| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| No other agonists produced SNB , except ( 1S , 3S ) ACPD , which may be attributable to a nonselective action at mGluR 1 . ^^^ |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| The N terminal fragment of Cupidin , which was able to associate with metabotropic glutamate receptor 1 ( mGluR 1 ) , also interacted with F actin in vitro . ^^^ In keeping with this , F actin immunocytochemically colocalized with Cupidin in cultured cerebellar granule cells , and a Cupidin mGluR 1 actin complex was immunoprecipitated from crude cerebellar lysates using an anti Cupidin antibody . ^^^ |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| Apparent EC 50 of DHPG for mGluR 1 was slightly lower than that of ( + ) 1 aminocyclopentane trans 1 , 3 dicarboxylic acid ( ACPD ) . ^^^ |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| The pharmacological profiles of these currents suggest that the Qm current is likely mediated by mGluR 1 or mGluR 5 , while the ACPD current is mediated by receptors that are pharmacologically distinct from any of the currently cloned mGluRs . . ^^^ |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| A number of electrostatic and hydrogen bonding interactions can be detected between mGluR 1 agonists such as L Glu ( 1 ) , Quis ( 2 ) , and ( 1S , 3R ) ACPD ( 4 ) and binding site residues . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| The weak but selective mGluR 1 agonist ( S ) 3 hydroxyphenylglycine ( 100 microM ) completely inhibited IAHP , and the mGluR 1 antagonist ( S ) 4 carboxyphenylglycine ( 500 microM ) reduced IAHP inhibition produced by 5 microM ACPD from 73 + / 6 % to 22 + / 4 % . ^^^ Although activation of mGluR 1 agonists can also stimulate adenylate cyclase and activate PKA , inhibition of PKA and the effect of forskolin on IAHP with the Walsh peptide did not affect ACPD inhibition of IAHP . 9 . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| Both Type 1 mGluRs ( mGluRs 1 and / or 5 ) and Type 2 mGluRs ( mGluRs 2 and / or 3 ) probably contributed to the cAMP increase because ( 1 ) ACPD and L CCG 1 , which are more active on Type 2 mGluRs , were more effective than DHPG , which is more active on Type 1 mGluRs ; and ( 2 ) there was a significant difference in the effect of ACPD on the increase in cAMP , comparing mGluR 1 knockout mice with control mice . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| We have studied the effect of metabotropic glutamate receptors on the second messenger cAMP , and how it varies with age in light and dark reared cats ; the overall level of the metabotropic glutamate receptors mGluR 1 , 2 / 3 , and 5 during development ; the laminar distribution of these receptors ; and how the physiological effect of the metabotropic glutamate receptor agonist ACPD varies with layer . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| In rat cortical slices , AIDA antagonized the stimulatory ( mGluR 1 mediated ) effect of ( 1S , 3R ) ACPD on the depolarization induced outflow of D [ 3H ] aspartate , disclosing an inhibitory effect ascribable to ( 1S , 3R ) ACPD activating mGluR 2 and / or mGluR 4 . ^^^ In cells transfected with mGluR1a , AIDA competitively antagonized the stimulatory responses of glutamate and ( 1S , 3R ) 1 aminocyclopentane 1 , 3 dicarboxylic acid [ ( 1S , 3R ) ACPD ] on phosphoinositide hydrolysis ( pA 2 = 4 . 21 ) . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| Aminobicyclo [ 2 . 2 . 1 . ] heptane dicarboxylic acids ( ABHD ) , rigid analogs of ACPD and glutamic acid : synthesis and pharmacological activity on metabotropic receptors mGluR 1 and mGluR 2 . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| Increased immunoreactivity for mGluR 1 and mGluR2 / 3 was seen in all cultures 3 days after a brief exposure to Mg2+ free medium . 1S , 3R 1 aminocyclopentane 1 , 3 dicarboxylic acid ( ACPD ) induced rapid peak responses and gradual accumulations of intracellular Ca2+ in neurons . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| In a previous study we reported that the addition of a carboxylic group to the mGlu receptor agonist aminocyclopentane 1 , 3 dicarboxylate ( ACPD ) changes its properties from agonist to antagonist at both mGlu 1 and mGlu 2 receptors , and resulted in an increase in affinity at mGlu 4 receptors , with isomers being either agonists or antagonists . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| The selective mGlu 1 receptor antagonist LY 367385 was found to reduce excitatory responses to iontophoretically applied ACPD and DHPG whereas the mGlu 5 agonist CHPG was resistant to antagonism . ^^^ |
|
| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| Previously we have demonstrated that activation of group 1 mGluRs ( mGluR 1 and mGluR 5 ) with the broad spectrum mGluR agonist 1S , 3R 1 amino 1 , 3 cyclopentanedicarboxylate ( ACPD ) produced potentiation of ionotropic glutamate responses . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| Other inhibitors were ( 1S , 3R ) 1 aminocyclopentane 1 , 3 dicarboxylate ( ACPD ) , a broad spectrum mGluR agonist with preference for groups 1 and 2 and the mGluR 1 agonists / mGluR 2 antagonists ( S ) 3 carboxy 4 hydroxyphenylglycine ( 3 , 4 CHPG ) and ( S ) 4 carboxy 3 hydroxyphenylglycine ( 4 , 3 CHPG ) . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| The mGluR 1 agonist ( 1S , 3R ) 1 amino cyclopentane 1 , 3 dicarboxylic acid ( ACPD ) significantly potentiated NMDA elicited currents . mGluR1alpha mediated potentiation of NMDA responses was eliminated by the PLC inhibitor U 73122 . ^^^ |
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| Interacting proteins: Q9NSB8 and Q13255 |
Pubmed |
SVM Score :0.0 |
| Agreeing predictions obtained by modelling Q 5 binding to different experimental conformations of mGlu 1 , Q 5 was bound partially to an mGluR binding site in the presence of 1mM ACPD . ^^^ |
|