| Interacting proteins: P23471 and Q9NRY4 |
Pubmed |
SVM Score :0.0 |
| Here , we report that Ptprz deficient mice exhibit impairments in hippocampus dependent contextual fear memory because of abnormal tyrosine phosphorylation of p 190 RhoGAP , a GTPase activating protein ( GAP ) for Rho GTPase . ^^^ We found that phosphorylation at Y 1105 , a major tyrosine phosphorylation site on p 190 RhoGAP , is decreased 1h after the conditioning in the hippocampus of wild type mice , but not of Ptprz deficient mice . ^^^ Pleiotrophin , a ligand for Ptprz , increased tyrosine phosphorylation of p 190 RhoGAP in B 103 neuroblastoma cells . ^^^ Furthermore , Ptprz selectively dephosphorylated pY 1105 of p 190 RhoGAP in vitro , and the tyrosine phosphorylation at Y 1105 controls p 190 RhoGAP activity in vivo . ^^^ These results suggest that Ptprz plays a critical role in memory formation by modulating Rho GTPase activity through dephosphorylation at Y 1105 on p 190 RhoGAP . . ^^^ |
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| Interacting proteins: Q9NRY4 and P23471 |
Pubmed |
SVM Score :0.0 |
| Here , we report that Ptprz deficient mice exhibit impairments in hippocampus dependent contextual fear memory because of abnormal tyrosine phosphorylation of p 190 RhoGAP , a GTPase activating protein ( GAP ) for Rho GTPase . ^^^ We found that phosphorylation at Y 1105 , a major tyrosine phosphorylation site on p 190 RhoGAP , is decreased 1h after the conditioning in the hippocampus of wild type mice , but not of Ptprz deficient mice . ^^^ Pleiotrophin , a ligand for Ptprz , increased tyrosine phosphorylation of p 190 RhoGAP in B 103 neuroblastoma cells . ^^^ Furthermore , Ptprz selectively dephosphorylated pY 1105 of p 190 RhoGAP in vitro , and the tyrosine phosphorylation at Y 1105 controls p 190 RhoGAP activity in vivo . ^^^ These results suggest that Ptprz plays a critical role in memory formation by modulating Rho GTPase activity through dephosphorylation at Y 1105 on p 190 RhoGAP . . ^^^ |
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