| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| Suv39h mediated histone H 3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin . ^^^ RESULTS : Here , we demonstrate a physical and functional link between the Suv39h HP 1 histone methylation system and DNA methyltransferase 3b ( Dnmt3b ) in mammals . ^^^ Consistently , the Suv39h dn ES cells display an altered DNA methylation profile at pericentric satellite repeats , but not at other repeat sequences . ^^^ While the Suv39h HMTases are required to direct H 3 K9 trimethylation and Dnmt3b dependent DNA methylation at pericentric repeats , DNA methylation at centromeric repeats occurs independent of Suv39h function . ^^^ Whereas in wild type cells Dnmt3b interacts with HP 1 alpha and is concentrated at heterochromatic foci , it fails to localize to these regions in Suv39h double null ( dn ) mouse embryonic stem ( ES ) cells . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| In this report we demonstrate that SUV39H1 represses transcription in a transient transcriptional assay when tethered to DNA through the GAL 4 DNA binding domain . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| Methyl CpG binding domain 1 ( MBD 1 ) interacts with the Suv39h1 HP 1 heterochromatic complex for DNA methylation based transcriptional repression . ^^^ These data indicate that MBD 1 may tether the Suv39h1 HP 1 complex to methylated DNA regions , suggesting the presence of a pathway from DNA methylation to the modifications of histones for epigenetic gene regulation . . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| The DNA methyltransferases associate with HP 1 and the SUV39H1 histone methyltransferase . ^^^ We find that SUV39H1 also binds to Dnmt 1 and , consistent with these interactions , SUV39H1 can purify DNA methyltransferase activity from nuclear extracts . ^^^ In addition , we show that HP1beta , a SUV39H1 interacting partner , binds directly to Dnmt 1 and Dnmt3a and that native HP1beta associates with DNA methyltransferase activity . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| Binding of AML 1 to SUV39H1 abrogates the transactivating and DNA binding properties of AML 1 and dissociates the net like nuclear structure of AML 1 . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| By immunoprecipitation and GST pull down , we show that DNMT3B interacts with HDAC 1 , HDAC 2 , HP 1 proteins , Suv39h1 , and the ATP dependent chromatin remodeling enzyme hSNF2H . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| Here , we found that LANA interacts with SUV39H1 histone methyltransferase , a key component of heterochromatin formation , as determined by use of a DNA pull down assay with a biotinylated DNA fragment that contained a LANA specific binding sequence and a maltose binding protein pull down assay . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| XCI chromatin remodeling genes , such as histone H 3 methylation enzymes ( SUV39H1 and SET 7 ) and DNA methylation enzyme ( DNMT 1 ) , were expressed during all early phases of embryogenesis . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| This effect is mediated by the previously described association of PML RAR with chromatin modifying enzymes ( histone deacetylases and DNA methyltransferases ) and by recruitment of the histone methyltransferase SUV39H1 , responsible for trimethylation of lysine 9 of histone H3 . . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| In this study , we used a methyl deficient model of rodent hepatocarcinogenesis to examine the roles of DNA , histone H 3 lysine 9 and histone H 4 lysine 20 methylation , and the level of the expression of Suv39h1 and Suv 4 20h2 histone methyltransferases in the carcinogenic process . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| RB recruits a number of proteins , including HDACs , SWI / SNF complex , lysine methyl transferase ( SUV39H1 ) and DNA methyltransferase ( DNMT 1 ) , all of which negatively regulate E2F activity with RB . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| This change is also associated with global relocation of heterochromatin protein HP 1 and histone H 3 methyltransferase Suv39h1 away from constitutive heterochromatin ; however , it does not affect DNA methylation or chromosome segregation , phenotypes commonly associated with impaired histone H 3 ( K 9 ) methylation . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| Taken together , our results suggest that Suv39h1 activity inhibits the activity of a sequence specific DNA binding protein that represses switch recombination to IgA . . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| However , in cells lacking the Suv39h1 , 2 methyltransferases responsible for K9H3 trimethylation and HP 1 binding at chromocenters , replication of chromocenter DNA was advanced by 10 15 % of the length of S phase . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| To address this issue , we examined the roles of DNA methyltransferase 1 ( Dnmt 1 ) and the H3K9 histone methyltransferase Suv39h1 in zebra fish development . ^^^ Embryos lacking Suv39h1 had organ specific terminal differentiation defects that produced largely phenocopies of Dnmt 1 morphants but retained wild type levels of DNA methylation . ^^^ |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O43463 and Q9UBC3 |
Pubmed |
SVM Score :0.0 |
| NA |
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