| Interacting proteins: Q9NYL2 and O14733 |
Pubmed |
SVM Score :0.0 |
| Mixed lineage kinase ZAK utilizing MKK 7 and not MKK 4 to activate the c Jun N terminal kinase and playing a role in the cell arrest . ^^^ Co expression of dominant negative MKK 7 but not MKK 4 and ZAK significantly attenuates JNK / SAPK activation . ^^^ This result suggests that ZAK activates JNK / SAPK mediated by downstream target , MKK 7 . ^^^ |
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| Interacting proteins: Q9NYL2 and O14733 |
Pubmed |
SVM Score :0.0 |
| Furthermore , dominant negative MKK 7 effectively blocked both TGF beta and ZAK induced ANF expression . ^^^ Our findings suggest that a ZAK mediates TGF beta induced cardiac hypertrophic growth via a novel TGF beta signaling pathway that can be summarized as TGF beta > ZAK > MKK 7 > ANF . . ^^^ |
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