| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| This is similar to the K ( d ) of SOCS 3 for the erythropoietin receptor . ^^^ |
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| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| Cis is an Src homology 2 domain containing protein , which binds to the erythropoietin receptor and decreases erythropoietin stimulated cell proliferation . ^^^ We show that Cis associates with the second tyrosine residue of the intracellular domain of the erythropoietin receptor ( Tyr 401 ) . ^^^ Because the proteasome inhibitors induced the accumulation of both the ubiquitinated form of Cis and the Cis erythropoietin receptor complexes , our results suggest that the ubiquitinated form of Cis could be involved in the proteasome mediated inactivation of the erythropoietin receptor . . ^^^ |
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| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| CIS is known to associate with the IL 3 receptor beta chain and erythropoietin receptor and to inhibit signaling mediated by IL 3 and erythropoietin . ^^^ |
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| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| We also demonstrate that MAPPIT can be used to screen complex complementary DNA libraries , and using this approach , we identify cytokine inducible SH 2 containing protein ( CIS ) and suppressor of cytokine signalling 2 ( SOCS 2 ) as interaction partners of the phosphotyrosine 402 ( Tyr 402 ) binding motif in the erythropoietin receptor ( EpoR ) . ^^^ |
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| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| Using two independent approaches , one involving inhibition of specific signaling molecules and the other employing cell lines that express particular EpoR mutants and thereby activate only subsets of signaling cascades , we demonstrate that induction of SOCS 1 , SOCS 2 , SOCS 3 , and cytokine inducible SH 2 containing protein ( CIS ) in response to EPO stimulation appears to depend on Stat 5 but not on mitogen activated protein kinase ( MAPK ) or phosphatidylinositol 3 kinase ( PI3K ) . ^^^ |
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| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| CIS reduces growth of erythropoietin receptor ( EpoR ) dependent cell lines , but its role in proliferation , differentiation , and survival of erythroid progenitor cells has not been resolved . ^^^ Retroviral expression of the GFP fusion proteins in BaF 3 EpoR cells revealed that both Tyr 401 in the EpoR and an intact SH 2 domain within CIS are prerequisites for receptor recruitment . ^^^ |
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| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| In T ER transformants expressing JAK 2 ( T JER ) , EPO induced tyrosine phosphorylation of the EPOR , JAK 2 , and STAT 5 , and consequently STAT 5 responsive genes including bcl 10 and cis 1 were normally induced . ^^^ |
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| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| Recently , the feedback inhibitor suppressor of cytokine signaling 3 ( SOCS 3 ) , also referred to as cytokine inducible SH 2 containing protein 3 ( CIS 3 ) , has been shown to act on Epo signaling by both binding to the EpoR and the EpoR associated Janus kinase 2 ( Jak 2 ) [ Sasaki , A . , Yasukawa , H . , Shouda , T . , Kitamura , T . , Dikic , 1 . & Yoshimura , A . ( 2000 ) J . ^^^ |
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| Interacting proteins: Q9NSE2 and P19235 |
Pubmed |
SVM Score :0.0 |
| These reverse mammalian protein protein interaction trap ( MAPPIT ) screens were developed to monitor interactions between the erythropoietin receptor ( EpoR ) and suppressors of cytokine signaling ( SOCS ) proteins , between FKBP 12 and ALK 4 , and between MDM 2 and p53 . . ^^^ |
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