| The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein ( WASp ) mediated actin polymerization to T cell antigen receptor endocytosis . ^^^ Here we report that WASp associates in T cells with intersectin 2 , an endocytic adaptor containing multiple domains including a Dbl homology ( DH ) domain with the potential to activate Rho GTPases . ^^^ Intersectin 2 association with WASp increases after TCR engagement , and its overexpression in Cos 7 cells induces WASp translocation to endocytic vesicles within which intersectin 2 colocalizes with both WASp and cdc 42 . ^^^ |