Identification and cDNA cloning of single stranded DNA binding proteins that interact with the region upstream of the human c myc gene . ^^^ We have previously reported that a c myc protein complex binds to the region upstream of the c myc gene , where exist an origin of cellular DNA replication ( ori ) and a transcriptional enhancer . ^^^ These single stranded DNA binding proteins were named MSSP , c myc gene single strand binding proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Different concentrations of ouabain ( 10 ( 9 ) to 10 ( 5 ) mol / L ) were added to either quiescent or proliferating cells , and the cell number , the rate of thymidine incorporation into DNA , and the transcription of c fos and c myc were examined . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Approaches to circumvent resistance will probably involve not only the rational development of a new generation of platinum based drugs ( e . g . , compounds designed to overcome reduced cisplatin accumulation or enhanced removal of cisplatin induced DNA adducts ) but also non platinum drugs which are capable of modulating resistance ( e . g . , modulators of signal transduction pathways , ras and myc oncogene expression and glutathione biosynthesis ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It was shown what microinjection of polyclonal antibodies to the myc protein specifically inhibits DNA synthesis in serum stimulated 3T3 Swiss cells during the first 6 h of the prereplicative period . ^^^ It was also shown what induction of expression of the antisense myc sequence in 3T3 Swiss cells leads to potent inhibition of DNA synthesis during the first 6 h of the prereplicative period . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A complementary DNA expression library was screened with a Myc fusion protein to identify proteins interacting with this domain , and a clone encoding the Rb related p 107 protein was isolated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We cloned and sequenced proviral LTRs integrated upstream of the cellular c myc gene from DNA obtained from thymic tumors induced by DEN region deletion mutant viruses in AKR mice . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The G C specific DNA binding drug , mithramycin , selectively inhibits transcription of the C MYC and C HA RAS genes in regenerating liver . ^^^ Mithramycin , a G C specific DNA binding drug , prevents the increased transcriptional activity of c myc and c Ha ras genes after hepatectomy but does not alter the transcriptional activity of the beta actin gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have previously shown that a c myc promoter element , termed the nuclease sensitive element or NSE , can form tandem intramolecular triplexes of the H DNA type and has a repeating sequence motif ( ACCCTCCCC ) 4 . ^^^ DNA may therefore be a dynamic participant in the transcription of the c myc gene . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
On the other hand , protein binding to the myc DNA consensus sequence correlated with N myc expression in neuroblastoma cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The effects of GM CSF and IL 3 were evaluated by studying clonal growth , 3H thymidine incorporation , BUDR / DNA bivariate flow cytometry , c myc and N myc oncogene expression , and myeloid surface markers . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In those instances in which a gene has been localized on dms , characterization of the remainder of the DNA , which far exceeds the size of the gene identified , has remained inconclusive , dms seen in the acute myeloid leukemia cell line HL 60 have been shown to harbor the c myc protooncogene . ^^^ The microdissected dm DNA detects multiple abundantly expressed transcripts distinct from c myc mRNA on Northern blots . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In order to clarify the role and interrelationship of c myc , interleukin 2 ( IL 2 ) , and transferrin receptor ( TfR ) expressions on PHA stimulated lymphocyte proliferation , we examined the effects of antisense oligodeoxynucleotides directed against c myc , TfR , and IL 2 mRNAs on DNA synthesis and cell cycle phase . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The Myc oncoprotein dimerizes with its partner , Max , to bind DNA , activate transcription , and promote cell proliferation , as well as programmed cell death . ^^^ These complexes behave as antagonists of Myc / Max through competition for common DNA targets , and perhaps permit cellular differentiation . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Differential binding of c Myc and Max to nucleosomal DNA . ^^^ We have used Max and derivatives of c Myc to characterize the effect of changes of dimerization partner on binding to nucleosomal DNA templates . ^^^ Surprisingly , modifying the c Myc dimerization interface or changing its dimerization partner to Max enables nucleosomal DNA binding . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA upstream of P 1 of both mouse and human c myc genes was transfected into cells as CAT constructs . ^^^ The presence of DNA 5 ' to the human or mouse myc genes results in increased expression of CAT following 20 min exposures of cells to 60 Hz elf EM fields . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mad and Mxi 1 , two members of the Myc related basic region helix loop helix / leucine zipper family of proteins , associate directly with Max to form sequence specific DNA binding heterodimers that are transactivation incompetent . ^^^ In contrast , mad and mxi 1 expression constructs bearing deletions in the basic region exerted only mild repressive effects on Myc transformation activity , suggesting that occupation of common DNA binding sites by transactivation incompetent Mad Max or Mxi 1 Max complexes appears to play a more dominant role in this suppression than titration of limited intracellular pools of Max away from active Myc Max complexes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This change in the expression of c fos and c myc mRNA and oncoprotein preceded an increased rate of [ 3H ] thymidine incorporation into mucosal DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA content analysis and detection of c myc and p 53 products using flow cytometry in resected lung cancer cases ] . ^^^ These rates are higher than the DNA abnormal expression rates of the c myc and p 53 genes ( 15 % and 12 % , respectively ) in our own data . ^^^ All 10 c myc positive cases showed DNA aneuploidy ; thus the positive rate for c myc products in the DNA aneuploidy cases was significantly different compared with the DNA diploidy cases ( p < 0 . 05 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this study , a dual laser flow cytometric technique employing three fluorescent dyes was used to quantify cellular changes in c myc protein , TCP , DNA and growth balance in exponentially growing and serum deprived U118MG , A 172 and HL 60 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The presence of c myc mRNA in human sperm cells was further confirmed by in situ hybridization using a digoxigenin labelled DNA probe , containing exon 2 of the c myc gene sequence . ^^^ The c myc specific DNA probe reacted with the postacrosomal mid piece and tail regions of both noncapacitated as well as capacitated methanol fixed sperm cells . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The effects of Myc on both gene expression and cell growth are differentially regulated by the recently described Max and delta Max proteins that can either cooperate or compete with Myc for sequence specific DNA binding . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The expression of four genes necessary for DNA synthesis in response to tumor promoters was examined : two nuclear proto oncogenes ( c myc and c fos ) , a transcription factor ( c jun / AP 1 ) and a key enzyme involved in polyamine synthesis ( ornithine decarboxylase ) . c jun mRNA levels are not modulated during the action of cytoskeletal disrupting drugs on TPA mediated mitogenesis , whereas c myc and c fos mRNA levels are similarly enhanced . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Lower concentrations of 4 HC ( 10 , 20 , or 50 microM / L ) failed to cause this effect , while higher concentrations ( > or = 200 microM / L ) produced random DNA fragmentation . 4 HC mediated internucleosomal DNA fragmentation was associated with a marked induction in c jun and significant reductions in bcl 2 and c myc oncogene expressions . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of topoisomerase 2 mediated DNA cleavage of the c myc gene during HL 60 differentiation . ^^^ In exponentially growing cells , treatment by mAMSA results in the formation of topoisomerase 2 mediated double strand DNA breaks in the c myc gene at positions where topoisomerase 2 would normally nick and reseal the two strands . ^^^ However , a DNA cleavage site located at the end of the first c myc exon ( position +3100 ) , was strongly stimulated by mAMSA and DMSO treatment . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Optimized USF and MYC DNA binding sites , which differ in the nucleotides bordering the hexanucleotide box displace the E C 4 factor in competition assays but with lesser efficiency than the E C 4 site itself . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A novel sequence specific DNA binding protein , CTCF , which interacts with the chicken c myc gene promoter , has been identified and partially characterized ( 5 . 5 . ^^^ In order to test directly whether binding of CTCF to one specific DNA region of the c myc promoter is important for chicken c myc transcription , we have determined which nucleotides within this GC rich region are responsible for recognition of overlapping sites by CTCF and Sp 1 like proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Identification of casein kinase 2 phosphorylation sites in Max : effects on DNA binding kinetics of Max homo and Myc / Max heterodimers . ^^^ Phosphorylation of these sites modulates DNA binding by increasing both the on and off rates of Max homo as well as Myc / Max heterodimers . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA binding properties of c Myc related bHLH / LZ oncoproteins . ^^^ Structural features and DNA binding properties of bacterially expressed c Myc related oncoproteins were examined . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We collected cells of the 327th passage of SO Rb 50 , purified its genomic DNA and detected it with Rb and c myc cDNA probes respectively ( normal human white blood cells DNA was the control ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Although Myc contains a bHLH LZ motif , it fails to bind DNA alone but can do so by forming heterodimers with an unrelated bHLH LZ protein , Max . ^^^ Activation by Max requires DNA binding and amino acids outside the bHLH LZ domain but is reduced compared with activation by Myc Max heterodimers . ^^^ Moreover , transcriptional activation by Myc Max heterodimers , but not Max Max homodimers , is strongly inhibited in vivo by specific sequences flanking the core CACGTG binding motif , presumably reflecting reduced DNA binding affinity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc and its partner protein , Max , dimerize and bind DNA in vitro and in vivo through basic / helix loop helix / leucine zipper motifs ( bHLH LZ ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Distinct DNA binding preferences for the c Myc / Max and Max / Max dimers . ^^^ The transcription factor c Myc and its dimerisation partner Max are members of the basic / helix loop helix / leucine zipper ( bHLH Z ) family and bind to the DNA core sequence CACGTG . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The yeast two hybrid system was used to screen a human complementary DNA ( cDNA ) library for proteins that associate with YY 1 , and a c myc cDNA was isolated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We report here that in normal human fibroblasts both compounds strongly inhibit the repair of damage induced by UV or 4 nitroquinoline 1 oxide in the transcriptionally active c myc gene , as indicated by the appearance of DNA strand breaks in carcinogen treated cultures that were subsequently incubated in the presence of either polymerase inhibitor . ^^^ We further demonstrate that the repair of UV photoproducts in the c myc gene can be monitored by photolysis ( 313 nm ) of DNA repaired in the presence of bromodeoxyuridine ( BrdUrd ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
C myc expression increased significantly 5 h after two times the minimal erythema dose ( 2 10 MED ) of UVR , while DNA synthesis of the irradiated skin had recovered from the UVR induced inhibition . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this study , [ a 32p ] dATP labelled probes of c myc , N ras and c erb B genes were employed to perform dot blot hybridisation with DNA extracted from 17 cases of primary ovarian cancer , 3 cases of recurrent ovarian cancer , 2 cases of germ cell ovarian cancer , 5 cases of serous cysadonoma and 4 cases of normal ovarian tissue . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc proto oncogene encodes nuclear phosphoproteins that bind DNA in a sequence specific fashion and appear to function as transcriptional activators . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The expression of c myc and c Ki ras oncogenes were examined by the use of DNA dot blot , RNA dot blot and Northern blot analyses . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F 1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The recent identification of Max , a nuclear phosphoprotein that dimerizes with members of the Myc protein family , has provided an additional tool to examine the role of the Myc oncoprotein as a sequence specific DNA binding protein and a potential regulator of gene transcription . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The cellular targets of DNA PK are nuclear , DNA binding , regulatory proteins including Sp 1 , Fos , Jun , Myc , the tumor suppressor protein p 53 , and RNA polymerase 2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The carboxyl terminal 92 residues of c Myc 92 display site specific DNA binding specificity for the consensus sequence 5 ' CACCACGTGGTG 3 ' ( Blackwell , T . ^^^ Helix 1 ( H 1 ) and leucine zipper peptides from the basic helix loop helix zipper domain of c Myc and Max were assayed as potential inhibitors of c Myc 92 DNA binding . ^^^ H 1 peptides with substitutions that confer greater helicity are found to inhibit c Myc 92 DNA binding . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Log phase growth , transformation with c myc , or infection of quiescent G 0 targets with herpes simplex virus 1 , which induces a competent state for DNA synthesis , all enhanced target cell susceptibility to CTL induced DNA fragmentation without altering the membrane lysis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , peak levels of the growth related proto oncogene c myc mRNA could be correlated with maximal increases of lung DNA content , although the initial increase in c myc mRNA preceded measurable changes of total lung DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Apoptosis was confirmed morphologically as evidenced by chromatin condensation , nuclear fragmentation and the formation of apoptotic bodies , and by DNA agarose gel electrophoresis which showed the pattern of double stranded DNA fragments that result from the activation of an endogenous endonuclease . [ C 14 ] Leucine incorporation studies at 1 hour demonstrated minimal protein synthesis inhibition at doses used , suggesting that c myc mRNA superinduction in this context may have been the result of mechanisms which were independent of the inhibition of synthesis of new proteins , such as interruptions in signal transduction . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Not only AIGF antisense but also c myc antisense inhibited androgen dependent growth . c myc antisense did not affect androgen induced AIGF mRNA expression . c myc antisense inhibited AIGF , but not bFGF induced DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc / Max heterodimers exhibit sequence specific DNA binding with much greater affinity than Myc homodimers . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Before stimulation of thymidine incorporation into cellular DNA , 5 HT elevated c myc and actin mRNAs . ^^^ Imipramine , fluoxetine , staurosporine , and cholera toxin inhibited the stimulations of both DNA synthesis and c myc and actin mRNA expressions by 5 HT . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Influence of amsacrine ( m AMSA ) on bulk and gene specific DNA damage and c myc expression in MCF 7 breast tumor cells . ^^^ Regions encompassing the transcriptionally active oncogenes , c myc and c fos , were found to be more susceptible to m AMSA induced strand breaks than the region encompassing the non transcribed alpha satellite DNA or the genome as a whole ( bulk DNA ) . ^^^ These findings demonstrate that m AMSA may produce more pronounced damage within specific genomic regions than in bulk DNA , m AMSA also preferentially altered expression of the c myc oncogene ; at an m AMSA concentration where growth was inhibited by between 70 and 80 % , steady state c myc mRNA levels declined to approximately 10 15 % of control levels within 2 3 hr ; furthermore , concentration dependent reductions in c myc expression appeared to coincide with growth inhibition . ^^^ In addition , inhibition of [ 3H ] thymidine incorporation after 2 hr directly paralleled inhibition of growth , suggesting an early effect at the level of DNA biosynthesis , possibly related to the down regulation of c myc expression . ^^^ It is proposed that specific lesions , e . g . , in regions surrounding the c myc gene , as well as generalized lesions in DNA may lead to growth inhibition mediated by down regulation of the expression of select growth regulatory genes , such as c myc . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Identification of amino acid base contacts in the Myc DNA complex by site specific bromouracil mediated photocrosslinking . ^^^ Myc binds to a 6 bp 2 fold symmetric DNA site : 5 ' C 3A 2C 1G+1T+2G+3 3 ' . ^^^ Using site specific 5 bromouracil mediated photocrosslinking , we show that His 336 of Myc contacts , or is close to , the thymine 5 methyl group at 2 fold symmetry related positions 2 and +2 of the DNA site in the Myc DNA complex . ^^^ Our results strongly suggest that homologous amino acids of Myc and Max make equivalent contacts in the respective protein DNA complexes . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A 27 base pair triplex forming oligonucleotide ( G 27 oligonucleotide ) targeted to the `` puf ' ' regulatory protein binding domain of the human c myc oncogene has been conjugated with the DNA binding molecule acridine ( G 27 conjugate ) in order to obtain a drug with high binding affinity as well as high sequence specificity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The product of the c myc gene ( c Myc ) is a sequence specific DNA binding protein that has previously been demonstrated to be required for cell cycle progression . ^^^ Here we report that the c Myc DNA binding site confers cell cycle regulation to a reporter gene in Chinese hamster ovary cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Both cases expressed abundant , normal sized C MYC transcript , but no rearrangement of C MYC DNA sequences could be detected using probes that span 80 kb around the C MYC coding sequences . ^^^ This combination may be a new recurrent abnormality , of central pathogenic importance in the transformation of B cells to high grade malignancies through simultaneous deregulation of BCL 2 and C MYC genes , constitutive expression of C MYC being driven by currently unknown DNA sequences on chromosome 9p13 . 3 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A human gene encoding the c myc purine binding transcription factor PuF was identified by screening of a cervical carcinoma cell complementary DNA library with a DNA fragment containing PuF binding sites . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , VM 26 produces an early ( within 2 3 h ) concentration dependent reduction in c myc expression ( and of DNA synthesis ) which parallels inhibition of cell growth , suggesting the possibility of effects of VM 26 at the level of genomic regions which regulate DNA replicative function . ^^^ Utilizing the newly developed alkaline unwinding / Southern blotting assay in the MCF 7 breast tumor cell line , it was determined that VM 26 induces damage within regions surrounding the c myc gene and the beta globin gene which exceeds that induced in both alpha satellite DNA and in L 1 repeat sequences ; damage within c myc and beta globin also exceeds that observed throughout the genome as a whole . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Similar 12 residue sequences are found in the DNA binding domain of many transcription factors including those of the TEA family , the Myc type of bHLH family , the MADS family , the Ets family and the OmpR family . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c fos , c Ha ras and c myc oncogenes have been proposed to play an important role in DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We found that the reconstituted hGM CSFR transduces signals in NIH3T3 fibroblasts and BA / F3 cells in response to human GM CSF to activate transcription of c fos , c jun and c myc protooncogenes . hGM CSF also induces protein tyrosine phosphorylation and DNA synthesis in both cell types . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Study of DNA methylation of the c myc gene in liver tumors of BCF 1 mice treated with various agents revealed frequent alteration from that in normal liver . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Effects of prostaglandins and hydroxyoctadecadienoic acid on epidermal growth factor dependent DNA synthesis and c myc proto oncogene expression in Syrian hamster embryo cells . ^^^ In contrast , PGE 2 inhibited EGF induced DNA synthesis and down regulated EGF stimulated c myc mRNA accumulation in a dose dependent manner , whereas PGF 2 alpha had no effect on these responses . ^^^ PGE 2 , but not PGF 2 alpha , induced a rapid increase in cAMP formation , and both forskolin and 8 ( 4 chlorophenylthio ) cAMP mimicked the inhibitory effects of PGE 2 on EGF dependent DNA synthesis and c myc mRNA accumulation , suggesting that the involvement of cAMP . ^^^ The results indicate that the modulation of EGF dependent DNA synthesis by PGE 2 , but not by HODEs , is associated with altered expression of the proto oncogene c myc in SHE cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot analysis was performed with a panel of DNA probes to detect rearrangements of c myc , bcl 1 , bcl 2 and bcl 3 in 14 cases of B cell non Hodgkin ' s lymphoma ( NHL ) with a clonal cytogenetic rearrangement involving the chromosome 14q32 locus and no known donor chromosome [ t ( 14 ; ? ) ( q 32 ; ? ) ] . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
All of the lines examined had a normal c myc DNA sequence , suggesting that the deregulation of c myc expression in colon cancer is not due to a cis mutation in this region . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
However , antibodies against c myc protein exert no effect on the formation of the p 65 DNA complex . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To improve the diagnostic accuracy and understanding of the pathogenesis of lymphoproliferative diseases ( LPDs ) occurring in immunosuppressed transplant recipients ( post transplantation LPD ) , clonality of Epstein Barr virus induced human LPDs in mice with severe combined immunodeficiency was examined by analyzing : 1 ) human immunoglobulin genes and their products , 2 ) the clonality of Epstein Barr virus DNA , and 3 ) genetic alteration of c myc or bcl 2 genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Whereas c Myb trans activated an SV 40 early promoter containing multiple copies of an upstream c Myb DNA binding site ( MBS 1 ) , and similarly the human c myc promoter , B Myb was unable to do so . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Specific signals that co localized with a differently labeled c myc probe on chromosome band 8q24 were obtained with genomic DNA from each cell line . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS : Tissues from 33 cases of Hodgkin ' s disease were studied for the presence of EBV DNA by polymerase chain reaction ( PCR ) and DNA in situ hybridisation ( DISH ) , for the presence of EBER 1 and EBER 2 EBV RNA by RNA in situ hybridisation ( RISH ) ; and for the presence of LMP , bcl 2 , and c myc proteins by immunohistochemical staining . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Opposite regulation of gene transcription and cell proliferation by c Myc and Max . c Myc and Max are nuclear phosphoproteins capable of forming DNA binding , homo and heteropolymeric complexes in vitro and in vivo . ^^^ Analysis of specific mutants indicates that transcriptional activation requires both the c Myc and the Max dimerization and DNA binding domains , as well as the c Myc transactivation function ; transcriptional repression by Max requires both DNA binding and dimerization . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The product of the human c myc protooncogene ( Myc ) is a sequence specific DNA binding protein . ^^^ Here , we demonstrate that the placement of the specific Myc DNA binding site CACGTG upstream of a luciferase reporter gene conferred Myc stimulated expression that was inhibited by the overexpression of the basic helix loop helix / leucine zipper protein Max . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the cell lines , the doubling time and the cell cycle distribution , as determined by flow cytometric DNA analysis , were examined to establish whether the level of myc gene family expression correlated with proliferative parameters . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Twenty seven samples of pleomorphic salivary adenoma ( PSA ) were examined for expression and structure of c myc , c Ha ras , c erbB 2 , c sis oncogenes by RNA dot blot , DNA dot blot and Southern blot hybridization . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A locus in feline DNA , termed flvi 2 , is commonly interrupted in naturally occurring and experimentally induced thymic lymphosarcomas containing LC FeLV ; thus , interruption of a gene encoded by flvi 2 may cooperate with the myc oncogene in the induction of T cell tumors by LC FeLV . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Fli 1 , p 53 , and Evi 1 were found to be rearranged in 72 % , 23 % , and 18 % of the tumors , respectively , whereas no DNA alteration were detected for c myc , c myb , Pim 1 , Evi 2 , and EpoR genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
HPV 16 and HCMV DNA homologous sequence and the status of cellular oncogene C myc DNA were examined in uterine cervical diseases with dot blot hybridization and Southern hybridization . ^^^ C myc DNA was widely detectable in uterine cervical carcinoma , but the manifestation of translocation , deletion or overexpression in cervical carcinoma was frequent . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We developed a modified in situ DNA RNA hybridization technique and demonstrated c myc proto oncogene transcripts in nodular sclerosis type Hodgkin ' s disease ( HD NS ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Binding of myc proteins to canonical and noncanonical DNA sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In uniquely end labeled human c myc DNA , camptothecin induced cleavage occurred exclusively at guanines and was markedly enhanced by hot piperidine treatment . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The primary tumors from 15 untreated patients with Burkitt ' s lymphoma were analysed for abnormalities in the coding region of the MYC gene by single stranded conformational polymorphism ( SSCP ) analysis followed by DNA sequencing . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This IL 6 induced TRE binding complex was abolished by anti Jun specific antibodies and was efficiently competed by an oligonucleotide that comprises the mouse homologue of a previously described human c myc negative DNA element . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Recombinant , chimeric transcription factors identified the transcriptional activation domain of BZLF 1 as being necessary to mediate DNA replication , a function which could not be substituted by any other transcription factor tested , including jun , E 2 , myc or VP16 . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Since c Myc may function as a DNA binding transcription factor , we examined whether c Myc regulates the latent period genes ( hsp and hsc 70 , MER 5 , Id and Spi 1 genes ) and the erythroid specific genes [ beta globin , glycophorin , delta aminolevulinic acid synthase ( ALAS E ) , GATA 1 and erythropoietin receptor ( EpoR ) ] in the MEL cell transformant having transferred c myc gene . ^^^ While c myc is thought to be involved in DNA replication , its overexpression showed no effect on the expression of proliferating cell specific nuclear antigen or DNA polymerase a . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The rate of expression of c myc and c Ha ras oncogenes in gastric cancer tissues was higher in the DNA aneuploid group than in the DNA diploid group . ^^^ Expression of c myc and c Ha ras oncogenes correlated with other prognostic factors such as DNA ploidy pattern and metastasis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of DNA sequences 5 ' of the c myc genes from both tumors demonstrated that rearrangements were caused by retroviral integrations 5 ' of c myc exon 1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using a chimeric construct containing the H 2Kb major histocompatibility class gene promoter linked to the c myc first exon , we show that transcriptional block is increased by the addition of a 25 bp DNA sequence from the c myc promoter . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Human Mad protein homodimerizes poorly but binds Max in vitro , forming a sequence specific DNA binding complex with properties very similar to those of Myc Max . ^^^ Both Myc Max and Mad Max heterocomplexes are favored over Max homodimers , and , unlike Max homodimers , the DNA binding activity of the heterodimers is unaffected by CKII phosphorylation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Oncogenic activity of the c Myc protein requires dimerization with Max . c Myc ( Myc ) and Max proteins dimerize and bind DNA through basic helix loop helix leucine zipper motifs ( b HLH LZ ) . ^^^ In addition , wild type max antagonizes myc function in a dose dependent manner , presumably through competition of Max Max and Myc Max dimers for common target DNA sites . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Differential patterns of DNA binding by myc and max proteins . c myc , N myc , and L myc genes are subject to highly variable degrees of tissue specific regulation . ^^^ The recently identified max protein dimerizes with c myc to promote its sequence specific DNA binding . max exists in two forms ( long and short ) that differ by virtue of a 9 amino acid insertion / deletion at the N terminus . ^^^ Each myc protein , alone and in association with max proteins , manifested a unique pattern of DNA binding . ^^^ Our results point to the existence of specific DNA binding preferences for each of the myc proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
High affinity DNA binding Myc analogs : recognition by an alpha helix . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When goldfish erythrophores isolated from the skin by tissue digestion and centrifugation in a Percoll density gradient were transfected in a monolayer culture with 5 Ha ras or 5 src oncogene either singly or in combination with 5 myc by means of calcium phosphate DNA co precipitation , there appeared a certain number of transformants manifesting a chromatoblast like profile and tumorous phenotypes as seen in the capability for unlimited growth , and piling up in a monolayer culture or colony formation in semi solid soft agar . ^^^ Little difference was observed in their transforming efficiency ( 0 . 2 0 . 3 transformants / micrograms DNA ) between the combinations of oncogenes applied but a tendency was noted that cells transfected with ras or src in combination with myc developed the capacity to grow for a longer period and differentiated at a later stage than those transfected solely with ras or src . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Stimulation of DNA synthesis was accompanied by a specific , sequential induction of protooncogene mRNA levels ; c fos mRNA was induced 23 fold at 0 . 5 h after readdition of EGF ; c myc mRNA was induced three to four fold by 0 . 5 h ; TGF alpha mRNA was induced sevenfold by 8 h ; K ras mRNA was induced fourfold by 26 h . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This cytotoxic response was accompanied by a temporal series of intracellular signals that are commonly triggered by a mitogenic stimulus : increased c fos ( 20 30 min ) and c myc ( 40 60 min ) expression , increased activity of ornithine decarboxylase ( 3 h ) , increased intracellular polyamine content ( 7 h ) and increased thymidine incorporation into DNA ( 14 h ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We found that the reconstituted hGM CSFR transduces signals in NIH 3T3 fibroblasts and BA / F3 cells in response to hGM CSF to activate transcription of the c fos , c jun , and c myc proto oncogenes . hGM CSF also induces protein tyrosine phosphorylation and DNA synthesis in both cell types . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA repair was assessed in the essential , active gene , dihydrofolate reductase ( DHFR ) , in the active c myc protooncogene , and in the transcriptionally inactive delta globin gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of DNA from two patients revealed five to tenfold amplification of c MYC oncogene in the leukemic cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Constitutive c myc expression in serum deprived Rat 1a cells caused a > 15 fold increase in the number of dead cells , accompanied by DNA fragmentation . ^^^ However , coexpression of bcl 2 with c myc in these cells led to a 10 fold increase in the number of live cells and a significant decrease in DNA fragmentation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
