| Interacting proteins: Q9NSE2 and Q99062 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9NSE2 and Q99062 |
Pubmed |
SVM Score :0.0 |
| In this paper we investigated the roles of SHIP and cytokine inducible Src homology 2 protein ( CIS ) in down modulating G CSFR signals and demonstrate that loss of their recruitment as a consequence of receptor mutations leads to aberrant signaling . ^^^ G CSF was found to induce the expression of CIS and of CIS bound to phosphopeptides corresponding to Tyr 729 and Tyr 744 of the G CSFR . ^^^ The expression of CIS was prolonged in cells with the SCN / AML mutant G CSFR lacking Tyr 729 and Tyr 744 , which also correlated with increased G CSFR expression . ^^^ These findings suggest that SHIP and CIS interact with distal phosphotyrosine residues in the G CSFR to negatively regulate G CSFR signaling by limiting proliferation and modulating surface expression of the G CSFR , respectively . ^^^ Loss of SHIP and CIS recruitment to the granulocyte colony stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia / acute myelogenous leukemia . ^^^ |
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| Interacting proteins: Q9NSE2 and Q99062 |
Pubmed |
SVM Score :0.0 |
| SOCS 1 and SOCS 3 also inhibited G CSF dependent cell proliferation , but the inhibitory effect of the two SOCS proteins on cell proliferation was diminished when Tyr 729 of the G CSF R was mutated . ^^^ These data indicate that Tyr 729 of the G CSF R is required for SOCS 1 and SOCS 3 mediated negative regulation of G CSF R signaling and that the duration and intensity of G CSF induced Stat 5 activation are regulated by two distinct mechanisms . . ^^^ |
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| Interacting proteins: Q9NSE2 and Q99062 |
Pubmed |
SVM Score :0.0 |
| Suppressor of cytokine signaling 3 is recruited to the activated granulocyte colony stimulating factor receptor and modulates its signal transduction . ^^^ |
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