| Interacting proteins: Q9NZC7 and P45983 |
Pubmed |
SVM Score :1.4133805 |
| The activated JNK 1 physically interacted with the phosphorylated WOX 1 , as determined by co immunoprecipitation . 1.4133805^^^ JNK 1 physically interacts with WW domain containing oxidoreductase ( WOX 1 ) and inhibits WOX 1 mediated apoptosis . 0.70699359^^^ Alteration of Tyr ( 33 ) to Arg ( 33 ) in WOX 1 abrogated its binding interaction with JNK 1 and its activity in mediating cell death , indicating that Tyr ( 33 ) phosphorylation is needed to activate WOX 1 . 0.65870384^^^ |
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| Interacting proteins: Q9NZC7 and P45983 |
Pubmed |
SVM Score :0.0 |
| In response to stress or apoptotic stimuli , WOX 1 became phosphorylated at Tyr 33 , which enabled its complex formation with activated p 53 and JNK 1 . ^^^ In contrast , transiently activated JNK 1 induced anti apoptotic response , and this protective activity inhibited WOX 1 induced apoptosis . ^^^ |
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