N and L Myc , like c Myc , contain adjacent basic region ( BR ) , helix loop helix ( HLH ) and leucine zipper ( LZ ) motifs , which characterize a family of DNA binding proteins . ^^^ N Myc , like c Myc , preferentially forms heterodimeric DNA binding complexes with Max protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using this method , termed `` hot PCR , ' ' 111 and 179 bp regions ( GC contents of 74 % and 76 % , respectively ) of the avian c myc proto oncogene were specifically amplified from cloned and genomic DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The removal of excess histones by DNA titration leads to an elevated level of c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA ploidy , c myc oncoprotein p 62 and 5 H ras oncoprotein p 21 in colorectal carcinoma . ^^^ DNA ploidy and expression of the c myc oncoprotein p 62 and the 5 H ras oncoprotein p 21 were examined in 54 colorectal carcinomas . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the quiescent mouse BP A 31 fibroblasts , prostaglandin F 2 alpha ( PGF 2 alpha ) induces the expression of cell cycle related genes c fos , c jun , and c myc , and after a delay of approximately 12 h the entry into the phase of DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A dominant negative mutant of Max that inhibits sequence specific DNA binding by Myc proteins . ^^^ Myc proteins are basic helix loop helix / leucine zipper proteins that bind to specific DNA sequences . ^^^ To investigate this , we constructed a dominant negative mutant of Max , named dMax , that inhibits sequence specific DNA binding of Myc proteins . ^^^ These data support the hypothesis that N Myc affects neuroblastoma gene expression through the formation of a DNA binding heterodimeric complex with Max in vivo . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Double transgenic mice bearing fusion genes consisting of mouse albumin enhancer / promoter mouse c myc complementary DNA and mouse metallothionein 1 promoter human transforming growth factor alpha complementary DNA were generated to investigate the interaction of these genes in hepatic oncogenesis and to provide a general paradigm for characterizing the interaction of nuclear oncogenes and growth factors in tumorigenesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Endogenous activation of c myc expression and DNA synthesis in serum starved neonatal rat smooth muscle cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA binding was necessary for c myc activation , as shown by the loss of function associated with mutation of Myb ' s DNA binding domain and by trans dominant repressor activity of the DNA binding , trans activation defective mutant . ^^^ Together these data reveal two cell lineage dependent pathways by which c Myb regulates c myc ; however , both pathways are mechanistically indistinguishable in that direct DNA binding by Myb is required for activating c myc whereas neither de novo protein synthesis nor other labile proteins are necessary . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Max protein forms specific DNA binding dimeric complexes with itself and with proteins of the c myc gene family . ^^^ To elucidate the role of max in regulating c myc functions and the effect of both proteins on cell proliferation and differentiation , we transfected murine erythroleukemia ( MEL ) cells with a full length wild type ( wt ) human max gene and a mutant containing a double point mutation in the basic region ( bm ) , which abolishes specific DNA binding . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The use of hybridization of restricted DNA of the nuclear matrix with appropriate probes revealed that the number of copies for oncogenes c fos and c myc within this DNA changes with alteration of the intracellular ratio of monovalent cation concentrations . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
As predictors of tumor response by radiotherapy , tumor with or without c myc amplification and DNA histogram pattern were analyzed and evaluated for patients ' prognosis . ^^^ There was no relation between c myc amplification and DNA ploidy pattern in this study . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Our experiments with MC 29 mutants demonstrate that c myc down regulation depends on the integrity of the 5 Myc DNA binding domain and occurs at the RNA level . ^^^ Upon synthesis , 5 Gag Myc enters the nucleus , forms complexes with its heterodimeric partner Max , and in this complex binds to DNA in a sequence specific manner . ^^^ While the nuclear localization signal is dispensable for transformation , minimal changes in the 5 Gag Myc DNA binding domain completely abolish its transforming potential , consistent with a role of Myc as a transcriptional regulator . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Max is a basic helix loop helix / leucine zipper ( bHLH / LZ ) protein that forms sequence specific DNA binding complexes with the c Myc oncoprotein ( Myc ) . ^^^ Gene regulatory properties of Myc helix loop helix / leucine zipper mutants : Max dependent DNA binding and transcriptional activation in yeast correlates with transforming capacity . ^^^ In addition , we have used yeast to investigate the role of the Myc helix loop helix ( HLH ) and leucine zipper ( LZ ) motifs in mediating Max dependent DNA binding and transcriptional activation in vivo using HLH / LZ mutants generated by site directed mutagenesis . ^^^ The results show that , while both motifs are essential for Myc to activate transcription , helix 2 of the HLH together with the contiguous LZ suffice to mediate complex formation with Max , whilst helix 1 is essential for sequence specific DNA binding of Myc Max complexes . ^^^ Furthermore , the ability of Myc HLH / LZ mutants to bind DNA and activate transcription in collaboration with Max correlates closely with their neoplastic transforming activity in higher eukaryotic cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Upon induction of exogenous MBP 1 expression , stable transfectants showed reduced c myc expression , cell death , and DNA fragmentation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA derived from medulloblastoma biopsies was analyzed to determine if deletions of the 17p region , mutations of the TP 53 gene , or amplification of the c myc , N myc , EGFR ( epidermal growth factor receptor ) , or MDM 2 ( murine double minute 2 ) genes was indicative of a poor prognosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Frequent occurrence of woodchuck hepatitis virus DNA ( WHV DNA ) integration into or in proximity to myc oncogenes and in the win locus of cellular genome in woodchuck hepatocellular carcinomas ( HCC ) has been described by several authors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Prevention of tumor formation in a mouse model of Burkitt ' s lymphoma by 6 weeks of treatment with anti c myc DNA phosphorothioate . ^^^ MATERIALS AND METHODS : Groups of 12 Emu myc mice were treated prophylactically for 6 weeks after weaning with anti c myc DNA phosphorothioate ( 20 mg / kg / day ) , scrambled control DNA , or saline , delivered by micro osmotic pumps . ^^^ CONCLUSIONS : Long term tumor resistance after anti c myc DNA therapy implies induction of a host response . ^^^ Prophylactic anti c myc DNA therapy might prevent lymphoma in asymptomatic individuals displaying c myc translocations . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Repair analysis of 4 hydroperoxycyclophosphamide induced DNA interstrand crosslinking in the c myc gene in 4 hydroperoxycyclophosphamide sensitive and resistant medulloblastoma cell lines . ^^^ The formation and disappearance of 4 HC induced DNA ICLs at the c myc gene were subsequently studied by DNA denaturing / renaturing gel electrophoresis and Southern blot analysis . 4 HC induced DNA ICLs in the c myc gene exhibited a dose dependent relationship . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Based on the homology with DNA binding consensus sequences of transcription factors , we identified in this promotor region several putative DNA binding sites for transcription factors , such as NF kappa B , Myb , Ets 1 , Myc , and ATF . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A novel DNA binding protein that recognizes the methylated c Myc binding motif . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A human recombinant cDNA clone that encoded 253 amino acids residues of a zinc finger protein ( THZif 1 ) was cloned by screening a cDNA library prepared from human promyelocytic leukemia HL 60 cells with synthetic oligodeoxynucleotide probes that corresponded to the amino acid sequences of tryptic peptides derived from the DNA binding protein specific for the nuclease hypersensitive element ( NHE ) of the human c myc gene . ^^^ Cotransfection , trans activation and in vitro transcription studies using the wild type form and THZif 1 with a mutated second zinc finger motif demonstrated that the DNA binding activity specific for H form DNA of NHE was a prerequisite for the negative regulation of the expression of the c myc gene . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Multiparameter flow cytometry was used to simultaneously measure nuclear DNA content , RB protein , and MYC or FOS protein per cell . ^^^ The amount of MYC and FOS per cell also increased throughout the cell cycle , but also more slowly than DNA during S . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Regulation of Myc and Mad during epidermal differentiation and HPV associated tumorigenesis . c Myc and Mad each form heterodimers with Max that bind the same E box related DNA sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Identification of transcriptionally induced Z DNA segments in the human c myc gene . ^^^ Using monoclonal antibodies against Z DNA three AluI restriction fragments of the human c myc gene were previously found to form Z DNA in agarose embedded , metabolically active permeabilized nuclei . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Molecular cloning and sequencing of the 5 myc gene revealed several unique mutations , including a large deletion affecting amino acids 49 to 124 and a 3 bp insertion within the basic DNA binding domain which converts Leu 362 to Phe Arg . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
None of the five patients with aneuploid DNA histograms at the anastomotic site had detectable amplification or translocation of K ras or c myc gene in mucosal tissue . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA binding was required but not fully sufficient for inhibition of Myc dependent transformation by USF , since deletion mutants containing only the DNA binding domains of USF 1 or USF 2 produced partial inhibition . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Double transgenic mice were examined on DNA synthesis , c myc mRNA and occurrence of hepatocelular carcinoma ( HCC ) . ^^^ These data suggest that HGF is the potent mitogen , stimulating DNA synthesis and up regulating c myc mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Gel mobility shift experiments with double stranded oligonucleotides containing this region gave rise to several specific DNA protein complexes , and the addition of specific antibodies indicated that proteins antigenically related to Sp 1 and c Myc were components of one or more of these bands . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
FEM cells transfected with the anti ras ribozyme were shown to have the longest doubling time , the least DNA synthesis , and the fewest colonies in soft agar when compared with transfectants with ribozymes against c fos or c myc mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The major types of genetic abnormalities that are frequently observed in breast tumors are amplification of protooncogenes ( MYC , ERBB 2 ) and DNA from chromosome band 11q13 ; mutation of TP 53 ; and loss of heterozygosity from chromosomes and chromosome arms 1 , 3p , 6q , 7q , 8p , 11 , 13q , 16q , 17 , 18q , and 22q . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Gene specific and strand specific DNA repair was measured in the actively transcribed genes dihydrofolate reductase ( DHFR ) , c myc , and p 53 , and in the transcriptionally inactive regions , delta globin and the 10 linked 754 domain . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS : MDA 231 cells were treated for up to 72 hours with 1 . 0 microM TAM alone or in the presence of 50 microM c myc antisense or nonsense oligonucleotides . c myc mRNA expression was determined by northern blot analysis , protein expression by western blot analysis , cell growth inhibition counts , and DNA cleavage by agarose gel electrophoretic analysis . ^^^ The induction of c myc by TAM was accompanied by internucleosomal DNA cleavage characteristic of apoptotic cell death . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Interestingly , the toxic effect exerted by 1 alpha , 25 ( OH ) 2D3 and its analogues is accompanied by several of the biochemical features of apoptosis , such as DNA fragmentation and induction of the c myc protooncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc gene encodes a sequence specific DNA binding protein that activates transcription of cellular genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The far upstream element binding protein ( FBP ) is one of several recently described factors which bind to a single strand of DNA in the 5 ' region of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , DNA synthesis peaked one day later and was reduced by 50 % in the cultured c myc and c myc / TGF alpha hepatocytes . ^^^ However , in hepatocytes isolated from c myc / TGF alpha mice , which show early appearance of preneoplastic lesions in vivo , the DNA synthesis continued for 6 days in culture in contrast to a sharp decrease in the labeling index of control and c myc hepatocytes after 3 4 days in culture . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Neurotrophin 3 increased binding activities in nuclear extracts of MC3T3 E 1 cells to TPA responsive element ( TRE ) , cyclic AMP responsive element ( CRE ) and serum responsive element ( SRE ) , but not binding activity in the nuclear extracts to c Myc binding DNA element . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using PCR , we retrospectively investigated the extent of c myc gene amplification in DNA extracted from stored blood smears from the patient . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mad 1 dimerizes with Max and recognizes the same DNA sequences as do Myc : Max dimers . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Although there is 100 % sequence identity in the DNA binding domains of the avian and human CTCF proteins , the regulatory sequences recognized by CTCF in chicken and human c myc promoters are clearly diverged . ^^^ Mutating the contact nucleotides confirms that CTCF binding to the human c myc P 2 promoter requires a number of unique contact DNA bases that are absent in the chicken c myc CTCF binding site . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequences covering the human c myc coding region and approximately 20 kb of flanking upstream and downstream sequences were cloned onto a prokaryotic F factor derived plasmid , which also contains a selectable marker and the plasmid origin of DNA replication oriP of Epstein Barr virus ( EBV ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The woodchuck hepatitis B virus ( WHV ) , unlike the two other viruses , induces a rapid carcinogenic process characterized by direct activation of myc proto oncogenes by insertion of viral DNA . ^^^ Existence of a functional N myc 2 gene as a potential target for insertional activation by viral DNA is therefore not restricted to the woodchuck species . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The reduction in c myc mRNA levels was concentration dependent and corresponded closely with growth arrest ( as well as with inhibition of DNA synthesis ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The finding that the neuronal model cell line PC 12 lacks the Myc DNA binding partner , the Max protein , and the demonstration that Myc is a repressor of gene activity as well as a transactivator , lead to models for Myc action in regulating cell growth . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA replication initiates non randomly at multiple sites near the c myc gene in HeLa cells . ^^^ The origin of replication of the c myc gene in HeLa cells was previously identified at low resolution within 3 . 5 kb 5 ' to the P 1 promoter , based on replication fork polarity and the location of DNA nascent strands . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequence analysis of the genetic recombination between Igh 6 and Myc in an uncommon BALB / c plasmacytoma , TEPC 1194 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Thus , the signals directed by this membrane proximal domain , which is essential for transducing a DNA synthesis signal , can be separated further into Stat 5 or c myc pathways . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The proto oncogene myc , which inhibits adipocyte differentiation , abrogates C / EBPalpha activation of gadd 45 . gadd 45 is known to be a target of the tumor suppressor p 53 in a G 1 checkpoint activated by DNA damage . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inhibition of c myc biosynthesis between 24 and 48 h hours slightly affected the DNA synthetic response . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The influence of Lp ( a ) on mesangial cell proliferation was assessed in a rat mesangial cell culture model by direct measurement of cell growth as well as analysis of DNA synthesis and mRNA levels of c fos and c myc , two growth associated ' immediate early response genes ' . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , in situ hybridization to c myc mRNA was carried out using DNA probe . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In HGF transgenic mice where DNA synthesis of hepatocytes is active , c myc is induced through an increased transcription rate by HGF . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Since transcriptional regulation of c myc is mediated through two nuclear factor kappa B ( NF kappa B ) sites in WEHI 231 , the effects of CD40L on DNA binding by this family of transcription factors were evaluated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA blot and previous PCR analysis confirmed the juxtaposition of BCL 2 major breakpoint region ( mbr ) with IGJH 6 , but also demonstrated a rearrangement within the first exon of MYC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of DNA double strand breaks by ionizing radiation at the c myc locus compared with the whole genome : a study using pulsed field gel electrophoresis and gene probing . ^^^ Ionizing radiation induced double strand breaks ( dsb ) in a human colon carcinoma derived cell line COLO320HSR were determined from the fragment size distribution of non specifically labelled DNA and Sfi 1 restriction enzyme digested DNA uniformly labelled with a c myc probe . ^^^ The dose effect relation for the induction of DNA dsb was linear with no significant difference between slopes for the curves in the whole genome ( 7 . 2 + / 0 . 3 10 10 ( 9 ) dsb / bp / Gy ) and in the 130 kbp restriction fragments containing c myc ( 6 . 5 + / 0 . 5 10 10 ( 9 ) dsb / bp / Gy ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We show that mutants of Myc with an altered basic region ( BR ; RR 366 , 367EE ) or deletion of the leucine zipper ( LZ ; delta aa 414 439 ) , changes which modify the DNA binding domain , or with deletions in the Myc amino terminal conserved regions box 1 ( dlMB 1 ; delta aa 46 55 ) and box 2 ( dlMB 2 ; delta aa 132 140 ) inhibit cooperation of wt Myc and activated Ras to transform rat embryo fibroblasts ( REF ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A specific DNA binding element in the promoter region of the c myc proto oncogene has been identified as AT rich domain of homopurine / pyrimidine stretches flanked by GC rich sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The results show that : ( 1 ) As2O3 triggers relatively specific NB 4 cell apoptosis at micromolar concentration , as proved by morphology , histogramic related nuclear DNA contents , and DNA gel eletrophoresis . ( 2 ) As2O3 does not influence bax , bcl 10 , c myc , and p 53 gene expression , but downregulates bcl 2 gene expression at both mRNA and protein levels . ( 3 ) As2O3 induces a significant modulation of the PML staining pattern in NB 4 cells and HL 60 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Number and size of GGT positive lesions , DNA synthesis of GGT positive cells , liver ODC activity and c myc and c Ha ras mRNA levels decreased as a consequence of SAM treatment A . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Since the N myc gene at 2p24 is amplified in NCI H 69 and the c myc gene at 8q24 is amplified in NCI H 82 , it is possible that these DNA fragments are co amplified with N myc or c myc in these cell lines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Many basic helix loop helix leucine zipper ( b HLH LZ ) proteins , including the Myc family and non Myc family , bind a common DNA sequence CACGTG , yet have quite different biological actions . ^^^ These results suggest that the DNA binding specificities of the Myc family and non Myc family b HLH LZ proteins , in the context of the cellular genes involved in Myc induced transformation , are shared . ^^^ The results also demonstrate that targeting mSin 3 to CACGTG sites via a non Myc family DNA binding domain is sufficient to oppose Myc activity in growth regulation . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It activates transcription of the c myc oncogene independently of its catalytic function , by binding to its promoter DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
REC primary , transfected with either c myc , H ras or cotransfected with c myc and H ras ( in ascending order of radioresistance and tumorigenicity ) , were used as an in vitro model system to determine if nuclear matrix mediated higher order DNA organization contributes to oncogene mediated radioresistance . ^^^ RESULTS : Induction and repair rates of DNA single and double strand breaks were similar for the relatively radiosensitive c myc transfected and the radioresistant c myc + H ras transfected cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
SPSF 1 and 2 binding sites are found in the minimal origin of replication of BPV 1 DNA and near the P 2 promoter of the cellular c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA repair was assessed in the essential gene dihydrofolate reductase ( DHFR ) as well as in each of its strands , in the proliferation inducible c myc gene and in the inactive delta globin gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of hepatoma cell apoptosis by c myc requires zinc and occurs in the absence of DNA fragmentation . ^^^ The requirement for zinc and absence of DNA fragmentation in c myc induced hepatoma cell apoptosis under serum free conditions provides further evidence of the complex regulation of apoptosis in different cell types . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot hybridization experiments show that pMC 540 treatment induces in situ DNA cleavage products in the 5 ' end of the c myc oncogene of L 1210 leukemia cells . ^^^ In cells pre treated with 50 microM ethidium bromide , an inhibitor of the Topo 2 dependent DNA cleavage , a subsequent treatment with pMC 540 failed to induce DNA cleavage , suggesting that the cleavage activity of pMC 540 was Topo 2 dependent . pMC 540 induced cleavage does not appear to correlate with the over expression of the c myc oncogene in these cells as another over expressed gene c myb was not affected . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer . ^^^ MYC family DNA amplification was present in 16 of 44 ( 36 % ) tumor cell lines established from previously treated patients compared to 7 of 52 ( 11 % ) of tumor cell lines established from untreated patients ( P = 0 . 009 ) . ^^^ MYC DNA amplification in tumor cell lines established from patients previously treated with chemotherapy continued to be associated with shortened survival ( P = 0 . 001 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Chromosomal translocations or DNA rearrangements affecting c myc occur in almost all murine plasmacytoma and human Burkitt ' s lymphoma tumors and are associated with a high incidence of exon 2 missense mutations and selective expression of the affected allele . ^^^ Each of these informative multiple myeloma cell lines selectively expresses only one c myc allele despite the apparent absence of chromosomal translocations or DNA rearrangements affecting c myc . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of DNA replication by transcription in the region upstream of the human c myc gene in a model replication system . ^^^ Relaxed circular DNA possessing a replication initiation zone located upstream of the human c myc gene and a T 7 promoter near the P 1 promoter of the gene was replicated in the presence of T 7 RNA polymerase . ^^^ DNA synthesis , which was dependent on both T 7 RNA polymerase and the replication proteins , was detected mainly in the promoter and upstream regions of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We investigated the effects of 1 , 25 ( OH ) 2D3 on nuclear protein binding to the c myc intron element ( MIE ) , a region of DNA within the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These data show that VES induces apoptosis in reticuloendotheliosis virus transformed lymphoid cells and suggest that decreases of c Myc protein and increases of c Jun protein and DNA binding capacity may be playing a role in VES mediated events leading to apoptosis in this cell type . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c myc / lacZ double transgenic mice . ^^^ The current study uses transgenic mice to examine hepatic HCA DNA adduct formation and mutagenesis in vivo and the impact of hepatic overexpression of the c myc oncogene on HCA induced mutagenesis . ^^^ DNA adduct studies showed that the levels of IQ and MeIQx DNA adducts were 2 3 fold higher in c myc / lacZ mice than in C57B1 / lacZ mice ; however , A alpha C DNA adducts were not statistically different between the two strains . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have also investigated the mechanism by which association with c Myc inhibits YY 1 ' s ability to regulate transcription . c Myc does not block binding of YY 1 to DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c Myc protein is involved in cell proliferation , differentiation and apoptosis though heterodimerization with Max to form a transcriptionally active sequence specific DNA binding complex . ^^^ Our results indicate that Myc Max heterodimers interact in vivo with a specific set of E box related DNA sequences and that Myc is likely to activate multiple target genes including a highly conserved DEAD box protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Therefore , we analyzed 20 serous tumors of LMP , 10 invasive serous ovarian carcinomas , and 7 benign serous cystadenomas by nonisotopic in situ hybridization ( seven different centromere specific probes ) as well as by flow and image DNA cytometry and compared the data with results of p 53 and Ki 67 immunohistochemistry , MYC DNA PCR analysis and with the clinical follow up . ^^^ There was no association between changes in the centromere signal number of chromosomes 8 and 17 and MYC DNA amplification and immunohistochemical p 53 accumulation , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A genomic alignment of the dimerization and DNA binding domains is presented for five genes of the c myc family , suggesting a hypothetical common ancestor gene . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In 32D abl cells , myc expression was found to be significantly higher than in the parental cells and was correlated with increased E2F 1 protein expression and DNA binding ability . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have previously determined that the amplified DNA present in the HL 60 promyelocytic leukaemia cell line contained 70 kb of continuous DNA sequences around the c myc gene . ^^^ In the work presented here we have further defined the HL 60 amplicon and find it to be of the order of 160 kb and to contain a large region of DNA from chromosome 8q24 that is located at least 260 kb telomeric to the c myc gene , joined to the 70 kb of DNA from the c myc gene region . ^^^ Both these chromosome 8 homologues retain a c myc gene as well as the region containing the coamplified DNA sequences indicating that the HL 60 amplicons were not generated by simple DNA deletion . ^^^ The constraint to maintain the novel DNA sequences coamplified with c myc gene DNA suggests that these sequences may play some role in maintaining the growth potential and / or differentiation capacity of the HL 60 cells . . ^^^ The amplicons in HL 60 cells contain novel cellular sequences linked to MYC locus DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have investigated by restriction fragment analysis genomic abnormalities involving the c myc gene in DNA isolated from adenomas and hepatocellular carcinomas ( HCCs ) . ^^^ Southern blot analysis of EcoRI restricted DNA from normal liver , early and late adenomas , 12 weeks ( EAs ) and 30 weeks ( LAs ) after initiation , and HCCs , showed 2 bands of 18 and 3 . 2 kb hybridizing with c myc , in all tissues . c myc amplification occurred in almost all HCCs , and in the majority of EAs and LAs . ^^^ These results were confirmed by dilution analysis . c myc amplification was also seen in adenomas and HCCs by Southern analysis with HindIII restricted DNA , and in HCCs by differential PCR . c myc mRNA increase occurred in all adenomas and HCCs , but it was higher in the lesions showing gene amplification . ^^^ Moreover , a 13 kb DNA extraband , hybridizing with c myc , was found in the HindIII restricted DNA from HCCs , but not in normal liver and adenomas , and a 7 . 1 kb extra band was present in EcoRI digested DNA from one LA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Current knowledge suggest that the change from normal mucosa to a small adenoma may be mediated by mutations of the APC gene and MCC gene on chromosome 5 , by chromosome 5 deletion , by c myc activation , and by DNA hypomethylation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Protein kinase C epsilon is necessary for erythropoietin ' s up regulation of c myc and for factor dependent DNA synthesis . ^^^ In the present study we demonstrate that up regulation of c myc requires the PKC epsilon isoform and that this pathway is required for erythropoietin induced DNA synthesis ( growth ) but apparently not for beta globin expression ( differentiation ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The inhibitors were found to suppress the phosphorylation of pRB , lead to the production of higher order E2F complexes , and suppress the expression of c myc and proliferating cell nuclear antigen ( PCNA ) to an extent that correlated with their ability to block DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Exposure to oxalate initiates DNA synthesis , induces the expression of one of the early growth response genes c myc and stimulates proliferation of quiescent cultures of LLC PK 1 cells . ^^^ Quiescent cultures of LLC PK 1 cells were exposed to oxalate in the presence and absence of c myc antisense and the effects of oxalate on c myc protein expression ( Myc ) , DNA synthesis and cell growth were assessed . ^^^ Further , pretreatment of cells with c myc antisense but not nonsense oligonucleotides blocked the oxalate induced initiation of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Furthermore , the cytotoxic effects of VCR and / or MXT had no correlation with c myc gene expression and DNA fragmentation was not observed . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Treatment with sodium arsenite resulted in a significant increase in cell proliferation , as indicated by increases in cell numbers , c myc gene expression , and incorporation of [ 3H ] thymidine into cellular DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
With this method , RNA is extracted from lymph node specimens and reverse transcribed to produce cDNA , which is then amplified using primers specific for c myc sequences that span introns , thus precluding amplification of genomic DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Of additional interest and again like Y box proteins , SSBP 1 is a member of a family of SSBPs that interact with RNA and are important in RNA processing , can interact with the promoter of retroviruses , and can interact with a gene linked to growth and DNA replication , c myc . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc acts through dimerization with Max to bind DNA and activate transcription . ^^^ Homologs of the myc and max genes were cloned from the fruit fly Drosophila melanogaster and their protein products ( dMyc and dMax ) were shown to heterodimerize , recognize the same DNA sequence as their vertebrate homologs , and activate transcription . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The activation was better executed when the c Myc binding element was positioned downstream to the promoter , which is the usual position of the c Myc DNA binding element in its genetic targets . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The THZif 1 protein bound specifically to the single stranded ( ss ) pyrimidine rich DNA of the NHE ( ss c myc NHE C ) with an apparent dissociation constant ( Kd ( app ) ) of 0 . 077 microM . ^^^ By contrast , no binding to the single stranded purine rich DNA of the NHE ( ss c myc NHE G ) was detected . ^^^ In the case of the binding of THZif 1 to methylated double stranded ( ds ) NHE ( ds c myc NHE me5CG ) , no significant binding to the DNA was observed . ^^^ The decrease in binding to DNA of THZif 1 was significant in the case of mutated ds c myc NHE , in which more than two sites of deoxycytidine residues were methylated . ^^^ Taken together , the results indicate that the THZif 1 protein exhibits preferential DNA binding activity with ss c myc NHE C , ds c myc NHE CG , and ts c myc NHE but not with ss c myc NHE G and ds c myc NHE me5CG in vitro . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The FBPs each bind sequence specifically to only one strand of the far upstream element ( FUSE ; originally identified upstream of c myc ) , and each possesses potent activation domains when fused to the GAL 4 DNA binding domain and assayed by transient transfection . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
