| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| The expression of Toll like receptor 2 ( TLR 2 ) protein was down regulated in BLP tolerant cells , whereas no significant differences in TLR 4 , MyD 88 , interleukin 1 receptor associated kinase 4 ( IRAK 4 ) , and TNF receptor associated factor 6 expression were observed between nontolerant and BLP tolerant cells , as confirmed by Western blot analysis . ^^^ |
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| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Endogenous IRAK 4 interacts with IRAK 1 and TRAF 6 in an IL 1 dependent manner , and overexpression of IRAK 4 can activate NF kappa B as well as mitogen activated protein ( MAP ) kinase pathways . ^^^ |
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| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Pellino 1 is required for interleukin 1 ( IL 1 ) mediated signaling through its interaction with the IL 1 receptor associated kinase 4 ( IRAK 4 ) IRAK tumor necrosis factor receptor associated factor 6 ( TRAF 6 ) complex . ^^^ We now report a mammalian counterpart of Pellino , termed Pellino 1 , which is required for NF kappa B activation and IL 8 gene expression in response to IL 1 , probably through its signal dependent interaction with IRAK 4 , IRAK , and the tumor necrosis factor receptor associated factor 6 ( TRAF 6 ) . ^^^ |
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| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Receptor proximal proteins involved in signalling by all TLRs include the adapter MyD 88 , 3 IRAKs ( IRAK 4 , IRAK and IRAK 2 ) , Tollip , Traf 6 and TAK 1 . ^^^ |
|
| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| TIRP also interacts with kinase inactive mutants of IRAK and IRAK 4 , IRAK 2 , IRAK M , and TRAF 6 . ^^^ |
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| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Gene knockout work has also established that LPS signal transduction requires the integrity of CD 14 , MD 2 , and , in part , MyD 88 , IRAK 4 , and TRAF 6 . ^^^ |
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| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| We now use cells lacking expression of TRAF 2 , TRAF 5 , TRAF 6 , IKKalpha , IKKbeta , IKKgamma , TAB 2 , IL 1 receptor associated kinase ( IRAK ) 1 , or IRAK 4 to assess their roles in LMP 1 mediated NF kappaB activation . ^^^ More surprisingly , NF kappaB responses were near normal in TRAF 2 and TRAF 5 double KO MEFs , IKKgamma KO MEFs , TAB 2 KO MEFs , and IRAK 4 KO MEFs but were highly deficient in TRAF 6 KO MEFs and IRAK 1 KO HEK 293 cells . ^^^ |
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| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| We provide evidence that this complex also involves IRAK 4 and TRAF 6 and provides the foundation for the TLR 9 dependent activation of the IFN genes . ^^^ |
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| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| Functional characterization of full length TLR 3 , IRAK 4 , and TRAF 6 in zebrafish ( Danio rerio ) . ^^^ This study reports the identification and characterization of a full length orthologue of mammalian TLR 3 , and the key TLR pathway signaling molecules IRAK 4 and TRAF 6 in the zebrafish . ^^^ Sequence analysis of zebrafish TLR 3 ( zfTLR 3 ) , IRAK 4 ( zfIRAK 4 ) , and TRAF 6 ( zfTRAF 6 ) revealed conserved domains shared with insect and mammalian genes . ^^^ |
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| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| The mRNA expression of many TLR related genes ( ICAM 1 , CD 14 , MyD 88 , LY 96 , TRIF , TICAM 2 , TIRAP , CD 83 , SOCS 1 , TNFAIP 3 , TOLLIP , IRAK 1 , IRAK 2 , IRAK 4 , and TRAF 6 ) was successfully detected in all of the tissues and cell lines . ^^^ |
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| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| In contrast to the interleukin 1 receptor / toll like receptor mediated NF kappaB pathways , the CTAR 2 mediated NF kappaB pathway does not require MyD 88 , IRAK 1 , or IRAK 4 for TRAF 6 engagement . ^^^ |
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| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NWZ3 and Q9Y4K3 |
Pubmed |
SVM Score :0.0 |
| NA |
|