| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| CIS 1 interacts with the Y 532 of the prolactin receptor and suppresses prolactin dependent STAT 5 activation . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| SOCS 1 was shown to associate with Jak 2 , whereas SOCS 2 was associated with the prolactin receptor . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| All of the 16 theoretical ( 24 = 16 ) proline configurations appear to exist in equilibrium in water The predominant ( 19 % ) conformation , trans 3 trans4 cis 6 trans8 , may reflect the configuration of the PRM prolines in the native PRL R . ^^^ Multiple cis trans conformers of the prolactin receptor proline rich motif ( PRM ) peptide detected by reverse phase HPLC , CD and NMR spectroscopy . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : The prolactin ( PRL ) receptor ( PRLR ) utilizes the JAK2 / STAT 5 pathway and induces expression of cytokine inducible SH 2 ( CIS ) / JAK2 binding ( JAB ) signaling inhibitors . ^^^ We and others recently showed that CIS 3 and JAB abolish PRLR mediated JAK 2 activation and STAT 5 activity , whereas CIS 1 , CIS 2 , and CIS 4 had a negligible effect . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| Ovine PRL induced CIS mRNA expression and a combination of oPRL and insulin induced SOCS 3 mRNA expression in adipocytes cultured in vitro for 0 240 min , demonstrating PRLR mediated direct effects in these cells . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| SOCS 1 binds JAK 2 and inhibits its phosphorylation ; SOCS 3 does not bind JAK 2 but binds the PRLR that may mediate its inhibition of JAK 2 ; and finally , CIS binds the PRLR but inhibits signal transducer and activator of transcription 5 rather than JAK2 . . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| The CTL clone expressed conventional PRL receptor ( PRLR ) , and PRL induced the expression of suppressor of cytokine signaling 3 ( SOCS 3 ) and increased the expression of SOCS 2 and cytokine inducible src homology 2 containing protein ( CIS , another member of the SOCS family ) . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| To that end , we compared : ( a ) the expression of GHR and PRLR mRNAs in 3T3 L 1 preadipocytes during the course of adipocyte differentiation ; ( b ) the induction of STAT 5 activity by GH and PRL during adipogenesis ; and ( c ) the acute effects of GH and PRL on the suppressors of cytokine signaling ( SOCS 1 3 and cytokine inducible SH 2 domain containing protein CIS ) and IGF 1 . ^^^ Our findings reveal disparities in the expression of PRLR and GHR during adipocyte development and differential effects of the hormones on STAT 5 , the SOCS proteins , CIS , and IGF 1 . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| The ability of five members of the cytokine inducible SH 2 protein family ( CIS 1 4 ) and JAK 2 binding ( JAB ) protein to affect prolactin receptor ( PRLR ) mediated activity was tested in human 293 embryonic kidney fibroblasts transiently transfected with rat PRLR , five concentrations of CIS / JAB Myc tagged cDNAs and a STAT 5 responsive reporter gene encoding luciferase . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| Overexpression of SOCS 1 led to a significant reduction in PRLR mediated tyrosyl phosphorylation of Jak 2 , PRLR , Stat 5 and the cytoplasmic protein tyrosine phosphatase SHP 2 . ^^^ Overexpression of SOCS 3 however , led to selective inhibition in PRLR mediated tyrosyl phosphorylation of Jak 2 , the PRLR as well as SHP 2 . ^^^ On the other hand , overexpression of SOCS 2 had no inhibitory effects on the tyrosyl phosphorylation status of the PRLR , Jak 2 , Stat 5 or SHP 2 in response to PRLR activation . ^^^ Finally , the role of SOCS proteins in regulating the biological activity of the PRLR was investigated . ^^^ Unlike SOCS 2 , both SOCS 1 and SOCS 3 abolished the ability of the PRLR to induce beta casein gene promoter activation . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| The proximal transduction pathways activated during PRLr associated signaling include the tyrosine kinases Jak 2 , Fyn and Tec , the phosphatase SHP 2 , the guanine nucleotide exchange factor Vav , and the signaling suppressor SOCS . ^^^ |
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| Interacting proteins: Q9NSE2 and P16471 |
Pubmed |
SVM Score :0.0 |
| Pregnancy failure also required the proinflammatory cytokine TNF alpha and correlated with the luteal induction of the prolactin receptor signaling inhibitors suppressor of cytokine signaling 1 ( Socs 1 ) and Socs 3 . ^^^ |
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