CpG DNA rescue of murine B lymphoma cells from anti IgM induced growth arrest and programmed cell death is associated with increased expression of c myc and bcl xL . ^^^ CpG DNA reversed anti IgM induced down regulation of c myc expression in WEHI 231 and up regulated myn , bcl 2 , and bcl xL mRNA expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Marrow cells were permeabilized and CD34+ and CD 34 cells were separately analyzed by FACS to detect : ( 1 ) a subdiploid ( sub G 1 ) DNA population , and ( 2 ) expression of Bcl 2 and c Myc oncoproteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA ploidy and MYC DNA amplification in ovarian carcinomas . ^^^ There is increasing evidence that DNA ploidy is a prognostic factor in ovarian carcinomas , but it is uncertain whether MYC DNA amplification is an epiphenomenon of DNA nondiploidy or a distinct biological change with an impact on the clinical course of the disease . ^^^ To clarify these issues we analysed DNA ploidy by flow and image cytometry and MYC copy number by polymerase chain reaction in archival material from ovarian carcinomas with known follow up . ^^^ MYC DNA amplification was seen in 33 . 8 % ( 26 / 77 cases ) of ovarian carcinoma . ^^^ There was no correlation between MYC DNA amplification and histological tumour type , histological grade , FIGO stage , DNA ploidy , proliferative activity or prognosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The major types of genetic alterations in breast cancer are amplification of protooncogenes ( ERBB 2 and MYC ) and DNA from chromosome band 11q13 ; mutation of p 53 ; and loss of heterozygosity on 1p , 3p , 8p , 11p , 13q , 16q , 17p , 17q , 18q . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cognate T cell help for CD 40 deficient B cells induces c myc RNA expression , but DNA synthesis requires an additional signal through surface Ig . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Growth rescue by Myc required dimerization with Max , DNA binding and an intact transcriptional activation domain , as previously shown for cellular transformation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In order to study the status of DNA methylation of specific oncogenes and the relationship between them and the pathological changes in gastric carcinoma , we analysed the methylated status of c myc , c Ha ras oncogenes by Southern blot hybridization . ^^^ Specimens were digested by the restriction endonucleases MspI / HpaII , which are able to cleave between methylated and non methylated cytosine at their nucleotide recognition site the DNA 5 ' CCGG sequence , and were hybridized with c myc , c Ha ras oncogene probes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The number of MYC copies correlated with cellular DNA content , as determined by using flow cytometry . ^^^ In peridiploid tumors ( DNA index 0 . 9 1 . 2 ; n = 7 ) , the MYC copy numbers / nucleus were 0 2 in five cases and 3 5 in two cases . ^^^ In contrast , the modal MYC copy numbers / nucleus among the 11 hyperdiploid tumors ( DNA index 1 . 3 1 . 9 ) were 0 2 in one case , 3 5 in four cases , 6 9 in five cases , and > 9 in one case . ^^^ However , in most cases , MYC gene duplication is probably secondary to polysomy of chromosome 8 and / or genomic endoreduplication ( i . e . , DNA aneuploidy ) . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The small constitutively expressed bHLHZip protein Max is known to form sequence specific DNA binding heterodimers with members of both the Myc and Mad families of bHLHZip proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA digests were subjected to Southern analysis using a c DNA probe for one of the following genes : DNA methyltransferase ( DMT ) , c Ha ras , c jun , c fos , and c myc proto oncogenes , p 53 tumor suppressor gene or gamma glutamyltranspeptidase . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These chemicals differ from the direct acting mutagens tested previously . 5 Azacytidine , a potent DNA methylation inhibitor , induced growth of large colonies in soft agar cultures of Rat 6 or Rat 6 / c myc cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this study we employed primary culture of adult rat hepatocytes to verify the effects of two different extracellular matrices ( collagen , matrigel ) on EGF stimulated DNA synthesis and c myc expression . ^^^ Our results confirm that in adult rat hepatocytes EGF induces DNA synthesis , preceded by a transient increase of c myc expression , when cells are cultured at low density on collagen . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Tumour DNA samples isolated from 36 patients with renal clear cell carcinoma were investigated for c myc and K ras amplification , using a quantitative dot blot hybridization . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These c Myc short ( c Myc S ) proteins lack most of the N terminal transactivation domain but retain the C terminal protein dimerization and DNA binding domains . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the present study , we have taken two approaches to study the relationship between c Myc expression and the reinitiation of DNA synthesis . ^^^ First , low concentrations of bombesin , in the presence of insulin , stimulated DNA synthesis in Swiss 3T3 fibroblasts in the absence of a large increase in c myc mRNA or protein levels . ^^^ These results indicate that cells in the G 0 phase of the cell cycle can be stimulated to reinitiate DNA synthesis with only marginal increases in Myc protein expression . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using an extensive series of deletion and site specific mutation constructs , we have identified five new phosphorylation sites in c Myc in the N terminal transactivation domain and near the C terminal DNA binding / heterodimerization domain . ^^^ Finally , mutations at these phosphorylation sites , either individually or in combination with previously described sites , did not affect the ability of c Myc to transactivate through the CACGTG Myc / Max DNA binding sites . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Increases in cardiac myocyte cell number , DNA synthesis and total cellular protein were observed in cells transfected with either c myc or c fos expression vectors compared with cells transfected with non coding vectors . 4 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Abnormal c myc oncogene DNA methylation in human bladder cancer : possible role in tumor progression . ^^^ However , a variable covalent alteration of c myc DNA existed in bladder cancer as compared to normal tissue . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To evaluate the anti cancer effects of folic acid at the molecular level , we determined plasma folic acid concentration by radioimmuno assay and the degree of total genomic DNA methylation by incubating DNA with 3H S adenosylmethionine ( 3H SAM ) in the presence of a methylase , and analyzed the methylation status of the c myc and c Ha ras oncogenes by Southern blotting in 21 patients with advanced gastric cancer . ^^^ The degree of total genomic DNA methylation of cancerous tissues was significantly lower than that of paracancerous and non cancerous tissues ; c myc and c Ha ras oncogenes from cancerous ( 10 / 21 , 5 / 10 ) and paracancerous ( 13 / 21 , 4 / 10 ) tissues were hypomethylated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The exchange of the single Myc binding site in the AMLPE by the two E box DNA motifs ( CACGTG ) present in the Myc responsive element of a human Myc target gene ( ornithine decarboxylase ) in front of a promoter reporter gene cassette results in a two fold enhanced beta galactosidase expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Partial amino acid sequencing revealed that one of the RNA binding proteins coincides with FBP ( far upstream element binding protein ) , previously characterized as a protein that resembles hnRNP K and which binds to a single stranded , pyrimidine rich DNA sequence upstream of the c myc gene to activate its expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transgenic mice carrying the c myc oncogene under control of woodchuck hepatitis virus ( WHV ) DNA sequences invariably develop hepatocellular carcinoma ( HCC ) , despite a temporally limited expression of the transgene in the neonatal liver . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The results presented here indicate that in DBA / 2N cells , run on transcription from both DNA strands can be readily detected in the regions of c myc and Pvt 1 that were efficiently repaired . ^^^ This finding indicates that , in BALB / cAnPt lymphoblasts , DNA repair 5 ' to c myc and in Pvt 1 is decoupled from the RNA transcription machinery . ^^^ This defect may be responsible for the inability of normal BALB / cAnPt lymphoblasts to repair DNA sequences in the c myc 5 ' flank and the Pvt 1 gene , inducing gene specific instability that predisposes these loci to genetic accidents , including chromosomal translocation , retroviral integration and other mutations . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Furthermore , experiments with 32D temperature sensitive p 53 cells indicate that aberrant tal 1 expression at the permissive temperature does not exert a proliferative effect but causes p 53 mediated apoptosis , i . e . , the tal 1 proliferative effect depends on the integrity of the cell cycle checkpoints of the host cell , as observed for c myc and other oncogenes . tal 1 mutant experiments indicate that ectopic tal 1 effects are mediated by both the DNA binding and the heterodimerization domains , while the N terminally truncated tal 1 variant ( M 3 ) expressed in T ALL malignant cells mimics the effects of the wild type protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A peptide nucleic acid ( PNA ) complementary to a unique DNA sequence in the second exon of the human myc proto oncogene was tested for its effects on transcription in colonic adenocarcinoma cells in which myc had been amplified and rearranged . ^^^ DNA hybridization site , the extent of inhibition at each sequence depending on the duration of exposure to PNA , and the distance between the downstream myc sequence and the PNA block . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the present study , we have found that the inhibition of NO production in bovine endothelial cells by an L arginine competitive antagonist induces DNA replication and promotes the transition from prereplicative to replicative phases of the endothelial cell cycle and an increase in c myc and c fos oncogene encoded protein expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The human colonic cell line Caco 2 responds to a reduction of ambient [ Ca++ ] o to levels at and below 0 . 25 mM by a twofold increase in [ 3H ] thymidine labelling of their DNA . [ Ca++ ] o signals sensed preferentially across the luminal aspect of Caco 2 cells , are rapidly ( 4 h ) transduced via PKC activation into up to sixfold increases in c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The MYC primers targeted a DNA sequence of about 460 bp from all the 59 mycoides cluster strains tested . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
AMCA induced topoisomerase cleavage sites on pBR 322 , C MYC and SV 40 DNA were investigated using agarose or sequencing gels . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the life history of ovarian cancers the stage , histology , tumor grade , age of the patient and gene abnormalities , both oncogenes ( c myc , H ra , new ) and oncosuppressor genes ( p 53 , in particular ) , DNA ploidy and steroid receptor status have important prognostic significance . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In order to test differences in target gene recognition of c Myc / Max , Max and USF dimers , we compared the DNA binding characteristics of these proteins in vitro using vaccinia viruses expressing full length c Myc and Max proteins . ^^^ The optimal conditions for DNA binding by either c Myc / Max , Max or USF dimers differ with respect to ionic strength and Mg2+ ion concentration . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Extending our previous efforts to characterize ovarian neoplasms by interphase cytogenetics , we analyzed a series of 32 mucinous tumors by nonisotopic in situ hybridization with seven different centromere specific probes as well as by flow and image DNA cytometry ; we then compared the data with results of p 53 and Ki 67 immunohistochemistry and MYC DNA PCR analysis and of the clinical follow ups . ^^^ The interphase cytogenetic results correlated neither with proliferative activity , immunohistochemical p 53 accumulation , MYC DNA amplification , nor postoperative outcome . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The basic region of c Myc and other basic helix loop helix ( b HLH ) containing proteins bind to the palindromic DNA sequences CANNTG . ^^^ Highly conserved asparagine in the basic domain of Myc is dispensable for DNA binding , transformation , and apoptosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Northern blot analysis indicated that the c myc overexpression is concomitant to DRB induced DNA fragmentation and that the increased mp 53 protein level was mainly a posttranscriptional event . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Results to date suggest that Myc Max influences cell growth and proliferation through direct activation of genes involved in DNA synthesis , RNA metabolism and cell cycle progression . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To examine whether c Myc functions through the CACGTG elements , a DNA fragment of RCC 1 intron 4 , exon 5 and part of intron 5 was joined to firefly luciferase cDNA to construct a reporter plasmid . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Pur alpha has been identified as a single stranded DNA binding protein that specifically binds to the purine rich strand present in the DNA replication initiation zone of the human c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of the Myc oestrogen receptor fusion protein ( MycER ) by 4 OH tamoxifen ( OHT ) leads to the activation of Cyclin E / Cyclin dependent kinase 2 ( CycE / Cdk2 ) complexes followed by the induction of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Previously we identified three sequence elements in the human c myc gene that adopt the Z DNA conformation in the transcribed gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The study of HPV 16 viral gene showed that the existence of HPV 16 DNA sequence was positively associated with c myc gene amplification in cervical cancerous samples . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Isolation and analysis of cellular DNA fragments directly binding to c Myc protein . c Myc protein , the product of cellular oncogene c myc , is thought to play an important role in the control of cell cycle progression by binding to the E box sequence ( CACGTG ) of cellular DNA , but only a few target genes are known . ^^^ We cloned two small human DNA fragments ( n 16 and r 37 ) that bound to c Myc protein in vitro by random screening . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cellular targets for activation by c Myc include the DNA metabolism enzyme thymidine kinase . ^^^ We show that activation of Myc triggers high levels of this normally strictly S phase regulated DNA metabolism enzyme in serum arrested G 0 cells and causes high and constant levels of TK expression throughout the entire ongoing cell cycle . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This effect is not shared either by the other HBV products and it is c myc mediated , as shown by the use of a dominant negative deletion mutant of c myc . pX also sensitize cells to programmed cell death after exposure to DNA damaging agents . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Many nuclei that were associated with muscle fibers expressed the C Myc oncoprotein but did not incorporate bromodeoxyuridine , a marker of DNA synthesis and activated satellite cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , analysis of E box DNA binding revealed that , although Myc Max complexes were lost rapidly after differentiation induction , formation of Mad 1 containing complexes only occurred during the later stages of the differentiation programme . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Comprehensive analysis of the clinical and pathobiological features of all 58 known cases of HIV related BCBL shows it to be a unique B cell neoplasm with a strong propensity for body cavity involvement without mass lesions and with little or no dissemination , poor prognosis , high grade usually immunoblastic morphology , late B cell phenotype and genotype , no associated c myc gene rearrangement , frequent presence of Epstein Barr virus ( EBV ) genome , and uniform association with HHV 8 DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Amplification of c myc was associated with S phase ( P < . 0003 ) , abnormal DNA index ( P < . 003 ) , and a negative estrogen receptor status ( P < . 01 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The modulation of specific proto oncogenes like myc , ras and TNF alpha during exposure to filarial parasitic proteins reveal elevated levels of expression of ras and TNF alpha as early as 2 hours , implicating their involvement prior to DNA fragmentation leading to pathogenesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Northern analysis of c myc mRNA in synchronized untreated cultures showed a transient increase previous to DNA synthesis that was decreased with TNF treatment . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Species specific Il 2 induced intracellular signals in AtT 20 cells known to be mediated by Il 2R beta , including a transient increase in c myc nuclear proto oncogene transcription and the dose dependent induction of DNA replication as measured by [ 3H ] thymidine incorporation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mad proteins are transcriptional repressors that antagonize transcriptional activation and transformation by Myc oncoprotein ; recent findings suggest that they repress transcription by recruiting histone deacetylases to target sites on DNA . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Activation of c Myc uncouples DNA replication from activation of G 1 cyclin dependent kinases . ^^^ In contrast , Myc has no discernible effect on the cell size at which DNA replication is initiated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using this technique we report that the DNA binding activity of c Myc containing complexes is reduced during induced differentiation of U 937 monoblasts and F 9 embryonic teratocarcinoma cells . ^^^ In general , the DNA binding activity of c Myc and Mad 1 correlate with their expression . ^^^ Analysis of the DNA binding activities of Myc / Max / Mad network complexes during induced differentiation of U 937 monoblasts and F 9 teratocarcinoma cells . ^^^ The bHLHZip protein Max interacts with both the Myc and Mad family proteins forming heterodimers which specifically bind certain E box DNA recognition sequences , thereby regulating transcription . ^^^ Although the main regulation of this network seems to be the control of myc and mad family gene expression , regulation at the level of DNA binding and transactivation may also be in operation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Upstream stimulatory factors ( USF ) 1 and 2 belong to the Myc family of transcription factors characterized by a basic / helix loop helix / leucine zipper domain responsible for dimerization and DNA binding . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mammalian cell growth is governed by regulatory activities that include the products of genes such as c myc and ras that act early in G 1 , as well as the E2F family of transcription factors that accumulate later in G 1 to regulate the expression of genes involved in DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Previous studies from our laboratory provided evidence for the operation of signal transduction pathways involving ras , myc , and staurosporine sensitive protein kinases in the regulation of DNA replication in irradiated cells . ^^^ Because ras and myc are also involved in the signal transduction elicited in response to ligand activation of growth factor receptors , we wondered whether growth factor receptors are upstream elements in the regulation of DNA replication in irradiated cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Alterations of level of total genomic DNA methylation and pattern of c myc , c Ha ras oncogene methylation in human gastric carcinogenesis . ^^^ RESULTS : The results indicated that both c myc and c Ha ras oncogene fragments containing CCGG sequence were hypomethylated in DNA samples from cancerous ( 10 / 21 and 5 / 10 ) and paracancerous ( 13 / 21 and 4 / 10 ) areas . ^^^ CONCLUSION : These results supported a strong correlation between DNA hypomethylation and gastric carcinogenesis , particularly methylated pattern of c myc and c Ha ras oncogenes fragments containing CCGG sequence was abnormal in gastric mucosa tissue from gastric cancerous and paracancerous areas . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of DNA methylation pattern of c myc oncogene in hepatocellular carcinoma ] . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Synthetic 15 mer directed at the region of the translational initiation site of c Ha ras , c myc proto oncogene ( ASO r , ASO m ) greatly inhibited the proliferation and DNA synthesis of T 24 cell line , inhibited the expression of rasp 21 , mycp 62 protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To evaluate both the incidence of c myc gene mutation and the relationship of this finding to the clinico pathologic characteristics of patients with cervical cancer , a polymerase chain reaction ( PCR ) based heteroduplex gel electrophoresis method was used to screen DNA extracted from 102 cervical invasive carcinomas referred to the Department of Obstetrics and Gynaecology , The Chinese University of Hong Kong . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA dependent protein kinase ( DNA PK ) has been known to catalyze phosphorylation of a number of regulatory factors involved in DNA replication and transcription such as simian virus 40 T antigen , p 53 , c Myc , Sp 1 , and RNA polymerase 2 ( Pol 2 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA from this phase was used for comparative genomic hybridization ( CGH ) analysis , confirming a previously known MYC amplification , and the integration sites were subsequently determined by single locus fluorescence in situ hybridization ( FISH ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , an electrophoretic mobility shift assay ( EMSA ) with ME1a1 DNA as probe demonstrated that the kinetics of the DNA binding activity of MAZ were closely correlated with the changes in the expression of CAT from the c myc promoter / CAT gene during the differentiation of P19EC cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A DNA binding element for a steroid receptor binding factor is flanked by dual nuclear matrix DNA attachment sites in the c myc gene promoter . ^^^ This paper describes the use of Southwestern blot and DNA gel shift analyses with RBF protein to identify a minimal 54 base pair RBF binding element in the matrix associated region ( MAR ) of the Pg regulated c myc gene promoter . ^^^ Southern blot analyses using nuclear matrix DNA suggests that there are dual MAR sites in the c myc promoter , which flank an intervening domain containing the RBF element . ^^^ These data suggest that a unique chromatin / nuclear matrix structure , composed of the RBF DNA element complex which is flanked by nuclear matrix attachment sites , serves to bind the PR and repress the c myc promoter . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA conformation , topology , and the regulation of c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
For these six informative lines ( and the corresponding tumor for one line ) there is selective expression of one c myc allele despite the apparent absence of translocation , DNA rearrangement , or amplification involving c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc gene encodes a sequence specific DNA binding protein involved in proliferation and oncogenesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We had delineated three subgroups of tumors showing distinct DNA amplification profiles and clinicopathological characteristics : group A , tumors showing amplification at 11q13 and / or 8p12 and / or 20q13 ; group B , tumors amplified at ERBB 2 and / or MYC and / or MDM2 / SAS ; and group C , tumors with no detectable amplification . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
No abnormalities of the c myc gene could be detected on the DNA level . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Conventional PCR was firstly applied to detect the chromosomal activities of several known ( origins associated with c myc , hsp 70 , beta globin , immunoglobulin mu chain enhancer ) and putative DNA replication origins ( autonomously replicating sequences obtained from enriched libraries of human origins of DNA replication from normal and transformed cells ) in four human cell lines ( HeLa , NSF , WI 38 and SK MG 1 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
One molar equivalent of A Max can totally abolish the DNA binding activity of a Myc : Max heterodimer . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The four major groups of transcription factors have been classified according to the motif in the DNA binding domains and include : ( 1 ) the helix turn helix group , which includes the Pit 1 / GHF 1 ( Pit 1 ) transcription factor ; ( 2 ) the zing finger group , which includes estrogen and other steroid hormone receptors ; ( 3 ) the leucine zipper group , which includes c fos protooncogene , and ( 4 ) the helix loop helix group , which includes the c myc oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Previous experiments established that a 67 bp DNA fragment of the rd 22 promoter is sufficient for dehydration and ABA induced gene expression and that this DNA fragment contains two closely located putative recognition sites for the basic helix loop helix protein MYC and one putative recognition site for MYB . ^^^ A cDNA encoding a MYC related DNA binding protein was isolated by DNA ligand binding screening , using the 67 bp region as a probe , and designated rd22BP1 . ^^^ The rd22BP1 cDNA encodes a 68 kD protein that has a typical DNA binding domain of a basic region helix loop helix leucine zipper motif in MYC related transcription factors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
SP receptor activation stimulates the mitogen activated protein ( MAP ) kinase pathway and the expression of immediate early genes ( e . g . , c Fos and c Myc ) , resulting in an increase in DNA synthesis in human astrocytoma U 373 MG cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
While both p 53 and c myc may be linked to the DNA damage response pathway , neither p 53 nor c myc are essential for growth arrest in response to ionizing radiation . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Bilateral kidneys were harvested for DNA electrophoresis , Western analysis for p 53 , Northern analysis for c myc expression , and light and electron microscopic analysis . ^^^ Verapamil pretreatment completely abolished DNA laddering and attenuated the microscopic evidence of apoptosis . p 53 levels were increased by I / R in the ischemic kidney and moderately increased in the contralateral organ . c myc mRNA levels were increased by the I / R insult . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Effect of hypoxia on DNA synthesis and c myc gene expression of pulmonary artery smooth muscle cells . ^^^ The present study was undertaken to observe the effect of hypoxia on DNA synthesis and c myc gene expression between newborn calf and adult bovine PASMC in vitro . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequence analysis of the t ( 12 ; 15 ) in five primary tumors revealed the co existence of precursor cells harboring genetic recombinations between the immunoglobulin heavy chain mu locus ( Igh mu ) and c myc with clonally related progenitors containing rearrangements between the immunoglobulin heavy chain alpha locus ( Igh alpha ) and c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have recently shown that overexpression of c myc and transforming growth factor alpha ( TGF alpha ) in the liver of double transgenic mice results in severe DNA damage , aberrant hepatic growth , and development of tumors at a much younger age than that observed in c myc single transgenic mice . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cyclin E / Ha ras transformed cells are highly tumorigenic in synergeneic rats , are able to form colonies in soft agar and show protection towards apoptosis upon serum starvation or DNA damage compared to cells transformed by the combination of Myc , cyclin D 1 or SV 40 large T antigen and Ha ras . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This protein is a known regulator of c myc and lysozyme gene expression , and it binds to a variety of diverse DNA sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The E2F element is a cis acting DNA sequence within the P 2 promoter of c myc proto oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inhibition of the proliferative effect of transforming growth factor alpha by c myc antisense DNA in human ovarian cancer cells . ^^^ Prior exposure of NIH : OVCAR 3 cells to an antisense myc OPT inhibited TGF alpha stimulated cell growth and DNA synthesis in a dose dependent and sequence specific manner over 4 days . c Myc protein expression was down regulated in the antisense myc treated cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Pretreatment of REF 52 cells with a low concentration of PALA , which slows DNA replication but does not trigger cell cycle arrest , followed by exposure to a high , selective concentration of PALA , promotes the formation of PALA resistant cells in which the physically linked cad and endogenous N myc genes are coamplified . ^^^ However , after DNA is damaged , the activated p 53 executes rapid apoptosis in these REF52 / N myc cells instead of the long term protective arrest seen in REF 52 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
RESULTS : Time and dose dependent decreases in DNA synthesis and cell viability were noted for all three prostate cancer cell lines after c myc As ODN treatment . ^^^ Further studies using LNCaP cells indicated that these changes were accompanied by an increase in the percentage of cells with less than 2N DNA content after c myc As ODN treatment . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MYC family genes were studied at the DNA , RNA , and protein level . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This clone contains a COX 3 mitochondrial DNA insert and two exons of human c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In vitro treatment of HL 60 or K 562 leukaemic cells with 100 microliters DFX also induced a rapid decrease in c myc mRNA and protein levels , followed by apoptosis and inhibition of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
