| BRCC 36 and BRCC 45 are novel components of the complex with sequence homology to a subunit of the signalosome and proteasome complexes . ^^^ In vivo , depletion of BRCC 36 and BRCC 45 by the small interfering RNAs ( siRNAs ) resulted in increased sensitivity to ionizing radiation and defects in G2 / M checkpoint . ^^^ |