| Pellino 1 is required for interleukin 1 ( IL 1 ) mediated signaling through its interaction with the IL 1 receptor associated kinase 4 ( IRAK 4 ) IRAK tumor necrosis factor receptor associated factor 6 ( TRAF 6 ) complex . ^^^ We now report a mammalian counterpart of Pellino , termed Pellino 1 , which is required for NF kappa B activation and IL 8 gene expression in response to IL 1 , probably through its signal dependent interaction with IRAK 4 , IRAK , and the tumor necrosis factor receptor associated factor 6 ( TRAF 6 ) . ^^^ The Pellino 1 IRAK IRAK 4 TRAF6 signaling complex is likely to be intermediate , located between the IL 1 receptor complex and the TAK 1 complex in the IL 1 pathway . . ^^^ |