CDDP and IL 1 treatment decreased the steady state expression of c myc RNA and induced significant degradation of the genomic DNA into internucleosomal sized DNA fragments which was further increased in the presence of both agents in these cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Furthermore , the integration and amplification site of human papillomavirus 16 DNA in the ASCC ( argyrophil small cell carcinoma ) cells were shown not to coincide with FRA8E , but to be involved in an extensively broad genomic region of 8q24 . 1 , including the c myc gene . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We demonstrate that these diets increase thymidine incorporation into DNA and net DNA content in renal tissue , and induce expression of the mRNA for the proto oncogene , c myc , and the histone , H2b . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Repair of ionizing radiation induced DNA double strand breaks ( dsb ) at the c myc locus in comparison to the overall genome . ^^^ MATERIALS AND METHODS : Pulsed field gel electrophoresis was performed on Sfi 1 restriction enzyme digested DNA , labelled with a c myc probe and on non specifically 14C labelled DNA of the adenocarcinoma cell line COLO320HSR after 400 Gy irradiation with 7 MeV electrons and repair incubation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA tetraplex formation in the control region of c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cytotoxicity was assayed by inhibition of [ 3H methyl ] thymidine uptake into DNA of Balb / c 3T3 and / or Myc 9E fibroblasts ( normal Balb / c 3T3 cells over expressing the c myc proto oncogene ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The NO effect on Oct 1 has some specificity ; as the NO donors had no effect on myc DNA binding activity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Identification and characterization of specific DNA binding complexes containing members of the Myc / Max / Mad network of transcriptional regulators . ^^^ In the past , eukaryotic cell derived complexes of the Myc / Max / Mad network of transcriptional regulators have largely been refractory to DNA binding studies . ^^^ We have developed electrophoretic mobility shift assay conditions to measure specific DNA binding of Myc / Max / Mad network complexes using a COS 7 cell based overexpression system . ^^^ Whereas the DNA binding activity of c Myc / Max complexes was down regulated , Max / Max binding increased , and Mnt / Max binding remained unchanged . ^^^ Our findings establish conditions for the analysis of DNA binding of Myc / Max / Mad complexes and indicate posttranslational regulation of the Max / Max complex . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Herein , the effects of SPC on DNA binding activity and transcription of the basic , helix loop helix , leucine zipper ( bHLH ZIP ) proteins Myc , Max , and USF were investigated because they regulate genes involved in mitogenesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The transactivation potential of Nm 23 H1 , a homolog of c myc transcription factor Nm 23 H2 / PuF was assessed in yeast as a fusion protein with the DNA binding domains ( DBDs ) of GAL 4 and LexA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Accelerated proliferative senescence of rat embryo fibroblasts after stable transfection of multiple copies of the c Myc DNA binding sequence . ^^^ In view of the role of c Myc as a transcription factor , most of these effects may be mediated via its binding to specific DNA sequences . ^^^ Here we studied the cellular reactions after manipulating the cellular concentration of c Myc DNA binding sites . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of DNA damage , inhibition of DNA synthesis and suppression of c myc expression by the anthracycline analog , idarubicin ( 4 demethoxy daunorubicin ) in the MCF 7 breast tumor cell line . ^^^ METHODS : Growth inhibition was evaluated using the MTT tetrazolium dye assay , induction of DNA strand breaks was determined by alkaline elution , inhibition of DNA synthesis was assessed by measuring the incorporation of labelled thymidine into DNA , modulation of the expression of the c myc oncogene was determined by Northern blotting and the induction of apoptosis was evaluated by alkaline unwinding , static field gel electrophoresis , terminal end labelling and assessment of cell morphology . ^^^ While DNA strand breakage was not evident below a concentration of 0 . 1 microM idarubicin , where growth inhibition exceeded 70 % , both the inhibition of DNA synthesis and suppression of c myc expression closely paralleled the profile of antiproliferative activity for idarubicin . ^^^ CONCLUSIONS : The results of these studies extend previous results from this laboratory indicating an association between suppression of c myc expression , inhibition of DNA synthesis and growth arrest by topoisomerase 2 inhibitors , as well as the lack of induction of apoptotic cell death by topoisomerase 2 inhibitors in MCF 7 breast tumor cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In vitro , Mmip 1 can inhibit DNA binding by Max Mad heterodimers and , in vivo , can reverse the suppressive effects of Mad proteins on c myc functions . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The repair of gamma ray induced DNA single strand breaks in transcribed ( protooncogene c myc ) and non transcribed ( human satellite 3 ) DNA of normal human fibroblasts and fibroblasts obtained from a patient with Cockayne ' s syndrome ( CS ) has been investigated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southern blot hybridization of DNA samples from 9 primary tumors of avian lymphoid leukosis ( LL ) rapidly induced by ALV infection 27 74 days post inoculation was carried out to search for rearrangement of the c myc gene with human c myc gene exon 3 as a probe . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The results reported here unambiguously revealed that the phosphatidic acid ( generated through the activation of Receptor Ck by cholesterol ) regulates mevalonate pathway , DNA synthesis as well as expression of genes coding for c fos , c myc and cyclin ' D ' . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The stomach cancer cell line , SNU 16 , in which c Myc expression is high due to gene amplification , showed programmed cell death detected by DNA fragmentation and morphological changes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Repair of cyclobutane pyrimidine dimers ( CPDs ) was measured in the transcriptionally active uracil DNA glycosylase ( UNG ) and c MYC loci . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inhibition of IkappaB degradation blocked CpG DNA induced NFkappaB activation and expression of c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The 5 ' flanking region does not contain a typical TATA box or the initiation consensus sequence , but it contains a CCAAT box , E boxes , and several DNA binding motifs such as c Myc , c Myb , and c Ets . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Gel shift assay and Southwestern blotting indicated that a nuclear protein factor specifically interacts with single or double strand DNA including this sequence , and the protein factor displays a highly potent binding to the sense strand DNA . cDNA cloning and gel shift analysis using anti MSSP 1 antibodies revealed that this protein factor is a chicken homolog of human MSSP 1 ( c myc gene single strand binding protein 1 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Constructs with the DNA for the c Myc epitope or for the green fluorescent protein indicate that RdeA is not compartmentalized . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have cloned one such MYC regulatory factor , termed CTCF , which is a highly evolutionarily conserved 11 zinc finger transcriptional factor possessing multiple DNA sequence specificity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
LD PCR can amplify up to 12 kb of DNA encompassing the c MYC and constant regions of the immunoglobulin heavy chain gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Conservation and continuity of periodic bent DNA in genomic rearrangements between the c myc and immunoglobulin heavy chain mu loci . ^^^ Periodic bent DNA was mapped in the human c myc and immunoglobulin heavy chain mu ( Ig mu ) loci . ^^^ A total of 12 DNA bend sites in the c myc gene and 11 sites in the Ig mu locus were aligned at average intervals of 694 . 2 + / 281 . 4 and 654 . 5 + / 222 . 7 bp respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The genes examined were dihydrofolate reductase ( DHFR ) and c myc , as well as total mitochondrial DNA ( mt DNA ) . ^^^ Although [ 3H ] thymidine incorporation , DNA polymerase alpha activity , total cellular DNA , DHFR , and c myc gene specific DNA replication stimulated by EGF are reduced with age , mt DNA replication is not affected by either EGF or age . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We isolated genomic DNA containing the entire sequence of ZF 5 , which was originally identified by its ability to repress the mouse c myc promoter and which was characterized as one of the POZ ( Poxvirus and zinc finger ) proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This antagonism relates partly to their ability to compete with Myc for the protein Max and for consensus DNA binding sites and to recruit transcriptional co repressors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In previous studies we have demonstrated that transforming growth factor ( TGF ) alpha / c myc double transgenic mice exhibit an enhanced rate of cell proliferation , accumulate extensive DNA damage , and develop multiple liver tumors between 4 and 8 months of age . ^^^ This phenomenon may account for the massive DNA damage and acceleration of hepatocarcinogenesis observed in the TGF alpha / c myc mouse model . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have also used the technique of PCR stop assay to detect the occurrence of DNA breaks within the P 2 promoter of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
C myc AS ODN effect on cell proliferation was estimated by evaluating the incorporation of 5 bromo 2 ' deoxy uridine into cellular DNA . ^^^ C myc AS ODN effect on cell proliferation was estimated by evaluating the incorporation of 5 bromo 2 ' deoxy uridine into cellular DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Two periods of the c myc gene activation were found by RNA DNA hybridization blotting during the first 12 h after the injection of CHI with the maxima at 3 4 and 9 10 h . ^^^ The NM associated chromatin was also found by DNA DNA hybridization blotting to have two periods of an increase in the amount of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS : The possibility of induction of apoptosis in human ovarian cancer cell line HO 8910 cells after treatment with TGF beta 1 was studied by using methods of DNA electrophoresis , P 1 staining , TdT mediated dUTP 10 nick end labeling and flow cytometer assay ( FCM ) ; and the kinetic change of expression of c myc was also studied by relative quantified RT PCR . ^^^ The typical apoptotic DNA ladder was present in genomic DNA preparation after treatment with TGF beta 1 for 60 hours , meanwhile , the expression of c myc in cells started to decrease beginning at treatment for 9 hours . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The myeloid leukemic cell line HL 60 was studied by using DNA gel electrophoresis , flow cytomery , McAb C myc , McAb Bcl 2 and CFU L . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In JD 40 and ST 486 cells , the amplified c myc sequences were found on high molecular weight chromosomes ST 486 cells also contained translocated C myc sequences in low molecular weight , extrachromosomal DNA , as did CA 46 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results suggest a correlation between Fos expression and the mitogen activated protein kinase pathway with initiation of DNA synthesis and a correlation between high levels of Myc mRNA and Src kinase activity with the regulation of cell migration . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
C myc gene amplification has been analysed in colorectal carcinomas by means of an innovative DNA fingerprinting method based on the arbitrarily primed PCR . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A cis element of the human c myc gene , known to be melted in vivo , and its associated single strand DNA binding protein were examined and found to comprise just such a protein DNA hinge . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Fluorescence in situ hybridization analysis with the yeast artificial chromosome ( YAC ) clone I 2 containing the C MYC gene at 8q24 and the chromosome 22 specific DNA library pBS 22 revealed that 12 was located on the der ( 8 ) t ( 8 ; 22 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MXI 1 encodes a basic helix loop helix protein that suppresses the transcriptional activity of the MYC oncoprotein by competing for the common dimerization partner , MAX , and binding to identical DNA sites . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The myc proto oncogenes are transcription factors that directly regulate the expression of other genes , by binding to the specific DNA sequence , CACGTG . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The oncoprotein c Myc ( a member of the helix loop helix leucine zipper ( b HLH LZ ) family of transcription factors ) must heterodimerize with the b HLH LZ Max protein to bind DNA and activate transcription . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
For instance , we found in the DNA of control cells from one patient five consecutive microsatellites on 9p up to 9p43 which were homozygous and in three other patients homozygosity was observed in band 8q24 , which includes the MYC gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Rearrangements of the sequence 5 ' to the c myc gene were examined by amplifying the region using inverse PCR followed by DNA sequencing . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
YY 1 can inhibit c Myc function through a mechanism requiring DNA binding of YY 1 but neither its transactivation domain nor direct interaction with c Myc . ^^^ The region in YY 1 required for inhibition corresponds to a functional DNA binding domain and is distinct from the domains necessary for direct binding to c Myc . ^^^ Furthermore the transactivation domain of YY 1 was not necessary suggesting that gene regulation by YY 1 , for example through DNA bending or displacement of regulators from DNA , could be the cause for the negative regulation of c Myc . ^^^ In addition YY 1 did not alter c Myc / Max DNA binding , further supporting an indirect mode of action . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
For 7 consecutive days , beginning 1 day after tumor cell transplantation , the mice were given either a DNA phosphorothioate oligonucleotide complementary to c myc codons 1 5 ( myc 6 ) or other c myc related oligonucleotides at a dose of 0 . 76 mg per day subcutaneously . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Two DNA constructs were used , one containing the Growth hormone ( GH ) gene and the other the c myc oncogene linked to the alphaA crystallin promoter ( CPV 1 plasmid ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of DNA damage , inhibition of DNA synthesis , and suppression of c myc expression by the topoisomerase 1 inhibitor , camptothecin , in MCF 7 human breast tumor cells . ^^^ These findings suggested that suppression of c myc expression could be related to the induction of DNA damage in this cell line . ^^^ The present studies were designed to determine whether the inhibition of topoisomerase 1 ( and the consequent induction of DNA strand breaks ) would also result in the suppression of c myc expression . ^^^ At camptothecin concentrations of 1 microM and below , there was no detectable damage ( single or double strand breaks ) in bulk DNA or suppression of c myc expression . ^^^ At camptothecin concentrations of 5 , 10 , and 25 microM , where suppression of c myc expression was observed , strand breaks in bulk DNA were also detected . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Subsequent Southern blot analysis of tumor DNA from the metastasis with the use of probes previously mapped to those regions indicated amplification of MYC at 8q23 24 and CDK 4 and MDM 2 at 12q13 15 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Fifty one meningiomas of diverse histological subtypes and grades were investigated with in situ end labelling of DNA fragments as well as immunohistochemical analysis of three apoptosis related genes : p 53 , bcl 2 and c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MSSP gene 2 encodes at least three alternative splicing products , MSSP 1 , MSSP 2 , and Scr 2 , which have been implied to function as factors regulating DNA replication , transcription , apoptosis induction , and cell cycle movement , via the interaction with C MYC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Extracted DNA was examined by Southern blot using probes corresponding to the EGFR , CDK 4 , MDM 2 , n MYC , CYCD 1 , PDGFR alpha , MET , c MYC oncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The SKY revealed that the DNA sequences of dmin are derived from materials of chromosome 8 , and CGH showed a high degree of overrepresentation only at 8q22 24 , indicating that in KY 821 only chromosomal material of 8q22 24 , containing MYC , is amplified in dmin . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Differential apoptotic behaviors of c myc , N myc , and L myc oncoproteins . c , N , and L myc are related nuclear oncoproteins that bind similar DNA sites and cooperate with activated ras oncogenes to transform primary fibroblasts . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inhibition of AP 1 and C / EBP binding and in the expression of c jun and c myc mRNA in the first 4 hours after PH , as well as the apparent lack of Fos in AP 1 complexes , had no effect on the timing or extent of DNA replication . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Gene amplifications of c myc , K sam , and c met were examined in cancer nuclei isolated from 154 primary gastric adenocarcinomas by fluorescence in situ hybridization ( FISH ) using cosmid probes for 8q24 ( c myc locus ) and 7q31 ( c met ) , as well as a DNA probe for K sam synthesized by PCR . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
By kinetic analysis , transient activation of c myc transcript by cadmium occurred before DNA fragmentation was induced by the metal , indicating an apparent correlation between induction of c myc mRNA and promotion of apoptosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Southwestern blotting ( DNA protein hybridization ) was applied to studying the anchoring of c myc on the nuclear matrix proteins in mouse thymic T lymphocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS : In the present study , using the human monoblastic cell line ( U 937 ) and human promyelocytic cell line ( HL 60 ) as an in vitro model , we analyzed the effect of two cytokins on proliferation inhibition with rate of 3H TdR incorporation , the cellular content of DNA , DNA indices , the cell cycle and the expression of c myc mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
By Southern blot hybridization , no change was detectable for c abl , c ras , c mos , and c myc protooncogenes in the chromosomal DNA of J 2 23 , J 3 27 , J 3 28 Clone 1 , and J 5 cell lines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These apoptotic effects of CDK 2 or CDK 3 are not accompanied by alterations of proliferation parameters , such as DNA distribution , time the cells spend in each phase of the cell cycle , thymidine incorporation into DNA , or cell size analyzed during Myc induced apoptosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Gel retardation analysis and experiments with reporter plasmids constructed from a DNA fragment of the RCC 1 gene indicated that the N Myc protein controls expression of RCC 1 by binding directly to CACGTG elements in the RCC 1 gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Expression of many mammalian genes is activated by the binding of heterodimers of the Myc and Max proteins to specific DNA sequences called the E boxes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Oxaliplatin at 200 microM induced approximately 1300 , approximately 1500 , approximately 800 , and approximately 300 lesions / 10 ( 6 ) bp in the human beta globin , c myc , and HPRT genes and in mitochondrial DNA , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Max heterodimers bound to their consensus DNA sequence were undetectable in cells treated with all trans retinoic acid and interferon alpha , indicating diminished c Myc functionality . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , the degree of c myc mRNA expression was similar after EE administration and PH , but the time course was different : c myc gene expression rose concomitantly with DNA replication after EE , while after PH it increased during the prereplicative phase . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Extra copies of myc , ccndl and erbB 2 were observed in 10 , 23 and 15 % , respectively , of 108 breast tumor DNA ; the largest observed numbers of gene copies were 4 . 6 , 18 . 6 and 15 . 1 , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Polymerase chain reaction ( PCR ) amplification of size fractionated nascent chromosomal DNAs revealed multiple replication initiation sites over a 12 kb region spanning the c myc origin , including the transcribed region and the 5 ' and 3 ' flanking DNA of the gene . ^^^ When a plasmid containing the 2 . 4 kb ARS region was transfected into HeLa cells , PCR mapping of nascent plasmid DNA confirmed that the plasmid replicated semiconservatively and autonomously and that replication did not initiate at random sites but rather began at multiple sites in a limited zone overlapping the c myc DNA insert . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc suppresses induction of the growth arrest genes gadd 34 , gadd 45 , and gadd 153 by DNA damaging agents . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Thus , our data analyzing both DNA binding and promoter activity in intact cells suggest that cad is a Myc target gene . ^^^ Our data indicate that a post DNA binding mechanism determines Myc target gene specificity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Genetic instability was studied by analyzing nine genetic abnormalities among those most frequently observed in breast tumor DNA , including amplification of proto oncogenes MYC and ERBB 2 and chromosome regions 7p , 11q13 , and 20q13 , and loss of heterozygosity on chromosome arms 1p , 3p , 7p , 7q , and 11p . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Design and properties of a Myc derivative that efficiently homodimerizes . bHLH and bHLHZip are highly conserved structural domains mediating DNA binding and specific protein protein interactions . ^^^ Omomyc sequestered Myc in complexes with low DNA binding efficiency , preventing binding to Max and inhibiting Myc transcriptional activator function . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hep3B cells treated with PGA2 / Delta12 PGJ 2 showed that a time dependent DNA fragmentation characterized by marked apoptosis and the elevation of c myc mRNA expression . ^^^ The transfection of c myc antisense oligomers in Hep3B cells significantly delayed the induction of HSP 70 expression and blocked formation of DNA fragmentation by PGA2 / Delta12 PGJ 2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When purified genomic DNA was treated with HN 2 in vitro , no significant difference in the extent of N alkyl purine or interstrand crosslink formation in the N ras , c myc or CD3delta genes was observed . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
RESULTS : The results showed that the hypomethylation rates of c myc and c N ras oncogenes were 30 % and 61 % respectively in human hepatocellular carcinoma , coinciding with a decreased level of global DNA methylation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequencing revealed that 15 of the 18 cDNA clones produced matches with the database for genes related to cell growth , protein synthesis , energy metabolism , oxidative stress or apoptosis ( including MYC , neuroleukin , copper zinc dependent superoxide dismutase , TC 4 RAS like protein , peptide elongation factor 1alpha , BNIP 3 , GATA 3 , NF 45 , cytochrome c oxidase 2 and triosephosphate isomerase mRNAs ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The major amplicon present in HL 60 cells is chimeric in nature being composed of 70 kb of DNA sequence derived from the MYC locus linked to 80 kb of novel DNA sequence derived from a non contiguous region located telomeric to the c myc gene at 8q24 ( Feo et al . , 1996 ) . ^^^ Analysis of the DNA sequences at the juncture of the MYC locus and the MCR suggest that these non syntenic regions were joined by nonhomologous recombination events . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It has been reported that HNE inhibits DNA synthesis , ornithine decarboxylase ( ODC ) activity and c myc expression in different leukemic cells lines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Interleukin 7 ( IL 7 ) and IL 15 , which have been identified as growth factors for CTCL cells , stimulated the DNA binding of JunD and two novel c Myc recognition site ( E box ) binding proteins , but not the DNA binding of c Myc / Max heterodimers . . ^^^ Constitutive and interleukin 7 / interleukin 15 stimulated DNA binding of Myc , Jun , and novel Myc like proteins in cutaneous T cell lymphoma cells . ^^^ We determined the composition of the jun and myc DNA binding complexes in three CTCL cell lines and malignant cells of seven Szary patients by electrophoretic mobility shift assays ( EMSAs ) and `` supershift ' ' assays in which specific antibodies against the different members of the tested gene families were included in the binding reactions . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The basic region / helix loop helix / leucine zipper ( B HLH LZ ) oncoprotein c Myc is abundant in proliferating cells and forms heterodimers with Max protein that bind to E box sites in DNA and stimulate genes required for proliferation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Results showed that 1 ) there was a significant increase in anchorage independent growth of all five types of foci ranging from 7 12 % ; 2 ) all five morphological types of transformed foci showed 8 15 % focal reconstruction ; 3 ) DNA from all five types of transformed foci induced transformation in NIH 3T3 cells at a level significantly above the control DNA ; 4 ) gene amplification studies indicated amplification in both K ras and H ras proto oncogenes ; however , c fos , c jun , and c myc did not show DNA amplification . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To investigate the potential clinical relevance of the amplification of the oncogenes c erbB 2 , c myc , and int 2 and the mutation of K ras in endometrial cancer , 112 tumors were examined using PCR based fluorescent DNA technology . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
PAF 400 is almost identical to TRRAP , which binds to c Myc and E2F , and has significant sequence similarities to the ATM superfamily including FRAP , ATM , ATR , and the catalytic subunit of DNA PK . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The inserted foreign DNA ( lambda gt10LacZ shuttle vector and / or pSVc myc plasmid ) was located at the middle of the long arms of chromosome 2 ( lambda DNA ) and / or chromosome 8 ( c myc ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
KS Y 1 cells transfected with a c Myc complementary DNA showed elevated rates of apoptosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In situ DNA fragment labelling and immunocytochemical analysis of these tumours reveals that they display enhanced levels of apoptosis , which is associated with elevated levels of Myc , Fos , Jun , and p 53 protein expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using the mitogen activated protein kinase kinase ( MEK1 / 2 ) inhibitor PD 98059 and dominant negative forms of Ras ( N 17 ) and ERK 1 ( K71R ) , we found that activation of Ras and extracellular signal regulated kinase ( ERK ) is necessary for colony stimulating factor 1 ( CSF 1 ) mediated c Myc expression and DNA synthetic ( S ) phase entry . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA was digested with MspI plus EcoRI or HpaII plus EcoRI and hybridised with a probe specific for the third exon of MYC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The alteration in IL 2 signaling included decreased tyrosine phosphorylation and DNA binding activity of STAT 5 and poor induction of the c Myc and c Jun pathways . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Twenty four formalin fixed , paraffin embedded IMTs for which clinical outcome was known were evaluated for cellularity , cytologic atypia , mitoses , ganglion like cells , inflammatory infiltrate , DNA ploidy by flow cytometric examination , and bax , bcl 2 , p 53 , and c myc expression by immunohistochemical analysis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Large T antigen ( LT ) expressed by the oncogenic DNA virus SV 40 transforms cells by interacting with and perturbing the normal function of several important cellular proteins including P 53 , RB , c MYC , and AP 2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Wild type BRCA 1 protein binds to a number of cellular proteins , including DNA repair protein Rad 51 , tumor suppressor p 53 , RNA polymerase 2 holoenzyme , RNA helicase A , CtBP interacting protein , c myc , BRCA 1 associated RING domain protein ( BARD 1 ) , BRCA 2 protein , etc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Since the apoptotic sensitivity of many cells is influenced by the status of the p 53 tumor suppressor gene , we investigated whether the induction of apoptosis by DNA damage or non genotoxic stress are also influenced by the p 53 status of cells with altered c Myc activity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We also compared levels of c and N myc oncogene expression and DNA copy number . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Effects of EGF and TGFbeta 1 on c myc gene expression and DNA synthesis in embryonic hamster palate mesenchymal cells . ^^^ The present study was undertaken to examine the effect of EGF , TGFbeta 1 and their combination on proliferation ( measured by DNA synthesis ) and on the expression of a growth related proto oncogene , c myc , in embryonic hamster palate mesenchymal cells ( HPMC ) . ^^^ It appears that EGF induced expression of c myc may be involved in advancing the HPMC in G 1 , and thus may contribute to the onset of DNA synthesis in HPMC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , cyclosporin A not only inhibits nuclear import of HIV 1 DNA but also inhibits expression of c Myc protein . ^^^ Because of these correlations , we tested whether c Myc is necessary for nuclear import of HIV 1 DNA . ^^^ Thus , c Myc appears to regulate HIV 1 DNA nuclear import via a mechanism distinct from those controlling entry into the cell cycle . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Differential effects of the widely expressed dMax splice variant of Max on E box vs initiator element mediated regulation by c Myc . dMax , a naturally occurring splice variant of the Myc binding protein Max , lacks the DNA binding basic region and helix 1 of the Helix Loop Helix domain ; dMax interacts with c Myc in vitro and in vivo , and inhibits E box Myc site driven transcription in transient transfection assays . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Further culturing of the cells in the presence of vitamin K 3 decreases the expression of the c myc gene , inhibits the activity of DNA dependent DNA polymerases , and leads to the subsequent development of apoptosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA content was abnormal in only 11 patients with atrophy and H pylori infection ; eight of these also had c Myc expression , associated in six cases with p 53 expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
ERK activity was approximately 2 fold higher in cycling BMM compared with growth arrested BMM ; in addition , CSF 1 stimulated BMM DNA synthesis was partially inhibited by PD 98059 , a specific inhibitor of MEK activation , suggesting a role for a mitogen activated protein ERK kinase ( MEK ) / ERK pathway in the control of DNA synthesis but surprisingly not in the control of cyclin D 1 mRNA or c myc mRNA expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have found that APAP inhibits serum growth factor activation of c myc expression , NF kappaB DNA binding , and Raf kinase . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A small catalytic DNA molecule targeting c myc RNA was found to be a potent inhibitor of smooth muscle cell ( SMC ) proliferation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The inhibition of both PDGF BB and EGF induced DNA synthesis by wt Cbl was reversed by co expression with Myc but not with Fos . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hepatic DNA adduct formation , in vivo mutagenicity , and hepatocarcinogenicity of MeIQx were examined in mice harboring the lacZ mutation reporter gene ( Muta mice ) and bitransgenic mice overexpressing the c myc oncogene . ^^^ Although there was a trend toward higher adduct levels in c myc mice , MeIQx DNA adduct levels were not significantly different between c myc / lambda lacZ and C57Bl / lambda lacZ mice after 30 weeks on diet . ^^^ Thus , it seemed that factors in addition to MeIQx DNA adduct levels , such as the enhanced rate of proliferation associated with c myc overexpression , may have accounted for a higher mutant frequency in c myc mice . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , we show that microinjection of holocytochrome c mimics the effect of c Myc activation , sensitizing cells to DNA damage and to the CD 95 pathway . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Detection of NV HB / s DNA and c myc mRNA in mice inoculated with hepatitis B nucleic acid vaccine NV HB / s ] . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
PURPOSE : To determine the sequences that flank sites of interchromosomal DNA rearrangements and to determine the relative frequency of inter and intrachromosomal rearrangements induced by 30 Gy gamma irradiation in a region 5 ' from exon 1 of the c myc gene in normal human fibroblasts ( IMR 90 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c Myc protein exhibits sequence specific DNA binding when dimerized with its partner Max , and DNA binding is mediated through the basic region , which recognizes the core sequence CACGTG ( Berberich et al . , 1992 ; Blackwell et al . , 1993 ; Blackwood and Eisenman , 1991 ; Prendergast and Ziff , 1991 ; Prendergast et al . , 1991 ) , but exhibits somewhat higher affinity for the more extended sequence ACCACGTGGT ( Berberich et al . , 1992 ; Blackwell et al . , 1993 ; Halazonetis and Kandil , 1991 ) . ^^^ There are three closely related Myc family proteins ( c Myc , N Myc and L Myc ) , each with documented oncogenic potential ( Birrer et al . , 1988 ; Schwab et al . , 1985 ; Yancopoulos et al . , 1985 ) and similar DNA binding properties ( Mukherjee et al . , 1992 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The C terminal domain ( CTD ) of c Myc mediates interaction with Max and physiological recognition of DNA target sequences , events needed for all biological actions . ^^^ Recently described interactions between the CTD and other cellular proteins , including YY 1 , AP 2 , BRCA 1 , TFII 1 , and Miz 1 , suggest levels of regulatory complexity beyond Max in controlling DNA recognition by c Myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc is one of the few proteins that is sufficient to drive resting cells into the cell cycle and promote DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Increased cell growth precedes DNA synthesis after myc activation in cells expressing myc estrogen receptor fuson constructs and cells lacking c myc exhibit a marked loss of protein synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
With respect to carcinogenicity , As can affect DNA repair , methylation of DNA , and increase radical formation and activation of the protooncogene c myc , but none of these potential pathways have widespread acceptance as the principal etiologic event . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , PDGF induced c myc RNA expression and DNA synthesis even though Src was not detectably activated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We found that ( 1 ) apoptosis , but not mitotic arrest , was inhibited in cells with constitutive expression of Bcl 2 ; ( 2 ) pretreatment of cells with the DNA synthesis inhibitor hydroxyurea blocked the mitotic arrest but not the apoptosis mediated by okadaic acid ; ( 3 ) down regulation of c myc gene was associated with apoptosis , but not with mitotic arrest ; and ( 4 ) inhibition of protein synthesis abrogated mitotic arrest , but not apoptosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We propose that an excessive increase in PCNA and a marked decrease in c myc protein of luteal cells lead to a disorder in the signals concerned with DNA synthesis , causing mitotic catastrophe and inducing apoptosis in luteal cells , and that structural luteolysis may be triggered . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In breast cancer , MYC has been studied mostly at the DNA level because of the poor quality of available antibodies against the protein product . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
