| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :1.2455449 |
| NOP 10 associates with NAP 57 as a prerequisite for NHP 2 binding . 1.2455449^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| Translation from ATG 2 and ATG 3 would give the N terminally truncated proteins NolA 2 and NolA 3 , respectively , lacking the DNA binding domain . ^^^ The expression of both NolA 2 and NolA 3 requires the presence of NolA 1 . ^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| Human H / ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP 2 and NOP 10 . ^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H / ACA small nucleolar RNP proteins Cbf5p , Nhp2p and Nop10p . ^^^ We show that the presence of the H / ACA snoRNP proteins Cbf5p , Nhp2p and Nop10p , but not Gar1p , is required for the accumulation of mature non polyadenylated hTR in yeast , while accumulation of TLC 1 RNA is not affected by the absence of any of these proteins . ^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| Box H / ACA small nucleolar ribonucleoprotein particles ( snoRNPs ) contain four essential proteins , Cbf5p , Gar1p , Nhp2p , and Nop10p , each of which , with the exception of Gar1p , is required for box H / ACA snoRNA accumulation . ^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| In Eukarya , H / ACA snoRNAs assemble into a ribonucleoprotein ( RNP ) complex comprising four proteins : Cbf5p , Gar1p , Nop10p and Nhp2p . ^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| Cbf5p , the putative pseudouridine synthase of H / ACA type snoRNPs , can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H / ACA snoRNAs . ^^^ In the present study , we have investigated the protein / protein interactions taking place between the four protein components of yeast box H / ACA small nucleolar RNPs ( snoRNPs ) , Cbf5p , Gar1p , Nhp2p , and Nop10p . ^^^ We provide evidence that Cbf5p , Gar1p , and Nop10p can form a complex devoid of Nhp2p and small nucleolar RNA ( snoRNA ) components of the particles and that Cbf5p and Nop10p can directly bind to each other . ^^^ We also show that the absence of any component necessary for assembly of box H / ACA snoRNPs inhibits accumulation of Cbf5p , Gar1p , or Nop10p , whereas Nhp2p levels are little affected . . ^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| The isomerization of up to 100 uridines to pseudouridines ( Psis ) in eukaryotic rRNA is guided by a similar number of box H / ACA small nucleolar RNAs ( snoRNAs ) , each forming a unique small nucleolar ribonucleoprotein particle ( snoRNP ) with the same four core proteins , NAP 57 ( also known as dyskerin or Cbf5p ) , GAR 1 , NHP 2 , and NOP 10 . ^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| METHODS : We screened blood or marrow cells from 124 patients with apparently acquired aplastic anemia and 282 control subjects for sequence variations in the TERT , DKC 1 , NHP 2 , and NOP 10 genes ; an additional 81 patients and 246 controls were examined for genetic variations in TERT . ^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| Nhp2p and Nop10p are essential for the function of H / ACA snoRNPs . ^^^ The 22 and 10 kDa polypeptides were identified as Nhp2p and a novel protein we termed Nop10p , respectively . ^^^ Nhp2p and Nop10p are specifically associated with all H / ACA snoRNAs and are essential to the function of H / ACA snoRNPs . ^^^ Cells lacking Nhp2p or Nop10p are impaired in global rRNA pseudouridylation and in the A 1 and A 2 cleavage steps of the pre rRNA required for the synthesis of mature 18S rRNA . ^^^ These phenotypes are probably a direct consequence of the instability of H / ACA snoRNAs and Gar1p observed in cells deprived of Nhp2p or Nop10p . ^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| The H / ACA snoRNPs each comprise a target site specific snoRNA and four core proteins , Nop10p , Nhp2p , Gar1p , and the pseudouridine synthase , Cbf5p , in yeast . ^^^ |
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| Interacting proteins: Q9NPE3 and Q9NX24 |
Pubmed |
SVM Score :0.0 |
| NA |
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