| Interacting proteins: Q9P0J0 and P40763 |
Pubmed |
SVM Score :0.65523508 |
| GRIM 19 itself co localizes with mitochondrial markers , and forms aggregates at the perinulear region with co expressed Stat 3 , which inhibits Stat 3 nuclear translocation stimulated by epidermal growth factor ( EGF ) . 0.65523508^^^ |
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| Interacting proteins: Q9P0J0 and P40763 |
Pubmed |
SVM Score :0.0 |
| The cell death regulator GRIM 19 is an inhibitor of signal transducer and activator of transcription 3 . ^^^ To understand the molecular bases for its cell death regulatory activity , we used a yeast two hybrid screen and identified that the transcription factor STAT 3 ( signal transducer and activator of transcription 3 ) binds to GRIM 19 . ^^^ GRIM 19 inhibits transcription driven by activation of STAT 3 , but not STAT 1 . ^^^ Mutational analysis indicates that the transactivation domain of STAT 3 , especially residue S 727 , is required for GRIM 19 binding . ^^^ Because GRIM 19 does not bind significantly to other STATs , our studies identify a specific inhibitor of STAT 3 . ^^^ |
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| Interacting proteins: Q9P0J0 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
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