AMSH mutant deleted of the C terminal half conferred dominant negative effects on signaling for DNA synthesis and c myc induction mediated by interleukin 2 and granulocyte macrophage colony stimulating factor . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The MAPK kinase ( MEK ) inhibitor PD 98059 blocked bFGF stimulated MAPK phosphorylation and resulted in both a decrease of c myc expression and inhibition of bFGF stimulated DNA synthesis in cSMCs . bFGF also increased PKC activity in cSMCs in a time dependent manner . ^^^ The inhibition of PKC by chelerythrine or its downregulation by phorbol 12 myristate 13 acetate ( PMA ) inhibited bFGF induced DNA synthesis and blocked the phosphorylation of MAPK and c myc expression in response to bFGF . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hence , TCE decreased the methylation both of total DNA and the promoters for the c jun and c myc genes and increased the expression of their mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc overexpression uncouples DNA replication from mitosis . c myc has been shown to regulate G ( 1 ) / S transition , but a role for c myc in other phases of the cell cycle has not been identified . ^^^ We have found that overexpression of c myc causes colcemid treated human and rodent cells to become either apoptotic or polyploid by replicating DNA without chromosomal segregation . ^^^ Our results also suggest that c myc induces DNA rereplication in this G ( 1 ) like state by activating CDK 2 activity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA replication starts at multiple discrete sites across the human chromosomal c myc region , including two or more sites within 2 . 4 kb upstream of the c myc gene . ^^^ Competitive PCR quantitation showed that the c myc origin construct substantially increased the amount of nascent DNA relative to that at the unoccupied acceptor site and to that after the insertion of non myc DNA . ^^^ These results provide biochemical and genetic evidence for the existence of chromosomal replicators in metazoan cells and are consistent with the presence of chromosomal replicator activity in the 2 . 4 kb region of c myc origin DNA . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA single strand breaks repair in human satellite 3 and total DNA single strand breaks in c myc gene in AT cells correlate with increased radiosensitivity of cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The formation of DNA protein complexes with 32P labelled oligonucleotides containing the E box or AP 1 site with cell extracts prepared during G 1 progression was correlated with the promoter activation and greatly reduced by immunodepletion of Myc or c Jun from the extracts . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Since covalent protein DNA complexes are known to serve the role of breaking and rejoining DNA strands , the present findings suggest that NM 23 H2 is involved in DNA structural transactions necessary for the activity of the c MYC promoter . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Enhanced DNA binding activity of AP 1 and Elk 1 correlated with increased gene expression of c fos , but not c jun , at 2 h . c myc gene expression was also induced by As ( 3 ) and As ( 5 ) , albeit at a later time point ( 6 h ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Phosphorylation of MAZ by CKII at this serine residue was required for maximum binding of MAZ to the pyrimidine rich DNA of the nuclease hypersensitive element ( NHE ) in the 5 ' end promoter region of the c myc gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A dose response for radiation induced intrachromosomal DNA rearrangements detected by inverse polymerase chain reaction . 10 ray induced intrachromosomal DNA rearrangements were detected in the 5 ' region of the MYC gene of cells of the human bladder carcinoma cell line , EJ 30 , by using PCR with inverted primers . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We analyzed the expression of c myc , bcl 2 , and bax and in situ end labeling DNA fragmentation in vascular smooth muscle cells of arterioles and endothelial cells of arterioles and capillaries . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS : We used dual probe fluorescence in situ hybridization and DNA probes for 8p22 ( lipoprotein lipase gene ) , centromere 8 ( 8cen ) , and 8q24 ( c myc gene ) to determine the corresponding copy numbers in tumor samples from 144 patients with high grade , advanced ( stage 3 ) prostate carcinoma . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this study we compared expression of DNA topoisomerase IIalpha , a marker of cellular proliferation , c myc , and cyclin D 1 in lung biopsy specimens showing diffuse alveolar damage ( DAD ) with control lung tissues . ^^^ We subsequently correlated DNA topoisomerase IIalpha , c myc , and cyclin D 1 expression with survival . ^^^ Immnuohistochemical stains for c myc , cyclin D 1 , and DNA topoisomerase IIalpha were performed on 10 cases of DAD ( 15 cases for DNA topoisomerase IIalpha ) and 10 control lungs . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Thus , no early activation parameters such as Ca ( 2+ ) flux or MYC induction were affected by lovastatin , whereas progression of cells into the second cell cycle as well as DNA synthesis was markedly reduced . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the younger rabbits , c Myc co localised with proliferating cell nuclear antigen , whereas in the hypertrophic zone of older rabbits , it was present in some chondrocytes the nuclei of which also contained DNA breaks . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA binding of Myc / Max / Mad network complexes to oligonucleotides containing two E box elements : c Myc / Max heterodimers do not bind DNA cooperatively . ^^^ Recent findings were interpreted to suggest that Myc / Max , but not Max / Max or USF complexes , bind cooperatively to DNA sequences that contain two E box elements . ^^^ To extend this finding we analyzed DNA binding of c Myc / Max complexes using a transient COS 7 expression system . ^^^ Thus ourfindings argue against cooperative DNA binding of Myc proteins as a selection mechanism for E box dependent transcription . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
No changes were observed , however , in the DNA binding activity of ATF 2 and Elk 1 , transcription factors involved in both the JNK and p 38 pathways of MAP signal transduction , nor in the gene expression of c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Methylation of CpG sites of the c myc gene was investigated in bisulfite treated DNA isolated from normal liver , HNs and HCCs . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The distal segment of the mitogenic signaling pathway , which consists of Rb phosphorylation , the release of E2F , the induction of c myc , cyclins E and A , and DNA synthesis , is distinguished by a multiplicity of nested positive feedback loops ; these would be expected to drive a mitogenic signal that entered the distal segment through at least one round of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In confluent cells that could not be induced to synthesize DNA , EGF treatment also promoted an increase in c myc mRNA to levels seen in subconfluent cultures . ^^^ These data indicate that in primary rat hepatocyte cultures , 1 ) the phosphoinositol 3 kinase pathway , perhaps through p70s6k activation , regulates DNA synthesis in response to insulin and EGF ; 2 ) the MAPKpathway is not involved in insulin and EGF induced DNA synthesis ; and 3 ) p44 / 42 MAPKs are involved the induction of c myc mRNA levels , although this induction is not required for DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
HBV DNA may act as an insertional mutagen in the myc family of genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
There are four known members of the Mad family that are indistinguishable in their abilities to interact with Max , bind DNA , repress transcription , and block Myc + Ras co transformation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mmip 2 can disrupt max mad DNA binding and can reverse the suppressive effects of mad proteins on c myc responsive target genes and on c myc + ras mediated focus formation in fibroblasts . ^^^ They interact with the bHLH ZIP protein max , compete for the same DNA binding sites as myc max heterodimers and down regulate myc responsive genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using dominant negative alleles of USF 1 we now show that DNA binding by USF at a Myc regulated E box limits the ability of another E box binding factor , TFE 3 , to activate a target gene of Myc in vivo and to stimulate S phase entry in resting fibroblasts . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA from the PTLD tissue revealed weak to moderate IgH gene rearrangement in four of six patients but no T cell receptor beta chain or c myc gene rearrangement on Southern blot analysis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c Myc oncoprotein and its dimerization partner Max bind the DNA core consensus sequence CACGTG ( E box ) and activate gene transcription . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Marmoratus Ha and Ki ras gene exon 1 and 2 regions were checked along with confirming the presence and expression patterns of the DNA repair gene O ( 6 ) methylguanine alkyltransferase ( O ( 6 ) MT ) and other oncogenes ( c src , c fos , and c myc ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We report that TNF induces DNA replication in growth arrested LE 6 cells and that its effect involves the activation of NFkappaB and STAT 3 and an increase in c myc and IL 6 mRNAs . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
For Burkitt ' s lymphoma and mouse plasmacytoma tumors , balanced translocation that juxtaposes c myc with one of the Ig loci is an early , invariant event that is mediated by B cell specific DNA modification mechanisms . ^^^ By contrast , for MM , dysregulation of c myc apparently is caused principally by complex genomic rearrangements that occur during late stages of MM progression and do not involve B cell specific DNA modification mechanisms . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This study attempts to identify markers indicative of the biological characteristics of cells isolated from samples of uveal melanoma , including adhesion ( ICAM 1 ) , immune reactivity ( MHC Class 1 and 2 ) , cell cycle control ( c erbB 2 , c myc ) and apoptosis control ( bcl 2 , p 53 ) using dual parameter ( DNA / MoAb ) flow cytometry . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The level of phosphorylated c Myc , a nuclear substrate for MAPK , was depressed from 16 48 h after apigenin treatment , finally leading to a programmed cell death involving DNA fragmentation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These lines are aneuploid with complex structural rearrangements and have DNA copy number imbalances involving multiple sites that include amplification of ERBB 2 and MYC proto oncogenes which are implicated in breast cancer pathogenesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA copy number changes and evaluation of MYC , IGF1R , and FES amplification in xenografts of pancreatic adenocarcinoma . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NF kappaB SN 50 also inhibited the KA induced up regulation of c Myc and p 53 , as well as internucleosomal DNA fragmentation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Interactions of the nuclear matrix associated steroid receptor binding factor with its DNA binding element in the c myc gene promoter . ^^^ These data support that the nuclear matrix binding site ( acceptor site ) for PR in the c myc gene promoter is composed of RBF dimers bound to a specific single stranded DNA element . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Genomic DNA extracted from tumor tissues was subjected to long distance polymerase chain reaction ( LD PCR ) using oligonucleotide primers for exon 2 of c MYC and for the four constant region genes of IGH . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MSSPs are believed to regulate DNA replication , transcription , apopotosis and cell cycle progression by interacting with the C MYC protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
ATF 2 at Ser 69 / 71 , forming a complex with Myc for DNA binding at CRE motif ; 3 ) Max at Ser 62 to combine DNA of E Box motif . p 38 MAPK can be activated by LPS , inflammatory cytokines , such as TNF and IL 1 , osmolarity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Antisense phosphorodiamidate morpholino oligomers ( novel DNA analogs ) were administered i . p . immediately after surgery to block expression of c myc within the first 24 h after PH . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
For each batch of experiments , DNA from the high c myc expressing cells , HL 60 , and DNA from the low expressing cells , K 562 , were served as positive and negative controls , respectively . c myc amplification was observed in 16 ( 94 . 1 % ) of 17 malignant lesions , 5 ( 41 . 7 % ) of 12 proliferative breast diseases with nuclear atypia , and 4 ( 16 . 7 % ) of 24 other benign lesions ( fibroadenoma or fibrocystic disease ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A dominant negative FBP DNA binding domain lacking effector activity or an antisense FBP RNA , expressed via replication defective adenovirus vectors , arrested cellular proliferation and extinguished native c myc transcription from the P 1 and P 2 promoters . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The effect of PKC beta 1 overexpression by transfection with its complementary DNA ( cDNA ) on indomethacin induced apoptosis and apoptosis related genes , including p 53 , p 21 ( waf1 / cip1 ) , and c myc , was further investigated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the following study , we used comparative genomic hybridization ( CGH ) to screen for DNA copy number changes along all chromosomes in 37 gastric carcinomas , and fluorescence in situ hybridization ( FISH ) with the C MYC and TP 53 probes in 14 cases for comparison . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We studied DNA amplification at eight genes or loci ( AIB 1 , CCND 1 , EMS 1 , ERBB 2 , FGFR 1 , MDM 2 , MYC , and RMC20C001 ) as well as p 53 mutations in a series of 640 breast cancer patients who had not received presurgical therapy and analyzed the correlations with survival DNA amplification was assessed by Southern blotting and was scored positive when exceeding three to five copies . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Tetrachlorodibenzo p dioxin ( TCDD ) induced changes in activities of nuclear protein kinases and phosphatases affecting DNA binding activity of c Myc and AP 1 in the livers of guinea pigs . ^^^ The effect of TCDD on nuclear proteins binding to the c Myc response element DNA was , on the other hand , biphasic : an initial increase of protein binding to the c Myc response element was followed by suppression . ^^^ The results showed that this in vitro phosphorylation treatment exacerbated this tendency of increased AP 1 and decreased c Myc binding to their respective response element DNAs , indicating that kinases and phosphatases present in the isolated nuclear protein preparation were active and capable of modifying protein binding to DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This phenomenon may account for the massive DNA damage and acceleration of hepatocarcinogenesis observed in the TGF alpha / c myc mouse model . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Indeed , both cellular effects induced by lipotransfected degraded DNA ( essentially , heterogeneous small DNA fragments ) are associated to p 53 activation and modulated by two apoptosis related genes , such as bcl 2 and c myc , which also modulate the apoptotic threshold to anticancer agents . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It is the regulatory subunit of the DNA dependent protein kinase that phosphorylates many proteins , including SV 40 large T antigen , p 53 , RNA polymerase 2 , RP A , topoisomerases , hsp 90 , and many transcription factors such as c Jun , c Fos , oct 1 , sp 1 , c Myc , TFIID , and many more . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA as an important target in radiation induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts . ^^^ PURPOSE : This study uses a radiation chemistry approach to determine if DNA is an important target for radiation induced apoptosis of myc ( MR 4 ) and myc plus ras ( 3 . 7 ) transfected rat embryo fibroblast cell lines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA probes for 3q27 , for 5p15 . 2 , and for the protooncogenes c myc ( 8q24 ) and c abl ( 9q34 ) , were used for 1 FISH examination of the interphase nuclei of paraffin sections of the tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Trichloroethylene ( TCE ) , dichloroacetic acid ( DCA ) , and trichloroacetic acid ( TCA ) are environmental contaminants that are carcinogenic in mouse liver . 5 Methylcytosine ( 5 MeC ) in DNA is a mechanism that controls the transcription of mRNA , including the protooncogenes , c jun and c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Microinjection of a Slap expressing construct into quiescent NIH 3T3 cells inhibited platelet derived growth factor ( PDGF ) induced DNA synthesis , and the inhibition was rescued by the transcription factor c Myc but not by c Jun / c Fos expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here we show that regulatable ectopic expression of cyclin E or transcriptionally active Myc can rapidly induce DNA synthesis in U2OS derived cell lines whose E2F activity is blocked by a constitutively active pRb ( pRbDeltacdk ) mutant . ^^^ Moreover , while abrogation of either endogenous E2F or Myc activity only delays and lowers DNA synthesis in synchronized U2OS cells or rat diploid fibroblasts , concomitant neutralization of both abolishes it . ^^^ Whereas ectopic Myc and E2F1 rescue the G ( 1 ) / S delay caused by pRbDeltacdk ( or dnDP 1 ) and MadMyc , respectively , cyclin E or Cdc25A can restore DNA replication even in cells concomitantly exposed to pRbDeltacdk and MadMyc . ^^^ Finally , proper transcription of cyclin E and Cdc25A at the G ( 1 ) / S transition requires both Myc and E2F activities , and subthreshold levels of ectopic cyclin E and Cdc25A synergistically restore DNA synthesis in cells with silenced Myc and E2F activities . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here we test the ability of dihydrotestosterone ( T ) covalently linked to PNA to act as a vector for targeting c myc DNA to prostatic cancer cell nuclei . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA binding analyses revealed that the most prominent network complex both in cycling and in differentiating cells was Mnt / Max , whereas c Myc / Max complexes were detectable only during peak c Myc expression periods . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Quiescent ( G 0 ) cells did not express c fos , c jun , c myc and cyclin A , but upon stimulation with mitogens ( fetal calf serum ( FCS ) , u PA , t PA ) the cyclin A mRNA expression was observed in concomitance with the activation of DNA synthesis . ^^^ Therefore u PA , t PA and FCS similarly modulate the expression of c fos , c jun , c myc , p 53 , p21CIP1 and cyclin A with only slight differences likely related to the time required for activation of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc and Mad are basic helix loop helix leucine zipper ( bHLH LZ ) proteins that heterodimerize with Max to bind DNA and thereby influence the transcription of Myc responsive genes . ^^^ Moreover , deletion of region 5 results in a protein that binds DNA weakly and no longer represses Myc dependent transcriptional activation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
By expressing POLG fusion proteins in cultured human cells , we show that the enzyme is targeted to mitochondria , where the Myc epitope tagged POLG is catalytically active as a DNA polymerase . ^^^ Transient expression of POLG myc variants D890N or D1135A inhibited endogenous mitochondrial DNA polymerase activity and caused mtDNA depletion . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
TGFalpha mRNA expression was shifted together with the DNA synthesis , but the expression of c myc , c fos , c jun , HGF , TGFbeta 1 , IL1beta did not delay . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Finally , no relationship is found between nuclear DNA fragmentation and increased N myc or c myc expression in individual cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The region upstream of the transcription start site is characterized by the presence of a TATA box at bases 32 / 26 , DNA binding elements for transcription factors c Myc , N Myc , Sp 1 and nuclear factor kappaB as well as putative activator protein ( AP ) 1 , cAMP response element binding protein ( CREB ) , hepatocyte nuclear factor ( HNF ) 1 , HNF 3 , TGT 3 , gut enriched Krppel factor ( GKLF ) , thyroid transcription factor ( TTF ) 1 and glucocorticoid receptor element ( GRE ) binding sites . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Morphological alteration of 10 ray induced partially transformed human cells by transfection with a small c myc DNA sequence . ^^^ On the other hand , a gel purified , small fragment of c myc DNA had a complete cell alteration activity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS : The modified promoter and 5 ' region of the rat C ( 3 ) 1 gene was fused to the coding region of the mouse c myc gene using recombinant DNA techniques . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Major DNA replication initiation sites in the c myc locus in human cells . ^^^ DNA replication initiation sites and initiation frequencies over 12 . 5 kb of the human c myc locus , including 4 . 6 kb of new 5 ' sequence , were determined based on short nascent DNA abundance measured by competitive polymerase chain reaction using 21 primer sets . ^^^ Furthermore , a comparison of the abundance of DNA replication intermediates over this same region of the c myc locus between HeLa and normal skin fibroblast ( NSF ) cells indicated that the relative distribution was very similar , but that nascent strand abundance in HeLa cells was approximately twice that in NSF relative to the abundance at the lamin B 2 origin . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MSSP , a protein binding to an origin of replication in the c myc gene , interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity . ^^^ MSSP has been identified as a protein that binds to both single and double stranded sequences of a putative DNA replication origin sequence in the human c myc gene . ^^^ MSSP possesses versatile functions , including stimulation of DNA replication , transcriptional regulation , apoptosis induction , and cell transformation coordinated by c Myc . ^^^ Furthermore , MSSP was released from the putative DNA replication origin of the c myc gene after it complexed with DNA polymerase alpha , and MSSP stimulated DNA polymerase activity in vitro . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Many of them utilise methods of gene therapy , but follow different strategies : ( 1 ) reintroduction of the tumour suppressor p 53 into a background lacking functional p 53 ; ( 2 ) suicide gene therapy with ganciclovir and a transduced gene for herpes simplex virus thymidine kinase controlled by the thyroglobulin promoter ; ( 3 ) strengthening of the antitumour immune response by expression of an adenovirus delivered interleukin 2 ( IL 2 ) gene ; ( 4 ) induction of an immune response by DNA vaccination against the tumour marker calcitonin ; ( 5 ) transduction of the thyroid sodium / iodide transporter gene to make tissues that do not accumulate iodide treatable by radioiodide therapy ; ( 6 ) blocking of the expression of the oncogene c myc by antisense oligonucleotides . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
However , the 2 . 7 kb DNA segment containing both this non canonical E box and an Inr like sequence does not constitute a Myc responsive element in a transient expression system . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cloning and sequencing of several of these fragments confirmed the previous finding of MYC amplification in the cell line D 341 Med and identified novel DNA sequences amplified in PNET / MB . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here , we describe a function for LXRalpha as a cAMP responsive regulator of renin and c myc gene transcriptions by the interaction with a specific cis acting DNA element , CNRE ( an overlapping cAMP response element and a negative response element ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A c Myc Max consensus DNA binding site was identified as an element important in the serum stimulation of HMG I / Y . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Two highly intensified spots were common in the two cancer cell lines and proven to be originated from DNA region containing the human c myc proto oncogene on chromosome 8 . ^^^ The degree of amplification of c myc DNA was similar to each other and was estimated to be 60 fold as compared to those from normal mucosa DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hepatic levels of methionine , SAM , and DNA methylation fell by approximately 40 % . c myc was hypomethylated , and its mRNA level increased . ^^^ Thus in the prefibrotic stage of alcoholic liver injury , there is already a switch in MAT expression , global DNA hypomethylation , increased c myc expression , and genome wide DNA strand break . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results suggest that , in addition to its DNA replication activity , CDC 6 also has a role as a transcriptional suppressor of c Myc . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
STAM 2 like STAM 1 is associated with Jak 2 and Jak 3 , and involved in the signaling for DNA synthesis and c myc induction mediated by IL 2 and GM CSF . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Distinct patterns of alteration of myc genes associated with integration of human papillomavirus type 16 or type 45 DNA in two genital tumours . ^^^ Different patterns of myc gene alterations may thus be associated with integration of HPV DNA in genital tumours , including the activation of the protooncogene via a mechanism of insertional mutagenesis and / or gene amplification . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using comparative genomic hybridization ( CGH ) , a region of high level DNA amplification was detected at 8q24 , the locus of the c MYC proto oncogene . ^^^ Fluorescence in situ hybridization ( FISH ) with a DNA probe specific for the human c MYC gene confirmed the extrachromosomal amplification of this proto oncogene in the dmin of the leukemic cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
BRCA 1 contains several functional domains that interact directly or indirectly with a variety of molecules , including tumor suppressors ( p 53 , RB , BRCA 2 and ATM ) , oncogenes ( c Myc , casein kinase 2 and E2F ) , DNA damage repair proteins ( RAD 50 and RAD 51 ) , cell cycle regulators ( cyclins and cyclin dependent kinases ) , transcriptional activators and repressors ( RNA polymerase 2 , RHA , histone deacetylase complex and CtIP ) and others . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
RESULTS : The c myc and c N ras oncogene fragments were hypomethylated in DNA samples derived from cancerous ( 30 . 3 % and 60 . 1 % ) and adjacent paracancerous ( 12 . 1 % and 30 . 3 % ) liver tissues . ^^^ CONCLUSION : The decrease of DNA methylation is present at the stage of liver carcinoma , and hypomethylation of c myc , c N ras genes is correlated with the tendency of infiltration and metastasis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Although DNA binding is clearly required , the mechanism by which recruitment of c Myc to target promoters results in transcriptional activation is highly debated . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Accordingly , lesions induced by bizelesin in these domains ( 2 . 13 and 7 . 06 lesions kbp ( 1 ) microM ( 1 ) , respectively ) markedly exceeded lesions in bulk DNA ( 0 . 87 lesions kbp ( 1 ) microM ( 1 ) ) or in regions with typically low motif density ( e . g . , 0 . 75 and 0 . 87 lesions kbp ( 1 ) microM ( 1 ) in a beta globin gene and c myc origin of replication regions , respectively ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA analyses of bone marrow mononuclear cells containing leukemic cells revealed rearrangement of the kappa light chain ( Igkappa ) gene and c myc and c jun proto oncogenes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
CTCF regulates transcription of several genes , like the human oncogene c myc or the chicken lysozyme gene by binding extremely divergent DNA sequences with different sets of its 11 zinc fingers . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Both lines have a 30 40 fold amplification of a large DNA domain containing the MYC oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Sodium butyrate markedly induced the c jun proteins level , whereas the c Myc protein was down regulated rapidly . c Jun protein may play an important role in the action of sodium butyrate since its induction preceded the onset of DNA fragmentation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hypomethylation and overexpression of c jun and c myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid promoted mouse liver tumors . ^^^ Methylation of the c jun and c myc genes , expression of both genes and DNA methyltransferase ( DNA MTase ) activity were determined in liver tumors initiated by N methyl N nitrosourea and promoted by DCA and TCA in female B6C3F1 mice . ^^^ Thus , DCA and TCA promoted carcinogenesis appears to include decreased methylation and increased expression of c jun and c myc genes in the presence of increased DNA MTase activity . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A pilot study on relationships of selected molecular factors ( c myc oncogene average gene copy numbers ( AGCN ) ; serum CEA and CA 15 . 3 antigen levels ; tumor cells ' DNA values ) , to the ex vivo chemosensitivity of primary female human breast cancer in a modified adenosine triphosphate cell viability chemosensitivity assay ( ATP CVA ) , was performed . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A pilot study on relationships of selected molecular factors [ erbB 1 , erbB 2 , erbB 3 , and c myc oncogene average gene copy numbers ( AGCN ) ; steroid receptors and pS 2 gene expression ; tumor cells ' DNA values ] to the ex vivo chemosensitivity of ovarian cancer in a modified adenosine triphosphate cell viability chemosensitivity assay ( ATP CVA ) , was performed . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A combination treatment of c myc antisense DNA with all trans retinoic acid inhibits cell proliferation by downregulating c myc expression in small cell lung cancer . ^^^ In conclusion , c myc antisense DNA in combination with other modalities for c myc downregulation may represent an attractive gene regulation based therapy of SCLC in the future . ^^^ Further efforts , however , using new oligodeoxynucleotide analogs , specific interventions for DNA delivery into cells , and more potent therapeutic agents are required to increase the potentiation of c myc downregulation and cell growth inhibition . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
FGF 2 elicits a strong mitogenic response in G0 / G1 arrested Y 1 adrenocortical cells , that includes a ) rapid and transient activation of extracellular signal regulated kinases mitogen activated protein kinases ( ERK MAPK ) ( 2 to 10 min ) , b ) transcription activation of c fos , c jun and c myc genes ( 10 to 30 min ) , c ) induction of c Fos and c Myc proteins by 1 h and cyclin D 1 protein by 5 h , and d ) onset of DNA synthesis stimulation within 8 h . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Fluorescence in situ hybridization ( FISH ) analysis of dissociated nuclei with DNA probes for MYC ( 8q24 ) / # 8 , cyclin D 1 gene ( CCND 1 ; 11q13 ) / # 11 , ERBB 2 ( 17q13 ) / # 17 , the androgen receptor gene ( AR ; Xq 12 ) / # 10 , and the retinoblastoma gene ( RB ; 13q14 ) was applied to formalin fixed tissue from 63 patients with advanced PC after androgen deprivation therapy ( ADT ) ; matched tumor tissue before ADT was also available in 22 of these cases . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc gene copy number was determined by quantitative PCR from genomic DNA of paraffin embedded tumors . c myc gene amplification was present in 5 of 62 cases ( 8 . 3 % ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Both Myc and Mad , as well as the more recently described Mnt and Mga proteins , form heterodimers with Max , permitting binding to specific DNA sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In support of a link to c Myc induced death processes , AEBSF , a serine protease inhibitor that inhibits apoptosis by c Myc , potently suppressed DNA degradation by Bin 1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In situ end labeling technique was used for the detection of nucleosomal DNA fragmentation of apoptotic cells , and Northern blot for the detection of expression of c myc , bcl 2 and p 53 genes in the lungs with COPD . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Prognostic markers such as amplification of the N myc and c myc , deletion of the 17p , and DNA ploidy are indispensable factors for the determination of diagnosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The use of SU 6656 confirmed our previous findings that Src family kinases are required for both Myc induction and DNA synthesis in response to PDGF stimulation of NIH 3T3 fibroblasts . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Apoptosis was measured at 48 hours by TUNEL assay for in situ DNA fragmentation and by immunohistochemical detection of c myc protein , a proto oncogene upregulated with apoptosis ( grade 0 = no stain ; +++ = most dense stain ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Differential regulation of P 53 , c Myc , Bcl 2 , Bax and AFP protein expression , and caspase activity during 10 hydroxycamptothecin induced apoptosis in Hep G 2 cells . 10 Hydroxycamptothecin ( HCPT ) , a DNA topoisomerase 1 ( Topo 1 ) inhibitor , exhibited a remarkable apoptosis inducing effect on human hepatoma Hep G 2 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Increases occurred in oxidative stress responsive genes HO 1 , QR , HSP 70 , GADD 45 , GADD 153 , p 21 ( WAF1 / CIP16 ) , GST ' s , GAPDH , TPX , and GPX 1 ( 0 ) ; transcriptional regulators c jun , c fos , jun B , c myc , and IkappaB ; protein repair components Rdelta , RC 10 2 , C 3 , RC 7 , HR6B ubiquitin conjugating enzyme and ubiquitin ; DNA repair components PCNA , msh 2 , and O 6 methylguanine DNA methyltransferase ; lipid peroxide excision enzyme PLA 2 ; and apoptogenic components TNFalpha , iNOS 1 and FasL . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , we show similar changes in the mRNA expression level of two early response genes , c myc and Berg 36 , as well as activation of the mitogen activated protein kinase family members p 44 ( extracellular signal regulated kinase 1 ) and p 42 ( extracellular signal regulated kinase 2 ) and activation of activator protein 1 ( AP 1 ) DNA binding activity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Biologic markers resulting from genetic lesions in lung cancer are grouped as follows : ( a ) oncogene amplification and overexpression ( aberrant gene expression ) and mutated tumor suppressor genes ras gene , myc gene , HER 2 / neu and survivin gene , p 53 and mutated beta tubulin gene ; ( b ) tumor biologic / radiobiologic factors tumor cell proliferation kinetics , hypoxia , intrinsic cellular radiosensitivity , gamma factor , and DNA content ; ( c ) enzymes and hormones : neuron specific enolase , serum lactate dehydrogenase , and enhanced glucose metabolic rate supported by increased glucose transporter protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Tumor site specific 5 ( H ) DJ ( H ) , 5 kappa J kappa , and c myc mutations were comparable in frequency , and a single point mutation gave rise to an EcoRI site in the testis c myc DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA fragmentation was preceded by the lowering of c myc mRNA in the DZA treated cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Castration induced DNA fragmentation was not observed at an early induction of c myc mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The ACTH inhibition of DNA synthesis stimulated by FGF 2 is reversed by transient transfection and induction of the MycER chimera ( fusion of c Myc and estrogen receptor ) , suggesting that c Myc down regulation is an efficient anti mitogenic mechanism activated by ACTH . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Additionally , the induction of these proteins by IFN was accompanied by : ( 1 ) a transient increase in p 21 ( WAF1 / CIP1 ) levels ; ( 2 ) an increase in the functional form of pRb and p 130 ; ( 3 ) an inhibition of the sequence specific DNA binding activity of E2F complexes ; and ( 4 ) a marked decrease in c Myc levels . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
FISH demonstrated increasing DNA copy of numbers of c erbB 2 , 20q13 . 2 ( AIB ) , c myc and cyclin D 1 during the development of Barrett ' s adenocarcinoma , and LOH confirmed DNA losses on 5q21 ( APC ) and 18q ( DCC ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The cells were harvested at specified times after serum repletion , then cellular DNA contents ( to estimate the proportions of cells in different phases of the cell cycle ) and the contents of alpha actin , c myc and c fos proteins were measured by flow cytometry . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Particular emphasis is put on the emerging parallel yet cooperative pathways of retinoblastoma protein ( pRB ) E2F and Myc , their convergence to control the activity of the cyclin dependent kinase 2 ( Cdk 2 ) at the G1 / S boundary , as well as the two waves of checkpoint responses at G1 / S : the rapid pathway ( s ) leading to Cdc25A degradation , and the delayed p 53 p21 cascade , both silencing the Cdk 2 activity upon DNA damage . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transcriptional activation by Myc is mediated through dimerization with Max and binding to the DNA consensus sequence CA ( C / T ) GTG ( the E box ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The molecular alterations analyzed were : the amplification of 11q13 region ( in the 29 cases ) , and the MYC and ERBB 1 oncogenes ( in 22 cases ) ; the integration of Human Papillomavirus ( HPV ) types 6b and 16 ( in 22 cases ) ; the loss of heterozygosity ( LOH ) of p 53 and N acetyltransferase 2 ( NAT 2 ) gene ( in 12 and 13 informative cases , respectively ) ; and the cellular DNA content ( in 13 cases ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The most C terminal region of HAP domains of NF YB and NF YC , and the Myc homology boxes , but not the C terminal bHLHZip domain , are indispensable for the coimmunoprecipitation , and also for the repression of PDGF beta receptor . c Myc binds NF Y complex without affecting the efficiency of NF Y binding to DNA . ^^^ However , the expression of Myc represses the transcriptional activation of NF YC when fused to the GAL 4 DNA binding domain . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Structure , function , and dynamics of the dimerization and DNA binding domain of oncogenic transcription factor 5 Myc . ^^^ The C terminal bHLHZip domain of 5 Myc , encompassing protein dimerization ( helix loop helix , leucine zipper ) and DNA contact ( basic region ) surfaces , was expressed in bacteria as a highly soluble p 15 ( 5 myc ) recombinant protein . ^^^ Dissociation constants ( K ( d ) ) for the heterodimer formed with the recombinant bHLHZip domain of the Myc binding partner Max ( p 14 ( max ) ) and for the Myc Max DNA complex were estimated using circular dichroism ( CD ) spectroscopy and quantitative electrophoretic mobility shift assay ( EMSA ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
L 1 ) induced DNA synthesis and activated CCDPK in a concentration dependent manner and a induced a marked c myc mRNA expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The results showed that in cultures from both rat strains ( 1 ) serum , basic fibroblast growth factor ( bFGF ) and thrombin induced DNA synthesis were inhibited by L phenylalanine dose dependently ; ( 2 ) L phenylalanine inhibited cell proliferation in response to serum in a concentration dependent manner ; ( 3 ) L phenylalanine inhibited serum induced proto oncogene c fos and c myc expression ; ( 4 ) L tyrosine , L histidine and D phenylalanine failed to mimic the inhibitory effect of L phenylalanine . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Most of the cells were rounded up by the antisense treatment and nuclear fragmentation and DNA ladder formation were detected after two days in antisense c myc treated cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Interestingly , the induction of c myc gene expression preceded the activity of DNA fragmentation in aminopterin treated cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of Rat 1 c myc null cells shows these same death stimuli induce apoptosis with characteristic features of nuclear condensation , membrane blebbing , poly ( ADP ribose ) polymerase cleavage , and DNA fragmentation ; however , this Myc independent apoptosis is not inhibited by Bcl 2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This rapid growth is not mediated by suppression of apoptosis , as normal and Myc transformed follicles showed similar rates of cell death by TUNEL immunohistochemical analysis of cells undergoing DNA degradation . ^^^ Measurements of DNA synthesis and mitotic index showed modest effects of Myc to increase lymphocyte proliferation , as normal lymphocytes already divide rapidly . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of bulk and c myc P 2 promoter specific DNA damage by an anti topoisomerase 2 agent salvicine is an early event leading to apoptosis in HL 60 cells . ^^^ Preferential damage in the P 2 promoter region of the oncogene c myc was detected , whereas no obvious DNA damage was found in the 3 ' region of the same gene . ^^^ It appears possible that DNA damage within such genomic regions is an early event , which could lead to growth inhibition mediated by alterations of the expression of selected proliferation regulatory genes , such as c myc , c fos and c jun , and ultimately cell death . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Subgroups of 4 5 mice were sacrificed at 3 , 6 and 24 h after therapy so that tumors could be examined for poly ( ADP ribose ) polymerase ( PARP ) and DNA ladder evidence for apoptosis and for BCL 2 , p 53 , p 21 , GADD 45 , TGF beta 1 and c MYC gene and protein expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We investigated the effects of Matrine on proliferation by trypan blue exclusion and differentiation by benzidine staining positive cells in K 562 cells , assayed the telomerase activity using PCR ELISA assay , analyzed cell cycle by fluorescence activated cell sorter analysis of the DNA content , and also determined the gene expression level of c myc , N ras and p 53 by northern blot and dot blot analysis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the present study , quantitative RT / PCR was used to assess the effect of model toxins cycloheximide ( CHX ) , a protein synthesis inhibitor , and N methyl N ' nitro N nitrosoguanidine ( MNNG ) , a DNA alkylating agent , on c myc mRNA levels in normal human bronchial epithelial ( NHBE ) and lung adenocarcinoma ( A 549 ) cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The Myc protein binds DNA and activates transcription by mechanisms that are still unclear . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A DNA microarray screen for genes involved in c MYC and N MYC oncogenesis in human tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of the DNA from the electron induced carcinomas indicated that K ras and / or c myc oncogenes were activated in all tumors tested , although only a small proportion of neon induced tumors showed similar activation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To determine whether GH stimulated DNA synthesis directly , we investigated the time course changes in mRNA expression of IGF 1 and the proto oncogene c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Nuclear factor kappaB ( NF kappaB ) and signal transducer and activator of transcription 3 ( STAT 3 ) DNA binding were assessed by electrophoretic mobility shift assay ( EMSA ) , interleukin 6 ( IL 6 ) mRNA by reverse transcription polymerase chain reaction ( RT PCR ) , c myc and c jun mRNAs by Northern blot analysis at 0 . 5 and 2 hours , p 53 and c Ha ras mRNAs by Northern blot analysis at 8 and 24 hours , and IL 1beta and TGF beta 1 by RT PCR at 24 hours . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The level of c myc expression was highly correlated ( r = 0 . 988 ) with tumor formation after inoculation of CAsE cells into nude mice and was also highly correlated ( r = 0 . 997 ) with genomic DNA hypomethylation . ^^^ In summary , a prominent overexpression of c myc , a gene frequently activated during hepatocarcinogenesis , is strongly correlated with several events possibly associated with arsenic induced malignant transformation , including hyperproliferation , DNA hypomethylation and tumor formation upon inoculation into nude mice . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Induction of genotoxic stress also results in a large reduction in global protein synthesis rates and therefore we investigated whether the c myc IRES was active following DNA damage . ^^^ Finally we showed that the proteins required for this process are downstream of the p 38 mitogen activated protein kinase ( MAPK ) / extracellular signal regulated protein kinase ( ERK ) / MEK ( MAPK / ERK kinase ) signalling pathways , since pre treatment of cells with inhibitors of these pathways before DNA damage is initiated inhibits both c myc IRES activity and expression of c Myc protein . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA from tumor and healthy tissue was evaluated for amplification of the oncogenes at 11q13 region ( CCND 1 , FGF 3 , FGF 4 and EMS 1 ) and of the oncogenes MYC and ERBB 1 ; for integration of the human papillomavirus ( HPV ) types 6b and 16 ; for loss of heterozygosity ( LOH ) at p 53 and NAT 2 ; and for the cellular DNA content . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using DNA flow cytometry and immunohistochemical staining techniques we determined the DNA content and the level of co expression of seven tumor associated proteins : proliferating cellular nuclear antigen ( PCNA ) , epidermal growth factor receptor ( EGFr ) , p 53 , c erbB 2 , H ras , c myc , and nm 23 . ^^^ In conclusion , this study demonstrates that the DNA content and genetic markers c myc , c erbB 2 , EGFr , H ras , p 53 , PCNA , and nm 23 do not predict survival after potentially curative resection of hepatic metastases from CRC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Samples were analyzed by FISH using 8 alpha satellite DNA probe and c myc gene cosmid probe . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Suppression of c myc expression and c Myc function in response to sustained DNA damage in MCF 7 breast tumor cells . ^^^ To further assess the involvement of c mvc in the DNA damage induced signal transduction pathways of the breast tumor cell , we determined the influence of sustained DNA damage on c myc expression , c Myc protein levels and c Myc function . ^^^ DNA strand breakage was accompanied by a decline in c myc transcripts and c Myc protein levels by > 90 % after VM 26 exposure for 24 hr . ^^^ The activity of a transcriptional target of the c Myc protein , ornithine decarboxylase , was reduced by approximately 75 % within 9 hr of DNA damage , in parallel to the declines in c myc mRNA and protein levels . ^^^ These studies indicate that non apoptotic pathways can also mediate cell death in the breast tumor cell and support the role of c myc expression , c Myc protein , and c Myc function as elements of the DNA damage response pathway in the breast tumor cell . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The gastrointestinal carcinogenesis is suggested to be associated with the decrease of total genomic DNA methylation ; hypomethylation of certain specific oncogenes such as c myc , c Ha ras , c fos and alpha fetoprotein ; and hypermethylation of the promoter of some tumor suppressor genes containing p 16 ( INK4A ) , E cadherin and hMLH 1 genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Statistically significant associations were found between c myc amplification and DNA aneuploidy ( P = . 0011 ) , and progesterone receptor negativity ( P = . 0071 ) , and c myc amplification also tended to be associated with high histologic grade ( P = . 064 ) , positive axillary nodal status ( P = . 080 ) , and a high S phase fraction ( P = . 052 ) . c myc amplification was not significantly associated with overall survival of patients with invasive cancer ( P = . 32 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Granulocytic differentiation of HL 60 cells , both spontaneous and drug induced , might require loss of extrachromosomal DNA encoding a gene ( s ) not c MYC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A role for c myc in DNA damage induced apoptosis in a human TP 53 mutant small cell lung cancer cell line . ^^^ Exposure to DNA damaging agents caused an increase of c Myc , a DNA damage responsive transcription factor . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Gene amplification was investigated in K ras , c myc , c fos , c jun , c sis , erb B 2 and p 53 using differential PCR while random amplified polymorphic DNA fingerprinting was employed to detect genomic instability . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of c myc DNA amplification in non small cell lung carcinoma in comparison with small cell lung carcinoma using polymerase chain reaction . ^^^ There are few data about c myc DNA amplification in histological types of lung cancer other than small cell carcinoma . ^^^ We studied 46 lung tumor specimens for c myc DNA amplification ( 15 adenocarcinomas , 15 squamous cell carcinomas , 6 large cell carcinomas , and 10 small cell carcinomas ) . ^^^ Polymerase chain reaction , digoxigenin DNA labeling , and electrophoresis were utilized to investigate the c myc copy number in the lung tumor specimens . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Analysis of immortal myeloid cells engineered to overexpress c Myc and E2F 1 DNA binding mutants revealed that DNA binding activity of these oncoproteins is required to suppress Bcl 2 expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
By both methods , c myc amplification was significantly associated with high histologic grade , negative progesterone receptor status , DNA aneuploidy , and high S phase fraction . c myc amplification was strongly associated with poor distant metastasis free survival when amplification was detected by CISH ( p = 0 . 0013 ) , but this association was weaker when FISH was used ( p = 0 . 16 for two color FISH and p = 0 . 065 for single color FISH ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These structures have been proposed to exist in biologically important regions of DNA , e . g . at the end of chromosomes and in the regulatory regions of oncogenes such as c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
STAM 1 and STAM 2A are involved in cytokine mediated signalling for DNA synthesis and c myc induction . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
BACKGROUND : MSSP , c myc single strand binding protein , works as a factor for DNA replication , transcription , apoptosis induction , and myc / ras cooperative transformation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inducible activation of c Myc in adult myocardium in vivo provokes cardiac myocyte hypertrophy and reactivation of DNA synthesis . c Myc , a protooncogene , mediates both proliferative and cellular growth in many cell types . ^^^ Activation of Myc also provoked cell cycle reentry in postmitotic myocytes , which led to increased nuclei per myocyte and DNA content per nuclei . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Separate lines of mice transgenic for myc and Cbfa 1 may provide a means of detecting oncogenic DNA containing genes belonging to different complementation groups . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NM 23 H2 / NDP kinase B has been identified as a sequence specific DNA binding protein with affinity for a nuclease hypersensitive element of the c MYC gene promoter ( Postel et al . , 1993 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Finally , using 99mTc labeled 15 mer antisense DNA against the c myc oncogene mRNA in MDA MB 231 cells , significantly more radiolabel was found in total mRNA for the antisense compared to the sense control DNA , both with and without liposome carrier . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The purpose of the study was to elucidate how DNA tetraplex ( also referred to as G quadruplex ) forming oligonucleotides mediate suppression of the human c myc gene at the level of transcription initiation . ^^^ A 22 base long oligonucleotide , which is rich in guanines and folds into an intrastrand DNA tetraplex under physiological conditions , was administered to a Burkitt ' s lymphoma cell line overexpressing a ( 8 : 14 ) translocated c myc allele . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The mechanisms might be direct and specific inhibition of the DNA synthesis and proliferation of cardiovascular cells which may be related to the inhibition of collagen alpha 2 ( 1 ) cDNA , c fos and c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Local intracoronary administration of antisense oligonucleotide against c myc for the prevention of in stent restenosis : results of the randomized investigation by the Thoraxcenter of antisense DNA using local delivery and IVUS after coronary stenting ( ITALICS ) trial . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MYC signals derived from the non translocated chromosome 8 were found equally distributed between the residual nucleus and the surrounding DNA halo . ^^^ In LY 66 cells , attachment to the residual nucleus was restricted to a DNA segment 30 to 50 kb downstream of MYC , while in monocytes it was dispersed over 80 kb around the MYC gene . ^^^ Distance measurements between MYC and IGK signals revealed shorter values than expected from their linear distance ( 325 kb ) , indicating a back folding of the DNA backbone . ^^^ Thus , there is strong evidence for a specific topological organization , which is functionally related to the MYC activation status with the specific folding of the DNA strand likely reflecting maintenance of a spatial interaction between IGK enhancer and MYC promoter elements . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We show that the estrogen receptor and c myc transcribed DNA sequences are associated with unfolded nucleosomes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To understand the mechanisms of Myc mediated apoptosis induced by DNA damage , we have characterized the death kinetics of three Rat 1 fibroblast cell lines that either overexpress Myc or lack Myc and their parental wild type cells following exposure to the DNA damaging agent VP 16 , and we monitored the changes in gene expression using microarray . ^^^ Thus , we have proposed that removal of Myc mediated repression of apoptotic signals , combined with Myc associated acceleration of the p 53 responsive pathway , results in complete and rapid cell death following DNA damage . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : Morphometric and immunohistochemical techniques were used to analyse DNA content , p 53 and c myc oncogene expression and cell proliferation on gastric biopsies of 53 children ( 27 Helicobacter pylori negative and 26 Helicobacter pylori positive ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We obtained DNA sequence data from the nuclear c myc and RAG 1 genes of the major passerine groups and here we demonstrate that the endemic New Zealand wrens ( Acanthisittidae ) are the sister taxon to all other extant passerines , supporting a Gondwanan origin and early radiation of passerines . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
When analysing the initiation mechanism of c Myc dependent amplification of the mouse ribonucleotide reductase R 2 ( R 2 ) gene , we observe c Myc dependent initiation of illegitimate DNA replication of the R 2 gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Abl is an effector of Src for growth factor induced c myc expression and DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Twenty four tumors obtained from patients with bladder cancer were analyzed by interphase cytogenetics using FISH with chromosome 8 and 17 centromere probes together with an YAC clone covering the c myc locus and three cosmid DNA probes covering the p 53 locus . ^^^ Both polysomy 8 and c myc copy gain were significantly correlated with p 53 deletions ( p < 0 . 01 ) and DNA ploidy ( p < 0 . 001 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hypomethylation of the c myc gene within 24 h of administering Wy 14 , 643 after a partial hepatectomy but not after a sham operation supports the hypothesis that the peroxisome proliferators prevent methylation of hemimethylated sites formed by DNA replication . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the present study , we investigated the effects of c Myc overexpression on the DNA damage induced G ( 1 ) / S checkpoint , in order to obtain mechanistic insights into how deregulated c Myc destabilizes the cellular genome . ^^^ A transient excess of c Myc activity , provided by the activated MycER , was similarly able to induce the inappropriate de novo DNA synthesis following IR . ^^^ Significantly , the transient expression of full length c Myc in normal mortal HMECs also facilitated entry into S phase and the inappropriate de novo DNA synthesis following IR . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
For example , WR 1065 treatment activates binding of the redox sensitive transcription factor NF kappa B to DNA and affects expression of a number of genes , including thymidine kinase , c myc , and manganese superoxide dismutase . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Flow cytometry analysis showed that Tan 2 A arrested NB 4 cell in G ( 0 ) / G ( 1 ) phase , inhibited cellular DNA synthesis , down regulated c myc and bcl 2 genes expression , and up regulated c fos and p 53 genes expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS : Fluorescence in situ hybridisation ( FISH ) was performed on paraffin sections with locus specific DNA probes for D7S486 , c myc , cyclin D 1 , Her 2 / neu , 20q13 . 2 and associated chromosomes 7 , 8 , 11 , 17 and 20 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mutation of either site abrogates DNA binding by c Myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Similarly , an increase of DNA copy number for the Her 2 / neu and c myc oncogenes was noted in all neoplasms . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To analyse the role of Pasteurella haemolytica Leukotoxin ( LKT ) in the mechanism of apoptotic cell death of bovine lymphocytes , we evaluated DNA fragmentation and p 53 and c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These include alterations in DNA ploidy , cellular proliferation markers ( PCNA , Ki 67 , Mcm 2 , MIB 1 , MIA , and CSE1L / CAS protein ) , nuclear morphology , the p 53 gene and its related molecule MD M 2 , other cell cycle regulators ( cyclin A , cyclin D , cyclin E , cdc 2 , p 27 , p 73 ) , oncogenes and their receptors ( such as ras , c myc , c fms , HGF , c met , and erb B receptor family members ) , apoptosis related factors ( Fas and FasL ) , as well as telomerase activity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Biochemical , cytological , cell cycle , and global gene expression analyses revealed that brief c Myc activation can induce DNA damage prior to S phase in normal human fibroblasts . ^^^ Deregulated c Myc partially disabled the p 53 mediated DNA damage response , enabling cells with damaged genomes to enter the cycle , resulting in poor clonogenic survival . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The Myc basic helix loop helix zipper domain determines dimerization with Max and binding to the DNA E box , both of which play a critical role in Myc regulation of growth , proliferation , tumorigenesis , and apoptosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA from tumour and healthy tissue was evaluated for amplification of the 11q13 region and of the MYC and ERBB 1 oncogenes , for integration of the Human Papillomavirus ( HPV ) , and for loss of heterozygosity ( LOH ) at p 53 and NAT 2 loci . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using deletion mutants we showed that the DNA binding domain of p 73 and the C terminal region of c Myc are required for the interaction . ^^^ Furthermore , p 73 stimulated the interaction of Max with c Myc and promoted binding of the c Myc Max complex to its target DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Expression analyses , DNA binding assays and chimeric promoter reporter experiments suggest that two genes , NM 23 H2 and N RAS , may indeed be direct targets for c MYC activation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This report describes a competitive PCR assay that was used to quantitate DNA damage induced by anticancer drugs within a 683 bp region of the c myc gene in human CEM leukemia cells . ^^^ Absolute quantitation of gene specific DNA damage ( attomoles or molecules of damaged DNA sequences ) was achieved by coamplification of a homologous internal standard that has the same primer binding sites and PCR amplification efficiency as c myc . ^^^ The variability ( standard error ) associated with four separate determinations of the amount of c myc sequence in 300 ng of DNA from untreated cells ( 6 . 80 + / 0 . 05 SE amol ) was less than 1 % of the mean . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A new paper implicates the Myc oncoprotein in the direct induction of DNA damage and consequent genome instability in cultured cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
As a basis for better defining whether steroids stimulate growth by a common mechanism or fall into sub groups with differing actions , the effects of 46 steroids on DNA synthesis and the expression of protooncogenes c fos and c myc were examined in primary cultures of normal rat hepatocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We are presently involved in evaluating the possible relationship between estrogens receptor expression , type of receptor , oxidative DNA damage and c myc in chronic liver disease . ^^^ The data on DNA adducts , c myc mRNA and variant estrogen receptor in patients with HCV or HBV related chronic liver disease are suggesting that those positive for variant liver estrogen receptor present higher genomic oxidative damage , as reflected in 8 OHdG levels . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Consequences of hepatic DNA hypomethylation include increased expression of c myc and DNA strand break accumulation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Various observations support the suggestion of a role of DNA methylation in chemoprevention by SAM : ( 1 ) Exogenous SAM reconstitutes the SAM pool in preneoplastic and neoplastic liver lesions . ( 2 ) DNA methylation is positively correlated with SAM : S adenosylhomocysteine ( SAH ) ratio in these lesions . ( 3 ) 5 Azacytidine , a DNA methyltransferase inhibitor , inhibits chemoprevention by SAM . ( 4 ) c Ha ras , c Ki ras , and c myc are hypomethylated and overexpressed in preneoplastic liver . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The objective was to determine the DNA integrity of the BRCA 1 tumor suppressor gene and the c myc proto oncogene after PTX . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : This study examines the effect of c myc antisense oligomers delivered in isolation as naked DNA and in combination with carboplatin upon the growth kinetics of an in vivo transplantable adenocarcinoma using rodents . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A DNA fragment from the human c myc origin region containing yeast ACS like elements also showed p 35 binding activity . ^^^ Like the ARS consensus sequence elements of yeast , ACS like elements found in c myc and lamin beta 2 origin regions may play similar roles in replication and indicate a conserved role for this DNA motif among eukaryotes . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mice deficient in both a nonhomologous end joining ( NHEJ ) DNA repair protein and the p 53 tumor suppressor develop lymphomas at an early age harboring amplification of an IgH / c myc fusion . ^^^ Subsequent DNA repair events juxtaposing IgH and c myc are mediated by a break induced replication pathway . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS : The effects and mechanism of KH on proliferation , differentiation and apoptosis of WEHI 3B cells in vitro were studied by semi solid colony culture , MTT assay , morphologic examination , NBT reduction test , NSE assay , DNA fragmentation in gel electrophoresis and RT PCR of c myc oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cytokeratin and several proliferation associated cellular antigens ( proliferating cell nuclear antigen ( PCNA ) , p 53 , c erbB / 2 and c myc ) were labeled with PE and FITC , which was followed by DNA staining using PI . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Whereas Stra 13 is known to regulate many important cellular functions and is known to cross regulate biological responses to other basic helix loop helix containing transcription factors , including c Myc and USF , it is unclear if this protein binds directly to DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To study the prevalence of the oncogenes c myc , IFN alpha ; c erbB 2 ; H ras codon 12 , 13 , and 61 ; c fos ; and E6 / E7 oncogenes of human papillomavirus ( HPV ) 16 in patients with invasive carcinoma of the cervix and their prognostic significance , genomic DNA and RNA were isolated from tissues of 275 patients in Singapore with nonmetastatic cervical cancer and 32 patients with normal cervix . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc suppression of the p 21 ( Cip 1 ) Cdk inhibitor influences the outcome of the p 53 response to DNA damage . ^^^ Myc is directly recruited to the p 21 ( Cip 1 ) promoter by the DNA binding protein Miz 1 . ^^^ As a result Myc switches , from cytostatic to apoptotic , the p 53 dependent response of colon cancer cells to DNA damage . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This phenotype is independent of p 53 status and can not be reproduced by overexpression of Bcl 2 or Myc and Bcl 2 but seems to counteract a cell cycle checkpoint mediated by DNA mismatch repair ( MMR ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mutational changes in beta catenin in exons 3 , 5 and 6 were detected by each PCR single strand conformational polymorphism analysis followed by direct DNA sequencing . mRNA expression and copy numbers of c myc and cyclin D 1 were determined by semiquantitative reverse transcriptase PCR and competitive genomic PCR . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Unsaturated fatty acids bind Myc Max transcription factor and inhibit Myc Max DNA complex formation . ^^^ We found that linoleic acid , isolated from Pollen Typhae , and other unsaturated fatty acids have strong inhibitory effects on the binding of Myc Max heterodimer to an E box DNA site ( CA ( C / T ) GTG ) . ^^^ The interaction of a fatty acid with a protein dimer , not with DNA , is assumed to block the entire Myc Max DNA complex formation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , the DNA amplification levels of ERBB 2 , MYC and CCND 1 , as measured by real time quantitative PCR , did not differ between IBC and non IBC . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We have therefore developed a 5 ' exonuclease fluorogenic PCR assay in a single tube balanced heminested format that simultaneously detects Mycobacterium tuberculosis complex ( MTC ) and members of the Mycobacterium genus ( MYC ) using the 16S ribosomal DNA target directly on clinical samples . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Results described a caspase 3 mediated cleavage of beta catenin , decreased transactivation of beta catenin / Tcf Lef , decreased promoter DNA binding activity of the beta catenin / Tcf Lef complex , and decreased levels of c Myc protein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MIBG also blocked the stimulation of DNA and RNA synthesis , prevented smooth muscle cell migration and suppressed the induction of c fos and c myc gene expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This protein sequence contains a basic DNA binding domain and two alpha helices separated by a loop , typical of a transcription factor belonging to the MYC sub family of bHLH genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Inhibition of c myc was specifically achieved by using phosphorodiamidate Morpholino oligomer ( PMOs ) , a novel , non toxic antisense DNA chemistry for inhibition of gene expression by an RNase H independent mechanism . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The results showed that the brain tissue neurons treated by traumatic brain injury underwent morphological changes of apoptosis , the DNA presented `` ladder ' ' break , the rate of neuronal apoptosis at different times ranged from 9 . 8 % to 14 . 0 % , but that of the control group was 1 . 7 % and the expressions of related apoptosis genes ( c myc , fas and fasL ) were increased . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA topoisomerase 2 inhibitor , etoposide , induces p21WAF1 / CIP1 through down regulation of c Myc in K 562 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
X ray structures of Myc Max and Mad Max recognizing DNA . ^^^ Molecular bases of regulation by proto oncogenic transcription factors . 10 ray structures of the basic / helix loop helix / leucine zipper ( bHLHZ ) domains of Myc Max and Mad Max heterodimers bound to their common DNA target ( Enhancer or E box hexanucleotide , 5 ' CACGTG 3 ' ) have been determined at 1 . 9 A and 2 . 0 A resolution , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This mechanism requires DNA binding of the Myc Max complex to Inr sequences . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Interactions of the DNA mismatch repair proteins MLH 1 and MSH 2 with c MYC and MAX . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The MITF protein is a member of the MYC supergene family of basic helix loop helix leucine zipper ( bHLHZip ) transcription factors and is known to regulate the expression of cell specific target genes by binding DNA as homodimer or as heterodimer with related proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here we have used clonal HeLa cell lines containing mutated c myc origin constructs integrated at the same chromosomal location to identify elements important for DNA replication . ^^^ We find that deletions of several segments of the c myc origin , including the DNA unwinding element and transcription factor binding sites , substantially reduced replicator activity , whereas deletion of the c myc promoter P 1 had only a modest effect . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It is the obligate partner of the related b HLH LZ proteins , c Myc and Mad 1 , with which it forms heterodimers on target DNA . ^^^ While c Myc and Mad 1 require Max for DNA binding , Max itself can form a homodimer that recognizes E box DNA sequences ( CACGTG ) in gene promoters that are targeted by c Myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The findings might explain how Myc interferes with cell cycle arrest in response to TGF beta , APC and DNA damage . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To help in characterizing mechanisms of growth control by these compounds , their effects on the expression of immediate early protooncogenes c fos and c myc have been examined and compared with other compounds that stimulate DNA synthesis in primary cultures of normal rat hepatocytes . ^^^ Unlike c fos mRNA , c myc mRNA was detectable in hepatocyte cultures without added growth factor , was augmented within 2 h of exposure to EGF , and was further increased by adding E ( 2 ) , other estrogens or a variety of other stimulators of DNA synthesis in hepatocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results indicate that NBS 1 is a direct transcriptional target of c Myc and links the function of c Myc to the regulation of DNA DSB repair pathway operating during DNA replication . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA microarray analysis and immunoblotting identified p 21 , Myc , 14 3 3 zeta , cyclin A , cyclin B 1 , and GADD 153 as genes constitutively overexpressed ( 2 to 10 fold ) in both MCF+FIR and MCF+SOD cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Similar but less potent potentiation was seen with DNA binding of cAMP responsive element binding protein ( CREB ) , while both polyamines were ineffective in affecting that of c Myc irrespective of the addition of MgCl ( 2 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It interacts directly or indirectly with a variety of important proteins , including oncogene proteins ( c myc , E2F ) , tumor suppressor proteins ( p 53 , RB , BRCA 2 ) , DNA damage repair proteins ( RAD 50 , RAD 51 ) , cell cycle regulators ( cyclin , CDK ) , transcriptional regulators ( RNA polymerase 2 ) and others related to the important biological events . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Thus , the binding of p202a results in the inhibition of the sequence specific binding to DNA of the c Fos , c Jun , E2F1 , E2F4 , MyoD , myogenin , and c Myc transcription factors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Human isoforms A and B of nm23 / nucleoside diphosphate ( NDP ) kinase , functionally important in development and cancer , have been reported to bind to DNA , and in particular isoform A to the PDGF A promoter and isoform B to the c myc promoter and to telomeric repeats . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The aim of this study was to elucidate potential molecular mechanisms in the progression to malignancy in phyllodes tumours . c myc and c kit were studied at the protein , RNA ( c myc only ) and DNA level . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Fifty Japanese clear cell renal cell carcinomas ( RCCs ) were examined by dual color FISH using cosmid DNA probes for 3p25 . 1 25 . 3 combined with probes for chromosome 3 centromere , 8p12 , 8p21 . 1 , 8p21 . 3 , 8p22 and 8q24 . 12 24 . 13 ( c myc ) , and chromosome 8 centromere . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We used bioinformatics to select consensus DNA elements ( CACGTG or E boxes ) situated in the 5 ' regulatory region of genes and measured Myc binding to those sequences in vivo by quantitative chromatin immunoprecipitation . ^^^ Strikingly , most promoter associated E boxes showed selective recovery with Myc , unlike non E box promoters or E boxes in bulk genomic DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To investigate whether UII acts as an autocrine / paracrine growth factor for renal epithelial cells , we have studied the effects of human UII ( hUII ) on DNA synthesis , cytosolic free Ca ( 2+ ) concentration ( [ Ca ( 2+ ) ] ( 1 ) ) , ERK activation , and protooncogene ( c myc ) expression in a porcine renal epithelial cell line ( LLCPK 1 ) . hUII stimulated [ ( 3 ) H ] thymidine uptake into quiescent cells in a dose dependent manner ( 10 ( 9 ) to 10 ( 7 ) M ) ; this effect was inhibited by a protein kinase C inhibitor ( GF109203X ) , a MAPK kinase inhibitor ( PD 98059 ) , and a calcium channel blocker ( nicardipine ) . ^^^ Neither phosphatidyl inositol 3 kinase inhibitors ( LY 294002 , wortmannin ) nor p 38 kinase inhibitor ( SB 203580 ) affected the hUII induced DNA syntheses . hUII rapidly ( within 5 min ) and dose dependently ( 10 ( 9 ) to 10 ( 7 ) M ) increased [ Ca ( 2+ ) ] ( 1 ) in fura 2 loaded cells . hUII also caused a rapid and transient activation of ERK1 / 2 and induction of c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Apoptosis induction mediated by DNA damage and long term culture was independent of c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : Extracted DNA from diagnostic biopsies of 78 untreated patients were analyzed by real time PCR with specific primers for c MYC , CCND 1 , and CDKN2A . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA array analysis revealed that expression of genes such as the RhoG and D 4 GDI genes was down regulated in TEL overexpressing cells , while that of the representative growth related genes such as the c myc , c fos and c jun genes was not remarkably changed . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Dysregulation of DNA repair pathways in a transforming growth factor alpha / c myc transgenic mouse model of accelerated hepatocarcinogenesis . ^^^ Previous work from our laboratory has implicated oxidative DNA damage and genetic instability in the etiology of transforming growth factor alpha ( TGFalpha ) / c myc associated hepatocarcinogenesis . ^^^ In contrast , oxidative DNA damage was lower in c myc single transgenic mice , consistent with less chromosomal damage and with later and more benign tumor formation . ^^^ We examined whether defects in the DNA repair pathways contribute to the acceleration of liver cancer in TGFalpha / c myc mice . ^^^ Thirty five percent ( 8 / 23 ) and 43 % ( 10 / 23 ) of DNA repair genes were constitutively up regulated in 10 week old TGFalpha / c myc and c myc transgenic livers , respectively , compared with wild type controls . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results indicate that c Myc degradation induced by DNA damage in the presence of TC contributes to induction of apoptosis of UV 41 cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Despite this oncogenic lesion , Y 1 cells retain tight regulatory mechanisms of cell cycle control typified by the sequential events comprising the mitogenic response triggered by FGF 2 in G0 / G1 arrested Y 1 cells : 1 ) activation of ERK1 / 2 and PI3K , by 5 minutes ; 2 ) induction of c Fos and c Myc proteins by 2 hours ; 3 ) induction of cyclin D 1 protein by 5 hours ; 4 ) phosphorylation of Rb protein between 6 and 8 hours ; 5 ) onset of DNA synthesis by 8 9 hours . ^^^ Ectopic expression of both c Myc and cyclin D 1 is not sufficient to drive G0 / G1 arrested Y 1 cells into S phase , but when the sustained expression of these two proteins is complemented by ACTH treatment it promotes G 1 phase progression and DNA synthesis initiation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Transcripts identified by the assay included those that facilitate tissue healing ( early growth response gene ( egr ) 1 ) , regulate inflammation ( interleukin ( IL ) 6 , tristetraproline ( ttp ) ) , cell growth ( c myc , cytokine inducible SH 2 containing protein ( cish ) 3 ) , apoptosis ( T cell death associated protein ( tdag ) 51 , pim 1 ) and DNA repair ( ephrin type A receptor 2 ( ephA 2 ) ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
SNP treatment reduces the DNA binding ability of the constitutively active NF kappa B heterodimer , p65 / p50 , and its consequent transactivation of the c myc promoter . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
An antisense mediated decrease in c Myc expression results in decreased cyclin D 1 expression and inhibition of DNA synthesis , mimicking the effects of antiestrogen treatment and emphasizing the importance of c Myc as an estrogen / antiestrogen target . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
About 85 % of the tumors showed increases in DNA copy numbers in the regions ( 2p and 8q ) harboring the myc family gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The DNA binding of c Myc and Max correlates extensively with gene expression throughout the genome , a hallmark attribute of general transcription factors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Demonstration of the existence of G quadruplex structures in telomeres of Stylonychia macronuclei and in the promoter of c myc in human cells has validated these secondary DNA structures as potential targets for drug design . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA synthesis was inhibited by addition of transforming growth factor beta 1 ( TGF beta 1 ) , and Northern blot analysis revealed that expression of c myc , a cell cycle related immediate early gene , was depressed by TGF beta 1 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Upon CD 40 induced expression of activation induced cytidine deaminase ( AID ) , DSBs increase in frequency and are resected to yield 5 ' and 3 ' protruding ends in hypermutating rearranged 5 genes , BCL 6 and translocated c MYC . 3 ' protruding ends would direct DSB repair through homologous recombination , as indicated by their exclusive presence in S / G2 and recruitment of Rad52 / Rad51 , leading to SHM , upon mispair by error prone DNA polymerases modulated by crosslinking of the B cell receptor for antigen . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
During the process of carcinogenesis , changes in hepatic gene expression of DNA repair proteins / enzymes ( XPA and XPC , xeroderma pigmentosum complementation groups A and C , respectively ; APE , apurinic / apyrimidinic endonuclease ) and of cell proliferation associated proteins ( c myc ; PCNA , proliferating cell nuclear antigen ; cyclin D 1 , cyclin B , and p34cdc2 ) were examined by RT PCR . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In two tumour sublines ( T . wt / BL and T . wt / Bc ) , established from mammary adenocarcinomas caused by mouse polyoma ( Py ) infection of nu / nu mice , integration of polyomavirus DNA sequences into the c myc gene locus was mapped . ^^^ A complete Py genome was found to be integrated just upstream from the c myc gene in T . wt / BL cell line , while only a part of the early Py region coding for the early proteins was inserted in the chromosomal DNA of T . wt / Bc cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA aneuploidy , p 53 and c myc expression disappeared after H . pylori eradication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Downregulation of cytochromes P 450 in growth stimulated rat hepatocytes : role of c Myc induction and impaired C / EBP binding to DNA . ^^^ The N terminal c Myc domain added to control nuclear extracts prevented C / EBP DNA binding . ^^^ CONCLUSIONS : EGF overexpresses c Myc , decreases C / EBP binding to DNA and downregulates CYPs . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA damage and c myc gene expression of NIH3T3 cell induced by superoxide anion ] . ^^^ OBJECTIVE : To study the DNA damage , membrane lipid peroxidation , and c myc gene expression of NIH3T3 cell induced by superoxide anion ( O2 . ) . ^^^ METHODS : The superoxide anion ( O2 . ) was produced by reactive system of xanthine xanthine oxidase ( 10 XO ) and the DNA EB complex , malondialdehyde ( MDA ) content and expression of c myc gene were measured by means of fluorescence , thiobarbituric acid ( TBA ) assay and DNA RNA situ hybridization with digoxigenin labeled probes respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
TUNEL detection analysis also revealed the DNA fragmentation and As2O3 decreased c myc gene expression was observed . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
RESULTS : As2O3 induced G 2 + M arrest of tumor cells such as GLC 82 , MGC 803 , SGC 7901 , Eca 109 and HeLa cells before inducing apoptosis and decreased c myc gene expression , whereas caused G 1 block of HPV 16 DNA immortalized cervical epithelial HCE16 / 3 cells and did not affect c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Defective double strand DNA break repair and chromosomal translocations by MYC overexpression . ^^^ MYC has not been previously implicated in a role in DNA repair . ^^^ Here we report that the overexpression of MYC disrupts the repair of double strand DNA breaks , resulting in a several magnitude increase in chromosomal breaks and translocations . ^^^ We found that MYC inhibited the repair of gamma irradiation DNA breaks in normal human cells and blocked the repair of a single double strand break engineered to occur in an immortal cell line . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
RESULTS : In the Molt cells , p 53 gene expression was increased following treatment while c myc was decreased after treatment shorter than 24 hours ; N ras expression was significantly reduced at picomolar concentration for 24 hour treatment ; cyclinD 1 and cdk 4 expression did not show any change ; DNA flow cytometry demonstrated that Molt cells were arrested or delayed predominantly in G 2 M . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Moreover , expression of a dominant negative c Myc mutant inhibited BPV 1 E 7 induced DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
AS2006A increased the number of cells positively stained with TdT mediated dUTP nick end labeling ( TUNEL ) , and upregulated the expression of the genes implicated with apoptosis , which included caspase 8 , c myc , iNOS , mdm 2 , NF kappaB 1 , 1 kappaBalpha and NF kappaB p 105 genes , as assessed by the membrane DNA array technique . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In rearranged Ig 5 , BCL 6 , and translocated c MYC genes , blunt DSBs are processed to yield resected DNA ends . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA sequence data were collected from a mitochondrial gene ( ND 2 ) and a nuclear gene ( c myc ) . ^^^ Phylogenetic analyses yielded concordant results between loci , with reciprocal monophyly of mitochondrial DNA haplotypes for all species and of c myc haplotypes for three of the four species . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In order to bind DNA , regulate target gene expression , and function in a biological context , c Myc must dimerize with another HLH ZIP protein , Max . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Amplification of eight oncogenes ( CCND 1 , FGF3 / FGF4 , EMS 1 , SAS , ERBB 2 , PDGFRA , MYC , and BCL 2 ) was detected by DNA microarrays in 9 of 20 tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this experimental system , we previously demonstrated that a high endogenous / exogenous level of amplification of c myc enhances serum deprivation and DNA damage induced apoptosis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In mouse embryo fibroblasts ( MEFs ) and in E micro myc transgenic B cells in vivo , c Myc acts in synergy with gamma IR to trigger apoptosis , but alone , when cultured in growth medium , it does not induce a DNA damage response . ^^^ Therefore , MYC may sensitize tumor cells to DNA damage by suppressing Bcl X . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the investigation of the relationship between the 8 OH dG and five cancer related genes , higher 8 OH dG levels were observed in lung cancer patients with over expression of K RAS and BCL 2 than those of negative expressed patients ( P value were 0 . 035 and 0 . 034 respectively ) , whereas the expression of P 53 , C MYC and hTERT were not correlated with level of 8 OH dG . 8 OH dG was an important biomarker that may reflect the oxidative DNA damages of cells , and 8 OH dG may affect K RAS and BCL 2 genes in the carcinogenesis of lung cancer . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Effects of c Myc overexpression on the DNA damage induced G2 / M checkpoint were studied in finite lifespan , normal human mammary epithelial cells ( HMECs ) . ^^^ Previously , we showed that c Myc attenuates G1 / S arrest and leads to an inappropriate entry of cells with damaged DNA into the S phase , following treatment with ionising radiation ( IR ) . ^^^ Introduction of DNA damage in c Myc overexpressing , normal mammary epithelial cells eventually induces apoptosis , indicating a dramatic sensitisation by c Myc of DNA damage induced apoptosis . ^^^ These two remarkable phenotypes , checkpoint attenuation and sensitisation to apoptosis , resulting from a deregulation of the protooncogene c myc , may produce a unique pattern of alternating cycles , consisting first of amplification of DNA damage , followed by apoptosis assisted selective pressure . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In the c myc expressing tumor areas , there were many dying or dead cells organized in clusters , termed `` dead cell islands . ' ' These cells exhibited shrinkage , DNA breakage as indicated by a positive TUNEL staining , and nuclear localization of apoptosis inducing factor , but a lack of typical apoptotic morphology , such as nuclear condensation and formation of cell membrane blebs and apoptotic bodies . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc MAR is also matrix associated in CEM cells while localizing to loop DNA in WI 38 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this study , we used a randomly amplified polymorphic DNA ( RAPD ) PCR approach to fingerprint DNA from microdissected normal and dysplastic cells and identified two recurrent genetic alterations on the long arm of chromosome 8 in OPLs , one mapping to 8q22 and the other to 8q24 near the MYC locus . ^^^ Hybridization of DNA from microdissected oral tumors to the array revealed alteration at 8q24 , with amplification of the BAC containing MYC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Reactivity of the Blm HMYC 55 conjugate ( and mismatch controls ) with a MYC mRNA 30 mer , a MYC DNA 30 mer , and a MYC 2 ' O methyl RNA 30 mer , nt 7041 7070 , was analyzed in 100 microM FeNH ( 4 ) SO ( 4 ) , 50 mM beta mercaptoethanol , 200 mM LiCl , 10 mM Tris HCl , pH 7 . 5 , at 37 degrees C . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc oncogene is one of the many relevant amplified genes contained within the extrachromosomal DNA compartment . ^^^ COLO 320 clone 3 and COLO 320 clone 21 cell lines contain the same number of amplified copies of c myc oncogene , but located respectively on extrachromosomal DNA , and intrachromosomally in homogeneously staining regions . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These effects were exacerbated in the absence of serum and associated with inhibition of tyrosine kinase activity , down regulation of RAS and MYC expression , and induction of apoptosis as indicated by DNA fragmentation . ^^^ In contrast , treatment of parental 32D cells with IL 3 , which is obligatory for cell survival and proliferation , increased tyrosine kinase activity , upregulated MYC and RAS expression and maintained DNA integrity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Cantharidin treated cells not only decreased expression of genes coding for proteins involved in DNA replication ( e . g . , DNA polymerase delta ) , DNA repair ( e . g . , FANCG , ERCC ) , energy metabolism ( e . g . , isocitrate dehydrogenase alpha , ADP / ATP translocase ) , but also decreased expression of genes coding for proteins that have oncogenic activity ( e . g . , c myc , GTPase ) or show tumor specific expression ( e . g . , phosphatidylinositol 3 kinase ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Promoter regions of transiently induced genes contained DNA motifs that bind auxin response ( ARFAT ) and silence element binding factors whereas genes induced by IAA during the entire experimental period contained MYC and ARFAT DNA motifs at higher frequencies . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
B and AP 1 DNA binding activity , down regulation of c myc , upregulation of Gadd 45 and p 53 , and activation of p 38 kinase . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Max interaction with Myc is required for DNA binding at so called E box sequences and Myc dependent transcriptional activation . ^^^ The repressor with similar DNA binding specificity raised the possibility that Mnt may serve a general role as a Myc antagonist . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
To explore the preparation method of liposome mediated 99m technetium labeled antisense oligonucleotides of c myc mRNA and lay foundations for antisense imaging and treatment , antisense oligonucleotides ( DNA ) with 15 bases and di functional chelate , hydrazino nicotinamide derivatives , were synthesized . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Degree of nucleolysis has critical significance for isolation of nuclear matrix ( NM ) specifically enriched in transcribed DNA sequences as demonstrated at the example of inactive ( c fos , c myc , and Ck ) and active ( p 53 , albumin , and 28S rRNA ) genes in resting hepatocytes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Phosphorylation at all three residues reduces the binding of Myc to DNA , either by blocking the requisite dimerization with Max ( through phosphorylation at S 373 and T 400 ) or by interfering directly with binding to DNA ( through phosphorylation at T 358 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A second peak of c myc expression was observed later , at the time of the wave of DNA synthesis . ^^^ No such expression was detected in sham operated rat quiescent hepatocytes . max expression increased around 4 16 h after hepatectomy , before the peaks of c myc and DNA synthesis . mxi 1 and mad 4 were slightly downregulated during liver regeneration . mnt / rox expression did not change . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The objective of this study was to determine the relationship between cytoplasmic and nuclear c myc staining , DNA index , and survival in patients with endometrial carcinoma . ^^^ In addition to cytoplasmic and nuclear c myc staining and DNA index , histologic type , stage , grade , depth of invasion , lymphvascular space invasion , and peritoneal cytology were evaluated as prognostic indicators . ^^^ DNA index was significantly higher in patients with nuclear c myc staining and no cytoplasmic staining ( DNA index 1 . 38 ) as compared to those patients whose tumors displayed cytoplasmic c myc staining but no nuclear c myc staining ( 1 . 18 ) ( P = 0 . 016 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In this study , APM and AA were studied immunohistochemically to detect c myc oncoprotein expression , and FISH was employed using a DNA probe for the c myc gene in archival tissue sections of cases of APM and AA of the breast . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using high density oligonucleotide arrays representing essentially all nonrepetitive sequences on human chromosomes 21 and 22 , we map the binding sites in vivo for three DNA binding transcription factors , Sp 1 , cMyc , and p 53 , in an unbiased manner . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Determination of binding constant of transcription factor myc max / max max and E box DNA : the effect of inhibitors on the binding . ^^^ The truncated myc and max proteins , only containing basic regions and helix loop helix / zipper ( b / HLH / Zip ) regions were over expressed in E . coli and used for the determination of the binding constant and of the inhibitory mechanism on myc max ( or max max ) DNA complex formation . ^^^ The equilibrium binding constant ( K ( 1 ) ) was determined using these kinetic parameters [ K ( XXD ) = ( 7 . 8+ / 2 . 6 ) x 10 ( 6 ) M ( 1 ) for max max and DNA or K ( XYD ) = ( 6 . 9+ / 2 . 2 ) x 10 ( 6 ) M ( 1 ) for myc max and DNA ] . ^^^ The truncated myc and max proteins , which were expressed in E . coli and contained only b / HLH / Zip regions were also used for the screening of inhibitors of myc max DNA complex formation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c Myc oncoprotein ( Myc ) is a DNA sequence specific transcription factor that regulates transcription of a wide variety of genes involved in the control of cell growth , proliferation , differentiation , and apoptosis and its deregulated expression is implicated in many types of human cancer . ^^^ Myc has an N terminal transcription activation domain ( TAD ) that interacts with various coactivators and a C terminal basic helix loop helix leucine zipper ( bHLHZip ) domain required for E box specific DNA binding and heterodimerization with its obligatory bHLHZip protein partner Max . ^^^ The analysis of the mechanisms by which the Myc : Max complex regulates transcription at the molecular level in vitro has been hampered by the difficulty in obtaining highly pure recombinant Myc : Max heterodimers that contain full length Myc with its complete TAD domain and that have sequence specific DNA binding activity . ^^^ Here , we describe a simple method to reconstitute recombinant Myc : Max complexes from highly purified full length proteins expressed in Escherichia coli that are soluble and highly active in E box specific DNA binding in vitro . ^^^ This procedure should facilitate the characterization of the DNA binding and transcription activation functions of full length Myc : Max complexes in vitro and in particular the role of Myc TAD interacting cofactors and Myc : Max post translational modifications . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It was established by the context analysis of DNA of the deleted fragment along with the flanking sequences that this region contained a number of transcription factor motifs ( Ets , SRF , and Myc ) , potentially capable of the regulation of the M CFF dependant c fms transcription . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The transcription factor Myc forms a complex with its partner Max and with the regulatory DNA sequences on its target genes . ^^^ We have recently shown that formation of the Myc / Max / DNA complex is inhibited by the stress responsive protein kinase Pak 2 signaling pathway through phosphorylation of Myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This review summarizes progress in controlling the extent of c Myc transcription , translation , interaction with other myc network members , DNA binding and transcriptional activation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHOD : Vascular smooth muscle cell was cultured , the protein levels of c fos , c myc , p 15 , p 16 , p 18 , p 19 were measured by Western blot method , cell cycle were examined with flow cytometry , and the DNA synthesis was determined by [ 3H ] TdR incorporation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Site specific loading of an MCM protein complex in a DNA replication initiation zone upstream of the c MYC gene in the HeLa cell cycle . ^^^ We have determined the locations of certain MCM and associated proteins by chromatin immunoprecipitation ( ChIP ) in a zone of initiation of DNA replication upstream of the c MYC gene in the HeLa cell cycle . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
For validation , the DNA sequence copy number changes of selected clones ( SNRPN , CMYC , HER 2 , ZNF 217 ) detected by aCGH were confirmed by fluorescence in situ hybridization ( FISH ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These heterodimers specifically bind E box DNA sequence ( CACGTG ) to activate ( e . g . c Myc / Max ) and repress ( e . g . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
By using the endogenous H DNA forming sequence found in the human c myc promoter , mutation frequencies in a reporter gene were increased approximately 20 fold over background in COS 7 cells . ^^^ These results implicate H DNA induced DSBs in c myc gene translocations in diseases such as Burkitt ' s lymphoma and t ( 12 ; 15 ) BALB / c plasmacytomas , where most breakpoints are found near the H DNA forming site . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Hence , DBA , like DCA and TCA , induced hypomethylation of DNA and of the c myc and IGF 2 genes , increased mRNA expression of both genes , and caused peroxisome proliferation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Our aim was to determine how the chromosomal breaks involved in these events relate physically to the MYC gene ; whether they map to the FRA8C site , the FRA8D site , or both ; and how they correlate with the occurrence of DNA flexibility domains . ^^^ DNA helix flexibility clusters were also found near known MYC translocation breakpoints in Burkitt lymphomas ( BL ) , but most BL breakpoints mapped clearly outside FRA8C . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
As an example application , we analyzed a regulatory region of the human c myc proto oncogene consisting of a single strand specific protein binding site within a DNA region that unwindsin vivo . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In contrast , in adult mice MYC overexpression induced cell growth and DNA replication without mitotic cell division , and mice succumbed to neoplasia only after a prolonged latency . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
It has been reported that iron can increase cell proliferation , mainly by stimulating DNA synthesis as well as by enhancing c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Class switching and Myc translocation : how does DNA break . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Assays to capture and measure transcriptionally generated torque and to trap short lived perturbations in DNA structure and conformation showed that the transient forces upstream of active promoters are large enough to drive the supercoil sensitive far upstream element ( FUSE ) of the human c myc into single stranded DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using DNA microarrays , expression profiling was performed following stimulation of cells with serum , with Myc , or with both . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
BACKGROUND / AIMS : Co expression of c Myc and TGF alpha in the mouse liver accelerates hepatocarcinogenesis and enhances DNA damage due to chronic oxidative stress . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Because p 300 does not substitute for all CREB binding protein ( CBP ) functions , we investigated whether CBP also negatively regulates c myc and prevents premature DNA synthesis . ^^^ The CBP depleted cells contained significantly reduced levels of the cyclin dependent kinase inhibitor p 21 and low levels of p 107 and p 130 ( but not pRb ) phosphorylation , suggesting that these factors , along with elevated levels of c Myc , contribute to induction of DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
However , mutational analysis of the p 21 promoter and the use of a Gal 4 Sp1 chimeric protein strongly suggest that c Myc affects Sp 1 transcriptional activity but not the binding of Sp 1 to the p 21 promoter . c Myc mediated impairment of Ras activity on p 21 expression required a transactivation domain , a DNA binding region , and a Max binding region . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
USF is a small family of basic helix loop helix leucine zipper ( bHLH zip ) transcription factors with DNA binding specificities similar to that of the c Myc oncoprotein . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc oncogene , located on 8q24 . 12 q24 . 13 , was the only gene with a marked up regulation located on a chromosome section with a gain of DNA copy number . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Like Myc , Mitf regulates gene expression by binding to DNA as a homodimer or as a heterodimer with another related family member , in the case of Mitf the Tfe 3 , Tfeb , and Tfec proteins . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Miz 1 has two functions in response to DNA damage : first , it is required for upregulation of a large group of genes , a function that is regulated by c Myc , but not by 14 3 3eta ; second , Miz 1 represses the expression of many genes in response to DNA damage in an Akt and 14 3 3eta regulated manner . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA damage , c myc suppression and apoptosis induced by the novel topoisomerase 2 inhibitor , salvicine , in human breast cancer MCF 7 cells . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Promising approaches and molecular markers include gene expression profiles , DNA ploidy , loss of heterozygosity and chromosomal aberrations as detected by CGH and FISH ( 1q , 17p , 17q ) , as well as oncogenes / tumor suppressor genes and their proteins ( TP 53 , PTEN , c erbB 2 , N myc , c myc ) , growth factor and hormonal receptors ( PDGFRA , VEGF , EGFR , HER 2 , HER 4 , ErbB 2 , hTERT , TrkC ) , cell cycle genes ( p 27 ) and cell adhesion molecules , as well as factors potentially related to therapeutic resistance ( multi drug resistance , DNA topoisomerase IIalpha , metallothionein , P glycoprotein , tenascin ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here we explore the use of myc HSP 70 , as an adjuvant , in DNA vaccination against lymphoma . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here , we show that the level of histone H 4 acetylation correlates with the frequency of replication initiation as measured by the abundance of short nascent DNA strands within the human c myc and lamin B 2 origins , but less well with the frequency of initiation across the beta globin locus . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The c myc DNA unwinding element binding protein modulates the assembly of DNA replication complexes in vitro . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using chromatin immunoprecipitations , we observed that Myc is recruited to this promoter following STAT 3 DNA binding . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
They respond to UV and oxidative DNA damage and involve varied functions such as DNA unwinding , transcription initiation , protein ubiquitination , nuclear receptor phosphorylation , promoter release and myc homeostasis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Double chromatin immunoprecipitation using antibodies to Cdk 2 and Puralpha reveals that both proteins colocalize in HeLa cells to DNA segments upstream of the c MYC gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Proof of principle has been established that inhibition of several cellular proto oncogenes , including DNA binding protein c myb , non muscle myosin heavy chain , PCNA proliferating cell nuclear antigen , platelet derived growth factor , basic fibroblast growth factor and c myc , inhibits smooth muscle cell proliferation in vitro and in several animal models . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Demonstration by real time polymerase chain reaction that cellular DNA alkylation by novel aminoindoline compounds affects expression of the protooncogene c myc . ^^^ Here we extend the in vitro mechanism of action studies by treating cells in culture and examining the DNA binding patterns within AT rich regions of the protooncogene locus c myc , using a real time polymerase chain reaction ( PCR ) stop assay . ^^^ These analyses demonstrate a concentration and time dependence for DNA alkylation at the chosen sites within the c myc locus , as well as a prompt and significant downregulation of c myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using fluorescent hybridization on stretched DNA molecules in two cervical cancer derived cell lines , we have elucidated the genomic structures of amplified regions containing HPV / myc genes over several hundreds of kilobases . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We demonstrate that if PML is absent , despite Myc binding to the DNA regulatory sequences is unchanged , the expression profile of several Myc target genes is altered . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Surface plasmon resonance and competition experiments with duplex DNA and other G quadruplexes further confirmed the selectivity of Se2SAP for the c MYC G quadruplex . ^^^ From this study , we have identified an expanded porphyrin that selectively binds with the c MYC G quadruplex in the presence of duplex DNA and other G quadruplexes . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Astler Coller B 1 and B 2 colorectal cancers differed significantly in DNA copy number of the genes , MOS ( p=0 . 04 ) , MYC ( p=0 . 007 ) , DDEF 1 ( p=0 . 004 ) , PTK 2 ( p=0 . 02 ) and PTP4A3 ( p=0 . 04 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
These results indicate that exposure to PEMF exerts biological effects on the intracellular PUT of MG 63 cells and DNA synthesis , influencing the genes encoding c myc and c fos gene expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Although we did not find a difference in the inhibitor of DNA binding / differentiation 2 ( Id 2 ) and c Myc protein contents between the denervated and control muscles , the protein content of tumour suppressor p 53 was significantly increased in both the nuclear and the cytosolic fractions with denervation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : Tumour tissues from 24 patients were investigated by Dot blot DNA hybridisation for c myc , Ha ras amplification and p 53 deletion , and by immunohistochemical method for cyclin D 1 , p 53 and p 21 overexpression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
PROCEDURES : Fluorescent in situ hybridization with DNA locus specific probe for C MYC genewas applied on tissue microarrays presented by 863 larynx tumors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
This was confirmed by northern blot analysis , PCR amplification on genomic DNA and fluorescent in situ hybridization ( FISH ) experiments on metaphase chromosomes . 2G1MycP2Tu1 cells produce hybrid rRNA MYC RNA molecules that are polyadenylated and processed by splicing reactions involving natural and cryptic splice sites . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Complicons affecting Igh / Myc have been reported previously in lymphomas of mouse models simultaneously deficient in Tp 53 and in genes of the nonhomologous end joining DNA repair pathway . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Mnt and Myc require interaction with Max for specific DNA binding at E box sites , but have opposing transcriptional activities . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Single stranded genomic DNA of recombinant M 13 phages was tested as an antisense molecule and examined for its usefulness in high throughput functional genomics . cDNA fragments of various genes ( TNF alpha , c myc , c myb , cdk 2 and cdk 4 ) were independently cloned into phagemid vectors . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
BACKGROUND : The c Myc oncogenic transcription factor heterodimerizes with Max , binds specific DNA sites and regulates transcription . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Nucleoside diphosphate kinase from Mycobacterium tuberculosis cleaves single strand DNA within the human c myc promoter in an enzyme catalyzed reaction . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Identification of Sox 2 as a novel c myc BUR binding protein was achieved through yeast one hybrid screening and the Sox2 / DNA interaction was confirmed by electrophoretic mobility shift assay and immunoprecipitation with Sox 2 antibody . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using complementary DNA arrays in hemimegalencephaly specimens , we found increased expression of cyclin D 1 and c myc messenger ribonucleic acids ( RNAs ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Downregulation of c myc protein by siRNA mediated silencing of DNA PKcs in HeLa cells . ^^^ We demonstrated that c myc protein level was suppressed more than 80 % by siRNA mediated silencing of DNA PKcs . ^^^ Using an E box enhancer ( c myc binding element ) driving a secreted alkaline phosphatase ( SEAP ) reporter strategy , we further found that the transcriptional activity of c myc was extremely suppressed by silencing DNA PKcs . ^^^ The highest suppression effect on c myc expression was observed in the cells transfected with the siRNA targeting the catalytic motif of DNA PKcs . ^^^ However , silencing DNA PKcs did not change the level of c myc mRNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Human prostate cancers frequently display DNA amplification in the 8q24 amplicon , which leads to an increase in the copy number of the c MYC gene , a finding that suggests a role for c MYC in human prostate carcinogenesis . ^^^ METHODS : We took advantage of the ability of retroviruses to integrate foreign DNA into human prostatic epithelium ( huPrE ) to generate cell lines that overexpress the c MYC protooncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We show that transcription of the immunoglobulin S regions and c MYC results in formation of similar DNA structures , ' G loops ' , which contain a cotranscriptional RNA : DNA hybrid on the C rich strand and single stranded regions and G 4 DNA on the G rich strand . ^^^ Aberrant targeting of AID to DNA structures formed upon c MYC transcription may therefore contribute to the genetic instability of c MYC in B cell malignancies . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS AND RESULTS : Downregulation of PKC by phorbol 12 myristate 13 acetate ( PMA ) inhibited bFGF induced DNA synthesis , the activation of MAPK , and the expression of c myc , demonstrating the involvement of PMA sensitive PKC isoforms in growth factor induced proliferation and the MAPK pathway . ^^^ Whereas blocking of the classical PKC isoforms had no influence , the suppression of PKC delta by genetic and pharmacological approaches inhibited the bFGF stimulated c Raf 1 MEK MAPK c myc signaling and DNA synthesis in cSMC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Differential 14 3 3 sigma DNA methylation and expression in c myc and activated H ras transformed cells under r and K selection . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The analyses of three templates for a human telomeric 22 mer , a wild type , and a mutant human c MYC promoter ( 18 and 22 mer ) DNA and their reactions with the 3 ' 5 ' exo ( ) Klenow fragment of DNA polymerase 1 demonstrate the usefulness of our protocol . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Determination of the dissociation constants for recombinant c Myc , Max , and DNA complexes : the inhibitory effect of linoleic acid on the DNA binding step . c Myc , the protein product of protooncogene c myc , functions in cell proliferation , differentiation , and neoplastic disease . ^^^ In this study , recombinant c Myc and Max proteins , encompassing DNA binding ( basic region ) and dimerization ( helix loop helix / leucine zipper ) domain of human origin , were expressed in bacteria as Myc 87 and Max 85 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Furthermore , these Ku deficient cells had a 4 . 5 , 3 . 4 and 4 . 3 fold decrease in nascent strand DNA abundance at the lamin B 2 , beta globin and c myc replication origins , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In male , but not female mouse kidney , DCA , TCA , and to a lesser extent , chloroform decreased the methylation of DNA and the c myc gene . ^^^ The ability of the DBPs to cause hypomethylation of DNA and of the c myc gene correlated with their carcinogenic and tumor promoting activity in mouse and rat kidney , which should be taken into consideration as part of their risk assessment . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Rats fed ethanol intragastrically for 9 weeks also exhibit a relative switch in hepatic MAT expression , decreased SAMe levels , hypomethylation of c myc , increased c myc expression , and increased DNA strand break accumulation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Abl tyrosine kinase regulates a Rac / JNK and a Rac / Nox pathway for DNA synthesis and Myc expression induced by growth factors . ^^^ The cytoplasmic tyrosine kinase Abl is a Src substrate required for platelet derived growth factor ( PDGF ) receptor signaling leading to Myc expression and DNA synthesis . ^^^ We concluded that cytoplasmic Abl operates on a Rac / JNK and a Rac / Nox pathway for PDGF induced Myc induction and DNA synthesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In addition , ( 1 ) many genes related to ribosome and proteasome biosynthesis were upregulated , ( 2 ) a large number of genes downregulated were in the complement and coagulation cascades , ( 3 ) a number of key regulatory genes , including members of the JUN , MYC , and NFkappaB families were downregulated , which appears to be in contrast to the rodent , where JUN and MYC are reported to upregulated after PPARalpha agonist treatment , ( 4 ) no transcriptional signal for DNA damage or oxidative stress was observed , and ( 5 ) transcriptional signals consistent with an anti proliferative and a pro apoptotic effect were seen . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over expression of c MYC . ^^^ Deregulated expression of the proto oncogene c MYC is associated with intracellular oxidative stress and increased DNA damage . ^^^ In a variety of cell lines , we show that ectopic MYC over expression results in the elevation of intracellular ROS levels and a concomitant increase in oxidative DNA damage , as assessed by levels of 8 oxo 7 , 8 dihydro 2 ' deoxyguanosine ( 8 oxo dG ) in the genomic DNA . ^^^ A mitochondrially targeted Vitamin E analog , TPPB , also protected cells from MYC elicited oxidative DNA damage , suggesting the involvement of mitochondria in increased ROS production . ^^^ Our studies implicate a role for ROS , and superoxide in particular , in MYC elicited oxidative DNA damage and cellular transformation , and point to a pharmacological role of antioxidants in cancer chemoprevention . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
N Myc is a transcription factor that forms heterodimers with the protein Max and binds gene promoters by recognizing a DNA sequence , CACGTG , called E box . ^^^ This study illuminates a central role of DNA methylation in controlling N Myc occupancy at gene promoters and modulating its transcriptional activity in cancer cells . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The ability of certain DNA sequences to form G quartet structures has been exploited recently to develop novel anti cancer agents including small molecules that promote G quartet formation within the c MYC promoter thereby repressing c MYC transcription and introducing G quartet forming oligodeoxynucleotides ( GQ ODN ) into cancer cells resulting in p 53 dependent cell cycle arrest and inhibition of DNA replication . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We identified localized DNA amplifications corresponding to oncogenes known to be amplified in SCLC , including MYC ( 8q24 ) , MYCN ( 2p24 ) and MYCL 1 ( 1p34 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The Myc : Max complex regulates specific genes by recognizing `` E box ' ' DNA sequences and promoter bound factors such as Miz 1 . ^^^ Our results further indicate that p 300 can acetylate DNA bound Myc : Max complexes and that acetylated Myc : Max heterodimers efficiently interact with Miz 1 . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Assembly of b / HLH / z proteins c Myc , Max , and Mad 1 with cognate DNA : importance of protein protein and protein DNA interactions . ^^^ Looked at from the perspective of the Max protein , the binding of DNA to Max significantly reduces the affinity of the Max protein for the second monomer , whether the second monomer is Myc , Mad , or Max . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Using RT PCR , we found that the mRNA expression for c myc , a tumor stimulator gene , was decreased , while that for regucalcin , which suppresses DNA synthesis , was increased . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The review then discusses recent observations showing that loss of the TS protein peroxiredoxin 1 ( prdx 1 ) and increased expression of the c onc protein c Myc , each leads to increased oxidative DNA damage . ^^^ The critical nature of the c onc TS interaction is underscored by that occurring between prdx 1 and c Myc , with the former protein regulating the production of DNA damaging reactive oxygen species by the latter . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We analyzed apoptosis ( TUNEL : DNA fragmentation ) ; cell proliferation ( immunohistochemistry ( IHC ) for Ki 67 ) ; c myc , bax and TGF beta 1 mRNA abundance ( RT PCR ) and TGF beta 1 protein ( IHC ) in endometrial explants . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Regulation of reactive oxygen species , DNA damage , and c Myc function by peroxiredoxin 1 . ^^^ They should also help in studying the relationship between oncogenes such as c Myc and DNA damage . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Our results indicate that Max could homodimerize , bind DNA , and repress transcription in vivo and that its mutant could be more efficient at repressing the expression of c Myc target genes . . ^^^ Max is the only protein in this network that recognizes and binds E Box DNA sequences as a homodimer in vitro and represses transcription of Myc target genes in vivo . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Apart from microsatellite instability , molecular alterations of cellular genes recognized in PTLD include alterations of c MYC , BCL 6 , p 53 , DNA hypermethylation , and aberrant somatic hypermutation of proto oncogenes . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
METHODS : In this study , we investigated the effects of FTI L 744 , 832 either alone or in combination with 5 fluorouracil ( 5 FU ; 1 microM / l ) and radiotherapy ( 2 , 6 , and 10 Gy ) on the colon cancer cell line DLD 1 with mutations in K , N and H ras , c myb , c myc , p 53 , fos , sis and DNA repair genes . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We evaluated the effects of d myo inositol 1 , 4 , 5 tris phosphate on cardiac hypertrophy . d myo inositol 1 , 4 , 5 tris phosphate augmented cardiac hypertrophy as evidenced by its effects on DNA synthesis , protein synthesis , and expression of immediate early genes c myc and c fos , beta myosin heavy chain , and alpha actin . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Fatty acids , inhibitors for the DNA binding of c Myc / Max dimer , suppress proliferation and induce apoptosis of differentiated HL 60 human leukemia cell . c Myc is instrumental in the progression of Burkitt ' s lymphoma including HL 60 human leukemia cells . ^^^ We tested fatty acids for their inhibitory effect on the DNA binding of c Myc / Max dimeric proteins of human origin , prepared as recombinant proteins encompassing DNA binding ( basic ) and dimerization ( HLHZip ) domain , and found that those suppress proliferation and induce apoptosis of DMSO differentiated HL 60 cells . ^^^ The analyzed IC 50 values of myristic acid , stearic acid , gamma linolenic acid , linoleic acid , linolenic acid and arachidonic acid by EMSA were 97 ( + / 3 ) , 2 . 2 ( + / 1 . 2 ) , 55 ( + / 5 ) , 32 ( + / 2 ) , 62 ( + / 12 ) , 22 ( + / 2 ) microM for DNA binding of recombinant c Myc / Max , respectively . ^^^ Our experiments demonstrated that the inhibitors for the DNA binding of c Myc / Max contribute to the downregulation of Myc dependent proliferation and to the inducement of apoptosis , and serve as an exploration of potent new inhibitors . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
BRCA 1 and c Myc associate to transcriptionally repress psoriasin , a DNA damage inducible gene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : In combination with DNA vector based RNAi , quantitative real time reverse transcription polymerase chain reaction , telomeric repeat amplification protocol enzyme linked immunosorbent assay , 3 ( 4 , 5 dimethylthiazolyl 2 ) 2 , 5 diphenyltetrazolium bromide assay , and xenograft tumor animal techniques , we first constructed three pTZU 6 + 1 shRNA hTERT vectors and their corresponding site mutated vectors , then transfected them into hepatocarcinoma HepG 2 , SMMC 7721 cells , and normal liver L 02 cells , respectively , injected them into xenograft hepatocarcinoma tumor tissues to induce RNAi , and then detected the alteration of cell and tumor proliferation , telomerase activity , hTERT , and c myc expression in each treatment . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Relationship of NKX3 . 1 and MYC gene copy number ratio and DNA hypomethylation to prostate carcinoma stage . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Tetraplex DNA transitions within the human c myc promoter detected by multivariate curve resolution of fluorescence resonance energy transfer . ^^^ Results are discussed in the light of recent observations implicating paranemic DNA motifs within the c myc NHE in regulation of the oncogene . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The combination of antisense c myc and PD 98059 resulted in near complete inhibition of ET dependent DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Activation of the phosphatidylinositol 3 kinase ( PI3K ) signaling pathway by insulin like growth factor 2 , inactivation of the p 53 tumor suppressor protein , loss of DNA damage repair mechanisms , and ectopic expression of Myc oncoproteins cooperate with Shh / Patched signaling to enhance tumor formation in mice . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here we find that translocations between c myc and the IgH locus ( Igh ) are induced in primary B cells within hours of expression of the catalytically active form of activation induced cytidine deaminase ( AID ) , an enzyme that deaminates cytosine to produce uracil in DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Genes were identified as overexpressed in regions of DNA gain on 3q , 6p , 8q , 9q , 16p and 18q , including the cancer genes BCL 2 and MYC . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Like Myc family proteins , Mxd and Mnt proteins use Max as a cofactor for DNA binding . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
We showed previously that c MYC directly activates the expression of the DNA double strand break repair gene NBS 1 , and NBS 1 overexpression contributes to transformation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Here we demonstrate that p 53 induction in response to Myc overexpression requires the ataxia telangiectasia mutated ( ATM ) kinase , a major regulator of the cellular response to DNA double strand breaks . ^^^ Deregulated Myc expression induces DNA damage in primary transgenic keratinocytes and the formation of gammaH2AX and phospho SMC 1 foci in transgenic tissue . ^^^ These findings suggest that Myc overexpression causes DNA damage in vivo and that the ATM dependent response to this damage is critical for p 53 activation , apoptosis , and the suppression of tumor development . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
HER 2 overexpression profoundly diminishes the transcriptional responses induced by TGF beta in the luminal MCF 7 breast cancer cell line and prevents target gene induction by a novel mechanism that does not involve the abrogation of Smad nuclear accumulation , DNA binding or changes in c myc repression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Furthermore , we report that Tom1L1 negatively regulates SFK mitogenic signaling induced by platelet derived growth factor ( PDGF ) through modulation of SFK receptor association : ( 1 ) Tom1L1 inhibits DNA synthesis induced by PDGF ; ( 2 ) inhibition is overcome by c myc expression or p 53 inactivation , two regulators of SFK mitogenic function ; ( 3 ) Src or Fyn coexpression overrides Tom1L1 mitogenic activity ; ( 4 ) overexpression of the adaptor reduces Src association with the receptor ; and ( 5 ) protein inactivation potentiates receptor complex formation , allowing increased SFK activation and DNA synthesis . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Expression of immediate early genes ( c fos , c jun , and c myc ) was augmented and activator protein 1 DNA binding activity was enhanced in untrained rats immediately after a single bout of exercise . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The specific DNA probe described herein is the oncogene c myc , although the tissue fluorescence in situ hybridization methodology presented is suitable for dual color studies of most unique sequence and chromosome specific control probes . ^^^ This allows the DNA to be available for hybridization with the labeled c myc probe . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
LZ family members Myc and Max , could not replace the PAS domains for either dimerization or DNA binding in the DR / Arnt heterodimer . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
DNA encoding H ras ( V 12 ) and c myc oncogenes may be transferred to the nucleus of the phagocyte but will only integrate and propagate in p 53 and p 21 deficient mouse embryonic fibroblasts , whereas normal cells are resistant to transformation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Bcl 2 suppresses DNA repair by enhancing c Myc transcriptional activity . ^^^ Bcl 2 and c Myc are two major oncogenic proteins that can functionally promote DNA damage , genetic instability , and tumorigenesis . ^^^ Here we found that Bcl 2 potently suppresses the repair of NNK induced abasic sites of DNA lesions in association with increased c Myc transcriptional activity . ^^^ The Bcl 2 BH4 domain ( amino acids 6 31 ) was found to bind directly to c Myc MBII domain ( amino acids 106 143 ) , and this interaction is required for Bcl 2 to enhance c Myc transcriptional activity and inhibit DNA repair . ^^^ Expression of nuclear targeted Bcl 2 enhances c Myc transcriptional activity with suppression of DNA repair but fails to prolong cell survival . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Oncogenes and the DNA damage response : Myc and E2F1 engage the ATM signaling pathway to activate p 53 and induce apoptosis . ^^^ Transgenic expression of Myc is found to cause DNA damage in vivo and ATM is shown to respond to this damage by inducing the accumulation and phosphorylation of p 53 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The siRNA duplex targeted to the exon 3 of c myc mRNA ( siRNA 1 ) was prepared by in vitro transcription using T 7 RNA polymerase and short double stranded DNA ( dsDNA ) templates . siRNA 1 was shown to efficiently decrease c myc mRNA expression in both tumor cell lines and to arrest their proliferation . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Furthermore , Cpd 5 inhibited c Myc transcriptional activity and DNA binding ability , and this inhibition was antagonized by ERK kinase ( MEK ) inhibitor U 0126 , implying that the ERK pathway was involved in regulating c Myc expression . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MYRA A inhibits Myc transactivation and interferes with the DNA binding activity of Myc family proteins but has no effect on the E box binding protein USF . ^^^ In contrast , MYRA B induces Myc dependent apoptosis without affecting Myc transactivation or Myc / Max DNA binding . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
AIM : To assess whether a correlation exists between oxidative DNA damage occurring in chronic HCV related hepatitis and expression levels of pro inflammatory cytokines , TGF alpha and c myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Recently determined structures of a number of Myc family proteins have provided significant insights into the molecular nature of complex assembly and DNA binding . ^^^ In this review , we focus on the lessons provided by these structures toward understanding ( 1 ) interactions that govern transcriptional repression by Mad via the Sin 3 pathway , ( 2 ) homodimerization of Max , ( 3 ) heterodimerization of Myc Max and Mad Max , and ( 4 ) DNA recognition by each of the Max Max , Myc Max , and Mad Max dimers . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Studies of individual c Myc target genes and their functional implications are now complemented by large surveys of c Myc target genes through the use of subtraction cloning , DNA microarray analysis , serial analysis of gene expression ( SAGE ) , chromatin immunoprecipitation , and genome marking methods . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Under certain conditions , aberrant c myc activity is associated with the appearance of DNA damage associated markers and karyotypic abnormalities . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
FarUpStream Element ( FUSE ) Binding Protein ( FBP ) binds the human c myc FUSE in vitro only in single stranded or supercoiled DNA . ^^^ Because transcriptionally generated torsion melts FUSE in vitro even in linear DNA , and FBP / FBP Interacting Repressor ( FIR ) regulates transcription through TFIIH , these components have been speculated to be the mechanosensor ( FUSE ) and effectors ( FBP / FIR ) of a real time mechanism controlling c myc transcription . ^^^ The in vitro recruitment of FBP and FIR to dynamically stressed c myc DNA paralleled the in vivo process . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
In HL 60 cells , DNA binding activity of c Myc and Mad 1 to the E box sequence of the hTERT promoter was inhibited and up regulated , respectively . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MYC activation associated with the integration of HPV DNA at the MYC locus in genital tumors . ^^^ In IC 1 , IC 2 and CAC 1 cells , HPV DNA was located within 58 kb of MYC , downstream , upstream , or within MYC . ^^^ In IC 3 and IC 6 cells , HPV DNA was located 400 500 kb upstream of MYC . ^^^ MYC mRNA and protein overexpression was observed in the five cell lines in which the HPV DNA was inserted close to the MYC locus , but in none of the lines where the insertion had occurred at other sites . ^^^ MYC activation , triggered by the insertion of HPV DNA sequences , can be an important genetic event in cervical oncogenesis . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
A conserved Myc protein domain , MBIV , regulates DNA binding , apoptosis , transformation , and G 2 arrest . ^^^ Thus , this conserved domain has an unexpected role in Myc DNA binding activity . ^^^ These data also provide a novel separation of Myc functions linked to the modulation of DNA binding activity . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Lack of correlation between DNA copy number and mRNA expression levels of c myc in gamma radiation induced mouse thymic lymphomas by using quantitative real time PCR . ^^^ In the remaining 9 tumours , c myc over expression was also accompanied with extra DNA copy numbers . ^^^ However , linear regression analysis showed a lack of correlation between increasing DNA copy numbers and mRNA over expression of c myc in these tumours ( r = 0 . 029 , p = 0 . 94 ) . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MYC overexpression may induce genomic damage at least in part by causing inappropriate DNA replication . ^^^ MYC may induce inappropriate DNA replication through the activation of Cyclin E / CDK2 . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Consistent with the gene expression profile , DNA binding activity of c myc and the nuclear protein concentration of its coactivator , upstream binding factor ( UBF ) , increased in the atrophied heart whereas protein levels of the c myc inhibitor MAD 1 decreased . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
The binding of the prereplication complex proteins Orc 1 , Orc 2 , Mcm 3 , Mcm 7 , and Cdc 6 and the novel DNA unwinding element ( DUE ) binding protein DUE B to the endogenous human c myc replicator was studied by chromatin immunoprecipitation . ^^^ These results show that proteins implicated in replication initiation are selectively and differentially bound across the c myc replicator , dependent on discrete structural elements in DNA or chromatin . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species . ^^^ Here we show that MYC can induce DNA breaks both in vitro and in vivo independent of increased production of reactive oxygen species ( ROS ) . ^^^ We found that MYC induces DNA double strand breaks ( DSBs ) independent of ROS production in murine lymphocytes in vivo as well as in normal human foreskin fibroblasts ( NHFs ) in vitro in normal ( 10 % ) serum , as measured by gammaH2AX staining . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
ATM controls c Myc and DNA synthesis during postnatal thymocyte development through regulation of redox state . ^^^ In this study , we show that c Myc expression progressively increases with age in primary thymocytes from Atm ( / ) mice and that the upregulation of c Myc parallels the elevated DNA synthesis in the cells , suggesting that deregulation of c Myc may drive the uncontrolled proliferation of thymocytes in Atm ( / ) mice . ^^^ Importantly , reduction of hydrogen peroxide by administration of the antioxidant N acetylcysteine to Atm ( / ) mice attenuates the elevation of Nrf 2 , c Myc , and DNA synthesis in their thymocytes , suggesting that ATM may control c Myc and DNA synthesis during postnatal thymocyte development by preventing accumulation of reactive oxygen species . . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Myc proteins are transcription factors that function within a network of transcriptional activators ( Myc ) and repressors ( Mxd / Mad and Mnt ) , all of which heterodimerize with the bHLHZ protein Mad and bind E box sequences in DNA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
B Myc is an endogenous , N terminal homologue of transcription factor c Myc that lacks the C terminal DNA binding and protein dimerization domain of c Myc . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
However , in contrast to Myc induced DNA synthesis , hypertrophic growth is independent of CycD 2 induced Cdk 2 activity . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
MAX serves as a cofactor for DNA binding by the various members of this network , which include the MYC family of oncoproteins and a group of putative MYC antagonists that include MNT , MXD 1 4 ( formerly MAD 1 , MXI 1 , MAD 3 and MAD 4 ) and MGA . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
Specific interaction between green fluorescent protein ( GFP ) tagged human alpha or gamma enolase ( 97 242 ) ( alpha or gammaENO ( 97 242 ) ) and the rhodamine labeled DNA fragment containing the c myc P 2 promoter was detected by a fluorescence resonance energy transfer ( FRET ) based assay , designated as a `` real time FRET assay . ' ' The approach of donor ( GFP ) and acceptor ( rhodamine ) was caused by the association between ENO ( 97 242 ) and the c myc P 2 promoter , and the time dependent increase in fluorescence intensity of the reaction mixture was observed at ex=400 nm and em=590 nm . ^^^
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q9UBC3 and P01106	Pubmed	SVM Score :0.0
NA